MetaboLINK is a novel algorithm for unveiling cell-specific metabolic pathways in longitudinal datasets by Jared Lichtarge, Gerarda Cappuccio, Gerarda Cappuccio, Soumya Pati, Soumya Pati, Alfred Kwabena Dei-Ampeh, Alfred Kwabena Dei-Ampeh, Senghong Sing, Senghong Sing, Senghong Sing, LiHua Ma, Zhandong Liu, Zhandong Liu, Mirjana Maletic-Savatic, Mirjana Maletic-Savatic, Mirjana Maletic-Savatic

“…This method is designed to reduce the dimensionality of large datasets while preserving significant variance. For the first time, we applied the PCA-GLASSO algorithm (i.e., MetaboLINK) to metabolomics data derived from Nuclear Magnetic Resonance (NMR) spectroscopy performed on neural cells at various developmental stages, from human embryonic stem cells to neurons.ResultsThe MetaboLINK analysis of longitudinal metabolomics data has revealed distinct pathways related to amino acids, lipids, and energy metabolism, uniquely associated with specific cell progenies. …”
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The Development of DNA Based Methods for the Reliable and Efficient Identification of Nicotiana tabacum in Tobacco and Its Derived Products by Sukumar Biswas, Wei Fan, Rong Li, Sifan Li, Wenli Ping, Shujun Li, Alexandra Naumova, Tamara Peelen, Esther Kok, Zheng Yuan, Dabing Zhang, Jianxin Shi

“…In this study, two sensitive and specific DNA based methods, one quantitative real-time PCR (qPCR) assay and the other loop-mediated isothermal amplification (LAMP) assay, were developed for the reliable and efficient detection of the presence of tobacco (Nicotiana tabacum) in various tobacco samples and commodities. …”
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Photochemical oxidation and landfarming as remediation techniques for oil-contaminated soil by M. Mambwe, K.K. Kalebaila, T. Johnson

“…Results suggest that photochemical oxidation may be used to effectively degrade oil and shorten remediation time. Photochemical oxidation is environmentally friendly and degrades oil faster than landfarming. …”
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Farmers’ perceptions of climate change, long-term variability and trends in rainfall in Apac district, northern Uganda by Francis Atube, Geoffrey M. Malinga, Martine Nyeko, Daniel M. Okello, Basil Mugonola, George William Omony, Ipolto Okello-Uma

“…Conclusion The mean seasonal rainfall for MAM and SON cropping seasons in Apac district were highly variable from different time points within the past 39 years (1980–2019), while June, July, and August (JJA) did not realize a significant change in rainfall within the same study period that the two cropping seasons (MAM and SON) in the district experienced remarkable variations in rainfall. …”
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The Fabrication and Evaluation of a Potential Biomaterial Produced with Stem Cell Sheet Technology for Future Regenerative Medicine by Shukui Zhou, Ying Wang, Kaile Zhang, Nailong Cao, Ranxing Yang, Jianwen Huang, Weixin Zhao, Mahbubur Rahman, Hong Liao, Qiang Fu

“…Then, acellular matrix was transplanted onto subcutaneous tissue for 1 week or 3 weeks; H&E staining and immunohistochemical analysis of CD68 expression and quantitative real-time PCR (qPCR) were performed to evaluate the immunogenicity and biocompatibility. …”
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Peran Interaktivitas dalam Penggunaan E-learning: Perluasan Model UTAUT by Yuni Marlina Saragih, Erwin Setiawan Panjaitan, Roni Yunis

“…It is intended that by adopting Microsoft Teams, interactions between instructors and students would be more frequent, on time, supportive, and productive. As a result, testing is required to determine the extent to which Microsoft Teams technology adoption and use at STMIK Mikroskil is required. …”
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Are the acute phase proteins related to anestrus in primiparous water buffaloes? Preliminary results by Frank Díaz-Huerta, Anthony Meléndez-Becerra, Justin Dijak, Héctor Nava-Trujillo

“…C-reac- tive protein averaged 60±24 mg/dL and 33±18 mg/dL for early and late postpartum buffaloes, respectively (p=0.137). At the same time, fibrinogen levels were 318.5±161.77 mg/dL for early postpartum and 318.83±69.78 mg/dL, respectively (p = 0.914). …”
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Sinking Skin Flap Syndrome following Posttraumatic Hydrocephalus by Ashish Chugh, Prashant Punia, Sarang Gotecha

“…Out of a total of 212 patients, thirty-eight patients (19%) developed posttraumatic hydrocephalus and out of 38, three presented with SSFS over the course of time. Two patients presented with hemiparesis of the side opposite to sunken flap while 1 other patient was brought by relatives in stuporous state. …”
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The Undocumented Experience by Izah Tahir

“…When I wanted to learn Spanish, I had an easier time than many of my classmates since I already knew Urdu and Punjabi. …”
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The Association between Type-2 Diabetes Duration and Major Adverse Cardiac Events after Percutaneous Coronary Intervention by Botey Katamu Benjamin, Chunguang Qiu, Zhanying Han, Wenjie Lu, Guoju Sun, Xiaofei Qin, Xule Wang, Xi Wang, Ran Li, Liang Pan

“…Angiographic and clinical follow-up were conducted 12 months after the procedures for all the patients and at any given time during the study when needed. Results. A significantly higher rate of myocardial infarction (MI) in diabetic patients with the longest diabetes duration (7.7% vs. 0% and 0.6%, P=0.001) was observed compared with groups of shorter duration. …”
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Physiological arterial pressure improves renal performance during normothermic machine perfusion in a porcine kidney DCD model by Yitian Fang, Gisela Ambagtsheer, Lin Xia, Marian C. Clahsen-van Groningen, Robert C. Minnee, Ron W.F. de Bruin

“…Methods: Twenty-seven slaughterhouse porcine kidneys were retrieved and subjected to 60 min of warm ischemia time to mimic DCD condition. These kidneys were randomized into 75 mmHg (subphysiological, n = 9), 95 mmHg (physiological, n = 9), and 115 mmHg NMP (high physiological, n = 9). …”
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Clinical and radiographic outcomes using standard length of cannulated screws for traditional Latarjet procedure by Juan M. Lopez-Ovenza, MD, Amaury Tapia, MD, Juan I. Duca, MD

“…Of these patients, 60 (87%) were available for final follow-up (n = 62 shoulders), with a mean age of 28.4 ± 9.5 years (range, 16-55 years) at the time of surgery. Fifty six males (93.3%) and 4 females (6.7%) were included. …”
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Tumor biomarkers contribute to the diagnosis and clinical management of the O-RADS MRI risk stratification system for epithelial ovarian tumors by Shengjie Xu, Weijian Gong, Xiyi Chen, Jiatong Wang, Yuan Zhu, Tao Zhang, Yun Gu, Jinxia Zheng, Juan Xu

“…Results A score of 3 was assigned to 66.67% of BeEOTs, 50.96% of BEOTs, and 13.80% of MEOTs, whereas cancer antigen 125 (CA125) ≥ 60.39 U/ml helped identify MEOTs with a low-risk time-intensity curve (TIC) for prompt surgical assessment. …”
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The association between body roundness index and new-onset hyperuricemia in Chinese population: the Kailuan cohort study by Xi Cai, Naihui Zhao, Xuemei Yang, Jiajia Ma, Yajing Liang, Yicheng Liao, Ruiyue Liu, Xinran Wen, Shuohua Chen, Guodong Wang, Na Li, Shouling Wu, Liufu Cui

“…A multivariate Cox regression model was used to test the correlation between BRI and hyperuricemia. At the same time, the restricted cubic spline was applied to solve the dose-response relationship between BRI and the risk of hyperuricemia.Then, stratified analysis was carried out using multivariate Cox regression according to age, sex, hs-CRP level, TG level, education level, smoking status and hypertension status. …”
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Breast Cancer Conditioned Media Modulate the Expression of Immune Checkpoints and Adhesion Molecules in Endothelial Cells by İpek Türkdönmez, Emel Şahin, Mehmet Şahin

“…Materials and Methods: In this study, the expression levels of some immune checkpoints, including lymphocyte-activation-protein 3 (LAG-3), V-domain Ig suppressor of T-cell activation (VISTA), Indoleamine-2,3-dioxygenase (IDO), IDO-2, programmed cell death 1 ligand (PD-L1), PD-L2, Cytotoxic T-lymphocyte associated protein 4, (CTLA-4), and some adhesion molecules, including E-cadherin, VE-cadherin, E-selectin, platelet EC adhesion molecule-1 (PECAM-1), vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), were measured using quantitative real-time polymerase chain reaction in HUVEC ECs preincubated with the conditioned media (CM) collected from normal (CRL-4010) and carcinoma cells (CRL-2329 and MDA-MB-231). …”
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Dual Fine-Grained network with frequency Transformer for change detection on remote sensing images by Zhen Li, Zhenxin Zhang, Mengmeng Li, Liqiang Zhang, Xueli Peng, Rixing He, Leidong Shi

“…Additionally, we develop a lightweight frequency transformer (LFT) with minimal parameters for detecting large-scale ground objects that undergo significant changes over time. This is achieved by incorporating a frequency attention (FA) module, which utilizes Fourier transform to model long-range dependencies and combines global adaptive attentive features with multi-level fine-grained features. …”
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UAV Hyperspectral Remote Sensing Image Classification: A Systematic Review by Zhen Zhang, Lehao Huang, Qingwang Wang, Linhuan Jiang, Yemao Qi, Shunyuan Wang, Tao Shen, Bo-Hui Tang, Yanfeng Gu

“…Furthermore, this article delves into cutting-edge research trends, such as lightweight model development, hyperspectral large models, multisource data fusion, and model interpretability, while also highlighting future trends for UAV hyperspectral remote sensing classification technology, particularly in real-time monitoring and intelligent applications.…”
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Pleural metastases from differentiated thyroid cancer: clinical features and long-term outcomes by Mengyue Liu, Juan Tang, Nan Sun, Chuang Xi, Chentian Shen, Song Hongjun, Quanyong Luo, Xianzhao Deng, Zhongling Qiu

“…The median age at the time of initial diagnosis of PM was 59 years (range: 34–79). …”
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The plasma metabolome of juvenile idiopathic arthritis varies according to subtype and underlying inflammatory status by Jooa Kwon, Melanie R. Neeland, Justine A. Ellis, Jane Munro, Richard Saffery, Boris Novakovic, Toby Mansell

“…A robust molecular signature that tracks with specific JIA features over time is urgently required, and targeted plasma metabolomics may reveal such a signature. …”
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Assessing customer satisfaction: the case of test prescribers at the clinical biology laboratory of Centre Muraz/ Institut National de Santé Publique, Burkina Faso by Dame Yenyetou, Issouf Sanou, Chérileila Thiombiano, Bakary Diamoutany Sogodogo, Adama Sanou, Soufiane D. Sanou, Mamoudou Cisse, Amariane M. M. Kone, Aline R. Ouoba, Dramane Kania, Michel K. Gomgnimbou, Ibrahim Sangare, Abdoul-Salam Ouedraogo

“…The questionnaire was distributed to the laboratory's prescribers, who were contacted ahead of time and consented. KoboToolbox, a data collection platform, was used. …”
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