Changes in sensor recorded activity patterns and neuropsychiatric symptoms after deep brain stimulation for Parkinson’s disease: 5 case reports by Lena C. Bruhin, Michael Single, Aileen C. Naef, Katrin Petermann, Mario Sousa, Matilde Castelli, Ines Debove, Marie E. Maradan-Gachet, Andreia D. Magalhães, Andreas A. Diamantaras, M. Lenard Lachenmayer, Gerd Tinkhauser, Julia Waskönig, Christopher M. el Achkar, Alia Lemkaddem, Mathieu Lemay, Paul Krack, Tobias Nef, Deborah Amstutz

“…Steps taken per hour, nighttime spent in bed and time spent outside were monitored with a smartwatch and ambient sensors placed in patient homes for an average of 20 days pre- and postoperatively. …”
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Sibling Species Composition and Susceptibility Status of Anopheles gambiae s.l. to Insecticides Used for Indoor Residual Spraying in Eastern Uganda by Julius Iga, Stephen Ochaya, Richard Echodu, Elizabeth A. Opiyo, Alex K. Musiime, Angella Nakamaanya, Geoffrey M. Malinga

“…The median knock-down time, KDT50, ranged from 6.6 to 81.4 minutes, while the KDT95 ranged from 21.6 to 118.9 minutes for 0.25% pirimiphos-methyl. …”
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Exotic Laguncularia racemosa drives rapid shifts in pond-to-mangrove restoration communities by Lin Zhang, Yamian Zhang, Yijuan Deng, Pingping Guo, Wenqing Wang, Mao Wang

“…The relative abundance of L. racemosa increased from 8 % in the fourth year to 57 % by the eighth year, during which time three native species disappeared from the plot. …”
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Effectiveness of treatment for different stages of diabetic retinopathy in type 2 diabetes by A.V. Serdiuk, S.Yu. Mogilevskyy, S.V. Zyablitzev, O.Yu. Denisiuk

“…Its risk was associated with the type of treatment, prothrombin time, and the value of the CRV, which determined the effectiveness of surgical and combined treatment. …”
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Three-dimensional ultrasound fusion imaging in precise needle placement for thermal ablation of hepatocellular carcinoma by Jiaming Liu, Yuqing Guo, Yueting Sun, Ming Liu, Xiaoer Zhang, Ruiying Zheng, Longfei Cong, Baoxian Liu, Xiaoyan Xie, Guangliang Huang

“…Plan of needle placement was made through a predetermined simulated ablation zone to ensure a 5 mm ablative margin with the coverage rate toward tumor and ablative margin. With real-time ultrasound and 3DUS fusion imaging, ablation needles were placed according to the plan. …”
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Intrahospital dissemination of multidrug-resistant Acinetobacter baumannii at a teaching hospital in Northeast of Mexico by Samantha Villarreal-Cruz, Adrián Camacho-Ortiz, Samantha Flores-Treviño, Licet Villarreal-Treviño, Paola Bocanegra-Ibarias

“…Among ST detected (ST1694, ST758, ST124, and ST490), ST124, which belongs to the high-risk CC636 clonal complex, is reported for the first time in Mexico. Conclusions: Long-term persistence and dissemination of A. baumannii clones were observed in specific hospital wards from two buildings in a tertiary-care hospital in Mexico. …”
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Application of information-based closed-loop management in optimizing surgical process (基于信息化的闭环管理优化手术流程的设计与实践) by ZHOU Liheng (周立恒), ZHU Xiaodong (朱小东), CHEN Qiannan (陈倩楠), LI Amin (李阿敏)

“…Medical staff operates the PDA to perform corresponding operations on patients who need surgery, and the information system captures the execution node (node set through the actual business content), the execution time and the integrated analysis of these data information to form a closed-loop style. …”
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Bisphenol Analogs Downregulate the Self-Renewal Potential of Spermatogonial Stem Cells by Seo-Hee Kim, Seung Hee Shin, Seok-Man Kim, Sang-Eun Jung, Beom-Jin Shin, Jin Seop Ahn, Kyoung Taek Lim, Dong-Hwan Kim, Kichoon Lee, Buom-Yong Ryu

“…We utilized flow cytometry, immunocytochemistry, real-time quantitative reverse transcription-PCR, and western blot analysis. …”

Men care too: a qualitative study examining women’s perceptions of fathers’ engagement in early childhood development (ECD) during an ECD program for HIV-positive mothers in Malawi... by Linda Richter, Thomas J Coates, Tijana Temelkovska, Pericles Kalande, Evelyn Udedi, Laurie Bruns, Siyenunu Mulungu, Julie Hubbard, Sundeep Gupta, Kathryn Dovel

“…However, most mothers believed fathers would not attend the PMTCT–ECD intervention due to concerns regarding HIV-related stigma at PMTCT clinics, time required to attend and perceptions that the intervention was intended for women.Conclusions Fathers were interested in an integrated PMTCT–ECD programme and actively practised ECD activities at home, but felt uncomfortable visiting PMTCT clinics. …”
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Construction and validation of a prognostic model for NK/T-cell lymphoma based on random survival forest algorithm by HUANG Zhen, HUANG Zhen, WU Yazhou

“…In the validation cohort, the area under the ROC curve (AUC) for the nomogram model at 1, 3, and 5 years was 0.745, 0.771, and 0.748, respectively, while the AUC for the RSF model was 0.764, 0.792, and 0.761 at the same time points. ROC curve analysis indicated that both models demonstrated good accuracy and discrimination in predicting OS. …”
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Electrocardiography interpretation competency among pediatric and child health residents at Addis Ababa University, Ethiopia by Helen Mintesnot, Henok Tadele, Hayat Ahmed, Tamirat Moges, Etsegenet Gedlu

“…Abstract Background Electrocardiography (ECG) interpretation competency is vital to ensure the timely initiation of life-saving treatment for emergent ECG conditions. …”
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Exploring environmental risk in soils: Leveraging open data for non-sampling assessment? by Silvia Aparisi-Navarro, Maria Moncho-Santonja, Beatriz Defez, Carla Candeias, Fernando Rocha, Guillermo Peris-Fajarnés

“…Traditional methods involving sample collection and lab analysis are effective but costly and time-consuming. This study explores whether geostatistical analysis with GIS and open data can provide a faster, more precise, and cost-effective alternative for HM contamination assessment without extensive sampling.Concentrations of nine HMs (Cu, Pb, Ni, Co, Mn, As, Cd, Sb, Cr) were analysed from 498 soil samples collected in two mining areas in Portugal: the Panasqueira and Aljustrel mines. …”
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Expression of Sclerostin in Osteoporotic Fracture Patients Is Associated with DNA Methylation in the CpG Island of the SOST Gene by Yanming Cao, Bin Wang, Ding Wang, Dongxiang Zhan, Caiyuan Mai, Peng Wang, Qiushi Wei, Yamei Liu, Haibin Wang, Wei He, Liangliang Xu

“…After extracting total RNA and protein, we checked the relative expression levels of SOST by quantitative real-time PCR and western blot. Also, immunohistochemical staining was performed to observe the expression of SOST protein in the bone samples. …”
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Body mass index impacts the lipid-lowing effects of statins in patients with type 2 diabetes by Lulu Sun, Zhuo Wang, Bai Wang, Yuxiang Jia, Qidi Zhao, Jingjun Zhao, Xingtao Huang

“…Lipid levels were assessed at two time points, and multivariate logistic regression analysis was used to identify factors influencing the reduction of low-density lipoprotein-cholesterol (LDL-C) levels and lipid control achievement.ResultsThis study included 289 patients, with 82 in normal weigh, 143 in overweight, and 64 in obese. …”
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Humanities education reform exploration and practice under outcomes-based education (OBE) by P. Yang

“…The OBE operates within the framework of the following core issues: the things students learn and the extent of student success, not the manner of learning; the place, the time of learning and the duration of training.OBE process implies ultimate involvement of students’ individual cognitive abilities to master competencies, which help adapt to future life. …”
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The effects of magnitude of calcium decline at the onset of lactation on serotonin dynamics and the serotonin-calcium axis by M.K. Connelly, R.M. Rodney, J. Kuehnl, J.P.N. Andrade, F. Sonnewend Andrade, S. Henschel, E. Block, I.J. Lean, L.L. Hernandez

“…Cows fed a −DCAD diet prepartum had greater circulating serotonin concentrations pre- and postpartum. Time series analyses demonstrated that the pooled mean effect size (ES) of the relationship between ionized Ca and serotonin 36 h before parturition was significantly positive (ES = 0.164) prepartum. …”
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The search for a blood-based biomarker for Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS): from biochemistry to electrophysiology by Krista S. P. Clarke, Caroline C. Kingdon, Michael Pycraft Hughes, Eliana Mattos Lacerda, Rebecca Lewis, Emily J. Kruchek, Robert A. Dorey, Fatima H. Labeed

“…One in four individuals are bed-bound for long periods of time, others have difficulties maintaining a job/attending school, incurring individual income losses of thousands, while few participate in social activities. …”
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ORGANISING A «SERATA ITALIANA»: A PROJECT-BASED LEARNING EXPERIENCE WITH FLEMISH STUDENTS OF L2 ITALIAN by Elisa De Cristofaro, Irene Cenni, Emma Grootvelt

“…This case study, which examined student portfolios and a questionnaire through Thematic Analysis, demonstrates the success of the applied PBL method in terms of student motivation and creativity, project management skills (collaboration, planning, networking), self-awareness, and a specific set of communication skills. At the same time, the observed level of stress among students suggests that this PBL approach would benefit from a well-balanced focus on both language acquisition and the accomplishment of the perceived purpose, namely, a well-attended, enjoyable, and relevant event. …”
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Exhaustion of CD8pos central memory regulatory T cell differentiation is involved in renal allograft rejection by Florian Kälble, Jonas Leonhard, Jonas Leonhard, Martin Zeier, Oliver Zivanovic, Matthias Schaier, Andrea Steinborn

“…In KTR with biopsy-confirmed rejection at the time of enrolment, an increased differentiation of RTE Tregs into CCR7negCD45RAposCD31neg terminally differentiated effector memory (CD31neg TEMRA Tregs) and CD31pos memory Tregs was observed. …”
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Single-cell transcriptome atlas of peripheral immune features to Omicron breakthrough infection under booster vaccination strategies by Yuwei Zhang, Shanshan Han, Qingshuai Sun, Tao Liu, Zixuan Wen, Mingxiao Yao, Shu Zhang, Qing Duan, Xiaomei Zhang, Bo Pang, Zengqiang Kou, Xiaolin Jiang, Xiaolin Jiang, Xiaolin Jiang

“…IntroductionThe high percentage of Omicron breakthrough infection in vaccinees is an emerging problem, of which we have a limited understanding of the phenomenon.MethodsWe performed single-cell transcriptome coupled with T-cell/B-cell receptor (TCR/BCR) sequencing in 15 peripheral blood mononuclear cell (PBMC) samples from Omicron infection and naïve with booster vaccination.ResultsWe found that after breakthrough infection, multiple cell clusters showed activation of the type I IFN pathway and widespread expression of Interferon-stimulated genes (ISGs); T and B lymphocytes exhibited antiviral and proinflammatory-related differentiation features with pseudo-time trajectories; and large TCR clonal expansions were concentrated in effector CD8 T cells, and clonal expansions of BCRs showed a preference for IGHV3. …”
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