Insular infraorbital neurovascular pedicle labial salivary gland transplantation for the treatment of severe dry eye disease: an IDEAL stage 0, 1 and 2a study by Jing Zhou, Xiaohong Chen, Mei Li, Ke Yang, Ying Jie, Yinghui Wang, Yingshi Piao, Yun Cheng

“…We designed a modified LSGT, called insular infraorbital neurovascular pedicle LSGT, and evaluated the postoperative efficacy.Design This is a prospective, single-centre, self-contained study.Setting The research was conducted at Beijing Tongren Hospital, Capital Medical University from July 2019 to March 2024.Participants Eight patients (nine eyes) with severe dry eye disease (DED) were enrolled in this study.Interventions All patients underwent insular infraorbital neurovascular pedicle LSGT and were followed up for at least 6 months postoperatively.Main outcome measure Key evaluation indices were best-corrected visual acuity (BCVA), Ocular Surface Disease Index (OSDI) score, tear break-up time (TBUT), Corneal Fluorescence Staining (CFS) score, and Schirmer I test (SIT).Results With a mean follow-up of 17.56±11.72 months, BCVA improved in four eyes and stabilized in five. …”
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Metastatic Uterine Leiomyosarcoma in the Upper Buccal Gingiva Misdiagnosed as an Epulis by Andrea Cassoni, Valentina Terenzi, Davina Bartoli, Oriana Rajabtork Zadeh, Andrea Battisti, Mario Pagnoni, Davide Conte, Alessandro Lembo, Sandro Bosco, Francesco Alesini, Valentino Valentini

“…In case of metastases, surgical excision can be performed considering extent of disease, number and type of distant lesions, disease free interval from the initial diagnosis to the time of metastases, and expected life span. We illustrate a case of uterine LMS metastasis in the upper buccal gingiva that occurred during chemotherapy in a 63-year-old woman that underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy for a diagnosis of LMS staged as pT2bN0 and that developed lung metastases eight months after primary treatment. …”
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Synergistic Antifungal Activity of Terbinafine in Combination with Light-Activated Gelatin–Silver Nanoparticles Against <i>Candida albicans</i> Strains by Atif Ullah, Fawad Ali, Farman Ullah, Sajid Khan Sadozai, Saeed Ahmed Khan, Sajid Hussain, Abdulwahed Fahad Alrefaei, Sajid Ali

“…These results were complemented by the findings of the time-to-kill assay, where the same strain showed a 3.2 log₁₀ CFU/mL decrease in viable cell count. …”
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Optimization of the "Loose Tea Blooming" Process for Guizhou Green Tea and Analysis of Characteristic Volatile Compounds by Linyao SONG, Hui XU, Siyao WU, Fengwei MA, Qiang FEI, Junyi DENG, Dajuan SHI, Yuze LIU, Yichen ZHAO, Xuan DONG, Su XU

“…The optimal preparation conditions for fermented tea were determined through single factor tests and response surface analysis, with the identified processing conditions being temperature at 28 ℃, water content at 40%, inoculation amount at 1‰, and fermentation time at 8 days. The final fermented tea exhibited a mellow taste, bright orange and yellow color, pure aroma, and achieved a comprehensive score of 83.75±2.52. …”
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Head-to-head comparison of pre-hospital qSOFA and lactate-qSOFA for predicting sepsis in patients with and without suspected infection. A multicenter prospective cohort study by Francisco Martín-Rodríguez, Raúl López-Izquierdo, Miguel A. Castro Villamor, Carlos delPozo-Vegas, Irene Sánchez-Soberón, Juan F. Delgado-Benito, Virginia Carbajosa Rodíguez, Rodrigues Leonardo, José Luis Martín-Conty

“…Conclusions An appropriate strategy for reducing the morbidity and mortality from sepsis must necessarily include the prompt identification of this time-dependent pathology by using all the tools at our disposal. …”
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Solid medical waste management practices and awareness in COVID-19 screening stations by S.E. Alzghoul, O.A. Smadi, T. Almomani, M.B. Alzghoul, O.M. Al-Bataineh

“…This is a study conducted among health care employees when an overwhelming amount of coronavirus disease cases were being recorded locally and worldwide, affecting transportation ability and minimizing time spent with screening station personnel.FINDINGS: The outcomes of the first module of the questionnaire revealed a high degree of medical waste management knowledge and awareness among healthcare staff. …”
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Evaluation of Real-World Evidence to Assess Effectiveness Outcomes of Janus Kinase Inhibitors for Rheumatoid Arthritis: A Systematic Review of US Studies by Gandy C, Bazzazzadehgan S, Bruera S, Huang Y

“…Persistence of JAKi in RA patients was reported in 14 studies, where the median persistence time in treatment was reported to be between 121– 516 days. …”
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High Glucose and Lipopolysaccharide Prime NLRP3 Inflammasome via ROS/TXNIP Pathway in Mesangial Cells by Hong Feng, Junling Gu, Fang Gou, Wei Huang, Chenlin Gao, Guo Chen, Yang Long, Xueqin Zhou, Maojun Yang, Shuang Liu, Shishi Lü, Qiaoyan Luo, Yong Xu

“…Simultaneously, the mRNA and protein levels of TXNIP, NLRP3, procaspase-1, and IL-1β were significantly induced by high glucose concentration and lipopolysaccharide in a dose-dependent and time-dependent manner in vitro. This induction by both high glucose and lipopolysaccharide was significantly inhibited by N-acetyl-L-cysteine. …”
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Urine proteomics defines an immune checkpoint-associated nephritis signature by Cassian Yee, Jamie S Lin, James P Long, Shailbala Singh, Yanlan Dong

“…Thus, there is an urgent need for non-invasive biomarkers that can rapidly and accurately distinguish ICI-AIN from other causes of AKI.The urine and plasma proteome contain actively secreted proteins that provide real-time insights into dynamic physiological processes. …”
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Seroprevalence of HSV-2 in multiple subgroups of infertile men with abnormal sperm parameters and those seeking sex selection: a case-control study by Mohamad Javad Mahmodi, Somayeh Shatizadeh Malekshahi, Haleh Soltanghoraee

“…In 2000, the World Health Organization (WHO) for the first time reported the association of STIs with male infertility. …”
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Diversity and Distribution of <i>Phytophthora</i> Species Along an Elevation Gradient in Natural and Semi-Natural Forest Ecosystems in Portugal by Carlo Bregant, Eduardo Batista, Sandra Hilário, Benedetto Teodoro Linaldeddu, Artur Alves

“…Finally, three species, <i>P. citricola</i>, <i>P. hedraiandra</i>, and <i>P. pachypleura</i>, are reported for the first time in the natural ecosystems of Portugal.…”
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Early Left Ventricular Systolic and Diastolic Dysfunction in Patients with Newly Diagnosed Obstructive Sleep Apnoea and Normal Left Ventricular Ejection Fraction by Lisulov Popovic Danica, Mirjana Krotin, Marija Zdravkovic, Ivan Soldatovic, Darko Zdravkovic, Milica Brajkovic, Vera Gardijan, Jelena Saric, Ruzica Pokrajac, Dragan Lovic, Predrag Stevanovic, Milina Tancic Gajic, Miodrag Vukcevic

“…Left ventricle isovolumetric relaxation time (IVRT) and mitral valve flow propagation (MVFP) were significantly longer in OSA patients than in controls. …”
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Development of a cell-penetrating peptide-based nanocomplex for long-term delivery of intact mitochondrial DNA into epithelial cells by Kyrie Wilson, Charles Holjencin, Hwaran Lee, Balasubramaniam Annamalai, Masaaki Ishii, Jeremy L. Gilbert, Andrew Jakymiw, Bärbel Rohrer

“…Here, we present for the first time a strategy to deliver an exogenous, fully intact, and healthy mtDNA template into cells to correct endogenous mtDNA mutations and deletions, with the potential to be developed into an efficient pan-therapy for inherited and/or acquired mtDNA disorders. …”
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Current research status and trends of potassium-competitive acid blockers in the treatment of acid-related diseases: a bibliometric analysis by Baoqiang Zhu, Long Chen, Xue Tao, Hong Zheng, Xia Li, Qingfang Wu, Enwu Long, Haixia Lin

“…Researchers were concerned about the evaluation of treatment regimens and efficacy comparison between P-CABs and traditional proton pump inhibitors (PPIs) in the treatment of ARDs. At the same time, researchers are also closely monitoring the potential adverse reactions and long-term adverse outcomes of clinical application of P-CABs for ARDs.ConclusionThe clinical application of P-CABs, represented by vonoprazan, in ARDs is receiving widespread attention from researchers. …”
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Klasifikasi Teks Hadis Bukhari Terjemahan Indonesia Menggunakan Recurrent Convolutional Neural Network (CRNN) by Muhammad Yuslan Abu Bakar, Adiwijaya Adiwijaya

“…Text classification has its own challenges related to several features whose dimensions are very large so that it increases computing time and causes difficulties in getting optimal results. …”
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MiR-125b-5p ameliorates ox-LDL-induced vascular endothelial cell dysfunction by negatively regulating TNFSF4/TLR4/NF-κB signaling by Wenshuai He, Limin Zhao, Pengfei Wang, Maojia Ren, Yunfei Han

“…Molecular mechanisms were elucidated through quantitative real-time PCR, western blot analysis, and luciferase reporter assays. …”
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Establishing a Surgical Procedure for Rhesus Epiretinal Scaffold Implantation with HiPSC-Derived Retinal Progenitors by Ziming Luo, Kang Li, Kaijing Li, Bikun Xian, Ying Liu, Sijing Yang, Chaochao Xu, Zhigang Fan, Shoutao Lu, Haijun Zhang, Jian Ge

“…Follow-up examination showed that retinal tack fixation was the only method to maintain the scaffolds attached to host retina for at least 3 weeks, which is the minimal time required for cell integration. Histological staining demonstrated slight glial fibrillary acidic protein (GFAP) accumulation in the retinal tack insertion area. …”
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The Link between Type III Reg and STAT3-Associated Cytokines in Inflamed Colonic Tissues by Xin Xu, Hirokazu Fukui, Ying Ran, Xuan Wang, Yoshihito Inoue, Nobuhiko Ebisudani, Heihachiro Nishimura, Toshihiko Tomita, Tadayuki Oshima, Jiro Watari, Hiroshi Kiyama, Hiroto Miwa

“…Gene expression of the Reg family and cytokines (IL-6, IL-17, and IL-22) was evaluated by real-time RT-PCR, and Reg IIIβ/γ expression was examined by immunohistochemistry. …”
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<i>Broussonetia papyrifera</i> Extract Can Be Used as a Raw Material Source for a Sterility Agent for <i>Microtus fortis</i> by Shuangye Wang, Tian Lan, Yunlin Zhao, Wanfu Liu, Tian Huang, Meiwen Zhang, Zhiyuan Hu, Zhenggang Xu

“…Though there were some positive effects on females, the reproductive parameters of coupled voles were inferior; the most treated couple exhibited an increased reproductive time, fetal counts, and reduced weight. It was also found that <i>M. fortis</i> responded negatively to the extract after a single treatment or long-term repeated treatment compared to a short-term repeated treatment. …”
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Wild relatives and interspecific hybrids of potato as source materials in breeding for resistance to golden nematode by N. V. Mironenko, E. V. Rogozina, A. A. Gurina, A. V. Khiutti, N. A. Chalaya, O. S. Afanasenko

“…Sequencing a fragment of the Gro1-4 gene showed that changes in the structure of this fragment in orthologous genes did not affect the feature of resistance to PGN pathotype Ro1.Conclusion. For the first time, sources of resistance to PGN were found among the North American species S. brachystotrichum (k-23201) and S. lesteri (k-24475). …”
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