MiR-155-Mediated Deregulation of GPER1 Plays an Important Role in the Gender Differences Related to Inflammatory Bowel Disease by Xiaojuan Shao, Jintao Li, Fumin Xu, Dongfeng Chen, Kaijun Liu

“…The serum cytokine levels in the patients with IBD and the health donors were detected by ELISA, and the estrogen receptor level measurements for all of the participants were assessed by immunohistochemistry (IHC) and quantitative real-time PCR (qPCR). The miR-155 levels were detected by qPCR in all of the participants, and miR-155−/− mice were used to investigate the mechanism of miR-155 in the pathogenesis of IBD. …”
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EV‐Elute: A universal platform for the enrichment of functional surface marker‐defined extracellular vesicle subpopulations by Willemijn S. deVoogt, Rowan Frunt, Raul M. Leandro, Casper S. Triesscheijn, Bella Monica, Ioanna Paspali, Mark Tielemans, Jerney J. J. M. François, Cor W. Seinen, Olivier G. deJong, Sander A. A. Kooijmans

“…When applying EV‐Elute, over 70% of bound EVs could be recovered from the beads in a pH‐ and incubation‐time‐dependent fashion. EV subpopulations showed intact integrity by electron microscopy and Proteinase K protection assays and showed uptake patterns similar to whole EV isolates in co‐cultures of peripheral blood mononuclear cells (PBMCs) and endothelial cells. …”
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A comprehensive analysis of molecular characteristics of hot and cold tumor of gastric cancer by Chenxi Lv, Tianwei Chen, Jiangtao Li, Yuqiang Shan, Hong Zhou

“…Results A total of 1,298 GC patients were included in this comprehensive analysis. For the first time, we identified and characterized immune “hot” and “cold” tumors in GC patients, revealing distinct molecular features associated with these tumor types. …”
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Efficacy of Endoscopic Radiofrequency Ablation for Treatment of Reflux Hypersensitivity: A Study Based on Rome IV Criteria by Yuan-Xi Jiang, Zhi-Yu Dong, Jun-Wen Wang, Ying Chen, Hui-Hui Sun, Shu-Chang Xu

“…The secondary outcomes were degree of satisfaction, medication use, acid exposure time (AET), low esophageal sphincter (LES) pressure, and total reflux episodes. …”
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The Effectiveness of Cancer Pain Management in a Tertiary Hospital Outpatient Pain Clinic in Thailand: A Prospective Observational Study by Suratsawadee Wangnamthip, Skaorat Panchoowong, Carolina Donado, Kimberly Lobo, Pimporn Phankhongsap, Pinyo Sriveerachai, Pramote Euasobhon, Pranee Rushatamukayanunt, Sahatsa Mandee, Nantthasorn Zinboonyahgoon, Charles B. Berde

“…Secondary outcomes included trends over time in BPI, ESAS, side effects, and analgesic use. …”
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Evaluation of the Performance of an Ocular Surface Modulator Containing ST-Lysyal Versus Hyaluronic Acid Eyedrops in Patients with Dry Eye Disease: A Pilot Study by Stefano Barabino, Andrea Rosa, Sara Marini, Carlo Domenico Bianchi, Maurizio Rolando

“…Inclusion criteria were a diagnosis of DED with symptoms lasting ≥ 6 months, Symptom Assessment in Dry Eye (SANDE) score ≥ 30, and at least one of the following: fluorescein staining of the cornea (score ≥ 3, NEI scale), conjunctival staining (Lissamine Green, score ≥ 3), or tear breakup time (T-BUT) ≤ 10 s. Data from the right eye were used for statistical analysis. …”
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Diversity and succession of microbial communities on typical microplastics in Xincun Bay, a long-term mariculture tropical lagoon by Shi Yunfeng, Wang Shuai, Wang Hui, Li Zhaoyang, Cai Jiali, Han Qiuying, Zhao Muqiu

“…With increasing exposure time, the biofilm attached to the surface of MPs became thicker and microbial composition showed some differences. …”
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Involvement of HLADQA1*05 in Patients with Inflammatory Bowel Disease Treated with Anti-TNF Drugs by Anna Pau, Ilaria Galliano, Elisa Barnini, Maddalena Dini, Antonio Pizzol, Alice Ponte, Stefano Gambarino, Pier Luigi Calvo, Massimiliano Bergallo

“…The presence of the HLA-DQA1*05 T>C allele variant was also tested using a Biomole HLA-DQA1 Real-time PCR kit. <i>Results</i>: The HLA-DQA1*05 rs2097432 T>C allele was present in 54% of patients on IFX and 69% of those on ADA. …”
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The performance of a machine learning model in predicting accelerometer-derived walking speed by Aleksej Logacjov, Tonje Pedersen Ludvigsen, Kerstin Bach, Atle Kongsvold, Mats Flaaten, Tom Ivar Lund Nilsen, Paul Jarle Mork

“…Results: Total recording time was ∼600 min (∼25 min per participant). Performance metrics for predicting walking speeds (i.e., slow, moderate, brisk) and jogging were largely similar for the dual and single accelerometer set-ups as well as for the different window lengths. …”
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Comparative analysis of counter-current and co-current downer reactors using particle image velocimetry and computational particle-fluid dynamics by Talal A. Aldugman, Mengmeng Cui, Abdulrahman Alzailaie, Abdullah Alhareth, Kenneth Langley, Lujain Alfilfil, Khalid Almajnouni, Jorge Gascon, Sigurdur Thoroddsen, Pedro Castaño

“…Simulations confirmed that the counter-current downer reactor has 69 % higher solid holdup and 98 % longer residence time than the co-current operation. Thus, the counter-current downer reactor demonstrated intermediate behavior between the classical co-current downer and riser reactors, offering flexibility for industrial applications.…”
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Changes in Techno-Functional Characteristics of Cow Colostrum Powder Prepared by Freeze Drying by Anamika Das, Raman Seth, Ayon Tarafdar, Swarnima Dey, Yogesh Kumar, Ranjna Sirohi

“…In this study, the optimum temperature/time combination of 60°C/45 min was used for the processing of cow colostrum. …”
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NKX6.3 modulation of mitotic dynamics and genomic stability in gastric carcinogenesis by Jung Hwan Yoon, Jeong-Kyu Kim, Jung Woo Eun, Hassan Ashktorab, Duane T. Smoot, Suk Woo Nam, Won Sang Park

“…Methods We employed a combination of in vitro and in vivo techniques to elucidate the impact of NKX6.3 depletion on mitotic dynamics and genomic stability in gastric epithelial cells. Quantitative real-time PCR and Western blot analyses were conducted to assess the expression of mitosis-related genes and proteins. …”
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Teaching communication skills to OTL-HNS residents: multisource feedback and simulated scenarios by Pier-Luc Beaudoin, Mathilde Labbé, Amanda Fanous, Meredith Young, Jamie Rappaport, Yoon Soo Park, John Manoukian, Lily H. P. Nguyen

“…No significant improvement across time was found for ratings by non-medical assessors. …”
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Productive performance of buffaloes (Bubalus bubalis) in two production systems and two slaughter weights by René Rodríguez-Florentino, David Hernández-Sánchez, Efrén Ramírez-Bribiesca, María M. Crosby Galván, Miguel Á. Mata-Espinosa, Luis A. de la Cruz-Cruz

“…Feeding buffaloes with concentrated diets and slaughtering them at 600 kg LW is related to better weight gains, but the time to reach this weight is longer than 300 days. …”
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The Pattern of mRNA Expression Is Changed in Sinoatrial Node from Goto-Kakizaki Type 2 Diabetic Rat Heart by F. C. Howarth, M. A. Qureshi, P. Jayaprakash, K. Parekh, M. Oz, H. Dobrzynski, T. E. Adrian

“…Heart rate and expression of genes were evaluated with an extracellular electrode and real-time RT-PCR, respectively. Rats aged 12-13 months were employed in these experiments. …”
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T-Cell Subpopulations and Differentiation Bias in Diabetic and Non-Diabetic Patients with Chronic Kidney Disease by Ana Cecilia Granda Alacote, Gabriela Goyoneche Linares, María Gracia Castañeda Torrico, Daysi Zulema Diaz-Obregón, Michael Bryant Castro Núñez, Alexis Germán Murillo Carrasco, Cesar Liendo Liendo, Katherine Susan Rufasto Goche, Víctor Arrunátegui Correa, Joel de León Delgado

“…The expression of helper T cell differentiation regulatory genes was assessed using real-time RT-PCR. Results: Both helper and cytotoxic effector memory T cell populations were found to be higher than naïve lymphocytes in CKD patients, regardless of T2D status. …”
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Impact of shock index (SI), modified SI, and age-derivative indices on acute heart failure prognosis; A systematic review and meta-analysis. by Mehrbod Vakhshoori, Niloofar Bondariyan, Sadeq Sabouhi, Mehrnaz Shakarami, Sayed Ali Emami, Sepehr Nemati, Golchehreh Tavakol, Behzad Yavari, Davood Shafie

“…<h4>Methods</h4>PubMed/Medline, Scopus and Web of science databases were screened with no time and language limitations till February 2024. …”
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Impact of Silent Cerebral Embolism during and after Left Atrial Appendage Occlusion on Long‐Term Cognitive Function by Kexin Wang, Zhe Wang, Caiyi Jin, Mingjia Xu, Mingfang Li, Hailei Liu, Zidun Wang, Hongwu Chen, Weizhu Ju, Minglong Chen

“…Patients with SCE exhibited a significant decline in cognitive function (Mini‐Mental State Examination) immediately after the procedure (P<0.001), which was not reversible during 1‐year follow‐up (P<0.001). Additionally, with time going on, the gap in cognitive function between patients with and without SCE became wider (SCE × 1 year: B=−4.81 [95% CI, −5.58 to −4.05]; P<0.001). …”
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Mesalazine-Induced Acute Pancreatitis in Inflammatory Bowel Disease Patients: A Systematic Review by Pan J, Li Z, Ye C, Zhang X, Yang Q, Zhang X, Zhou Y, Zhang J

“…Rechallenge with mesalazine led to recurrence of AP in 21 cases, with a shorter median time to symptom onset.Conclusion: Mesalazine-induced AP is a rare but significant adverse reaction, not related to drug dosage, and can occur at any point during treatment, typically within two weeks. …”
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Field measurement of atmospheric CO₂ column abundance based on portable laser heterodyne radiometer by Yong Wang, Yong Wang, Maolei Zhang, Maolei Zhang, Jiapeng Wang, Jiapeng Wang, Gang Wang, Gang Wang, Ruyue Cui, Ruyue Cui, Lei Dong, Lei Dong, Hongpeng Wu, Hongpeng Wu

“…To enhance performance, the radio frequency (RF) circuit system of the radiometer was thoroughly optimized, including adjustments to the filter bandwidth and the integration time of the lock-in amplifier. These improvements significantly enhanced the spectral signal-to-noise ratio (SNR) to a high level of 130 and achieved a spectral resolution of 0.0083 cm⁻1. …”
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