Artificial intelligence-assisted platform performs high detection ability of hepatocellular carcinoma in CT images: an external clinical validation study by Rongxue Shan, Chenhao Pei, Qianrui Fan, Junchuan Liu, Dawei Wang, Shifeng Yang, Ximing Wang

“…However, the variety of CT images, the misdiagnosis and missed diagnosis, and the inconsistent diagnosis among different radiologists pose challenges to accurate detection which demands sufficient clinical experience and can be time-consuming and labor-intensive. Purpose To evaluate the detection performance of an artificial intelligence (AI)-assisted platform for HCC by the external validation dataset. …”
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Understanding “Alert Fatigue” in Primary Care: Qualitative Systematic Review of General Practitioners Attitudes and Experiences of Clinical Alerts, Prompts, and Reminders by Illin Gani, Ian Litchfield, David Shukla, Gayathri Delanerolle, Neil Cockburn, Anna Pathmanathan

“…Finally, in the context of the Wider system and their Embedding Over Time, suggestions included sharing best practices for CR use and involving GPs in their design. …”
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Establishment and application of a rapid new detection method for antimicrobial susceptibility testing of Klebsiella pneumoniae based on MALDI-TOF MS by Yapei Zhang, Fanghua Fan, Xuan Wang, Jie Zhu, Shilei Dong

“…Our objective was to establish a matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS)-based antimicrobial susceptibility test (AST) for K. pneumoniae that produces reliable results within a few hours. …”
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Non-lytic spread of poliovirus requires the nonstructural protein 3CD by David Aponte-Diaz, Jayden M. Harris, Tongjia Ella Kang, Victoria Korboukh, Mohamad S. Sotoudegan, Jennifer L. Gray, Neela H. Yennawar, Ibrahim M. Moustafa, Andrew Macadam, Craig E. Cameron

“…Using high-angle annular dark-field scanning transmission electron microscopy to monitor PV-induced autophagosome biogenesis, for the first time, we show that virus-induced autophagic signals yield normal autophagosomes, even in the absence of virions. …”
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Behavior of soil aggregates in reclaimed farmland with different restoration durations: Mediating factors and mechanisms by Zhaoxinyu Liu, Junying Li, Lina Gao, Xinju Li, Wen Song, Luofan Li, Yulong Zang, Gengdi Zhang

“…In the early stages of reclamation, inorganic cementing agents were crucial for maintaining RMS aggregation and SOC sequestration. Over time, particulate organic carbon and microbial activity became dominant in aggregate formation. …”
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Constraints on triggered seismicity and its control on permeability evolution by Derek Elsworth, Ziyan Li, Pengliang Yu, Mengke An, Fengshou Zhang, Rui Huang, Zihan Sun, Guanglei Cui, Tianyu Chen, Quan Gan, Yixin Zhao, Jishan Liu, Shimin Liu

“…This scaling relation is exact at early times but degrades with successive MEQs, but provides a method for characterizing crustal permeability evolution using MEQs, alone. …”
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Reduced Expression of Antimicrobial Protein Secretory Leukoprotease Inhibitor and Clusterin in Chronic Rhinosinusitis with Nasal Polyps by Yanran Huang, Ming Wang, Yu Hong, Xiangting Bu, Ge Luan, Yang Wang, Ying Li, Hongfei Lou, Chengshuo Wang, Luo Zhang

“…The 10 most abundant AMPs expressed differentially in CRSwNP patients were verified by real-time PCR, and of these, the expression and regulation of secretory leukoprotease inhibitor (SLPI) and clusterin (CLU) were investigated further. …”
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Dihydrotanshinone I enhanced BRAF mutant melanoma treatment efficacy by inhibiting the STAT3/SOX2 signaling pathway by Xing Luo, Yi Duan, Jinwei He, CongGai Huang, Jun Liu, Yifan Liu, Mengdei Xu, Qiong Dai, Zhihui Yang

“…In this study, we investigated the effect of dihydrotanshinone I on the MAPK pathway inhibitor resistance of BRAF mutant malignant melanoma.MethodAfter treating A375, A375R, and A2058 cells with DHT or a combination of DHT and BRAF/MEK inhibitors, WB and Real-Time RT-qPCR were used to confirm the activation of the MAPK and STAT3/SOX2 pathways. …”
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Bell’s palsy misdiagnosis: characteristics of occult tumors causing facial paralysis by Eun-Jae Chung, Damir Matic, Kevin Fung, S. Danielle MacNeil, Anthony C. Nichols, Ruba Kiwan, KengYeow Tay, John Yoo

“…An occult tumor was identified upon review of the original MRI in one patient and at follow-up MRI in 8 patients. The mean time interval between the initial and follow-up imaging was 30.8 months. …”
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Effect and Safety of Transcutaneous Auricular Vagus Nerve Stimulation on Recovery of Upper Limb Motor Function in Subacute Ischemic Stroke Patients: A Randomized Pilot Study by Dandong Wu, Jingxi Ma, Liping Zhang, Sanrong Wang, Botao Tan, Gongwei Jia

“…Heart rate (HR) and blood pressure (BP) were measured before and after each taVNS intervention. At the same time, any adverse effects were observed during the procedure. …”
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Cryptococcal Meningitis: A Retrospective Cohort of a Brazilian Reference Hospital in the Post-HAART Era of Universal Access by Aline Z. de Azambuja, Gustavo Wissmann Neto, Guilherme Watte, Luciana Antoniolli, Luciano Z. Goldani

“…The age of the patients ranged from 5 to 67 years. The median time of hospitalization was 28 days. The most common underlying disease was HIV (82%), followed by solid transplant (10%). …”
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Advancing precision medicine: the transformative role of artificial intelligence in immunogenomics, radiomics, and pathomics for biomarker discovery and immunotherapy optimization by Luchen Chang, Jiamei Liu, Jialin Zhu, Shuyue Guo, Yao Wang, Zhiwei Zhou, Xi Wei

“…In radiomics, AI can analyze high-dimensional features from computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography/computed tomography (PET/CT) images to discover imaging biomarkers associated with tumor heterogeneity, treatment response, and disease progression, thereby enabling non-invasive, real-time assessments for personalized therapy. Pathomics leverages AI for deep analysis of digital pathology images, and can uncover subtle changes in tissue microenvironments, cellular characteristics, and morphological features, and offer unique insights into immunotherapy response prediction and biomarker discovery. …”
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Impact of religious fasting on ocular dryness: objective and subjective assessment by Amal F. Alomari, Sara Issa, Asma Musleh, Mohammad Abusamak, Mohammad Abusamak, Omar Bdair, Omar Bdair, Saif Aldeen AlRyalat, Saif Aldeen AlRyalat, Alanoud Al-Wakfi, Mohammed Jaber, Ahmad Alloubani, Haitham Sahawneh, Haitham Sahawneh, Muhannd El-Faouri, Ayman Abdul Aziz, Muawyah Al Bdour

“…NIKBUT values during the fasting times were higher than during the non-fasting times; however, the difference was statistically non-significant. …”
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Cardioattentionnet: advancing ECG beat characterization with a high-accuracy and portable deep learning model by Youfu He, Youfu He, Youfu He, Yu Zhou, Yu Zhou, Yu Qian, Jingjie Liu, Jinyan Zhang, Debin Liu, Qiang Wu, Qiang Wu

“…Looking ahead, this technology is anticipated to provide improved medical services for patients with heart disease through continuous, non-invasive monitoring and timely intervention.…”
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The efficacy of open transanal drainage tube against anastomotic leakage in left-sided colorectal cancer surgery: a propensity score matching study by Gen Tsujio, Tatsunari Fukuoka, Atsushi Sugimoto, Ken Yonemitsu, Yuki Seki, Hiroaki Kasashima, Yuichiro Miki, Mami Yoshii, Tatsuro Tamura, Masatsune Shibutani, Takahiro Toyokawa, Shigeru Lee, Kiyoshi Maeda

“…PSM was performed between the OPEN and CLOSED groups on the basis of the following 13 factors: age, sex, BMI, diabetes mellitus (DM), smoking history, modified Glasgow prognostic score (mGPS), ASA-PS, location of distal tumor edge, operative procedure, surgical approach, operative time, intraoperative blood loss, and pathological stage. …”
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Farmer perception of impacts of fall armyworm (Spodoptera frugiperda J.E. Smith) and transferability of its management practices in Uganda by Andrew Kalyebi, Michael H. Otim, Tom Walsh, Wee Tek Tay

“…The objectives of this study were to: (i) document local farming practices that have been useful to manage FAW, (ii) establish farmers’ perspective on the time of FAW’s arrival to their localities, (iii) investigate the economic impact (yield) of FAW to maize farmers, (iv) establish the farmers’ perception on the current status of the FAW, and (v) document alternative practices used to manage the FAW and the perceived efficacies. …”
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Effectiveness of a Videoconference-Based Cognitive Behavioral Therapy Program for Patients with Schizophrenia: Pilot Randomized Controlled Trial by Masayuki Katsushima, Hideki Nakamura, Yuki Shiko, Hideki Hanaoka, Eiji Shimizu

“…The vCBTp program was conducted once a week, with each session lasting for 50 minutes, for a total of 7 sessions conducted in real-time and in a one-on-one format remotely using a loaned tablet computer (iPad). …”
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Protective Effect of Opuntia dillenii (Ker Gawl.) Haw. Seed Oil on Gentamicin-Induced Nephrotoxicity: A Biochemical and Histological Analysis by Mohamed Bouhrim, Noureddine Bencheikh, Hamada Imtara, Nour Elhouda Daoudi, Hamza Mechchate, Hayat Ouassou, Loubna Kharchoufa, Mostafa Elachouri, Hassane Mekhfi, Abderrahim Ziyyat, Abdelkhaleq Legssyer, Mohammed Aziz, Mohamed Bnouham

“…In addition, the results of the present study showed for the first time that Opuntia dillenii seed oil reduced renal toxicity in gentamicin-induced nephrotoxicity in rats. …”
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Blowing Out the Candle: How to Quench Galaxies at High Redshift—An Ensemble of Rapid Starbursts, AGN Feedback, and Environment by Lucas C. Kimmig, Rhea-Silvia Remus, Benjamin Seidel, Lucas M. Valenzuela, Klaus Dolag, Andreas Burkert

“…We analyze observable metrics to predict future quenching at high redshifts, finding that on shorter timescales <500 Myr, the ratio M _bh / M _* is the best predictor, followed by the burstiness of the preceding star formation, t _50 – t _90 (time to go from 50% to 90% stellar mass). On longer timescales, >1 Gyr, the environment becomes the strongest predictor, followed by t _50 – t _90 , indicating that at high redshifts the consumption of old gas and lack of new gas are more relevant for long-term prevention of star formation than the presence of a massive AGN. …”
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Serotonin-Exacerbated DSS-Induced Colitis Is Associated with Increase in MMP-3 and MMP-9 Expression in the Mouse Colon by Menglu Chen, Lei Gao, Pan Chen, Dandan Feng, Yalin Jiang, Yongchao Chang, Jianjun Jin, Fong-Fong Chu, Qiang Gao

“…MMPs and tissue inhibitors of MMPs (TIMPs) mRNA were measured by real-time quantitative RT-PCR in mouse colon and in human Caco-2 cells and neutrophils. …”
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