IL-17 triggers PD-L1 gene transcription in NSCLC cells via TRIM31-dependent MEF2C K63-linked polyubiquitination by Shuai Ying, Ningxia Wu, Yuting Ruan, Wen Ge, Pei Ma, Tongpeng Xu, Yongqian Shu, Yingwei Wang, Wen Qiu, Chenhui Zhao

“…Although NSCLC immune escape is partly due to the interaction between PD-1 and PD-L1 and PD-L1 expression can be upregulated in cancer cells upon stimulation with IL-17, the underlying mechanism of IL-17-triggered PD-L1 gene transcription in NSCLC cells remains elusive. Methods RT‒PCR, real-time PCR, and IB were used to assess the levels of PD-L1, MEF2C, and TRIM31 in NSCLC tissues as well as in IL-17–stimulated H1299 or PC9 cells. …”
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Subcutaneous sarilumab for the treatment of hospitalized patients with moderate to severe COVID19 disease: A pragmatic, embedded randomized clinical trial. by Westyn Branch-Elliman, Ryan Ferguson, Gheorghe Doros, Patricia Woods, Sarah Leatherman, Judith Strymish, Rupak Datta, Rekha Goswami, Matthew D Jankowich, Nishant R Shah, Thomas H Taylor, Sarah T Page, Sara J Schiller, Colleen Shannon, Cynthia Hau, Maura Flynn, Erika Holmberg, Karen Visnaw, Rupali Dhond, Mary Brophy, Paul A Monach

“…SOC was not pre-specified and could vary over time, e.g., to include antiviral or other anti-inflammatory drugs.…”
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بررسی اثر یک دوره تمرین ترکیبی بر فرایند میوژنز از طریق مسیر ژن‌های Decorin/sparc فیبرهای عضلانی تند و کند انقباض موش‌های صحرایی نر نابالغ... by محمد رضا خلیلی فر, محمد رضا فدائی چافی, علیرضا علمیه

“…برای بررسی بیان ژن دکورین و اسپارک از روش Real-Time PCR استفاده گردید.یافته‌ها: بر اساس آنالیز آماری، مشخص شد در گروه‌ تمرین بیان ژن اسپارک (0/001 ≥ P) و دکورین (0/001 ≥ P) در عضله‌ی نعلی و بیان ژن اسپارک (0/028 ≥ P) و دکورین (0/001 ≥ P) در عضله‌ی دوقلو دارای مقادیر بالاتری نسبت به گروه شاهد بود. …”
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ViT-Based Face Diagnosis Images Analysis for Schizophrenia Detection by Huilin Liu, Runmin Cao, Songze Li, Yifan Wang, Xiaohan Zhang, Hua Xu, Xirong Sun, Lijuan Wang, Peng Qian, Zhumei Sun, Kai Gao, Fufeng Li

“…These inspection techniques take too much time and affect patients’ compliance and cooperation, while difficult for clinicians to comprehend the principle of detection decisions. …”
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Impact of host climate model on contrail cirrus effective radiative forcing estimates by W. Zhang, K. Van Weverberg, K. Van Weverberg, K. Van Weverberg, C. J. Morcrette, C. J. Morcrette, W. Feng, W. Feng, K. Furtado, K. Furtado, P. R. Field, P. R. Field, C.-C. Chen, A. Gettelman, P. M. Forster, D. R. Marsh, A. Rap

“…Here, we implement the contrail parameterisation developed for the Community Atmosphere Model (CAM) in the UK Met Office Unified Model (UM), allowing us to compare, for the first time, the impact of key features of the host climate model on contrail cirrus ERF. …”
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Interferenceless coded aperture correlation holography for five-dimensional imaging of 3D space, spectrum and polarization by Narmada Joshi, Vipin Tiwari, Tauno Kahro, Agnes Pristy Ignatius Xavier, Tatsuki Tahara, Aarne Kasikov, Kaupo Kukli, Saulius Juodkazis, Aile Tamm, Joseph Rosen, Vijayakumar Anand

“…In this study, five-dimensional (5D) imaging along 3D space, spectrum and polarization in I-COACH is proposed and experimentally demonstrated for the first time. The proposed technique exploits the polarization-dependent light modulation characteristics of spatial light modulators to record polarization-dependent intensity distributions, which are distinguished by significant blurring between orthogonal polarization states. 5D I-COACH is implemented by inter-connecting all five dimensions in a single frame, and image recovery is attempted from different configurations of recorded point spread intensity distributions and response-to-object intensity distributions along 5D using recently developed deconvolution techniques. …”
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Circulating MicroRNAs in Patients with Psoriasis Treated with Anti-IL-23: A Cohort Study by Federico Diotallevi, Giulia Matacchione, Anna Campanati, Elena Marinelli Busilacchi, Nadia Viola, Ilaria Pace, Beatrice Fontana, Roberta Roncarati, Massimiliano Bonafè, Manuela Ferracin, Jacopo Sabbatinelli, Fabiola Olivieri

“…Findings were validated in a separate cohort of 23 patients using quantitative real-time PCR (qRT-PCR). T-regulatory cell (Treg) numbers and pro-inflammatory cytokine levels were also assessed. …”
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Presenting a Multi-objective Mathematical Model for Smart Grids Considering Load Response Programs by Mohammad Hossein Tahari-Mehrjardi, Aliyeh Kazemi, Hamed Shakouri Ganjavi

“…These programs enhance energy consumption patterns during peak load times, resulting in appropriate pricing and grid reliability. …”
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Dual Role of α-MSH in Colitis Progression: Mediating Neutrophil Differentiation via Bone Marrow by Liao X, Liu H, Li Y, Zhang W, Dai Q, Wei H, Zhou J, Xie X, Zhou H

“…These findings offer vital guidance for optimizing personalized treatment of IBD, emphasizing the importance of carefully managing the timing and dosage of α-MSH for its effective clinical application.Keywords: IBD, α-MSH, hematopoietic stem cells, neutrophils, inflammation…”
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Faktor-faktor yang Berhubungan Dengan Unmet Need KB Pasca-Salin IUD post-placenta di Kamar Rawat Pasca-bersalin RSUP DR. M. Djamil periode Januari-Maret 2013 by Sari Handayani Utami, Desmiwati Desmiwati2, Endrinaldi Endrinaldi

“…<br />Kata kunci: faktor yang berhubungan, unmet need, KB pasca-salin, IUD post-placenta<br />Abstract<br />The women in post-partum period have unmet need rate to contraception, whereas it’s approriate time to start using contraception. One of recent post-partum contraception method is IUD post-placenta. …”
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LncRNAs in serum-derived extracellular vesicles are potential biomarker and correlated with immune infiltration in gastric cancer by Juan Ding, Yunyan Teng, Rongshu Cui, Jin Liu, Ke Xiao, Zhaogang Dong, Yi Zhang, Xiaofei Xu

“…LncRNAs were further validated in training and validation sets using quantitative real-time reverse transcription polymerase chain reaction.ResultsA total of 37,684 lncRNAs were obtained, and 10 lncRNAs were selected based on the criteria (P &lt; 0.05 and |log2FoldChange| ≥1). …”
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Individual mobility prediction by considering current traveling features and historical activity chain by Xiaotong Zhang, Zhipeng Gui, Yuhang Liu, Dehua Peng, Qianxi Lan, Zhangxiao Shen, Huan Chen, Yuhui Zuo, Yao Yao, Huayi Wu, Kai Li, Kun Qin

“…Specifically, (1) we construct current traveling features by extracting real-time moving states, and represent spatiotemporal correlations between traversed road intersections using word embedding; (2) we learn travel intentions as a probability vector for each historical trip, and combine it with spatiotemporal features to construct historical activity chain; (3) we construct an individual mobility prediction model using Long Short-Term Memory (LSTM) network and spatiotemporal scoring mechanism, to capture short-term and long-term dependencies in current trip and historical activity chain, respectively. …”
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Effect of postpartum clinical guideline on maternal outcomes in iranian women: a randomized controlled clinical trial by Leila Abdoli Najmi, Sakineh Mohammad-Alizadeh-Charandabi, Shayesteh Jahanfar, Fatemeh Abbasalizadeh, Haniyeh Salehi Poormehr, Mojgan Mirghafourvand

“…Abstract Background The postpartum period is a vital time for women, infants, spouses, parents, caregivers and families. …”
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The peculiar characteristics and advancement in diagnostic methodologies of influenza A virus by Muhammad Asif Raza, Muhammad Asif Raza, Muhammad Awais Ashraf, Muhammad Awais Ashraf, Muhammad Nabeel Amjad, Muhammad Nabeel Amjad, Ghayyas Ud Din, Ghayyas Ud Din, Bei Shen, Yihong Hu, Yihong Hu

“…Precise and early detection of IAV strain is crucial for quick treatment using antiviral drugs and unraveling epidemiological patterns to curb epidemics and pandemics on time. Advancements in diagnostic methodologies have enabled us to detect the IAV at early stages by overcoming the limitations of previously used diagnostic tests, further preparing us to combat future epidemics more effectively. …”
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Multivitamin Supplementation and Fertility Outcome: A Retrospective Single-Center Cohort Study and the Clinical and Medicolegal Value of Nutritional Counseling by Giuseppe Gullo, Simona Zaami, Adriana Vita Streva, Sofia Burgio, Valentina Billone, Yulia Kotlik, Elena Chitoran, Silvia Ganduscio, Giovanni Baglio, Antonio Perino, Gaspare Cucinella

“…In the study group, a shorter administration time and lower dosages of gonadotropins required to reach follicle maturity were also observed compared to controls, with fewer dose adjustments during stimulation compared to the starting dose. …”
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Concentrated Solar Power and Photovoltaic Systems: A New Approach to Boost Sustainable Energy for All (Se4all) in Rwanda by Noel Hagumimana, Jishi Zheng, Godwin Norense Osarumwense Asemota, Jean De Dieu Niyonteze, Walter Nsengiyumva, Aphrodis Nduwamungu, Samuel Bimenyimana

“…Heavy usage of conventional power has led to the depletion of fossil fuels. At the same time, it has highlighted its unfriendly relationship with the environment because of carbon dioxide (CO2) emission, which is a major cause of global warming. …”
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Intensitas Penggunaan Media Sosial Instagram dan Akhlak Siswa di Sekolah by Miftahul Fikri, Nurhamzah Nurhamzah, Shofia Limas Erintania

“…Then from the results of interviews regarding the morals of students at school, researchers get bad information, where many students are often cool to play smartphone without regard to the manners in the surroundings and opened up smartphone during class time. From this, researchers are interested in seeing the relationship between the two. …”
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Examining Specific Theory-of-Mind Aspects in Amnestic and Non-Amnestic Mild Cognitive Impairment: Their Relationships with Sleep Duration and Cognitive Planning by Areti Batzikosta, Despina Moraitou, Paschalis Steiropoulos, Georgia Papantoniou, Georgios A. Kougioumtzis, Ioanna-Giannoula Katsouri, Maria Sofologi, Magda Tsolaki

“…Mediation analysis applied to examine potential direct and indirect effects of sleep duration on ToM tasks indicated that total sleep time had significant indirect effects through cognitive planning—mainly as rule violation total score—on specific ToM aspects. …”
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Long-term Breast Shape Analysis After Short-scar Reduction Mammaplasty: A Critical View by Daniel Hilewitz, MD, Oren Ganor, MD, Neta Adler, MD, Asaf Olshinka, MD, Dafna Shilo Yaacobi, MD, Lior Har-Shai, MD, Tamir Shay, MD, Michael Icekson, MD, Dean Ad-El, MD, Sagit Meshulam-Derazon, MD

“…The mean sternal notch-to-nipple and upper breast-to-nipple distances decreased postoperatively by 22% and 43%, respectively, and remained stable over a mean time of 110.1 ± 65.58 weeks. The nipple-to-inframammary fold distance, which was intraoperatively shortened by an average of 63%, elongated back to 88% of its preoperative measurements. …”
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Effect of Liuzijue on Pulmonary Function of Patients with Ischemic Stroke and Hemiplegia by CHEN Yannan, ZHANG Hongxin, DENG Lijin, WENG Meihua, HU Jingwen, ZHOU Hongjuan, YOU Shijing, CHEN Jinxiu

“…The control group received routine treatment, nursing care, and early rehabilitation training; in addition to these interventions, the experimental group received Liuzijue respiratory training, and the patients were instructed with nasal inspiration and mouth expiration method, and the expiration was carried out in accordance with the Liuzijue sequence of "xu" "he" "hu" "si" "chui" "xi" 30 min/time, once a day, 5 days a week, lasting for 12 weeks. …”
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