Immune-endocrine crossroads: the impact of nuclear receptors in Tuberculosis and Chagas disease by Ana R. Pérez, Ana R. Pérez, Oscar A. Bottasso, Oscar A. Bottasso, Oscar A. Bottasso, Natalia E. Santucci, Natalia E. Santucci

“…Unlike acute inflammation, which helps the host respond to pathogens, chronic inflammation leads to metabolic disorders and a dysregulated neuro-immuno-endocrine response. Over time, disturbances in cytokine, hormone, and other compound production foster an unbalanced, detrimental defensive response. …”
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Effects of a high-fat diet on the lipid profile of oocytes in mice by E. Yu. Brusentsev, E. A. Chuyko, K. A. Okotrub, T. N. Igonina, I. N. Rozhkova, D. S. Ragaeva, S. V. Ranneva, V. A. Naprimerov, S. Ya. Amstislavsky

“…A high-fat diet caused larger body weight in female mice compared with the control (p < 0.001; 44.77±1.46 and 35.22±1.57, respectively), and increased the blood levels of cholesterol (p < 0.05; 2.06±0.10 and 1.78±0.10, respectively) and triglycerides (p < 0.05; 2.13±0.23 and 1.49±0.21, respectively). At the same time, this diet does not affect the level of unsaturation of lipids in immature (0.207±0.004 in the experiment and 0.206±0.002 in the control) and matured oocytes (0.212±0.005 in the experiment and 0.211±0.003 in the control). …”
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Digital Twins for Clinical and Operational Decision-Making: Scoping Review by Vahid Riahi, Ibrahima Diouf, Sankalp Khanna, Justin Boyle, Hamed Hassanzadeh

“…DTs are virtual representations of products, systems, or processes that interact bidirectionally in real time with their actual counterparts. Although DTs have diverse applications from personalized care to treatment optimization, misconceptions persist regarding their definition and the extent of their implementation within health systems. …”
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Intravenous anesthesia with high-flow nasal cannula improves recovery in elderly undergoing ureteroscopic lithotripsy: a prospective controlled study by Lifei Tang, Ran Guo, Yaochen Quan, Haiwen Zhang, Yingcong Qian, Youjia Yu, Shaoyong Song, Jian Li

“…Secondary outcomes included PACU stay duration, time to out-of-bed mobilization, length of hospital stay, airway dryness scores, surgeons’ satisfaction, and postoperative complications. …”
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Characterization of the Beekeeping Value Chain: Challenges, Perceptions, Limitations, and Opportunities for Beekeepers in Kayonza District, Rwanda by Borden Mushonga, Landouard Hategekimana, Gervais Habarugira, Erick Kandiwa, Alaster Samkange, Basiamisi Victor Ernest Segwagwe

“…Forty-one percent of the respondents lacked adequate information on beekeeping, 25% had inadequate time to work on apiaries, 24% had inadequate technical knowledge and implements, and 10% needed additional labour for managing apiaries. …”
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Importance of reference group selection in the evaluation of cancer incidence by Alexandra K. Mueller, Brandon Vaeth, Andrew C. Todd, Christopher R. Dasaro, Jiehui Li, Baozhen Qiao, Paolo Boffetta, David J. Prezant, Charles B. Hall, David G. Goldfarb, Rachel Zeig-Owens

“…Abstract Elevated cancer incidence has been reported among World Trade Center (WTC)-exposed responders, with some incidence rate ratios (IRRs) varying over time. This study describes the influence that different reference populations have on relative cancer incidence and temporal trends. …”
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Multi-Feature Driver Variable Fusion Downscaling TROPOMI Solar-Induced Chlorophyll Fluorescence Approach by Jinrui Fan, Xiaoping Lu, Guosheng Cai, Zhengfang Lou, Jing Wen

“…The downscaled SIF products showed a strong correlation with TanSIF and GOSIF products (R² > 0.8), and consistent trends with GPP further confirmed the reliability of the 1 km SIF product. Additionally, a time series analysis of Shandong Province’s wheat-growing areas revealed a strong correlation (R² > 0.8) between SIF and multiple vegetation indices, underscoring its utility for regional crop monitoring.…”
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Effect of Extraction and Preservation Methods on the Microbiological and Physicochemical Quality of Pentadesma butyracea Butter Produced in a Traditional Area in Benin by Marius Eric Badoussi, Yann E. Madode, Célestin K. C. Tchekessi, Laurenda Honfozo, Ifagbémi Bienvenue Chabi, Kamirou Chabi Sika, Arlette Adjatin, Joseph D. Hounhouigan, Paulin Azokpota

“…It is important to continue this investigation by storing butter for a longer period of time with more appropriate packaging.…”
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The newborn behavioural observations (NBO) system embedded in routine postpartum care in at-risk families in Iceland: a randomised controlled trial by Lisbeth Valla, Kari Slinning, Tore Wentzel-Larsen, Gun-Mette Røsand, Stefanía Birna Arnardóttir

“…Mixed effects models were used to estimate group differences in learning outcomes and maternal confidence across three time points. Two sample t-tests were used to compare the two groups’ EAS scores. …”
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Plasma S100A8/A9 level predicts response to immune checkpoint inhibitors in patients with advanced non-small cell lung cancer by Tadahiro Kuribayashi, Rie Kinoshita, Kiichiro Ninomiya, Go Makimoto, Toshio Kubo, Kammei Rai, Eiki Ichihara, Katsuyuki Hotta, Masahiro Tabata, Yoshinobu Maeda, Katsuyuki Kiura, Shinichi Toyooka, Masakiyo Sakaguchi, Kadoaki Ohashi

“…Sixty-two patients were men, 54 had adenocarcinoma, 74 had performance status (PS) 0–1, and 47 received ICIs as first-line treatment. The median time to treatment failure (TTF) for ICIs was 5.7 months, and the median overall survival (OS) was 19.6 months. …”
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Effect of central sensitization on postoperative cognitive dysfunction in total knee arthroplasty patients: a retrospective study by Qiqi Yang, Qiqi Yang, Chunning Li, Min Ye, Xinhua Zhou, Xinhua Zhou, Weiran Li, Fei Li, Fei Li

“…Data were collected at six time points: preoperatively (T0), intraoperatively (T1), and postoperatively on days 1 (T2), 3 (T3), 7 (T4), and 30 (T5). …”
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Imagery Rescripting (ImRs) and Eye Movement Desensitization and Reprocessing (EMDR) as treatment of childhood-trauma related post-traumatic stress disorder (Ch-PTSD) in adults: eff... by Martine Daniëls, Marie-Louise Meewisse, Annet Nugter, Sophie A. Rameckers, Eva Fassbinder, Arnoud Arntz

“…No statistically significant differences were found between ImRs and EMDR regarding changes in Schema Modes over time. No significant changes were observed during the waitlist period.Conclusions: ImRs and EMDR showed improvements in Schema Modes when primarily targeting Ch-PTSD. …”
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IL-33 Deficiency Attenuates Lung Inflammation by Inducing Th17 Response and Impacting the Th17/Treg Balance in LPS-Induced ARDS Mice via Dendritic Cells by Li Cheng, Yang Jiao, Wei Jiang, Xin Zhang, Liping Zhang, Gongwei Jia

“…The mRNA expression levels of IL-33 and RORγt were measured by quantitative real-time polymerase chain reaction (qRT-PCR). Th17 and Treg cell frequencies were determined by flow cytometry. …”
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The Promising Effect of Tocilizumab on Chronic Antibody-Mediated Rejection (cAMR) of Kidney Transplant by Łukasz Świątek, Miłosz Miedziaszczyk, Dominik Lewandowski, Filip Robakowski, Piotr Tyburski, Marta Jakubowska, Marek Karczewski, Ilona Idasiak-Piechocka

“…The mean loss of eGFR in time was −0.141 mL/min/1.73 m² (95% CI: −0.409 to 0.126; <i>p</i> = 0.298) and was found to be statistically insignificant. …”
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Extraction Socket Seal Technique for Socket Preservation after Tooth Extraction: An Innovative Approach. by Abduljaleel Azad Samad, Jodal M Ahmed, Hundren M Ali, Omed Shihab, Ahmed Haider, Dainius Karpavicius

“…Conclusions: We concluded that the Extraction Socket Seal (ESS) technique offers a very simple and time-saving technique for alveolar ridge preservation after tooth extraction for both anterior and posterior extraction sockets, and it provides a good seal for the graft material and the soft tissue anatomy was well preserved. …”
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Diagenetic Modifications and Reservoir Heterogeneity Associated with Magmatic Intrusions in the Devonian Khyber Limestone, Peshawar Basin, NW Pakistan by Mumtaz M. Shah, Saifullah Afridi, Emad U. Khan, Hamad Ur Rahim, Muhammad R. Mustafa

“…Coarse crystalline marble formed due to contact metamorphism at the time of dolerite emplacement. The second phase of dolomitisation (Dol. …”
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Noninvasive Evaluation of EGFR Expression of Digestive Tumors Using 99mTc-MAG3-Cet-F(ab′)2-Based SPECT/CT Imaging by Dai Shi, Yiqiu Zhang, Zhan Xu, Zhan Si, Yuan Cheng, Dengfeng Cheng, Guobing Liu

“…Cet-F(ab′)2 was conjugated with NHS-MAG3 for 99mTc radiolabeling. The best imaging time was determined using a biodistribution assay at 1, 4, 16, and 24 h after injection of the 99mTc-MAG3-Cet-F(ab′)2 tracer. …”
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Unusual Thermo‐Enhanced Second Harmonic Generation in Organic Configurationally‐Locked Polyene Crystals by Yi Liu, Pengfei Zhu, Qingshun Fan, Zihao Zhao, Linjie Wei, Yu Ma, Haojie Xu, Wuqian Guo, Junhua Luo, Zhihua Sun

“…Organic configurationally‐locked polyene represents an exciting NLO family with large second harmonic generation (SHG) effects, whereas it is a huge blank to switch and modulate their NLO property through external stimuli. For the first time, here present unusual thermo‐enhanced SHG activities are presented in a polyene‐based NLO compound, 2‐{3‐[2‐(4‐pyrrolidinphenyl)vinyl]‐5,5‐dimethylcyclohex‐2‐enylidene}malononitrile (1), giving a record‐high magnitude of SHG enhancement up to ≈170% during its isomorphic phase transition. …”
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Respiratory pathogen spectrum and epidemiological trends in Hainan Province: a retrospective analysis from 2017 to 2023 by Lvying Wu, Jianan Zhang, Zhiming Wu, Hua Pei, You Zhang

“…Co-infection pattern analysis showed that “M. pne-dominant viruses” co-infection type was prevalent across all three time periods. Conclusion M. pne, Flu-B, Flu-A, and PIV were found to be the main causative pathogens of RTI patients in Hainan Province, and their prevalence levels and seasonal patterns had changed during large-scale NPI and COVID-19 pandemic.…”
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Are facility service delivery models meeting the sexual and reproductive health needs of adolescents in Sub-Saharan Africa? A qualitative evidence synthesis by Yusupha Sanyang, Saikou Sanyang, Alice Norah Ladur, Mamady Cham, Nicola Desmond, Florence Mgawadere

“…However, several barriers were identified: negative attitudes of health workers, financial constraints, transportation challenges, waiting time, intimidating environments, and lack of confidentiality pose a challenge to the effectiveness of the model. …”
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