Tailored BEST Exercise Protocol in Heart Failure Rehabilitation by Kevin Triangto, Basuni Radi, Bambang Budi Siswanto, Tresia Fransiska Ulianna Tambunan, Teuku Heriansyah, Alida Rosita Harahap, Aria Kekalih, Ade Meidian Ambari, Bambang Dwiputra, Dwita Rian Desandri, Hajime Katsukawa, Anwar Santoso

“…Poor responders also improved in chest expansion, sit-to-stand time, and postural balance, with minor 6MWT gains (407.33±72.50 meters). …”
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Angel or devil: the dual roles of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucopyranoside in the development of liver injury based on integrating pharmacological techniques: a system... by Jiajie Jiang, Jiajie Jiang, Qixiu Wang, Qiang Wu, Bobin Deng, Cui Guo, Jie Chen, Jinhao Zeng, Yaoguang Guo, Xiao Ma

“…STATA and Python were used for statistical analysis, including dose-effect maps, 3D maps and radar charts to show the dose-time-effect relationship of TSG on hepatoprotection and hepatotoxicity.ResultsAfter a rigorous screening process, a total of 24 studies encompassing 564 rodents were selected for inclusion in this study. …”
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Noncoding RNA profiling in omentum adipose tissue from obese patients and the identification of novel metabolic biomarkers by Yongjiao Zhang, Yongjiao Zhang, Ao Chen, Ao Chen, Sumei Lu, Dong Liu, Xiaolei Xuan, Xiaofei Lei, Mingwei Zhong, Fei Gao

“…Subsequent analyses included functional annotation with GO and KEGG pathway mapping, validation via real-time quantitative polymerase chain reaction (qRT‒PCR), the exploration of protein‒protein interactions (PPIs), and the identification of key regulatory genes through network analysis.ResultsThe results indicated that, compared with those in healthy individuals, various lncRNAs, circRNAs, and miRNAs were significantly differentially expressed in obese subjects. …”
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Long-Term Follow-Up of Patients with Advanced Colorectal Liver Metastasis: A Survival Analysis from the Randomized Controlled Multicenter Trial LIGRO by Dennis Björk, MD, Kristina Hasselgren, MD, PhD, Bård I. Røsok, MD, PhD, Peter N. Larsen, MD, PhD, Ernesto Sparrelid, MD, PhD, Gert Lindell, MD, PhD, Nicolai A. Schultz, MD, PhD, Bjorn A. Bjørnbeth, MD, PhD, Bengt Isaksson, MD, PhD, Anna Lindhoff Larsson, RN, Magnus Rizell, MD, PhD, Bergthor Björnsson, MD, PhD, Per Sandström, MD, PhD

“…The estimated median follow-up time was 93 months. Estimated median overall survival times were 45 months in the ALPPS group and 27 months in the TSH group (P = 0.057), with 5-year survival rates of 31% and 20%, respectively. …”
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Un service de table en bronze et argent soigneusement rangé dans une cave à Reims/Durocortorum by Michaël Brunet, Fabienne Médard, Magalie Cavé, Stéphane Sindonino

“…The degree of alteration of the remains does not allow us to state with certainty the wealth of the domus to which this cellar belonged, but the proximity of three hypocausts, which were abandoned at the same time, suggests that it was associated with a comfortable Roman dwelling. …”
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To construct and validate a risk score model of angiogenesis-related genes to predict the prognosis of hepatocellular carcinoma by Duangui Gao, Yuan Lu, Tianpeng Jiang, Qinghong Duan, Zhi Huang

“…Finally, in the three pairs of HCC tissues and tissue adjacent to carcinoma by real-time fluorescent quantitative PCR (qRT_PCR) and western blotting (WB) to evaluate angiogenesis-related genes (ATP2A3 AEBP1 PNMA1, PLAT) expression level in HCC, and AEBP1 was knocked out in HCCLM3 cells, which is to study AEBP1 biological function in HCC. …”
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The Superiority of Removable Contact Splints in the Healing of Diabetic Foot during Postoperative Care by Vladimíra Fejfarová, Jaroslav Pavlů, Robert Bém, Veronika Wosková, Michal Dubský, Andrea Němcová, Alexandra Jirkovská, Bedřich Sixta, Karol Sutoris, Filip Thieme, David G. Armstrong, Eliška Vrátná, Jitka Hazdrová, Věra Lánská

“…., the number of healed patients, healing time, and duration of antibiotic (ATB) therapy) and secondary outcomes (e.g., number of reamputations and number and duration of rehospitalizations) with regard to the operation regions across all study groups. …”
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Genotyping of potato samples from the GenAgro ICG SB RAS collection using DNA markers of genes conferring resistance to phytopathogens by I. V. Totsky, I. V. Rozanova, A. D. Safonova, A. S. Batov, Yu. A. Gureeva, E. K. Khlestkina, A. V. Kochetov

“…Conducting a permanent phenotypic evaluation is associated with difficulties, for example, it is not always possible to work with pathogens, and phenotypic evaluation is very costly and time consuming. However, the use of DNA markers linked to resistance genes can significantly speed up and reduce the cost of the breeding process. …”
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Integration of single-cell transcriptomics and bulk transcriptomics to explore prognostic and immunotherapeutic characteristics of nucleotide metabolism in lung adenocarcinoma by Kai Zhang, Kai Zhang, Luyao Wang, Huili Chen, Lili Deng, Mengling Hu, Ziqiang Wang, Yiluo Xie, Chaoqun Lian, Xiaojing Wang, Xiaojing Wang, Jing Zhang

“…The model’s predictive validity was evaluated using KM survival and timeROC curves. Based on the prognostic model, LUAD patients were classified into different nucleotide metabolism subtypes, and the differences between patients of different subtypes were explored in terms of genomic mutations, functional enrichment, tumor immune characteristics, and immunotherapy responses. …”
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Determining the effect of frailty on survival in advanced ovarian cancer: study protocol for a prospective multicentre national cohort study (FOLERO) by Daniel Hunde, Niklas Ekerstad, Mihaela Asp, Päivi Kannisto, Madelene Wedin, Charlotte Palmqvist, Pernilla Dahm-Kähler, Yvonne Brandberg, Mirna Abraham-Nordling, Kristina Åhlund, Vilhelm Mörlin, Nina Groes-Kofoed, Sahar Salehi

“…The result of the study will have a direct impact on clinical management and patient-selection as the results are expected to have a high external validity. Total study-time is 5 years, with 3 years of accrual. All participating centres started accrual by September 2024. …”
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The hydraulic performance and clogging characteristics of a subsurface drip irrigation system operating for five years in the North China plain by Li Zaiyu, Mo Yan, Gao Hao, Gong Shihong, Zhang Yanqun, Li Guangyong, Wu Feng

“…Owing to the well-designed pressure regulation and air exhaust system used in this SDI research, along with higher soil moisture in the crop root zone, the negative linear relationship between Dra and mc was most significant (p < 0.01). Based on time projection, this SDI system could operate normally for 8–11 years (Dra, Cu ≥ 80 %). …”
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A multidimensional assessment of adverse events associated with paliperidone palmitate: a real-world pharmacovigilance study using the FAERS and JADER databases by Siyu Lou, Zhiwei Cui, Yingyong Ou, Junyou Chen, Linmei Zhou, Ruizhen Zhao, Chengyu Zhu, Li Wang, Zhu Wu, Fan Zou

“…Noteworthy, unexpected signals not listed in the drug label were also identified, such as psychosexual disorders, prolactin-producing pituitary tumors, suicide attempt, and sudden death. The median onset time for all ADEs was 40 days. Furthermore, gender-based difference in risk signals was detected. …”
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Elevated Circulating Levels of Inflammatory Markers in Patients with Acute Coronary Syndrome by Hamad Al Shahi, Kazunori Shimada, Katsumi Miyauchi, Takuma Yoshihara, Eiryu Sai, Tomoyuki Shiozawa, Ryo Naito, Tatsuro Aikawa, Shohei Ouchi, Tomoyasu Kadoguchi, Tetsuro Miyazaki, Hiroyuki Daida

“…The levels of inflammatory cytokines and chemokine were measured by using real-time quantitative polymerase chain reaction and immunoassays. …”
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Detection and characterization of bovine hepacivirus in cattle and sheep from Hulunbuir, northeastern China by Jingge Ma, Jingge Ma, Zhiwei Wei, Liang Li, Wei Wang, Ziyan Liu, Ziyan Liu, Ning Liu, Feng Wei, Xiangyu Zheng, Zedong Wang

“…Recombination analysis revealed the intergenerational relationships among the viral strains obtained from cattle and sheep.ConclusionWe identified genetic diversity in subtype G strains in cattle and detected a BovHepV strain in a sheep for the first time in northeastern China, confirming cross-species transmission and co-circulation between cattle and sheep, thus expanding the virus’s host range.…”
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Impact of antibiotic prophylaxis on gut microbiota in colorectal surgery: insights from an Eastern European stewardship study by Irina Cezara Văcărean-Trandafir, Roxana-Maria Amărandi, Iuliu Cristian Ivanov, Loredana Mihaiela Dragoș, Mihaela Mențel, Ştefan Iacob, Ştefan Iacob, Ana-Maria Muşină, Ana-Maria Muşină, Elena-Roxana Bărgăoanu, Cristian Ene Roată, Cristian Ene Roată, Ștefan Morărașu, Ștefan Morărașu, Valeri Țuțuianu, Marcel Ciobanu, Mihail-Gabriel Dimofte, Mihail-Gabriel Dimofte

“…We analyzed fecal samples collected from patients before and 7 days post-antibiotic treatment, focusing on the V3–V4 region of the 16S rRNA gene.ResultsOur findings indicate that inconsistent antibiotic prophylaxis policies—varying in type, dosage, or therapy duration—significantly impacted the gut microbiota and led to more frequent dysbiosis compared to stricter prophylactic antibiotic practices (single dose, single product, limited time).DiscussionWe emphasize the need for standardized antibiotic prophylaxis protocols to minimize dysbiosis and its associated risks, promoting more effective antimicrobial use, particularly in low- and middle-income countries (LMICs).…”
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Fatty acids from soybeans: compatibility with Panonychus citri (Acari: Tetranychidae) and its two predators☆ by Qayyoum Muhammad Asif, Khan Bilal Saeed, Song Zi-Wei, Yi Tian-Ci, Inayat Rehan, Akram Muhammad Irfan, Mobarak Syed Husne, Li Dun-Song

“…Soybean oil showed the least toxicity, with the highest LT50 (Lethal Time) values for N. californicus (LDM: 1.19 h, TSM: 1.27 h). …”
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New Approach to Improving the Prognosis of Ischemic Stroke by Regulating SCFAs with Acupuncture-Rehabilitation Therapy Based on Gut-Brain Axis by TANG Qiang, LIU Chong, CHAI Fanglei, ZHANG Jinpeng, LI Hongyu, ZHU Luwen

“…Inflammation plays an important role in the progression of stroke.The inflammatory response of ischemic stroke is a dynamic process,which occurs within a short time after ischemia and then affects the central nervous system. …”
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Spatial and seasonal determinants of arthropod community composition across an agro-ecosystem landscape by P. Burgess, G.S. Betini, A. Cholewka, J.R. deWaard, S. deWaard, C. Griswold, P.D.N. Hebert, A. MacDougall, K.S. McCann, J. McGroarty, E. Miller, K. Perez, S. Ratnasingham, C. Reisiger, D. Steinke, E. Wright, E. Zakharov, J.M. Fryxell

“…Significant effects of time remained after accounting for environmental variables, with little independent effect of spatial distance. …”
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Reproductive strategies in loggerhead sea turtle Caretta caretta: polyandry and polygyny in a Southwest Atlantic rookery by Laís Amorim, Lara Chieza, Jake A. Lasala, Sarah de Souza Alves Teodoro, Wesley D. Colombo, Ana Carolina Barcelos, Paula Rodrigues Lopes Guimarães, João Luiz Guedes da Fonseca, Ana Claudia Jorge Marcondes, Alexsandro Santos, Sarah Vargas

“…Our research aimed to investigate the presence of multiple paternity in loggerhead turtle (Caretta caretta) nests for the first time in Brazil. We analyzed 534 hatchlings from 43 nests associated with 42 females during the 2017/18 to 2019/20 nesting seasons, using four highly polymorphic, species-specific microsatellite markers (nDNA). …”
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Pengembangan Automated Image Analysis untuk Menentukan Jumlah Bakteri Tahan Asam (BTA) pada Kasus Tubercolosis by Safri Adam, Puji Astuti, Puspa Amalia, Fadli Sukandiarsyah

“…However, in practice, manual calculations with a limited field of view on a microscope require a fairly long processing time. During the covid19 pandemic, the efficiency of daily diagnostic work including BTA examinations must be increased due to the limited ATLM personnel in the field who are also working to deal with Covid19. …”
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