3,5,6,7,8,3’,4’- Heptamethoxyflavonoid inhibits TGF-β1-induced epithelial–mesenchymal transition by regulating oxidative stress and autophagy through MEK/ERK/PI3K/AKT/mTOR signalin... by Yiting Wang, Zhiheng Ma, Weiwen Peng, Qinglian Yu, Wenjie Liang, Liu Cao, Zhuqiang Wang

“…Various experiments confirmed that HMF regulated the expression levels of Nrf2, keap-1, HO-1, ROS, MDA, SOD, GSH, and played a role in reducing oxidative stress. At the same time, HMF significantly activated autophagy by increasing expressions of Beclin-1 and LC3B as well as enhancing autophagosome content. …”
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Microbiota governs host chenodeoxycholic acid glucuronidation to ameliorate bile acid disorder induced diarrhea by Zishen Lin, Yue Feng, Jinping Wang, Zhaoyue Men, Xi Ma

“…Results Here, we reveal for the first time that core microbiota derived I3C represses gut epithelium glucuronidation, particularly 3β-glucuronic CDCA production, which reaction is mediated by host UDP glucuronosyltransferase family 1 member A4 (UGT1A4) and necessary of BA disorder induced diarrhea. …”
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Perennial disaster patterns in Central Europe since 2000 and implications for hospital preparedness planning – a cross-sectional analysis by Maik von der Forst, Maximilian Dietrich, Felix C. F. Schmitt, Erik Popp, Markus Ries

“…We conducted a cross-sectional analysis of the Emergency Events Database EM-DAT for disasters in Central Europe (Germany, France, Denmark, The Netherlands, Belgium, Luxembourg, Switzerland, Austria, Czech Republic, and Poland) between January 2000 and December 2023. Time distribution of disasters, patterns and longitudinal trends, were analyzed to discuss impact on disaster preparedness in hospitals. …”
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Non-thermal atmospheric plasma treatments enhance the growth, photosynthesis, metabolite accumulation, and nutritional value of geranium (Pelargonium graveolens L’Herit) leaves by Hussein S. Mohamed, Dalia Shehata, Ahmed M. Mahmoud, Maha H. Khalaf, Mohammad K. Okla, Mohamed A. El-Tayeb, Yasmeen A. Alwasel, Ibrahim A. Alaraidh, Ali El-Keblawy, Izabela Josko, Mohamed S. Sheteiwy

“…NTAP was applied at a frequency of 13.56 MHz, exposure time of 15 s, discharge temperature of 25 °C, and power levels (T1 = 50, T2 = 80, and T3 = 120 W). …”
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Advancing dental biofilm models: the integral role of pH in predicting S. mutans colonization by Jay S. Sangha, Valentina Gogulancea, Thomas P. Curtis, Nicholas S. Jakubovics, Paul Barrett, Aline Metris, Irina D. Ofiţeru

“…The advantage of this combination of in vitro and in silico models is that we can study the influence of one parameter at a time and aim for direct validation. Our work demonstrates the utility of individual-based models for simulating diverse conditions affecting dental biofilm scenarios, such as the frequency of glucose intake, sucrose pulsing, or integration of pathogenic or probiotic species. …”
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Global, regional, and national burden of young COPD, 1990–2021, with forecasts to 2050: a systematic analysis for the global burden of disease study 2021 by Yi Zhu, Tao Shen, Ruixin Guo, Ke Liu, Xiyu Cao, Xiuli Yang, Chuantao Zhang

“…Joinpoint regression analysis examined the time trend from 1990 to 2021. Annual percentage change (APC) and average annual percentage change (AAPC) were calculated. …”
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Prevalence and investigation of Cytomegalovirus (HCMV) in blood donors from the main blood establishment in Rio de Janeiro/Brazil by Agildo da Silva Oliveira, Jéssica Gonçalves Pereira, Gabrielle Tantos Nunes, Ivanildo Pedro de Sousa Junior, Dmitry José de Santana Sarmento, Josiane Iole França Lopes, Luiz Amorim Filho, Vanessa Salete de Paula

“…Materials and methods: Here, we investigated the serological and molecular prevalence of HCMV among 980 blood donors from the main blood bank in Rio de Janeiro, Brazil, using chemiluminescence and real-time PCR (TaqMan). The data underwent univariate, bivariate, and multivariate statistical analyses using the SPSS program, version 20.0. …”
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The first experience of two-stage treatment of transsphincteric fistulas of rectum by means of fibrin sealant by S. A. Frolov, A. M. Kuzminov, V. Yu. Korolik, I. S. Bogormistrov, M. O. Chernozhukova, Sh. T. Minbayev

“…Its lowinvasiveness and minimal tissue traumatization provides decrease in postoperative morbidity rate and decreases patient rehabilitation time. At repeated administration of this method the recurrence rate decreases to 6% at preservation of anal sphincter function. …”
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Variability of the photoperiod response in guar (Cyamopsis tetragonoloba (L.) Taub.) genotypes of different geographic origin by S. B. Teplyakova, V. A. Volkov, E. А. Dzyubenko, E. К. Potokina

“…Prolonged daylight exposure is an obstacle to the timely transition of guar to flowering, which dramatically affects its productivity. …”
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Nursing management of pressure ulcers in a patient with diabetes and Alzheimer’s disease (1例糖尿病合并阿尔兹海默症患者压疮护理体会) by ZHANG Yixuan (张艺璇), WANG Chunhong (王春红), HOU Nina (侯妮娜), XU Weihong (徐卫红), ZHAO Xin (赵欣), LIU Huan (刘欢), TANG Ling (唐玲)

“…Comprehensive interventions including regular exercise, shortening bedridden time and enhancing the skin management are effective to improve the wound healing of the patient with diabetes and Alzheimer‘s disease. …”
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Assessing the association between household air pollution exposure and child heath in Mongolia: a birth-cohort study by Zaiyou Dai, Katherine E. Woolley, Emma Dickinson-Craig, Tsogzolma Bayandorj, Narangerel Gombojav, Bazarragchaa Tsogt, David Warburton, G. Neil Thomas, Semira Manaseki-Holland

“…Linear and Cox proportional hazard model were used to assess the association between HAP and child health outcomes at each time point, adjusting for child, maternal and environmental confounding factors. …”
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DeepGenMon: A Novel Framework for Monkeypox Classification Integrating Lightweight Attention-Based Deep Learning and a Genetic Algorithm by Abdulqader M. Almars

“…Moreover, the findings demonstrate the model’s ability to achieve an inference time of 2.9764 s on dataset 1 and 2.1753 s on dataset 2. …”
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Upregulation of Tumor Necrosis Factor-α-Induced Protein 8-Like 2 mRNA Is Negatively Correlated with Serum Concentrations of Tumor Necrosis Factor-α and Interleukin 6 in Type 2 Diab... by Yongliang Liu, Xinmei Wang, Yan Zhao, Peiqing Zhao, Lianqing Wang, Qiaoli Zhai, Xiaowei Zhang, Wenxiu Tian, Xinxin Xiang, Tao Li

“…TIPE2 expression was measured by Western blotting and real-time polymerase chain reaction (RT-PCR) in peripheral blood mononuclear cells (PBMCs) isolated from T2DM patients and healthy controls, and tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hsCRP), interleukin 6 (IL-6), and other related biometabolic parameters were detected using a nephelometer or by ELISA. …”
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Leptospirosis Risk Assessment in Rodent Populations and Environmental Reservoirs in Humanitarian Aid Settings in Thailand by Panadda Krairojananan, Kasima Wasuworawong, Surachai Leepitakrat, Taweesak Monkanna, Elizabeth W. Wanja, Silas A. Davidson, Betty K. Poole-Smith, Patrick W. McCardle, Alyssa Mann, Erica J. Lindroth

“…A surveillance program was conducted at Engineering Civil Assistance Program (ENCAP) training sites using real-time PCR, dark-field microscopy, and 16S rRNA gene sequencing to detect <i>Leptospira</i> in rodents and environmental samples. …”
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The scoping, design, and plasma physics optimization of the Eos neutron source stellarator by C.P.S. Swanson, D.A. Gates, S.T.A. Kumar, M.F. Martin, T.G. Kruger, D.W. Dudt, P.J. Bonofiglo, the Thea Energy team

“…It appears possible at this time for a facility with a medium-scale and medium-strength stellarator whose required facility electric power is less than 40 MW to produce $2.5\times 10^{17}$ neutrons s ^−1 for the production of radioisotopes. …”
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Intermittent Preventive Treatment of Malaria in Pregnancy: Assessment of the Sulfadoxine-Pyrimethamine Three-Dose Policy on Birth Outcomes in Rural Northern Ghana by Francis Anto, Ibrahim Haruna Agongo, Victor Asoala, Elizabeth Awini, Abraham Rexford Oduro

“…A survey was carried out at the War Memorial Hospital in Navrongo, Ghana, among mothers who had delivered within ten weeks and were seeking postnatal care. Data on time of first ANC, number of visits, receipt of IPTp-SP, and birth outcomes were extracted from the antenatal records of 254 mothers. …”
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STING agonist-based treatment promotes vascular normalization and tertiary lymphoid structure formation in the therapeutic melanoma microenvironment by Walter J Storkus, Ronald J Fecek, Manoj Chelvanambi, Jennifer L Taylor

“…Treated and control tumors were isolated at various time points to assess transcriptional changes associated with VN and TLS formation via quantitative PCR (qPCR), with corollary immune cell composition changes in isolated tissues determined using flow cytometry and immunofluorescence microscopy. …”
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Exosomal miR-122 derived from M2 macrophages induces osteogenic differentiation of bone marrow mesenchymal stem cells in the treatment of alcoholic osteonecrosis of the femoral hea... by Guoping Le, Riyou Wen, Huaixi Fang, Zhifa Huang, Yong Wang, Hanwen Luo

“…Abstract Alcoholic osteonecrosis of the femoral head (AIONFH) is caused by long-term heavy drinking, which leads to abnormal alcohol and lipid metabolism, resulting in femoral head tissue damage, and then pathological necrosis of femoral head tissue. If not treated in time in clinical practice, it will seriously affect the quality of life of patients and even require hip replacement to treat alcoholic femoral head necrosis. …”
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Nouveaux éléments concernant l’amphithéâtre antique de Saintes (Charente-Maritime) : l’arène aux iiie et ive s. apr. J.-C. by Bastien Gissinger

“…Robin in collaboration with Inrap– at the time this article was written. Perhaps this study will bring further nuances to the data acquired from the partial exploration of the arena of this emblematic Julio-Claudian building.…”
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The nonlinear association between lipoprotein(a) and major adverse cardiovascular events in acute coronary syndrome patients with three-vessel disease by Qianhui Li, Shuailei Xu, Junxian Shen, Fengnian Sun

“…A total of 1504 patients were included, with a median follow-up time of 38 months. Univariate Cox regression analysis showed that patients with higher Lp(a) levels had a significantly increased incidence of MACE (P < 0.001). …”
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