Clinical Features and Contributing Factors of Excessive Daytime Sleepiness in Chinese Obstructive Sleep Apnea Patients: The Role of Comorbid Symptoms and Polysomnographic Variables by Chuan Shao, Huan Qi, Ruyi Lang, Biyun Yu, Yaodong Tang, Lina Zhang, Xun Wang, Ling Wang

“…Logistic regression analysis showed waist circumference, memory loss, work/commute disturbances, and sleep efficiency were independently associated with mild to moderate EDS, and the microarousal index, apnea-hypopnea index (AHI), and saturation impair time below 90% were independent contributing factors of mild to moderate EDS. …”
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Levels of apoptosis factors in mitochondria of brain cortex cells in female С57ВL/6 mice in dynamics of B16/F10 melanoma growth combined with comorbidity by E. M. Frantsiyants, I. V. Neskubina, N. D. Cheryarina, E. I. Surikova, A. I. Shikhlyarova, V. A. Bandovkina, L. A. Nemashkalova, I. V. Kaplieva, L. K. Trepitaki, P. S. Kachesova

“…CNP, levels of calcium in murine brain cortex mitochondria were 1.4 times higher (p < 0.05) than in the comparison group at the same time; in 2 weeks the levels declined by 80.1 times and after 3 weeks declined by 37.7 times. …”
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A novel approach to regulate glucose uptake in an anaplastic thyroid cancer cell line by Shabnam Heydarzadeh, Ali Asghar Moshtaghie, Maryam Daneshpour, Mehdi Hedayati

“…Moreover, herein, for the first time, we decided to investigate the anti-thyroid cancer effects of a bioactive phytochemical and establish a signaling link between curcumin and the glucose uptake metabolism of anaplastic thyroid cancer cells. …”
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Factors influencing the kinetics of MSU crystal depletion measured with dual-energy CT in patients with gout by Tristan Pascart, Victor Laurent, Charlotte Jauffret, Aurore Pacaud, Vincent Ducoulombier, Julie Legrand, Stéphane Verdun, Laurène Norberciak, Jean-François Budzik

“…In multivariable analysis, time (in days) with a multilevel coefficient of −0.06 (95% CI: −0.08 to −0.03, p<0.001), hypertension (coefficient: 41.87, 95% CI: 16.38 to 67.18, p<0.01) and SU level <5.0 mg/dL (coefficient: −39.46, 95% CI: −70.93 to −8.34, p=0.02) were the only variables significantly associated with MSU crystal volume change.Conclusion In patients with DECT-measured MSU crystal deposition, reaching the <5.0 mg/dL SU target provides more extensive and rapid crystal dissolution than reaching the <6.0 mg/dL SU target.…”
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Inflammatory burden index as a prognostic marker in patients with advanced gastric cancer treated with neoadjuvant chemotherapy and immunotherapy by Jiao-Bao Huang, Zhi-Yong Zhou, Jun Lu, Ji-Yun Zhu, Bin Lai, Sheng-Xun Mao, Jia-Qing Cao

“…The median cycle of neoadjuvant therapy was 4(3-4). The median survival time was 85.1%(1 years), 65.6%(2 years), and 47.4%(3 years).Univariate analysis showed that IBI was an independent risk factor for non-TR(residual tumor cells>50%) (HR=1.08,95%CI:1.00-1.45,p<0.001)and OS(HR=1.04,95%CI:1.03-1.05,p<0.001). …”
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Impact of pharmacist-led educational intervention on knowledge of self-management among asthmatic patients: a prospective cohort study by Ahmad Khan, Saima Mushtaq, Amjad Khan, Nafees Ahmad, Shahzadi Sidra Saleem, Rubina Aman, Shahzadi Sadia Saleem, Ayesha Bibi, Saifullah Mehsud, Ivan R Green, Sheikh Abdur Rashid, Kifayat Ullah Shah

“…This study aims to assess the impact of pharmacist-led educational intervention on knowledge of self-management among asthmatic patients.Design A pre–post cohort study.Setting Outpatient department of a tertiary care hospital affiliated with Quaid-i-Azam University, Pakistan.Participants Approximately 265 adult asthmatic patients selected through a spirometry process, aged ≥18 years, were approached. 240 patients gave consent to participate in the study and were divided into control and treatment groups.Interventions The educational intervention consisted of individual patient counselling using educational material with time varied according to each patient’s comprehension and previous knowledge.Primary and secondary outcome measures Assessment consisted of a 14-item Asthma Self-Management Knowledge Questionnaire (ASMQ) quantifying a patient’s self-management knowledge through an ASMQ score and its change following an educational intervention.Results Disease self-management knowledge was low with an average raw ASMQ score of 4.1 (max 14); which equates to a transformed score of 29.34 (max 100) and the proportion of patients who correctly answered more than 50% of questions were 16.7% preintervention. …”
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The effect of repetitive transcranial magnetic stimulation on sleep quality in patients with more than mild depressive mood: a systematic review and meta-analysis by Yu’ang Liu, Silang Huang, Xinxin Zhang, Huangying Liao, Weiguo Liu, Zhi Zhang, Xianhui Qu, Ziwen Wang

“…Subgroup analyses showed that the group using the 1-Hz stimulation frequency, the group with more than 4 weeks of treatment time, and the group with rTMS alone had better efficacy in treating the sleep quality of patients with more than mild depressive mood using rTMS, with the use of combination treatment or not being the main source of heterogeneity.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42023467971…”
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Effect of Bloodletting Therapy on Patients with Spastic Wrist Dorsiflexion Dysfunction after Stroke by LIN Wanqing, XIE Xuemin, CHEN Bin, ZHENG Xinyi

“…Yangxi (LI 5), Yangchi (TE 4), Daling (PC 7) acupoint of the affected hand were selected for acupuncture treatment, Yangxi (LI 5) acupoint was straightly needled 0.5-0.8 inch, Yangchi (TE 4) and Daling (PC 7) acupoints were straightly needled 0.3-0.5 inch, 30 minutes each time, once a day, five times a week, continous treatment for four weeks. …”
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Changes in the histological structure of tissues and organs of pikeperch (Sander lucioperca Linnaeus, 1758) and perch (Perca fluviatilis Linnaeus, 1758) from the Zaporizhzhia Reser... by P. Korzhenevska, T. Sharamok, A. Doroshenko

“…Among the studied fish of the lower part of the reservoir, the largest count of erythrocytes with pathological changes was observed in pikeperch, it was 1.32 times higher than in perch. Among fish of the Samara Bay, the highest count of pathologies in blood cells was also noted for pikeperch and was 1.17 times higher compared to that of perch. …”
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Spatial and Temporal Variations in 94-GHz Radar Backscatter From a Springtime Snowpack by William D. Harcourt, Duncan A. Robertson, David G. Macfarlane, Brice R. Rea, Mike R. James, Mark Diggins, Blair Fyffe

“…We measured an increase in <inline-formula><tex-math notation="LaTeX">$\sigma ^{0}$</tex-math></inline-formula> of <inline-formula><tex-math notation="LaTeX">$\sim$</tex-math></inline-formula>10 dB over 24 h during which time the daytime (09:00&#x2013;18:00) average air temperature reduced from 2.2 to 0.3 <inline-formula><tex-math notation="LaTeX">$^{\circ }$</tex-math></inline-formula>C. …”
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Overexpression of miR-124 enhances the therapeutic benefit of TMZ treatment in the orthotopic GBM mice model by inhibition of DNA damage repair by Yuchen Wei, Peng Wang, Jianhui Zhao, Xin Fan, Jun Jiang, Xiuli Mu, Yuzhou Wang, Angang Yang, Rui Zhang, Shijie Hu, Zhangyan Guo

“…In the mechanistic study, we for the first time identified that RAD51, a key functional molecule in DNA damage repair, is a novel and bona fide target of miR-124 in GBM cells. …”
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Progressively complex neurorehabilitation: from a severe coma to a vegetative state, minimal consciousness ... and the Phoenix bird survives and is reborn from its ashes by Andreea-Iulia Vlădulescu-Trandafir, Aurelian Anghelescu, Ana-Andreea Cristea, Gelu Onose

“…The patient had slight improvements in motor and cognitive abilities, resulting in simple voluntary gestures and affective response schemes. In time, he progressed to a minimally conscious state; he responded to verbal stimuli through blinking and reactive adequate affective mimic in the context of persistent expressive aphasia. …”
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Rapid identification of high-temperature Daqu Baijiu with the same aroma type by UV-VIS sensor of HBT combined with Zn2+ by Yanmei Zhu, Yuanyuan Su, Yipeng Cang, Hengye Chen, Wanjun Long, Wei Lan, Xue Jiang, Haiyan Fu

“…Conclusions: This method not only improves the specificity of spectral detection, and the amount of information extracted from Baijiu samples, but also the detection time is shortened to less than 3 min, and the accurate identification of high-temperature Daqu Baijiu with the same aroma type was realized. …”
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Influence of High-Frequency Repetitive Transcranial Magnetic Stimulation on Neurobehavioral and Electrophysiology in Patients with Disorders of Consciousness by Jian-Min Chen, Qing-Fa Chen, Zhi-Yong Wang, Yang-Jia Chen, Nan-Nan Zhang, Jian-Wen Xu, Jun Ni

“…The outcome measures of performed pre- and postintervention included the latencies of the N20 and N20-P25 amplitudes of SEP, brainstem auditory-evoked potential (BAEP) grade, JFK Coma Recovery Scale-Revised (CRS-R) score, and Glasgow Coma Scale (GCS) score; any adverse events were recorded at any time during the intervention. Result. Following six weeks of treatment, a significant increase was observed in the total CRS-R and GCS scores, and the N20-P25 amplitudes of patients in the two groups were compared with that obtained from preintervention (all p values < 0.05). …”
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Search for and functional annotation of multi-domain PLA2 family proteins in flatworms by M. E. Bocharnikova, I. I. Turnaev, D. A. Afonnikov

“…Our results made it possible for the first time to systematically identify PLA2 sequences in flatworms, and demonstrated that their evolution is subject to gene loss processes characteristic of parasite genomes in general. …”
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Intricate interplay of CRISPR-Cas systems, anti-CRISPR proteins, and antimicrobial resistance genes in a globally successful multi-drug resistant Klebsiella pneumoniae clone by Jianping Jiang, Astrid V. Cienfuegos-Galletd, Tengfei Long, Gisele Peirano, Tingyu Chu, Johann D. D. Pitout, Barry N. Kreiswirth, Liang Chen

“…The molecular epidemiology, population structure, and time phylogeny were investigated. The virulome, resistome, and mobilome were analyzed, and the recombination in the capsular region was studied. …”
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Interleukin IL1a and IL6 gene polymorphism: search for association with APOE genotype and clinical course of sporadic Alzheimer’s disease by G. Pšemeneckienė, K. Petrikonis, D. Rastenytė

“…Genotyping of IL1A -889C>T (rs1800587) and IL6 -174G>C (rs1800795, Intron type) was performed using real-time PCR (RT-PCR). Results. The distribution of IL1A -889C>T genotypes did not differ between APOE ε4 carriers (APOE4+: C/C – 52.9%, C/T – 41.2%, T/T – 5.9%) and APOE negative AD patients (APOE4-: C/C – 55.6%, C/T – 37.0%, T/T – 7.4%; p=0.887). …”
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Antibiotic knowledge and influencing factors among residents in China: a cross-sectional survey by Sixian DU, Yaqing LIU, Xiaoxu YIN, Haoran NIU, Feng JIANG, Liwen GONG

“…According to the multivariate logistic regression analysis, antibiotic knowledge scores were significantly influenced by the following factors (all P < 0.05): individuals with middle school education or below compared to those with a master′s degree or above (β = – 2.047, OR = 0.129), those with a medical education background compared to those without (β = – 1.430, OR = 0.239), full-time workers compared to other occupations (β = 0.387, OR = 1.472), healthcare workers compared to non-healthcare workers (β = – 0.674, OR = 0.510), individuals with chronic diseases compared to those without (β = 0.753, OR = 2.123), and those who self-rated their health as "very good" compared to "average" (β = 0.647, OR = 1.910). …”
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Web-based interventions for fear of cancer recurrence: A scoping review with a focus on suggestions for the development and evaluation of future interventions. by Solveiga Zibaite, Sheela Tripathee, Helen Moffat, Beatrix Elsberger, Sara Maclennan

“…Fourth, while web-based interventions do not involve the costs of transportation, traveling time, space, equipment, cleaning, and other expenses, further cost utility analyses should be performed. …”
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Impact of new coalbed methane wells on old well productivity and its controlling factors: a case study of Shizhuangnan block in Qinshui Basin by Xueting HAN, Shangzhi MENG, Guangjing LIU, Zhenyu REN, Shu TAO, Xinyang MEN, Ziyang WEI

“…While the production can be significantly restored by manual real-time unclogging, failure in unclogging results in a substantial decrease in gas production. …”
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