Optineurin overexpression ameliorates neurodegeneration through regulating neuroinflammation and mitochondrial quality in a murine model of amyotrophic lateral sclerosis by Shumin Zhao, Shumin Zhao, Ranran Chen, Ranran Chen, Yi An, Yali Zhang, Yali Zhang, Cheng Ma, Ying Gao, Ying Gao, Yanchao Lu, Yanchao Lu, Fei Yang, Fei Yang, Xue Bai, Xue Bai, Jingjing Zhang, Jingjing Zhang, Jingjing Zhang

“…However, the role of the OPTN gene in ALS caused by SOD1 mutations is ambiguous.MethodsThe murine Optn lentivirus and empty vector lentivirus were injected into SOD1G93A mice after discovering variations in Optn expression over time. The phenotype onset date, life span, locomotor activity, and pathological changes in the spinal cord were determined and recorded subsequently. …”
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Characterizing Glycemic Control and Sleep in Adults with Long-Standing Type 1 Diabetes and Hypoglycemia Unawareness Initiating Hybrid Closed Loop Insulin Delivery by Susan Kohl Malone, Amy J. Peleckis, Laura Grunin, Gary Yu, Sooyong Jang, James Weimer, Insup Lee, Michael R. Rickels, Namni Goel

“…Whether use of a hybrid closed loop (HCL) insulin delivery system with integrated continuous glucose monitoring (CGM) designed for improving glycemic control, relates to better sleep across time in this population remains unknown. The purpose of this study was to describe long-term changes in glycemic control and objective sleep after initiating hybrid closed loop (HCL) insulin delivery in adults with type 1 diabetes and hypoglycemia unawareness. …”
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Characteristics of TSPO expression in marmoset EAE by Irene Falk, Dragan Maric, Emily Leibovitch, Pascal Sati, Jennifer Lefeuvre, Nicholas J. Luciano, Joseph Guy, Seung-Kwon Ha, David R. Owen, Franklin Aigbirhio, Paul M. Matthews, Daniel S. Reich, Steven Jacobson

“…The shift in TSPO expression from Iba + microglia/macrophages to astrocytes over time is similar to patterns suggested by earlier neuropathology studies in MS. …”
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Innovative CO2-NBs-assisted ultrasonication for the phytochemical extraction of peanut (Arachis hypoga) shells: Synthesis and characterization of CO2-nanobubbles by Nayyar Iqbal, Miral Javed, Ramy M. Khoder, Areej Areej, Renyu Zheng, Shanbai Xiong, Ibrahim Khalifa, Hassan Barakat, Youming Liu

“…Response surface methodology (RSM) provided optimization parameters, including ultrasonic power of 358.76 W, surfactant concentration of 4.54 %, and extraction time of 41.41 min. HPLC analysis identified distinct peaks corresponding to polyphenolic compounds such as gallo-catechin, catechin gallate, resveratrol, and luteolin, confirming their presence and concentrations in the peanut shell extract (PSE). …”
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Workplace violence against healthcare professionals in a multiethnic area: a cross-sectional study in southwest China by Ying Wang, Qunhong Wu, Mingli Jiao, Kexin Jiang, Huiying Fang, Yameng Wang, Haonan Jia, Ruohui Chen, Lifeng Wei, Gangyu Zhang, Yuanheng Li, Jingqun Li, Xiaowen Jia, Omar Yacouba Ismael, Jingfu Mao

“…Both Han and ethnic minority participants considered security measures as the most useful intervention, while changing the time of shift the most useless one.Conclusion Our study comprehensively described WPV towards healthcare professionals in a multiethnic minority area. …”
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Effectiveness of screening for colorectal cancer with a faecal occult-blood test, in Finland by J Pitkäniemi, K Seppä, M Hakama, O Malminiemi, T Palva, M-S Vuoristo, H Järvinen, H Paimela, P Pikkarainen, A Anttila, L Elovainio, T Hakulinen, S Karjalainen, L Pylkkänen, M Rautalahti, T Sarkeala, H Vertio, N Malila

“…In 2012, the programme covered 43% of the target age population in Finland.Results The median follow-up time was 4.5 years (maximum 8.3 years), with a total of 1.6 million person-years. …”
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VACCIMEL, an allogeneic melanoma vaccine, efficiently triggers T cell immune responses against neoantigens and alloantigens, as well as against tumor-associated antigens by Ibel Carri, Ibel Carri, Erika Schwab, Juan Carlos Trivino, Erika M. von Euw, Morten Nielsen, Morten Nielsen, José Mordoh, María Marcela Barrio

“…On the other hand, we observed that the immunogenic epitopes are not conserved across patients, despite sharing HLA and that immune responses fluctuate over time. Finally, a positive correlation between VACCIMEL antigen expression and the intensity of the T cell responses was found. …”
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Lymphatic leaks – success of intranodal lymphangiogram first strategy by Alan Campbell, Diana Velazquez-Pimentel, Matthew Seager, Richard Hesketh, Julian Hague, Jowad Raja, Jocelyn Brookes, An Ngo, Miles Walkden, Anthie Papadopoulou, Daron Smith, Borzoueh Mohammadi, Ravi Barod, Mohammed Rashid Akhtar, Jimmy Kyaw Tun, Deborah Elise Low, Ian Daniel Renfrew, Tim Fotheringham, Conrad von Stempel

“…Clinical success was defined as reduction in drain output to less than 20 mL per 24 h, or no further insensible lymph leak. Time to clinical success after ILAG and adjunctive embolisation was recorded. …”
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Impact of landscape patterns on river water quality: Spatial-scale effects across an agricultural-urban interface by Kun Mei, Haonan Shi, Yupeng Wu, Randy A. Dahlgren, Xiaoliang Ji, Minmin Yang, Yueru Guan

“…In this study, we onducted an in-depth and meticulous exploration of the relationship between the landscape patterns and water quality in the Wen-Rui Tang River watershed at four distinct spatial scales (single subwatershed, dynamic subwatershed, riparian buffer, and reach buffer) and two time scales (dry season and rainy season). Regression models were used to investigate the quantitative impact of landscape patterns on water quality, redundancy analysis was employed to assess the overall explanatory power, and non-parametric point-of-change analysis was applied to evaluate variations in water quality along landscape gradients and identify critical landscape threshold ranges. …”
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Species-specific mercury speciation in billfishes and its implications for food safety monitoring and dietary advice by Anaïs Médieu, David Point, Valérie Allain, Nathalie Bodin, Mélanie Lemire, Pierre Ayotte, Zahirah Dhurmeea, Matthieu Waeles, Laure Laffont, Antoine Le Gohalen, François Roupsard, Anne Lorrain

“…Yet, no matter the species, the frequency of recommended weekly billfish meals decreased with increasing fish size, given that mercury naturally accumulates over time. When assessing potential risks of billfish consumption, we therefore recommend measuring methylmercury, rather than total mercury, and relying on a large number of samples to cover a broad range of fish sizes. …”
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Evaluation of the association between bevacizumab concentration and clinical outcomes in patients with breast cancer brain metastasis by Chih-Ning Cheng, Yun-Jung Tsai, Huai-Hsuan Chiu, Tom Wei-Wu Chen, Ching-Hung Lin, Yen-Sheng Lu, Ching-Hua Kuo

“…Furthermore, a positive correlation was observed between time-weighted average concentration of plasma bevacizumab and CSF penetration of etoposide on day 2 (post-bevacizumab) relative to day 1 (pre-bevacizumab) (r = 0.83; p = 0.042). …”
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Exploring the metabolic dynamics, storage stability, and functional potential of Lacticaseibacillus rhamnosus Probio-M9-fermented milk by Xiaoye Liu, Kaiyang Liu, Jie Yang, Hui Qiao, Lai-Yu Kwok, Wenyi Zhang

“…Metabolite profiles were generated using ultra-high performance liquid chromatography coupled with quadrupole time-of-flight MS with multiple segment extraction. …”
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Artificially Cultivated Ophiocordyceps sinensis Alleviates Diabetic Nephropathy and Its Podocyte Injury via Inhibiting P2X7R Expression and NLRP3 Inflammasome Activation by Chao Wang, Xiao-xia Hou, Hong-liang Rui, Li-jing Li, Jing Zhao, Min Yang, Li-jun Sun, Hong-rui Dong, Hong Cheng, Yi-Pu Chen

“…The expression of mRNA and protein of P2X7R and NLRP3 inflammasome (NLRP3, ASC, and caspase-1) and downstream effectors (IL-1β and IL-18), as well as podocyte-associated molecules, was determined by real-time quantitative PCR and Western blot assay, respectively. …”
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Testing a multi-behavioral intervention to improve oral health behaviors in the pediatric dental surgery population: protocol for the PROTECT trial by Joanna Buscemi, Teresa G. Borowski, David Avenetti, Lisa Tussing-Humphreys, Lisa Tussing-Humphreys, Lisa Tussing-Humphreys, Molly Martin, Molly Martin, Marc S. Atkins, Teresa Marshall, Michael Berbaum, Helen H. Lee, Helen H. Lee

“…Our two primary outcomes are parental assisted toothbrushing (twice/day, 2 min each time) and reduced added sugar consumption (less than 10% of overall daily caloric intake). …”
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Effects of temporal, spatial, and environmental factors on ciliates community in northeastern South China Sea, with notes on co-occurrence patterns of environment, phytoplankton, a... by Weiwei Liu, Zijun Cheng, Shaowei Wen, Gang Li, Zhixin Ke, Daning Li, Yehui Tan

“…This study improves our understanding for the mechanisms of community structuring of microzooplankton in the open sea across both space and time.IMPORTANCECiliates are important components of microplanktons and play a crucial role in global nutrient cycling. …”
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Identifikasi Tanaman Obat Indonesia Melalui Citra Daun Menggunakan Metode Convolutional Neural Network (CNN) by Budi Setiyono, Muhammad Riv’an Arif, Qonita Qurratu Aini, Theophil Henry Soegianto, Jasti Ohanna, Ricky Andrean Fernanda Gunawan, Ayu Putri Rizkia

“…Indonesian people have used plants as traditional medicine since ancient times. At this time, human knowledge in recognizing the types of medicinal plants is decreasing due to humans' limited memory. …”
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„Wykazy czasopism MNiSW 2017 i 2019”, „ICI Journal Master List 2014–2017” a polskie czasopisma z historii nauki, historii, filozofii nauki oraz naukoznawstwa by Michał Kokowski

“…In addition, it was hoped that for the good of Polish science, some errors of the “List of journals of the Ministry of Science and Higher Education of the Polish Republic 2019” would be removed in a short time, as some magazines received too low marks (this statement results from a comparison of journals’ achievements, including bibliometric indicators). …”
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Efficacy and safety of ondansetron orally soluble pellicle for preventing moderate- to high-emetic risk chemotherapy-induced nausea and vomiting by Lu Sun, Jia Ma, Yajuan Zhou, Xiaofang Ying, Gai Liang, Guoliang Pi, Ying Li, Yan Luo, Jianping Bi, Hanping He, Yi Peng

“…Methods In total, 163 patients with malignant tumours received 24 mg of ondansetron via orally soluble pellicles at 30 min before chemotherapy (8 mg each time for three consecutive administrations). The incidence rates of nausea and vomiting in the three days after chemotherapy were recorded. …”
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Segmentation of Dynamic Total-Body [18F]-FDG PET Images Using Unsupervised Clustering by Maria K. Jaakkola, Maria Rantala, Anna Jalo, Teemu Saari, Jaakko Hentilä, Jatta S. Helin, Tuuli A. Nissinen, Olli Eskola, Johan Rajander, Kirsi A. Virtanen, Jarna C. Hannukainen, Francisco López-Picón, Riku Klén

“…Clustering time activity curves of PET images have been used to separate clinically relevant areas of the brain or tumours. …”
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Taxonomic composition and biodiversity of the gut microbiome from patients with irritable bowel syndrome, ulcerative colitis, and asthma by A. Y. Tikunov, A. N. Shvalov, V. V. Morozov, I. V. Babkin, G. V. Seledtsova, I. O. Voloshina, I. P. Ivanova, A. V. Bardasheva, V. V. Morozova, V. V. Vlasov, N. V. Tikunova

“…A signif icant increase in the proportion of Halomonas and Vibrio sequences in the gut microbiota in patients with BA has been described for the f irst time.…”
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