Elucidating the metabolic mechanisms and active constituents of ZuoGui Wan in combatting postmenopausal osteoporosis: A metabolomics and network pharmacology approach by Yanchen Feng, KaiKai Shi, Dingming Li, Shunzhi Yang, Xue Dang, Jinyao Li, Yan Chen, Jianping Yao, Yunke Zhang, Lu Sun, Feixiang Liu

“…Conclusion: this study comprehensively revealed the metabolic mechanism and active ingredients of ZGW against PMOP for the first time, providing a new perspective on the study of the mechanism of ZGW against PMOP.…”
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Effects of coenzyme Q10 on endothelial and cardiac function in patients undergoing haemodialysis: study protocol for a pilot randomised controlled trial by Yongxing Xu, Enhong Han, Jianjun Gao, Xinlou Li, Xiaowen Zuo, Huaping Jia, Fugui Liang, Lei Xie

“…Eligible patients undergoing haemodialysis in our haemodialysis centre will be randomly allocated to the CoQ10 and control groups. The follow-up time is 12 months. The primary outcome is to assess the change of brachial artery endothelial-dependent flow-mediated dilation, left ventricular systolic function, diastolic function and Myocardial Performance Index at 12 months from baseline. …”
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Ethnic disparities in HbA1c and hypoglycemia among youth with type 1 diabetes: beyond access to technology, social deprivation and mean blood glucose by Suma Uday, John Stuart Pemberton, Zhide Fang, Stuart A Chalew

“…There were no differences between groups for age, MBG, time in range (3.9–10.0 mmol/L), diabetes duration, gender, insulin delivery method (multiple daily injections vs continuous subcutaneous insulin infusion), or percent sensor use (PSU). …”
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Efficacy and Safety of an Aflibercept Treat-and-Extend Regimen in Treatment-Naïve Patients with Macular Oedema Secondary to Central Retinal Vein Occlusion (CRVO): A Prospective 12-... by Jose Garcia-Arumi, Francisco Gómez-Ulla, Navea Amparo, Enrique Cervera, Alex Fonollosa, Luis Arias, Javier Araiz, Juan Donate, Marta Suárez de Figueroa, Lucia Manzanas, Jaume Crespí, Roberto Gallego

“…Results. 24 eyes (24 patients) were included; mean (SD) age: 62.8 (15.0) years; 54.2% male; median (IQR) time since diagnosis: 7.6 (3.0, 15.2) days. Mean BCVA scores significantly improved between baseline (56.0 (16.5)) and Month 12 (74.1 (17.6)); mean (95% CI) change: 14.8 (8.2, 21.4); P=0.0001. …”
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A deep learning-based method for the intelligent identification of the quantity of coals flushed out during borehole hydraulic flushing by Xiaojun LI, Mingyang ZHAO, Miao LI

“…The improved YOLOv8n algorithm was applied to the real-time videos from four drilling sites of borehole hydraulic flushing for gas drainage, yielding respective identification accuracies of 100.0%, 93.3%, 95.7%, and 93.1%, with an average of 95.5%, meeting the accuracy requirements for the automatic identification of coal quantity flushed out during borehole hydraulic flushing. …”
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Comprehensive analysis of the 5-HTTLPR allelic polymorphism effect on behavioral and neurophysiological indicators of executive control in people from different ethnic groups in Si... by A. N. Savostyanov, D. V. Bazovkina, S. A. Lashin, S. S. Tamozhnikov, A. E. Saprygin, T. N. Astakhova, U. N. Kavai-ool, N. V. Borisova, A. G. Karpova

“…The S/S genotype was associated with an increased level of personal anxiety and at the same time with a better ability to the self-control of behavior in the SSP experiment. …”
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New prognostic model in patients with advanced urothelial carcinoma treated with second-line immune checkpoint inhibitors by Ernest Choy, Yohann Loriot, Fabio Calabrò, Cora N Sternberg, Guillermo De Velasco, Daniel Castellano, Roubini Zakopoulou, Aristotelis Bamias, Nicholas James, Axel Merseburger, F Lopez-Rios, Mario Kramer, Kimon Tzannis

“…The development and internal validation of a prognostic model for overall survival (OS) was performed using Cox regression analyses, bootstrapping methods and calibration.Results In 936 patients, ECOG PS, alkaline phosphatase, hemoglobin, neutrophil-to-lymphocyte ratio, liver metastases, bone metastases and time from last chemotherapy were identified as independent prognostic factors. …”
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Analysis of the interaction mechanism between straw soil rotary tillage blade during rotary tillage process by Zhaojie Wang, Xiangyu Li, Junwei Li, Yuntao Qiu, Tianlong Gu, Hailong Wang

“…The results of the orthogonal test showed that under the conditions of rotary ploughing operation with straw spreading, the bending angle of 122°, the tine spacing of 14.5 mm, and the cutter roll speed of 255 r·min− 1 were the better parameter combinations, at which time the minimum rotary torque of 15.327 N·m was achieved, and the maximum number of straw contact bond breaks was 2443. …”
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A non-aseptic bioprocess for production and recovery of 2,3-butanediol via conversion of crude glycerol and corn steep liquor at pilot-scale by Dimitris Karayannis, Nikos Angelou, Gabriel Vasilakis, Ioannis Charisteidis, Alexandros Litinas, Seraphim Papanikolaou

“…The salting-out extraction (SOE), consisting of ethanol (24 %) and K2HPO4 (25 %), recovered 91.7 % of BDO from the fermentation medium and was studied for the first time in a glycerol-based medium. The study suggests the potential industrialization of the bioprocess through sustainable, pilot-scale and low-cost bioconversion of biodiesel-derived crude glycerol and CSL or digestate into BDO.…”
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Clinical efficacy of low‐dose Perampanel correlates with neurophysiological changes in familial adult myoclonus epilepsy 2 by Antonietta Coppola, Claudia Cuccurullo, Gianmaria Senerchia, Marica Rubino, Liana Veneziano, Francesco Brancati, Luigi Baratto, Valentina Virginia Iuzzolino, Leonilda Bilo, Pasquale Striano, Raffaele Dubbioso

“…PER treatment significantly reduced UMRS total scores (p = 0.001) and action‐myoclonus subscores (p = 0.002), irrespective of disease duration, age at onset, or testing time (p >0.05). Patients with more severe baseline myoclonus demonstrated significant improvements. …”
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Design and fabrication of a device for cleaning greenhouse roofs by Ahmed Amin, Xiaochan Wang, Zhao Lianyuan, Yinyan Shi, Ren Xiaoyan, Mahmoud Okasha, Reda Hassanien Emam Hassanien

“…Moreover, the traditional way of cleaning greenhouse roofs using ladders is laborious and time-consuming, requires a lot of water, and puts too much pressure on the roof. …”
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Mapping and assessment of land cover change and ecological stability: a case of three transects in Slovakia by Jana Vojteková, Matej Vojtek, Martin Boltižiar, František Petrovič, Matej Masný, Bohuslava Gregorová

“…Aim of the study: The aim of this paper is to analyze and assess the land cover change in three transects in Slovakia by applying the coefficient of ecological stability and the coefficient of anthropogenic impact in four different time horizons (1950, 1990, 2000, and 2020). Based on the specific natural and socio-economic factors influencing landscape formation and change, we chose three transects from the territory of Slovakia as study areas. …”
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Hyaluronic Acid (800 kDa) Supplementation of University of Wisconsin Solution Improves Viability of Osteochondral Grafts and Reduces Matrix Metalloproteinase Expression during Cold... by Takuya Yamada, Kentaro Uchida, Kenji Onuma, Gen Inoue, Jun Aikawa, Shotaro Takano, Hiroyuki Sekiguchi, Hisako Fujimaki, Masayuki Miyagi, Masashi Takaso

“…In contrast, UW solution supplemented with either 1900 or 6000 kDa HA did not markedly improve the cell viability of the OCT. Real-time PCR analysis revealed that the levels of matrix metalloproteinases 2, 3, and 9 were significantly decreased in OCT stored in UW solution supplemented with 800 kDa HA. …”
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Quantum machine learning with Adaptive Boson Sampling via post-selection by Francesco Hoch, Eugenio Caruccio, Giovanni Rodari, Tommaso Francalanci, Alessia Suprano, Taira Giordani, Gonzalo Carvacho, Nicolò Spagnolo, Seid Koudia, Massimiliano Proietti, Carlo Liorni, Filippo Cerocchi, Riccardo Albiero, Niki Di Giano, Marco Gardina, Francesco Ceccarelli, Giacomo Corrielli, Ulysse Chabaud, Roberto Osellame, Massimiliano Dispenza, Fabio Sciarrino

“…A relevant example for photonic platforms has been provided by the Boson Sampling paradigm and its variants, which are known to be computationally hard while requiring at the same time only the manipulation of the generated photonic resources via linear optics and detection. …”
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Efficacy of soft palatal augmentation prosthesis for oral functional rehabilitation in patients with dysarthria and dysphagia: a protocol for a randomised controlled trial by Naoki Kodama, Tomonori Yokoyama, Takao Mukai, Kana Takao, Takashi Hiraoka, Nobuyuki Arai, Jitsuro Yano, Hiroaki Nagatsuka, Yousuke Manda, Kozo Hanayama, Shogo Minagi

“…Primary outcomes are the single-word intelligibility test score and pharyngeal transit time (PTT). Secondary outcomes are tongue function (evaluated based on maximum tongue pressure, repetitions of tongue pressure and endurance of tongue pressure), articulation function (evaluated based on speech intelligibility, oral diadochokinesis, Voice-Related Quality of Life (V-RQOL)) and swallowing function (evaluated using Eating Assessment Tool-10). …”
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The influence of intermittent venovenous hemodiafiltration on the course of acute kidney injury in multiple trauma victims by V.M. Dubyna, O.V. Kravets

“…HDF allowed to effectively reduce indicators of the renal complex and normalize the potassium level, and at the same time did not have a negative effect on hemostasis or other indicators of homeostasis. 72.9 % of victims needed two HDF sessions, 47.9 % — three, 31.3 % — four or more. …”
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River water quality monitoring using machine learning with multiple possible in-situ scenarios by Dani Irwan, Saerahany Legori Ibrahim, Sarmad Dashti Latif, Chris Aaron Winston, Ali Najah Ahmed, Mohsen Sherif, Amr H. El-Shafie, Ahmed El-Shafie

“…The study looks into the possibility of estimating WQI solely using dissolved oxygen (DO) and pH as predictors because the chemical parameters in the current Malaysian WQI calculation method takes some time to compute. This research provides insight into the accuracy, precision, and general performance of these models in predicting water quality by looking at the residuals of various scenarios and evaluating performance metrics across different machine learning models. …”
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Prognostic Impact of miR-224 and RAS Mutations in Medullary Thyroid Carcinoma by Elisabetta Cavedon, Susi Barollo, Loris Bertazza, Gianmaria Pennelli, Francesca Galuppini, Sara Watutantrige-Fernando, Simona Censi, Maurizio Iacobone, Clara Benna, Federica Vianello, Stefania Zovato, Davide Nacamulli, Caterina Mian

“…In this group, REarranged during transfection (RET) and rat sarcoma (RAS) mutation status were assessed by direct sequencing in the tumor tissues. Quantitative real-time polymerase chain reaction was used to quantify mature hsa-miR-224 in tumor tissue. …”
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Epigenetic alterations of 11beta-hydroxysteroid dehydrogenase 1 gene in the adipose tissue of patients with primary aldosteronism by Yoshimichi Takeda, Masashi Demura, Mitsuhiro Kometani, Shigehiro Karashima, Daisuke Aono, Seigo Konishi, Shin-ichi Horike, Makiko Meguro-Horike, Takashi Yoneda, Yoshiyu Takeda

“…The mRNA level of HSD11B1 was quantified using real-time PCR. Isolated DNA was treated with bisulfite and amplified using primers specific to the human HSD11B1 promoter region. …”
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Photosynthetic Pigments with Potential for a Photosynthetic Antenna: A DFT Analysis by Jesús Francisco Monzón-Bensojo, Manuel A. Flores-Hidalgo, Diana Barraza-Jiménez

“…CRDFT (chemical reactivity density functional theory) and TD-DFT (time-dependent DFT) methods were employed in ground-state and excited-state calculations, respectively. …”
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