A sterol panel for rare lipid disorders: sitosterolemia, cerebrotendinous xanthomatosis and Smith-Lemli-Opitz syndrome by Alexander Bauer Westbye, Lili L. Dizdarevic, Sandra R. Dahl, Emil Andreas Asprusten, Yngve Thomas Bliksrud, Anita Lövgren Sandblom, Ulf Diczfalusy, Per M. Thorsby, Kjetil Retterstøl

“…Existing methods to measure sterols in blood, particularly plant sterols, are often laborious and time consuming. Partly as a result, clinical access to sterol measurements is limited in many parts of the world. …”
Get full text

HIV-1 resistance mutations and genetic diversity among children failing antiretroviral treatment in five healthcare facilities in Benin, West Africa. by Edwige Hermione Dagba Gbessin, Edmond Tchiakpe, René Kpemahouton Keke, Nicole Vidal, Michel Kiréopori Gomgnimbou, Haziz Sina, Euloge Senan Adjou, Aldric Afangnihoun, Moussa Bachabi, Akadiri Yessoufou, Abdoul-Salam Ouedraogo, Lamine Baba-Moussa

“…Viral loads were measured using the m2000 RealTime Abbott platform. Genotyping was carried out with the commercial Viroseq kit. …”
Get full text

Luteal Phase Stimulation in the Same Cycle Is an Effective Strategy to Rescue POSEIDON Poor Responders with No Embryos after the First Follicular Stimulation by Abha Majumdar, Gaurav Majumdar, Neeti Tiwari, Anu Singh, Shweta Mittal Gupta, Ruma Satwik

“…This can be considered a potentially valuable option for women with poor ovarian reserve/response to maximise the number of oocytes retrieved in a single ovarian cycle in the shortest possible time. Aims: The aim of this study was to evaluate the efficacy of the DuoStim protocol in women classified as POSEIDON poor responders undergoing in vitro fertilization by comparing the embryological outcomes between the follicular and luteal phase stimulations in the same menstrual cycle. …”
Get full text

Efficacy of Duloxetine for Postspine Surgery Pain: A Systematic Review and Meta‐Analysis by Abdulsalam Mohammed Aleid, Faisal Alshehri, Naif Alasiri, Fatimah Alhomoud, Shouq Alsaegh, Mohammed Alrasheed, Salem Aljaddua, Ali Alasiri, Asma Boukhari, Abdulmonem Ali Alhussain, Bipin Chaurasia, Saud Nayef Aldanyowi

“…The following search terms were Used in combination using the Boolean operators ((Duloxetine Hydrochloride) AND ((Pain, Postoperative) OR (Postoperative Period) OR (Postoperative Cognitive Complications) OR (Delayed Emergence from Anesthesia) OR (Postoperative Care) OR (spine surgery)) without time constrain for the search. Meta‐analysis was performed using Review Manager (RevMan version 5.4) on the extracted outcome data that present in at least 3 of the included studies. …”
Get full text

Gastrointestinal complaints in patients with anorexia nervosa in the timecourse of inpatient treatment by Caroline Riedlinger, Caroline Riedlinger, Nazar Mazurak, Nazar Mazurak, Norbert Schäffeler, Andreas Stengel, Andreas Stengel, Andreas Stengel, Katrin Elisabeth Giel, Katrin Elisabeth Giel, Stephan Zipfel, Stephan Zipfel, Paul Enck, Paul Enck, Isabelle Mack, Isabelle Mack

“…In addition to treatment time, the strongest predictors were ED pathology at admission for the development of abdominal pain, constipation, reflux, and total GI symptoms; stress for the development of constipation and total GI symptoms; and depression for constipation.ConclusionsInforming patients with AN about the course of GI symptoms and their improvement during weight rehabilitation may help support compliance during treatment.…”
Get full text

High serum CA19-9 predicts severe cholecystitis in calculous cholecystitis patients by Shouwen Wang, Dachen Zhou, Wanjin Chen, Qi Guo, Liujin Hou, Ruolin Wu, Wei Wang, Muhammad Annus Khan, Muhammad Ahmad, Fan Huang, Meijuan Zheng, Guobin Wang, Hongchuan Zhao, Xiaoping Geng, Xiaojun Yu

“…Conclusions This study demonstrated that higher level of serum CA19-9 correlates with more severe cholecystitis in calculous cholecystitis patients for the first time, which will provide helpful information for clinical practice and basic research in related field.…”
Get full text

Influence of different priming treatments on germination potential and seedling establishment of four important hemp (Cannabis sativa L.) cultivars by Saba Latif, Rahmatullah Qureshi, Abdul Rauf, NoshinIlyas, Qaiser Hussain, Syed Sabir Hussain Shah, Sabith Rehman, Arshad Mahmood Khan, Nasrullah Khan, Mostafa A. Abdel-Maksoud, Abdul Malik, Sabiha Fatima, Bushra Hafeez Kiani

“…A randomized complete block design (RCBD) was used, and experimental data (in triplicate) were analyzed through analysis of variance (ANOVA) using a time-to-event approach. The findings revealed that IBA significantly (p < 0.05) improved seed germination rates, with CBD Pink Kush achieving the highest germination response (83%) among the tested cultivars. …”
Get full text

The association of origin and environmental conditions with performance in professional IRONMAN triathletes by Beat Knechtle, Mabliny Thuany, David Valero, Elias Villiger, Pantelis T. Nikolaidis, Marilia S. Andrade, Ivan Cuk, Thomas Rosemann, Katja Weiss

“…The fastest athletes originated from Switzerland, the fastest race courses were IRONMAN Brazil Florianopolis, IRONMAN Barcelona, and IRONMAN Louisville. The fastest race times were achieved in water temperature warmer than 22 °C and air temperature between 19 and 26 °C.…”
Get full text

Predicting cardiovascular outcomes in Chinese patients with type 2 diabetes by combining risk factor trajectories and machine learning algorithm: a cohort study by Qi Huang, Xiantong Zou, Zhouhui Lian, Xianghai Zhou, Xueyao Han, Yingying Luo, Shuohua Chen, Yanxiu Wang, Shouling Wu, Linong Ji

“…Transition analysis examined the changes in risk stratification over time. Results The ML-CVD-C score achieved a C-index of 0.80 (95% CI: 0.78–0.82) in the testing cohort, significantly outperforming the ML-CVD-C (base) score, China-PAR, and PREVENT, which had C-index values of 0.62–0.65. …”
Get full text

How to increase value and reduce waste in research: initial experiences of applying Lean thinking and visual management in research leadership by Annmarie Touborg Lassen, Jesper Ryg, Torben Knudsen, Vibeke Andersen, Torkell Ellingsen, Mohammad Naghavi-Behzad, Anna-Marie Bloch Münster, Aleksander Krag, Tahir Masud, Oke Gerke, Kim Brixen, Kirsten Kyvik, Kristian Kidholm, Malene Grubbe Hildebrandt, Jørgen Ejler Pedersen, Henrik J Ditzel, Annette Langhoff, Gert Nielsen

“…Concerns were lack of evidence for using Lean methods in research leadership and that the model itself could be a time consumer. Some lessons learnt were that adding Lean tools in research leadership should not just provide increased research productivity, but also improve other important key performance indicators such as quality of research and patient-relevant results. …”
Get full text

Combining Unity with machine vision to create low latency, flexible and simple virtual realities by Yuri Ogawa, Raymond Aoukar, Richard Leibbrandt, Jake S. Manger, Zahra M. Bagheri, Luke Turnbull, Chris Johnston, Pavan K. Kaushik, Jaxon Mitchell, Jan M. Hemmi, Karin Nordström

“…For tethered walking animals, we used FicTrac to track the motion of a trackball. In both cases, real‐time tracking was interfaced with Unity to control the location and rotation of the tethered animal's avatar in the virtual world. …”
Get full text

Clinical Laboratory Validation Study of a High Sensitivity Troponin I Assay on a POCT (Point of Care Testing) Device by Fabio Grunspun Pitta, Adriana Caschera Leme, Simone Rodrigues Gomes, Tarsila Perez Mota, Fernanda Vieira Paladino, José Leão de Souza Júnior, Rosemeire de Paula Braz, Thais Cristine Rodrigues Leonel Lamounier, Jéssica Buzin Gomes Ferreira, Carlos Eduardo dos Santos Ferreira

“…The biggest concern regarding the techniques for troponin evaluation is the time required between collection and delivery of the result. …”
Get full text

Study on the interaction between β-carotene and gut microflora using an in vitro fermentation model by Zhixian Li, Zhuqing Dai, Enjuan Shi, Peng Wan, Guijie Chen, Zhongyuan Zhang, Yayuan Xu, Ruichang Gao, Xiaoxiong Zeng, Dajing Li

“…After 24 h fermentation, the degradation rate of β-carotene was (64.28 ± 6.23)%, which was 1.46 times that of the group without gut microflora. Meanwhile, the production of VA was nearly 2 times that of the group without gut microflora, indicating that the gut microflora can metabolize β-carotene into VA. β-Carotene also influences the production of short-chain fatty acids (SCFAs), the production of total SCFAs in 0.5 mg/mL β-carotene (BCM) group was (44.00 ± 1.16) mmol/L, which was 2.26 times that of the blank control (BLK) group. …”
Get full text

Deteksi Land Surface Temperature Menggunakan Citra Landsat: Studi Kasus Kota Jababeka dan Sekitarnya by Abdul Rohman Zaky, Suhendra Suhendra, Muhammad Ayub Arwin

“…The study's findings revealed that the average LST increased by 3.03 ºC between 1990 and 2000, and subsequently, there were consecutive decreases in the average LST during the following time intervals: 2.39 ºC between 2000 and 2010 and 0.54 ºC between 2010 and 2020. …”
Get full text

Causal relationship between 412 gut microbiota, 1,400 blood metabolites, and diabetic nephropathy: a randomized Mendelian study by Bo-Ning Cao, Cai-Yan Zhang, Zhen Wang, Yao-Xian Wang, Yao-Xian Wang

“…The results were heterogeneous and multi-efficacious.ConclusionsFor the first time, MR analysis provides supportive evidence for a bidirectional causal relationship between microbiota and diabetic nephropathy and identifies specific genes associated with the disease. …”
Get full text

Mental Health Impacts of the COVID-19 Pandemic on Australian Children and Adolescents with a Medical Condition: Longitudinal Findings by Louise M. Crowe, Cathriona Clarke, Dan Geraghty, Ben Collins, Stephen Hearps, Remy Pugh, Nicola Kilpatrick, Emma Branson, Jonathan M. Payne, Kristina Haebich, Natalie McCloughan, Christopher Kintakas, Genevieve Charles, Misel Trajanovska, Ivy Hsieh, Penelope L. Hartmann, Sebastian King, Nicholas Anderson, Vicki Anderson

“…Covariates such as older child age, increased parent stress and child screen time contributed to greater mental health difficulties. …”
Get full text

Efficacy and Safety of CART Cell Therapy in Aggressive B‐Cell Lymphomas Involving the Gastrointestinal Tract by Lixia Ma, Yimeng Dou, Rui Liu, Teng Xu, Fan Yang, Peihao Zheng, Shaomei Feng, Yuelu Guo, Hui Shi, Fei Xue, Biping Deng, Xiaoyan Ke, Kai Hu

“…Their median follow‐up time was 22.49 months, while the medians of overall survival (OS) and progression‐free survival (PFS) were 10.88 and 5.47 months, respectively. …”
Get full text

The Rickettsia actin-based motility effectors RickA and Sca2 contribute differently to cell-to-cell spread and pathogenicity by Cuong J. Tran, Zahra Zubair-Nizami, Ingeborg M. Langohr, Matthew D. Welch

“…Compared with Sca2-spread, RickA-spread involves the formation of longer protrusions that exhibit larger fluctuations in length and take a longer time to be engulfed into neighboring cells. We further compared the roles of RickA and Sca2 in vivo following intradermal (i.d.) infection of Ifnar1−/−; Ifngr1−/− mice carrying knockout mutations in the genes encoding the receptors for IFN-I (Ifnar1) and IFN-γ (Ifngr1), which exhibit eschars and succumb to infection with wild-type (WT) R. parkeri. …”
Get full text

The role of paternal support in breastfeeding outcomes: a meta-analytic review by Si-si Zhou, Jia Lu, An Qin, Yang Wang, Wei Gao, Hong Li, Lin Rao

“…The meta-analysis results indicated that the rate of exclusive breastfeeding was significantly higher in the intervention group compared to the control group at various time points: within one week postpartum (RR 1.28; 95% CI 1.16, 1.42); at 30–42 days postpartum (RR 1.12; 95% CI 1.02, 1.23); and at three months postpartum (RR 1.35; 95% CI 1.21, 1.50). …”
Get full text

Prediction Efficiency of Postoperative Acute Kidney Injury in Acute Stanford Type A Aortic Dissection Patients with Renal Resistive Index and Semiquantitative Color Doppler by Huai Qin, Yaqiong Li, Nan Zhang, Tiezhu Wang, Zhanming Fan

“…Univariate analysis showed that RRI, SQC Doppler grade, length of stay in ICU, time of CPB, and length of stay in hospital were significant predictors of PAKI. …”
Get full text