When can cancer patient treatment nonadherence be considered intentional or unintentional? A scoping review. by Leon Wreyford, Raj Gururajan, Xujuan Zhou

“…The concept of Information differs between Patient and Physician; 3.Inadequate time. 4. The need for Treatment Concordance is vague or missing from concepts; 5. …”
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Disproportionality analysis of upadacitinib-related adverse events in inflammatory bowel disease using the FDA adverse event reporting system by Shiyi Wang, Xiaojian Wang, Jing Ding, Xudong Zhang, Hongmei Zhu, Yihong Fan, Changbo Sun

“…Subgroup analysis indicated that the most prevalent AEs among the elderly included pulmonary embolism, cataract, and sepsis, whereas the 18–65 age group most frequently reported acne, abdominal pain, and nasopharyngitis. The median onset time for AEs related to upadacitinib was 41.00 days (interquartile range [IQR] 10–141.5 days), with the majority occurring within 3 months of treatment initiation (n = 269, 66.09%), particularly in the first month (n = 171, 42.01%).ConclusionOur findings affirm clinical observations and reveal potential new AE signals for upadacitinib, underscoring the need for prospective clinical studies to verify these results and clarify their clinical relevance. …”
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Role of the professional critical care team in improving the quality of critical care in the hospital (危重症专业小组在提升医院危重症护理水平中的作用探讨) by PENG Jine (彭金娥), WANG Siyi (王思懿), WU Xuehua (吴雪花)

“…According to the statistics of the work of the critical care professional team in 2020, 95 times of consultations, 4 times of general nursing training, 10 times of training for N3-grade nurses, 35 times of multidisciplinary nursing rounds and 300 times of department visits were conducted, respectively. …”
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Tocilizumab modulates the activity of the classical and alternative complement pathways in rheumatoid arthritis patients by Iván Ferraz-Amaro, Iván Ferraz-Amaro, Sergio Santos-Concepción, Javier Castro-Hernández, Maria Vanesa Hernández-Hernández, Beatriz Tejera Segura, Cristina Luna, Esmeralda Delgado-Frias, Federico Díaz-González, Federico Díaz-González, Federico Díaz-González

“…Multivariable linear mixed models were used to determine changes in the complement system cascades over time.ResultsAfter adjustment for disease activity, basal levels of the classical and alternative pathways decreased significantly after TCZ treatment. …”
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Unraveling the genetic spectrum of inherited deaf-blindness in Portugal by Telma Machado, Telmo Cortinhal, Ana Luísa Carvalho, Francisco Teixeira-Marques, Rufino Silva, Joaquim Murta, João Pedro Marques

“…A total of 55 genetic variants were identified across 16 different genes; 11 of these variants are novel and herein reported for the first time. Conclusions This is the first study to describe the genetic profile of patients with dual sensory impairment in Portugal, highlighting the genetic heterogeneity associated with inherited deaf-blindness. …”
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Is There a Noninvasive Source of MSCs Isolated with GMP Methods with Better Osteogenic Potential? by Carla C. G. Pinheiro, Alessander Leyendecker Junior, Daniela Y. S. Tanikawa, José Ricardo Muniz Ferreira, Reza Jarrahy, Daniela F. Bueno

“…To evaluate whether greater osteogenic potential of the established mesenchymal stem cell strains was associated with an increase in the expression profile of neural crest genes, real-time qPCR was performed on the following genes: SRY-box 9, SRY-box 10, nerve growth factor receptor, transcription factor AP-2 alpha, and paired box 3. …”
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Early Postoperative Pain Control and Inflammation for Total Knee Arthroplasty: A Retrospective Comparison of Continuous Adductor Canal Block versus Single-Shot Adductor Canal Block... by Xiaojuan Yang, Jun Dong, Wei Xiong, Fusen Huang

“…Secondary outcomes included patient-controlled bolus, time of first postoperative ambulation, range of knee flexion and extension, inflammation cytokines on Pre and POH48, percentage of remedial analgesics treatment, incidence of adverse events and complications, hospital stay and cost, and Numerical Rating Scale (NRS) satisfaction scores at discharge. …”
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Effects of 24-hour urine-output trajectories on the risk of acute kidney injury in critically ill patients with cirrhosis: a retrospective cohort analysis by Jia Wang, Dongdong Niu, Xiaolin Li, Yumei Zhao, Enlin Ye, Jiasheng Huang, Suru Yue, Xuefei Hou, Jiayuan Wu

“…More attention should be paid to the dynamic nature of urine-output changes over time, which may help guide early intervention and improve patients’ prognoses.…”
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Glaucoma laser treatments: modern approaches and practice guidelines by M.H. Rabadanova, Zh.G. Oganezova, E.A. Egorov, D.V. Katz, V.V. Novoderezhkin

“…It is underpinned by several important advantages of this modality: it has demonstrated high efficacy; can be performed in outpatient settings without general anesthesia; is well-tolerated by patients; can be repeated over time and combined with surgeries; and is considered as a cost-effective treatment. …”
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Protocol for a systematic review and individual participant data meta-analysis for risk factors for lung cancer in individuals with lung nodules identified by low-dose CT screening by Matthew Callister, Harry J de Koning, Robert C Rintoul, Carolyn Horst, Arjun Nair, John K Field, Christine D Berg, Samantha Quaife, Rhian Gabe, Stephen Duffy, Sam Janes, Philip AJ Crosbie, Mark M Hammer, Panos Alexandris, Michael PA Davies

“…Therefore, there is a need to identify individuals who need no interval CT between screening rounds.Methods and analysis The aim of this study is to identify risk factors predictive of LC, which are known at the time of the scan, in patients with LDCT screen-detected lung nodules. …”
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Incidence of opportunistic infections and its predictors among HIV/AIDS patients on antiretroviral therapy in Gondar University Comprehensive and Specialized Hospital, Ethiopia by Mequanente Dagnaw, Haileab Fekadu, Adhanom Gebre Egziabher, Tesfaye Yesfue, Meera Indracanti, Alemu Tebeje

“…Epi-dataTM Version 4.5 was used to enter data, and StataTM Version 16 was used to analyze the data. The time interval between opportunistic infections was estimated using the Kaplan Meier survival curve. …”
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Analysis of the sensitization activity of Moringa oleifera leaves protein by Juan Lu, Juan Lu, Xiaoxue Liu, Xiaoxue Liu, Wenjie Li, Wenjie Li, Chuyu Xi, Chuyu Xi, Dan Feng, Dan Feng, Shuang Song, Shuang Song

“…The optimal combination of extraction process was: extraction time of 6 h, material-liquid ratio of 1:8, and ammonium sulfate saturation of 60%. …”
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Improvement of soil quality through biochar in rice under wastewater irrigated soil: Effects on heavy metals reduction by Sayon Mukherjee, Satish Kumar Singh, Raimundo Jiménez Ballesta, Abhik Patra, Surendra Singh Jatav

“… Purpose: Rice, a global staple, can accumulate high levels of heavy metals especially Chromium (Cr) when grown in a soil irrigated with tannery effluent over time, potentially reaching toxic levels for human consumption. …”
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Investigating Smartphone-Based Sensing Features for Depression Severity Prediction: Observation Study by Yannik Terhorst, Eva-Maria Messner, Kennedy Opoku Asare, Christian Montag, Christopher Kannen, Harald Baumeister

“…This process, called smart sensing, allows a fine-grained assessment of various features (eg, time spent at home based on the GPS sensor). Based on its prevalence and impact, depression is a promising target for smart sensing. …”
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First note of QTL mapping of low vigor traits using the updated F2 ‘Koroneiki’ linkage map of olive by Irene Granata, Aparna S. Balan, Aparna S. Balan, Claudio Di Vaio, Antonino Ioppolo, Tiziano Caruso, Silvia Fretto, Jubina Benny, Antonio Giovino, Daniel James Sargent, Francesco Paolo Marra, Annalisa Marchese

“…Results underscore a strong genetic control of these traits, with a consistent correlation observed over time. We identified two candidate genes — Acid Phosphatase 1, Shikimate O-hydroxycinnamoyltransferase, and a SNP Marker likely associated with Calcium Responsive Proteins — each potentially interacting with plant hormones to influence growth. …”
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Die Entstehung der Entstehung by Thomas Christensen

“…I will conclude with some thoughts as to why the question of tonality’s origins suddenly seemed to have become such a pressing issue of vital importance to German musicologists writing in the 1950s and 60s. At the same time, I will show how Dahlhaus’s analytic thoughts concerning the beginning of harmonic tonality reveal surprising resemblance to his thoughts concerning the loosening of tonality in the late 19th century, particularly in the music of Wagner.…”
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Impact of Early-Life Microbiota on Immune System Development and Allergic Disorders by Norbert Dera, Katarzyna Kosińska-Kaczyńska, Natalia Żeber-Lubecka, Robert Brawura-Biskupski-Samaha, Diana Massalska, Iwona Szymusik, Kacper Dera, Michał Ciebiera

“…Therefore, an appropriate lifestyle, rational antibiotic therapy as well as the way of completing the pregnancy are indispensable in the prevention of the above conditions. At the same time, considering the intestinal microbiota of the newborn in relation to the genera and phyla of bacteria that have a potentially protective effect, it is worth noting that the use of suitable probiotics and prebiotics seems to contribute to the protective effect.…”
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Assessment of physiological status of felids as indicator of their welfare in the wild by Ekaterina V. Pavlova, Evgeny A. Ivanov, Vadim E. Kiriluk, Vyacheslav V. Rozhnov

“…Values of N:L depended also on the time spent to get blood samples. In the big felid species effects of glucocorticoids on the WBC ratio (neutrophilia) were obtained in blood samples from anesthetized animals, taken more than 2 hours after capture. …”
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Platform for laser-driven X-ray diagnostics of heavy-ion heated extreme states of matter by P. Hesselbach, J. Lütgert, V. Bagnoud, R. Belikov, O. Humphries, B. Lindqvist, G. Schaumann, A. Sokolov, A. Tauschwitz, D. Varentsov, K. Weyrich, B. Winkler, X. Yu, B. Zielbauer, D. Kraus, D. Riley, Zs. Major, P. Neumayer

“…We report on commissioning experiments at the high-energy, high-temperature (HHT) target area at the GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt, Germany, combining for the first time intense pulses of heavy ions from the SIS18 synchrotron with high-energy laser pulses from the PHELIX laser facility. …”
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Infectious keratitis following photorefractive keratectomy: a 13-year study at a tertiary center by Alireza Attar, Hossein Jamali, Julio Ortega-Usobiaga, Golnoush Mahmoudinezhad, Dagny Zhu, Mohammad Mohammadi

“…The odds of keratitis during the COVID-19 pandemic were 7.05 times higher (95% CI: 1.58 to 31.52, p-value = 0.015) than outside this timeframe (February 2020 to August 2023). …”
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