Intravenous Administration of Bone Marrow-Derived Mesenchymal Stem Cells Induces a Switch from Classical to Atypical Symptoms in Experimental Autoimmune Encephalomyelitis by Mónica Kurte, Javiera Bravo-Alegría, Alexander Torres, Vania Carrasco, Cristina Ibáñez, Ana María Vega-Letter, Catalina Fernández-O’Ryan, Carlos E. Irarrázabal, Fernando E. Figueroa, Rodrigo A. Fuentealba, Claudia Riedel, Flavio Carrión

“…Interestingly, regardless of time administration, MSCs significantly reduced IL-6 and also T-bet, RORγT, and Foxp3 mRNA levels in brain samples of EAE mice. …”
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‘Communication, that is the key’: a qualitative investigation of how essential workers with COVID-19 responded to public health information by Yanbing Chen, Claire Buckley, Elizabeth Alvarez, Conor Buggy, Mark Roe, Mary Codd, Anne Drummond, Carolyn Ingram, Penpatra Sripaiboonkij, Carla Perrotta, Mary Archibald, Vicky Downey, Natalia Rachwal

“…Objectives To understand how essential workers with confirmed infections responded to information on COVID-19.Design Qualitative analysis of semistructured interviews conducted in collaboration with the national contact tracing management programme in Ireland.Setting Semistructured interviews conducted via telephone and Zoom Meetings.Participants 18 people in Ireland with laboratory confirmed SARS-CoV-2 infections using real-time PCR testing of oropharyngeal and nasopharyngeal swabs. …”
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Estimating hip impact velocity and acceleration from video-captured falls using a pose estimation algorithm by Reese Michaels, Tiago V. Barreira, Stephen N. Robinovitch, Jacob J. Sosnoff, Yaejin Moon

“…By applying OpenPose to each video, we generated a time series of hip positions in the video, which were then analyzed using custom MATLAB code to calculate hip impact velocity and acceleration. …”
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Erbin Regulates Tissue Factors Through Ras/Raf Pathway in Coagulation Disorders in Sepsis by Yang C, Lei C, Jing G, Xia Y, Zhou H, Wu D, Zuo J, Gong H, Wang X, Dong Y, Aidebaike D, Wu X, Song X

“…However, the role of Erbin in coagulation disorders in sepsis and the relationship between Erbin and macrophage regulation of coagulation function are still unclear.Methods: At the cellular level, macrophages were treated with lipopolysaccharide (LPS) or MEK inhibitor (PD98059), protein expression levels were detected by Western blot, co-immunoprecipitation (Co-IP), and immunofluorescence, mRNA expression levels were detected by quantitative real-time polymerase chain reaction (qPCR), and the concentration of tissue factor (TF) in cell supernatant was detected by enzyme linked immunosorbent assay (ELISA). …”
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The potential of aloe vera gel utilization for skin wound healing in rats based on GC–MS and HPLC chemical profile by Nadia Mohamed Said Arafa, Huda Mohammad Ahmad Hummadi, Gehan Moustafa Badr

“…Abstract Background Wound healing is a restoration process of tissue integrity and function targeting reducing the healing time and complications with priority of available, acceptable and affordable medication. …”
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Lactylation-driven TNFR2 expression in regulatory T cells promotes the progression of malignant pleural effusion by Yao Liu, Qiong Zhou, Siyu Zhang, Wenbei Peng, Haolei Wang, Xuan Xiang, Linlin Ye, Xiaoshan Wei, Zihao Wang, Qianqian Xue

“…Notably, lactate metabolism blockade combined with immune checkpoint blockade (ICB) therapy effectively enhanced the efficacy of ICB therapy, prolonged the survival time of MPE mice, and improved immunosuppression in the microenvironment of MPE.Conclusions The study explains the mechanism that regulates TNFR2 expression on Treg cells and its function in MPE progression, providing novel insights into the epigenetic regulation of tumor development and metabolic strategies for MPE treatment by targeting lactate metabolism in Treg cells.…”
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Neuroprotection against Amyloid-β-Induced DNA Double-Strand Breaks Is Mediated by Multiple Retinoic Acid-Dependent Pathways by Julien Colas, Natacha Chessel, Allaeddine Ouared, Emmanuelle Gruz-Gibelli, Pascale Marin, François R. Herrmann, Armand Savioz

“…Thus, the PPARβ/δ receptor, known for its antiapoptotic function, might for these short-time treatments play a role in neuroprotection via PPARβ/δ-RXR heterodimerization and possibly expression of antiamyloidogenic genes. …”
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FTA-Net: Frequency-Temporal-Aware Network for Remote Sensing Change Detection by Taojun Zhu, Zikai Zhao, Min Xia, Junqing Huang, Liguo Weng, Kai Hu, Haifeng Lin, Wenyu Zhao

“…Therefore, a new frequency-temporal-aware network (FTA-Net) is proposed, it recognizes changes by means of a frequency-domain temporal fusion module and supervised attention to multilevel time-difference features, while reducing the model size. …”
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ITS amplicon sequencing revealed that rare taxa of tea rhizosphere fungi are closely related to the environment and provide feedback on tea tree diseases by Yuanqi Zhao, Weiwei Ran, Wenming Xu, Yuehua Song

“…On this basis, it was found that tea tree diseases affect the symbiotic relationships of fungal taxa. At the same time, we found that rare taxa have stronger cooperative relationships in response to environmental changes and explored their participation in soil processes based on fungal trait sets. …”
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African animal trypanocide resistance: A systematic review and meta-analysis by Keneth Iceland, Kasozi, Ewan, Thomas MacLeod, Susan, Christina Welburn

“…To address resistance, most preclinical studies increased the dosage and the treatment time, and this failed to improve the patient’s prognosis. …”
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Investigating the Effect of Coffee Husk Ash as Partial Replacement of Cement in Concrete C30. by Niwainamani, Laban

“…The initial and final setting time of OPC - CHA at 5% replacement was observed to be 79 minutes and 431 minutes respectively. …”
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The Effect of Covid-19 Pandemic on Local Government Performance in Service Delivery. A Case Study of Kabale District Local Government. by Musinguzi, Joshua

“…Many lives have been lost, and the social and economic impact will be felt for some time to come. In every crisis, however. there is opportunity. …”
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The Impact of Family Conflicts on Socio-Economic Prosperity: A Case Study of Muko Sub-County Rubanda District. by Akankwasa, Winfred

“…., the results of the study have revealed that some conciliators do not know the law related to inheritance and succession, that is why we recommend them to learn that law and other rules and regulation in force in the country; the findings of the study have proven that some conciliators are biased, so we recommend them to be impartial in order to mediate parts on family based conflicts fairly and the study concluded that it has been revealed by the findings that family based conflicts have a negative impact on economic prosperity of families where dealing with these conflicts bring about spending and consumes time that could be devoted in generating income activities. …”
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Assessment of the Impact of Floods to the Local Community in Nyarusiza Sub-County Kisoro District. by Murengezi, Innocent

“…The findings of the study on objective one revealed that the main cause of floods in communities is due to Heavy Rainfall. During this time, rainwater flows and is collected in dams. When this tired or collected water reaches beyond the storage capacity limit, it ends up in flood. …”
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Teachers' Motivation and Students' Academic Performance in Schools in Kanungu Town Council Kanungu District. by Arineitwe, Benson

“…The study findings on the effects of the motivation of teachers on students' performance of Kanungu town council Kanungu district were; that the motivation of teachers increases their self-esteem and ability to teach comfortably hence students' good academic performance, motivation of teachers leads to attraction of competent teachers which leads to quality work, hence students' good performance, teachers' motivation helps them to work very well and confidently loving their job which encourage students to work hard and love studies good performance and motivating teachers makes them appreciate their job and as they keep on it for a long time making manpower hence, good students academic performance. …”
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Enhance Research and Innovation in ICT products, Applications, and Services by Businge, Phelix Mbabazi

“…The study adopted a cross-sectional descriptive survey design to collect data at one point in time from all the selected secondary schools. The quantitative approach was the main approach while the qualitative was the complementary approach. …”
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Effect of High-Risk Versus Low-Risk Pregnancy at the First Antenatal Care Visit On the Occurrence of Complication During Pregnancy and Labour Or Delivery in Kenya: A Double-Robust... by Kadengye, Damazo T., Odero, Henry Owoko, Izudi, Jonathan

“…Multivariable adjusted analysis showed that women with high-risk pregnancy at the time of first ANC attendance had a higher occurrence of pregnancy during pregnancy (adjusted OR (aOR) 1.22, 95% CI 1.02 to 1.46) and labour or delivery (aOR 1.20, 95% CI 1.03 to 1.41). …”
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Types, Magnitude and Factors Associated with Medication Administration Errors Among Nurses in Rubanda East Health Sub District. by Atuhaire, Oliva

“…The majority (64.17%) administered underdoses, 54.17% administered overdoses, 50.00% gave the wrong drug, 60.83% administered medication at the wrong time, 43.33% used the wrong route, and 62.50% reported poor documentation. …”
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Impacts of Tax Laws on the Performance of Small and Medium Enterprises: A Case Study of Kabale Municipality Kabale District. by Abaasa, Ruth

“…The results aligned well with theoretical expectations, with 70 (47%) of respondents agreeing that tax laws are often complex and challenging for SMEs to navigate, requiring time, expertise, and sometimes external assistance from tax professionals or accountants. …”
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Impact of Gender-Based Violence on Social Wellbeing in Rukiga District: A case Study of Muhanga Town Council Rukiga District. by Amanya, Grace

“…., domestic violence has also resulted in women losing time needed for productive work, gender violence also has an impact on girls' education, domestic violence often sabotages women’s efforts to gain employment, acquire job skills. …”
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