Tumor aggression-defense index–a novel indicator to predicts recurrence and survival in stage II-III colorectal cancer by Tong Wu, Lin Fang, Yuli Ruan, Mengde Shi, Dan Su, Yue Ma, Ming Ma, Bojun Wang, Yuanyu Liao, Shuling Han, Xiaolin Lu, Chunhui Zhang, Chao Liu, Yanqiao Zhang

“…Among stage II CRC, chemotherapy was significantly correlated with improved recurrence times in individuals with intermediate (95% CI 0.19–0.59, P < 0.001) and high (95% CI 0.36–0.95, P = 0.031) TADI. …”
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Clinical validation and optimization of machine learning models for early prediction of sepsis by Xi Liu, Meiyi Li, Xu Liu, Yuting Luo, Dong Yang, Hui Ouyang, Jiaoling He, Jinyu Xia, Fei Xiao, Fei Xiao, Fei Xiao

“…Our findings also suggested that male patients with bacterial infections and high procalcitonin levels, lower albumin levels, or prolonged prothrombin times were more likely to develop sepsis.…”
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Enhanced Piezoelectric Properties of Poly(L‐lactide) Nanocomposite Microfiber Scaffolds Due to Polydopamine‐Coating of Barium Titanate Nanoparticles by Richard Schönlein, Xabier Larrañaga, Asier Panfilo, Yu Li, Aitor Larrañaga, Guoming Liu, Alejandro J. Müller, Robert Aguirresarobe, Jone M. Ugartemendia

“…This contribution presents, for the first time, a nanocomposite strategy to enhance the piezoelectric properties of PLLA, while maintaining cytocompatibility. …”
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Neuroprotective Effects of Eugenol Acetate Against Ischemic Stroke by Chen L, Zhang R, Xiao J, Liang Y, Lan Z, Fan Y, Yu X, Xia S, Yang H, Bao X, Meng H, Xu Y, Yu L, Zhu X

“…Liqiu Chen,1,2,&ast; Ran Zhang,1,2,&ast; Jing Xiao,1,2,&ast; Ying Liang,1,2 Zhen Lan,3 Yingao Fan,2 Xi Yu,2 Shengnan Xia,2– 5 Haiyan Yang,2– 5 Xinyu Bao,2– 5 Hailan Meng,1– 6 Yun Xu,1– 6 Linjie Yu,1– 6 Xiaolei Zhu1– 6 1Department of Neurology, Nanjing Drum Tower Hospital, Clinical College of Nanjing University of Chinese Medicine, Nanjing, 210008, People’s Republic of China; 2Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, People’s Republic of China; 3Department of Neurology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, 210008, People’s Republic of China; 4State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, 210008, People’s Republic of China; 5Jiangsu Provincial Key Discipline of Neurology, Nanjing, 210008, People’s Republic of China; 6Nanjing Neurology Medical Center, Nanjing, 210008, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Linjie Yu; Xiaolei Zhu, Department of Neurology, Nanjing Drum Tower Hospital, Clinical College of Nanjing University of Chinese Medicine, Nanjing, 210008, People’s Republic of China, Email yulinjie126@126.com; zhuquelee@126.comObjective: To explore the neuroprotective effect of Eugenol Acetate (EA) on post-stroke neuroinflammation and investigate the underlying mechanisms.Methods: For in vitro experiments, primary microglia were pre-incubated with EA for 2 hours, followed by lipopolysaccharide (LPS) stimulation for 24 hours or Oxygen-Glucose Deprivation (OGD) treatment for 4 hours. Real-time quantitative PCR, enzyme-linked immunosorbent assay (ELISA) and Western blot were performed to examine the expression levels of inflammatory cytokines in primary microglia. …”
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Effect of Daily Fiber Intake Among Cirrhotic Patients With and Without Portosystemic Shunts by Simona Parisse, Sara Carnevale, Elio Damato, Flaminia Ferri, Monica Mischitelli, Mario Corona, Pierleone Lucatelli, Alfredo Cantafora, Adriano De Santis, Domenico Alvaro, Maurizio Muscaritoli, Stefano Ginanni Corradini

“…By adjusting for confounders in logistic regression models we found that improvement in MELD over time was inversely associated with insoluble fiber consumption expressed in milligrams per kilogram (mg/kg) body weight in CIRs without PSs [odds ratio (OR): 0.968; 95% confidence interval (CI): 0.939, 0.997; P = 0.005] but with soluble fiber consumption in CIRs with PSs [OR: 0.946; 95% CI: 0.912, 0.982; P = 0.001]. …”
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Lidar estimates of birch pollen number, mass, and CCN-related concentrations by M. Filioglou, P. Tiitta, P. Tiitta, X. Shang, A. Leskinen, P. Ahola, S. Pätsi, A. Saarto, V. Vakkari, V. Vakkari, U. Isopahkala, M. Komppula

“…Lidar remote sensing of pollen is an emerging research field, and in this study, we present for the first time retrievals of particle number, mass, CCN, giant CCN (GCCN), and ultragiant CCN (UGCCN) concentration estimations of birch pollen derived from polarization lidar observations and specifically from a PollyXT lidar and a Vaisala CL61 ceilometer at 532 and 910 nm, respectively.…”
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MRI to digital medicine diagnosis: integrating deep learning into clinical decision-making for lumbar degenerative diseases by Baoyi Ke, Wenyu Ma, Junbo Xuan, Junbo Xuan, Yinghao Liang, Liguang Zhou, Wenyong Jiang, Jing Lin, Guixiang Li

“…Additionally, the testing time of the deep learning program was significantly shorter than that of manual identification, and the differences were statistically significant (P &lt; 0.05).ConclusionsDeep learning technology based on the PP-YOLOv2 algorithm can be used to identify normal intervertebral discs, lumbar disc herniation, and lumbar spondylolisthesis from lumbar MRI images. …”
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Neurodevelopmental outcomes of very low birth weight preterm infants during the COVID-19 pandemic by Yen-Chen Lin, Hung-Yang Chang, Chia-Huei Chen, Jui-Hsing Chang, Wai-Tim Jim, Chyong-Hsin Hsu, Chia-Ying Lin, Yu-Xiang Song, Cheng-Wei Chen, Tzu-Yu Liu, Mary Hsin-Ju Ko

“…CG had significantly longer hospital stay and delayed follow-up time compared to PCG. No significant differences were observed in the composite cognitive, language, and motor scores between two groups. …”
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Clinically relevant orthotopic pancreatic cancer models for adoptive T cell transfer therapy by Gregory B. Lesinski, Chrystal M. Paulos, Maggie Phillips, Jacklyn Hammons, Isaac Karpovsky, Zaid Mahdi, Natalie K. Horvat, Megan M. Wyatt, Margaret A. Hall, Cameron J. Herting, Richard A. Moffitt

“…Interestingly, we found that chimeric antigen receptor (CAR) T cells redirected to recognize mesothelin on these tumors that signal via CD3ζ and 41BB (Meso-41BBζ-CAR T cells) infiltrated the tumors of mice bearing stroma-devoid KPC-Luc orthotopic tumors, but not MT-5 tumors.Conclusions Our data establish for the first time a reproducible and realistic clinical system useful for modeling stroma-rich and stroma-devoid PDAC tumors. …”
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Evaluation and Management of Patients with Hematoma After Gynecologic and Obstetric Surgery by Bekir Kahveci, Mehmet Obut, Serhat Ege, Mete Sucu, Nurullah Peker, Osman Uzundere, Gaye Kahveci, Mehmet Sukru Budak

“…In addition, 4 patients (13.3%) had relaparotomy, 5 patients (16.7%) underwent percutaneous radiological drainage and 8 (26.7%) received blood transfusion. The mean time of resorption of the hematoma was 4.6 ± 2.0 days. …”
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Explore the factors related to the death of offspring under age five and appraise the hazard of child mortality using machine learning techniques in Bangladesh by Ashikur Rahman, Md. Habibur Rahman

“…Although the child mortality rate in Bangladesh is declining over time, it still needs to drop even more in order to meet the Sustainable Development Goals (SDGs). …”
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Effect of Cardiac Exercise Rehabilitation on Epicardial Adipose Tissue Thickness in Patients with Coronary Heart Disease by Xing XING, Xinying GE, Ao GENG, Hongyan JIANG

“…Aerobic exercise (including flat-panel walking, treadmill) was the main exercise content, combined with impedance exercise and flexible balance training with three times a week, 30-90 minutes every time. Patients in the control group only took CHD secondary preventive drugs. …”
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Performance simulation study of plastic scintillator arrays for stability monitoring applications by Z. Chen, Z.W. Pan, Z. Wang, Z.Y. He, Z.B. Lin, T.Y. Yang, Y. Wang, Z.Y. Zhang, J.D. Liu, S.B. Liu, B.J. Ye, L.W. Chen, Y.H. Yu

“…A sub-millimeter position resolution is achievable by selecting a proper data taking time. The triangular scintillator strips always outperform rectangular ones of the same size and placement. …”
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Clinical outcomes of early remdesivir administration in hospitalized patients at high risk for severe COVID-19 during the Omicron wave by Yeon Ju La, Won Sup Oh, Changhyup Kim, Myoung-nam Lim, Yong Duk Jeon

“…We included patients aged ≥ 18 years who had symptom onset within 7 days and had at least one risk factor for disease progression at the time of diagnosis. We compared the clinical outcomes between the early remdesivir administration group and the group not administered early remdesivir. …”
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Deciphering Immunometabolic Landscape in Rheumatoid Arthritis: Integrative Multiomics, Explainable Machine Learning and Experimental Validation by Dong Q, Wu J, Zhang H, Chen X, Xu X, Chen J, Shi C, Luo L, Zhang D

“…Machine learning models identified hub genes, which were validated via quantitative real-time PCR (qRT-PCR). Then, potential small-molecule drugs were screened using the Connectivity Map (CMAP) and molecular docking. …”
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First Experiences with Fusion of PET-CT and MRI Datasets for Navigation-Assisted Percutaneous Biopsies for Primary and Metastatic Bone Tumors by Hagen Fritzsche, Alexander Pape, Klaus-Dieter Schaser, Franziska Beyer, Verena Plodeck, Ralf-Thorsten Hoffmann, Patricia Hahlbohm, Elisabeth Mehnert, Anne Weidlich

“…<b>Conclusions:</b> Navigation-assisted percutaneous tumor biopsy resulted in correct, histologically useable diagnoses in all patients and reached a higher accuracy and first-time success rate (diagnostic yield: 100%) in comparison to CT-guided biopsies. …”
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Physical modelling of damage mechanism of slopes containing near horizontal weak layers under rainfall conditions by Zhigang TAO, Chuang XU, Songyuan LIU, Yong LI, Kexin XIU

“…From the results of displacement monitoring, it can be seen that the slope cracks can be up to 35 mm wide, indicating that the slope slippage damage. ② From the numerical simulation analysis, it can be seen that the slope deformation increases significantly under rainfall conditions, and the maximum deformation can be up to 40 cm without anchoring measures. At the same time, the closer to the coal seam position, the larger the area of the plastic zone of slope shear damage, and the landslide body appears to have a large area of shear damage after sliding along the weak layer of the rock body, which verifies the deformation form of slope shear-slip damage. ③ From the comparative analysis of the NPR anchor cable reinforcement scheme and the PR anchor cable reinforcement scheme, it can be seen that the supporting effect of the NPR anchor cable is much better than that of the PR anchor cable, the maximum displacement of the slope under the NPR anchor cable support is reduced by 17.6 cm, while the maximum displacement of the slope under the PR anchor cable support is reduced by only 10.3 cm. …”
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Circular RNA RHOT1 Regulates miR-142-5p/CCND1 to Participate in Chondrocyte Autophagy and Proliferation in Osteoarthritis by Gu Man, Haiwen Yang, Kai Shen, Donghong Zhang, Julin Zhang, Hao Wu, Hongyu Zhang, Jinhuan Wang

“…The function of circRHOT1 in the regulation of OA was assessed by CCK-8, colony formation, flow cytometry analysis, quantitative real-time PCR, Western blot analysis, and luciferase reporter gene assay in chondrocytes. …”
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The effects of Thymus capitatus essential oil topical application on milk quality: a systems biology approach by Ralph Nehme, Chiara Gini, Elise Vanbergue, Sergine Even, Filippo Biscarini, Sonia Andrés, Lucie Rault, Faustine Noel, Valerie Hardit, Said Bouhallab, David M. Pereira, Riadh Ksouri, Philippe Roussel, Secundino López, Paola Cremonesi, Bianca Castiglioni, Donatella Caruso, Fiorenza Faré, Manuela Fontana, Fabrizio Ceciliani, Latifa Abdennebi-Najar

“…This study aimed to investigate the impact of Thymus capitatus essential oil (TCEO), known for its high antibacterial and antioxidant properties, on milk microbiota using 16S rRNA sequencing, the lipidomic profile via liquid chromatography-quadrupole time-of-flight mass spectrometry, udder skin microbiota, and inflammatory biomarkers of dairy cows at the end of lactation. …”
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Implementasi Algoritma BFCC dan kNN pada Embedded System untuk Deteksi Dini Bronchitis by Septiyo Budi Perkasa, Barlian Henryranu Prasetio, Eko Setiawan, Edita Rosana Widasari, Dahnial Syauqy

“…The results obtained an average computation time of 4.452 seconds and CPU usage of 26%, and kNN accuracy of 73% from the calculation of the Euclidean distance with a neighbor value = 5. …”
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