In Silico Identification of New Anti-SARS-CoV-2 Main Protease (Mpro) Molecules with Pharmacokinetic Properties from Natural Sources Using Molecular Dynamics (MD) Simulations and Hi... by Harrison Onyango, Patrick Odhiambo, David Angwenyi, Patrick Okoth

“…Unfortunately, the traditional drug development methods are time-consuming and expensive. In this study, computational algorithms were utilized for virtual screening of a library of natural compounds in the ZINC database for their affinity towards SARS-CoV-2 Mpro. …”
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Trying to Kill a Killer; Impressive Killing of Patient Derived Glioblastoma Cultures Using NK-92 Natural Killer Cells Reveals Both Sensitive and Highly Resistant Glioblastoma Cells by Jane Yu, Hyeon Joo Kim, Jordyn Reinecke, James Hucklesby, Tennille Read, Akshata Anchan, Catherine E. Angel, Euan Scott Graham

“…Of value in this study has been the application of ECIS (Electric Cell–Substrate Impedance Sensing) biosensor technology to monitor the glioblastoma cells in real-time, enabling temporal assessment of the NK-92 cells. …”
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Impact of the COVID-19 pandemic on utilisation of facility-based essential maternal and child health services from March to August 2020 compared with pre-pandemic March–August 2019... by Grace J Chan, Delayehu Bekele, Bezawit Mesfin Hunegnaw, Kimiko Van Wickle, Chalachew Bekele, Fanos Ashenafi Gebremeskel, Michelle Korte, Christine Tedijanto, Lisanu Taddesse

“…We aimed to assess maternal, newborn and child health (MNCH) service utilisation during the first 6 months of the COVID-19 pandemic compared with prior to the pandemic.Methods We conducted a mixed study design in eight health facilities that are part of the Birhan field site in Amhara, Ethiopia and compared the trend of service utilisation in the first 6 months of COVID-19 with the corresponding time and data points of the preceding year.Result New family planning visits (43.2 to 28.5/month, p=0.014) and sick under 5 child visits (225.0 to 139.8/month, p=0.007) declined over the first 6 months of the pandemic compared with the same period in the preceding year. …”
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MXene−Graphene Oxide Heterostructured Films for Enhanced Metasurface Plasmonic Biosensing in Continuous Glucose Monitoring by Rui Li, Hongli Fan, Youqian Chen, Shaoping Yin, Gang L. Liu, Yanan Li, Liping Huang

“…Abstract Non‐invasive biosensors have attracted attention for their potential to obtain continuous, real‐time physiological information through measurements of biochemical markers, such as one of the most important—glucose, in biological fluids. …”
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Research on ultrasonic testing method for tangential contact stress based on equivalent medium theory by Nana Niu, Yongsheng Zhao, Zhifeng Liu, Ying Li, Lele Liu

“…An ultrasonic acoustic time difference model considering changes in contact surface material parameters is constructed based on the principle of acoustic elasticity of ultrasound. …”
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RNA-Seq-Based Gene Expression Pattern and Morphological Alterations in Chick Thymus during Postnatal Development by Zhouyiyuan Xue, Abdur Rahman Ansari, Xing Zhao, Kun Zang, Yu Liang, Lei Cui, Yafang Hu, Ranran Cheng, Xiaolong Zhang, Juming Zhong, Huazhen Liu

“…The expression pattern revealed by RNA-seq was validated by quantitative real-time PCR (qPCR) analysis of four important genes, which are PCNA, CCNA2, CCNB2, and CDK1. …”
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Estimates of disclosure and victimization rates for fishery observers in the maritime workplace by Lacey Jeroue, Lacey Jeroue, Craig Faunce, Andy Kingham, Jaclyn Smith

“…When disclosure and victimization are teased apart, the effectiveness of risk reduction strategies can be better assessed over time.…”
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Learning and forecasting open quantum dynamics with correlated noise by Xinfang Zhang, Zhihao Wu, Gregory A. L. White, Zhongcheng Xiang, Shun Hu, Zhihui Peng, Yong Liu, Dongning Zheng, Xiang Fu, Anqi Huang, Dario Poletti, Kavan Modi, Junjie Wu, Mingtang Deng, Chu Guo

“…We produce training data by evolving the system for a number of time steps, and with this, we fully quantify the correlated noise and accurately predict the dynamics of the system for times beyond the training data. …”
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Gut microbiota derived metabolite trimethylamine N-oxide influences prostate cancer progression via the p38/HMOX1 pathway by Yuhua Zhou, Jing Lv, Shengkai Jin, Chaowei Fu, Bo Liu, Yang Shen, Menglu Li, Yuwei Zhang, Ninghan Feng, Ninghan Feng, Ninghan Feng, Ninghan Feng

“…A high-choline diet increases the risk of fatal prostate cancer, potentially mediated by the conversion of choline to the trimethylamine N-oxide (TMAO) by the gut microbiota.MethodsThe CCK8 assay was employed to investigate whether TMAO affects the proliferation ability of prostate cancer cells and to determine the appropriate drug concentration. Subsequently, CCK8 time gradients, colony formation assays, and EdU assays measured TMAO’s influence on cell proliferation. …”
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Automatic detection, identification and counting of deep-water snappers on underwater baited video using deep learning by Florian Baletaud, Florian Baletaud, Florian Baletaud, Sébastien Villon, Antoine Gilbert, Jean-Marie Côme, Sylvie Fiat, Corina Iovan, Laurent Vigliola

“…Stereo-Baited Remote Underwater Video Stations (BRUVS) can provide valuable quantitative information on fish stocks, but manually processing large amounts of videos is time-consuming and sometimes unrealistic. To address this issue, we used a Region-based Convolutional Neural Network (Faster R-CNN), a deep learning architecture to automatically detect, identify and count deep-water snappers in BRUVS. …”
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Challenges and barriers to physician decision-making for prescribing and deprescribing among patients with multimorbidity in eastern China’s primary care settings: a qualitative st... by Ming Yan, Zhijie Xu, Andrew Farmer, Yu Xia, Mi Yao, Lingyan Wu, Xinmei Zhou, Liyan Han

“…The challenges were further compounded by multiple barriers, including clinical inertia among physicians, patient resistance to medication changes, inadequate decision support and training, and time constraints in clinical consultation.Conclusions The complexity of prescribing and deprescribing decisions faced by PCPs in treating patients with multimorbidity in China is influenced by interconnected factors related to physicians, patients, technology and working environment. …”
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Social and economic impacts of non-communicable diseases by gender and its correlates: a literature review by Concepción García-Morales, Ileana Heredia-Pi, Carlos M. Guerrero-López, Emanuel Orozco, Enai Ojeda-Arroyo, Gustavo Nigenda, Edson Serván-Mori

“…Conclusions NCDs pose a significant social and economic burden due to their impact on the health of the population, healthcare systems, and the economies of households and nations, which will likely increase over time. This impact is closely related to gender, although it has been scarcely documented. …”
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Bioinformatics insights into mitochondrial and immune gene regulation in Alzheimer's disease by Tian Meng, Yazhou Zhang, Yuan Ye, Hui Li, Yongsheng He

“…After platform removal, there was a notable increase in the path complexity and time required to reach the target quadrant, suggesting a reduction in spatial memory capacity in AD mice. …”
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Military Aspects of the Lithuanian-Polish Conflict of 1918-1920 by Vytautas Lesčius

“…Vilnius remained in their hands for only 5 days this time since they were unable to resist the onslaught on the city by the Bolsheviks.   …”
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Effect of Five Elements Music Concrete Hypnosis Technique on Subthreshold Depression after Stroke by ZHANG Jiale, ZHOU Xia, LIU Jianxian, QIAN Qian, WANG Qin, WANG Zhensong

“…Both groups were treated for 30 minutes a time, once a day, six times a week, lasting for four weeks. …”
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Genome-Wide Identification and Expression Analysis of Eggplant Reveals the Key MYB Transcription Factor Involved in Anthocyanin Synthesis by Jiaqi Ai, Wuhong Wang, Tianhua Hu, Haijiao Hu, Yaqin Yan, Jinglei Wang, Yunzhu Wang, Na Hu, Hongtao Pang, Chonglai Bao, Qingzhen Wei

“…The quantitative real-time PCR (qRT-PCR) analysis results showed that SmeMYB175 was regarded as the most likely key transcription factor regulating anthocyanin synthesis in calyx. …”
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Predictive modeling for durability characteristics of blended cement concrete utilizing machine learning algorithms by Bo Fu, Hua Lei, Irfan Ullah, Mohammed El-Meligy, Khalil El Hindi, Muhammad Faisal Javed, Furqan Ahmad

“…However, determining these parameters requires time-consuming and resource-intensive physical experiments. …”
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Damage mechanical properties of sandstone under combined action of freeze-thaw and load by Yongjun SONG, Jinghui CAO

“…Engineering rock mass in cold regions is subjected to the combined action of freeze-thaw and load for a long time, which causes deterioration in the mechanical properties of the rock mass. …”
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Comprehensive agrobiological assessment and analysis of genetic relationships of promising walnut varieties of the Nikitsky Botanical Gardens by Yu. V. Plugatar, I. I. Suprun, S. Yu. Khokhlov, I. V. Stepanov, E. A. Al-Nakib

“…Despite the significant demand in the domestic market in Russia, the industrial production of walnut fruits in Russia is currently underdeveloped. At the same time, there is a need to update the assortment with new highly productive varieties adapted to local agro-climatic conditions and having high quality nuts that are competitive at the world level. …”
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Prospective and Longitudinal Analysis of Lymphocyte Subpopulations in SARS-CoV-2 Positive and Negative Pneumonia: Potential Role of Decreased Naïve CD8⁺ in COVID-19 Pati... by Makhabbat Bekbossynova, Lyudmila Akhmaltdinova, Kuanysh Dossybayeva, Ainur Tauekelova, Zauresh Smagulova, Tatyana Tsechoeva, Gulsimzhan Turebayeva, Aliya Sailybayeva, Zhanar Kalila, Takhmina Mirashirova, Timur Muratov, Dimitri Poddighe

“…Peripheral blood lymphocyte subsets were assessed (with a specific focus on the memory markers) at 6 time points after the disease onset until 12 months. …”
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