The Modular and Integrated Data Assimilation System at Environment and Climate Change Canada (MIDAS v3.9.1) by M. Buehner, J.-F. Caron, E. Lapalme, A. Caya, P. Du, Y. Rochon, S. Skachko, M. Bani Shahabadi, S. Heilliette, M. Deshaies-Jacques, W. Chang, M. Sitwell

“…<p>The Modular and Integrated Data Assimilation System (MIDAS) software (version 3.9.1) is described in terms of its range of functionality, modular software design, parallelization strategy, and current uses within real-time operational and experimental systems. MIDAS is developed at Environment and Climate Change Canada for both operational and research applications, including all atmospheric data assimilation (DA) elements of the Canadian operational numerical weather prediction systems. …”
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Determining the association of hyperoxia while on extracorporeal life support with mortality in neonates following Norwood operation by Beshish Asaad G., Aljiffry Alaa, Xiang Yijin, Evans Sean, Scheel Amy, Harriott Ashley, Patel Shayli, Amedi Alan, Harding Amanda, Davis Joel, Shashidharan Subhadra, Kwiatkowski David M.

“…Conclusion: Neonates with hyperoxia (PaO2 > 182 Torr) during the first 48-hour of ECLS post-Norwood operation had 5 times higher odds of mortality in the unadjusted analysis, however, this was insignificant when adjusting for confounding variables. …”
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Human placental extract improves liver cirrhosis in mice with regulation of macrophages and senescent cells by Natsuki Ishikawa, Yusuke Watanabe, Yuichirou Maeda, Tomoaki Yoshida, Naruhiro Kimura, Hiroyuki Abe, Akira Sakamaki, Hiroteru Kamimura, Takeshi Yokoo, Kenya Kamimura, Atsunori Tsuchiya, Shuji Terai

“…In vitro and in vivo, real time-PCR and immunostaining were performed for HPE mechanistic analysis. …”
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Examining differences in exposure to digital marketing of unhealthy foods reported by Canadian children and adolescents in two policy environments by Laura Vergeer, Carolina Soto, Mariangela Bagnato, Elise Pauzé, Ashley Amson, Tim Ramsay, Dana Lee Olstad, Vivian Welch, Monique Potvin Kent

“…Abstract Background There has been relatively little research on youth’s exposure to food marketing on digital media, which is important as new digital platforms emerge and youth spend more time online. Evidence evaluating different policy approaches to restricting digital food marketing to children is also limited. …”
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Sprengel deformity: What is the functional outcome of conservative treatment versus surgical correction? by C. Antfang, A. Frommer, G. Gosheger, G. Toporowski, A. Laufer, J. D. Rölfing, R. Roedl, B. Vogt

“…The median Rigault score was lowered from 3 (IQR 3–3) to 1 (IQR 1–2). The median time to return to daily life was 3 months (IQR 2.2–3.5). …”
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Evidence for the Involvement of Lipid Rafts and Plasma Membrane Sphingolipid Hydrolases in Pseudomonas aeruginosa Infection of Cystic Fibrosis Bronchial Epithelial Cells by Domitilla Schiumarini, Nicoletta Loberto, Giulia Mancini, Rosaria Bassi, Paola Giussani, Elena Chiricozzi, Maura Samarani, Silvia Munari, Anna Tamanini, Giulio Cabrini, Giuseppe Lippi, Maria Cristina Dechecchi, Sandro Sonnino, Massimo Aureli

“…We also report for the first time that Pseudomonas aeruginosa infection causes a recruitment of plasma membrane-associated glycosphingolipid hydrolases into lipid rafts of CuFi-1-infected cells. …”
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The Rapid Effect of Bisphenol-A on Long-Term Potentiation in Hippocampus Involves Estrogen Receptors and ERK Activation by Xiaowei Chen, Yu Wang, Fang Xu, Xiaofei Wei, Junfang Zhang, Chuang Wang, Hua Wei, Shujun Xu, Peiyun Yan, Wenhua Zhou, Istvan Mody, Xiaohong Xu, Qinwen Wang

“…In the present study, for the first time we investigated the effect of different doses of BPA on hippocampal LTP in rat brain slices. …”
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Effect of long-term transcutaneous auricular vagus nerve stimulation in multiple system atrophy-cerebellar subtype: a case report by Zhao-Di Wang, Zhao-Di Wang, Xiao-Ping Cheng, Zhen-Yi Liu, Di Wu, Jun Ni, Chuan-Juan Chen, Chuan-Juan Chen, Xin-Yuan Chen, Xin-Yuan Chen

“…Hence, we performed taVNS treatment for one MSA-C patient to explore whether taVNS could alleviate patient’s motor and non-motor symptoms.Case presentationA 65-year-old woman diagnosed with MSA-C received taVNS treatment for the following duration and course: once a day, 40 min a time, 20 times a month continually for 12 months. …”
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CASC8 activates the pentose phosphate pathway to inhibit disulfidptosis in pancreatic ductal adenocarcinoma though the c-Myc-GLUT1 axis by Hong-Fei Yao, Jieqiong Ge, Jiahao Chen, Xiaoyan Tang, Chunjing Li, Xiao Hu, Abousalam Abdoulkader Ahmed, Yunlong Pu, Guihua Zhou, Tongyi Zhang, Zhiwei Cai, Chongyi Jiang

“…Protein stability, western blotting and quantitative real-time PCR assays were performed to reveal potential molecular mechanism. …”
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Volumetric trans-scale imaging of massive quantity of heterogeneous cell populations in centimeter-wide tissue and embryo by Taro Ichimura, Taishi Kakizuka, Yoshitsugu Taniguchi, Satoshi Ejima, Yuki Sato, Keiko Itano, Kaoru Seiriki, Hitoshi Hashimoto, Ko Sugawara, Hiroya Itoga, Shuichi Onami, Takeharu Nagai

“…We applied the imaging technique to 1.2 cm-wide section of mouse brain, and successfully observed various regions of the brain with sub-cellular resolution in a single FOV. We also performed time-lapse imaging of a 1-cm-wide vascular network during quail embryo development for over 24 hr, visualizing the movement of over 4.0×105 vascular endothelial cells and quantitatively analyzing their dynamics. …”
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The levels of osteopontin in human milk of Chinese mothers and its associations with maternal body composition by Huijuan Ruan, Qingya Tang, Xuan Zhao, Yajie Zhang, Xuelin Zhao, Yi Xiang, Wei Geng, Yi Feng, Wei Cai

“…Conclusions: The levels of OPN in human milk of Chinese mothers showed dynamic changes with the extension of lactation time. The OPN in human milk was related to the mother’s body composition but not related to related humoral factors.…”
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Effect of Whole Wheat Noodles on Biochemical Indexes and Histopathology of Type 2 Diabetic Rats by Li WU, Yuan ZHANG, Chunhong TANG, Huan YOU, Haijun CHANG, Shuai ZHANG

“…The high-fat group was injected intraperitoneally with streptozotocin (STZ) solution at one time to establish a type 2 diabetic rat model. Then, the diabetic rats were intervened with low, medium, and high doses of whole wheat noodles feed for 8 weeks, respectively. …”
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Real‐World Study of EGFR‐TKI Rechallenge With Another TKI After First‐Line Osimertinib Discontinuation in Patients With EGFR‐Mutated Non‐Small Cell Lung Cancer: A Subset Analysis o... by Kei Sonehara, Kazunari Tateishi, Kiyotaka Yoh, Kazuhiro Usui, Yukio Hosomi, Kazuma Kishi, Go Naka, Kageaki Watanabe, Shu Tamano, Kohei Uemura, Hideo Kunitoh

“…The most common rechallenge EGFR‐TKI was afatinib (n = 24, 45.3%), followed by gefitinib (n = 16, 30.2%) and erlotinib (n = 8, 15.1%). The real‐world time to treatment failure (rwTTF) was 7.3 months. …”
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Mid-term outcome and quality of life after Bentall procedure: single-center experience by I. O. Stetsyuk, L. R. Stetsiuk, B. M. Todurov, I. Yu. Mokryk, V. I. Zaviiskyi, I. P. Nechai, V. B. Demyanchuk, O. V. Zelenchuk

“…The average duration of the operations was 244.48 ± 7.67 minutes, the total duration of artificial blood circulation was 138.73 ± 6.47 minutes, aorta clamping time – 95.82 ± 4.79 minutes. The mean duration of hospital staying was 16.98 ± 0.91 days, intensive care unit – 4.84 ± 0.33 days. …”
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Call to Action: Lead Pharmacy into the Next Decade by Kerry K Fierke, Gardner Lepp, Bridget McGugan, Marta Brooks, Gregory Zumach

“…Call to Action Through our work as scholars, we can provide evidence-based, pertinent, timely solutions to address these issues, in ways that make it easily transferable to broad audiences. …”
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Establishment and practice of the Traditional Chinese Medicine nursing clinic under the mode of Green treatment of tumor (肿瘤中医绿色护理门诊的建立与实践) by LIU Shuhong (刘书红), ZHAO Yanan (赵亚楠), YAN Kang (严康)

“…In the construction of tumor-green Traditional Chinese Medicine(TCM) nursing clinic, a series of standards, scientific management modes and modified outpatient operation quality control system have been formulated. At the same time, tumor-green nursing technical specifications and standards have been formulated, and a Chinese version of pan-Canadian Oncology Symptom Triage and Remote Support (COSTaRS) Scale has been introduced for the overall, dynamic and comprehensive evaluation of tumor patients. …”
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Association of ERAP1 and ERAP2 gene polymorphisms and ERAP2 protein with the susceptibility and severity of rheumatoid arthritis in the Ukrainian population by Iryna Kril, Iryna Kril, Andrzej Wiśniewski, Agnieszka Tarnowska, Khrystyna Lishchuk-Yakymovych, Yaryna Bojko, Piotr Kuśnierczyk, Valentyna V. Chopyak, Izabela Nowak

“…Patients with mild disease activity (DAS28 &lt; 3.2) released a concentration of ERAP2 four times lower than that of patients with severe disease activity (DAS28 &gt; 5.1). …”
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Sex-differences in the risk of carpal tunnel syndrome: results from a large Ontario, Canada worker cohort by Fanni R. Eros, Paul A. Demers, Jeavana Sritharan

“…Methods The Occupational Disease Surveillance System (ODSS) links accepted lost time compensation claims to health administrative databases. …”
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Dynamic 19F-MRI of pulmonary ventilation in lung transplant recipients with and without chronic lung allograft dysfunction by Mary A. Neal, PhD, Saskia Bos, MD, PhD, Charlotte W. Holland, MRCP, Kieren G. Hollingsworth, Gerard Meachery, FRCP, Arun Nair, MD, FRCP, James L. Lordan, FRCP, Andrew J. Fisher, FRCP, PhD, Peter E. Thelwall, PhD

“…Background: By the time chronic lung allograft dysfunction (CLAD), with its main phenotypes bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS), is diagnosed by pulmonary function testing, irreversible damage to the lung allograft may already have occurred. …”
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What have we learnt from histology about the efficacy of coronary imaging modalities in assessing plaque composition? by Nathan Angelo Lecaros Yap, Zahid Khan, Zahid Khan, Xingwei He, Jae-Geun Lee, Soe Maung, Kimberley R. Morgan, Tingquan Zhou, Helle Precht, Patrick W. Serruys, Patrick W. Serruys, Hector M. Garcia-Garcia, Yoshinobu Onuma, Sean Hynes, Sebastian Kelle, Anthony Mathur, Anthony Mathur, Andreas Baumbach, Andreas Baumbach, Christos V. Bourantas, Christos V. Bourantas

“…Intravascular imaging was introduced for this purpose 40 years ago enabling for the first time in vivo plaque characterization. Since then, several studies have evaluated the efficacy of the existing intravascular imaging modalities in assessing plaque pathology and composition and their potential in guiding intervention and predicting vulnerable plaques. …”
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