Use of isavuconazole in mucormycosis: a systematic review by Shobha Sanjeewani Gunathilaka, Reshani Kaumada Keragala, Kasun Madhumal Gunathilaka, Sujanthi Wickramage, Sachithra Ravindi Bandara, Indika Sanjeewa Senevirathne, Asela Sampath Jayaweera

“…Articles reporting any studies, case series, or case reports on any form of mucormycosis exclusively involving human subjects published in English were included. There were no time restrictions involved. We extracted crucial data, such as publication year, country, disease form, isavuconazole dosage, frequency, duration, overall outcomes, and reported adverse effects. …”
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Highly Active Carbonic Anhydrase of the Thylakoid Lumen of <i>Chlamydomonas reinhardtii</i> by Vasily V. Terentyev, Liubov I. Trubitsina, Anna K. Shukshina, Ivan V. Trubitsin, Natalia N. Rudenko

“…The recombinant protein α-CA CAH3 (rCAH3) from the thylakoid lumen obtained in the present study showed more than three times higher activity compared to CAH1 and more than 11 times higher compared to previous studies with rCAH3. …”
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Optimization of Flaxseed Meal Protein Extraction Process and Study of Protein Structure and Functional Properties by Tingting LUO, Jingjing LI, Haiyue HU, Yajun HE, Yuzhuo LI, Lingxuan ZHAO, Lina WANG, Chen YANG, Jianming WANG

“…The results showed that the optimal extraction conditions of FPI were as follows: Extraction pH10, extraction temperature 45 ℃, extraction time 90 min, and material-liquid ratio 1:25 g/mL. …”
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An eCIRP inhibitor attenuates fibrosis and ferroptosis in ischemia and reperfusion induced chronic kidney disease by Fangming Zhang, Zhijian Hu, Asha Jacob, Max Brenner, Ping Wang

“…In the WT mice at the time of reperfusion, they were treated with C23 (8 mg/kg) or vehicle. …”
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Evaluating Community Engagement Strategies to Manage Stigma in Two African Genomics Studies Involving People Living with Schizophrenia or Rheumatic Heart Disease by Megan M. Campbell, Olivia P. Matshabane, Sibonile Mqulwana, Michael Mndini, Mohamed Nagdee, Dan J. Stein, Jantina De Vries

“…While the schizophrenia group reported more alienation and less stigma resistance than the RHD group, both groups demonstrated increased stigma resistance over time, after participating in the workshops. Hearing from others living with and managing the same illness normalised participants’ own experiences and encouraged them. …”
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Tattoo ink exposure is associated with lymphoma and skin cancers – a Danish study of twins by Signe Bedsted Clemmensen, Jonas Mengel-From, Jaakko Kaprio, Henrik Frederiksen, Jacob von Bornemann Hjelmborg

“…The analysis addressed effects of time-varying exposure. Results In the case-control study, individual-level analysis resulted in a hazard of skin cancer (of any type except basal cell carcinoma) that was 1.62 times higher among tattooed individuals (95% CI: 1.08–2.41). …”
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Rational strategies for designing next-generation oncolytic viruses based on transcriptome analysis of tumor cells infected with oncolytic herpes simplex virus-1 by Naeme Javid, Shahriyar Abdoli, Majid Shahbazi, Majid Shahbazi

“…Subsequently, the expression of hub genes was verified by real-time polymerase chain reaction (qRT-PCR) in MDA-MB-231 (a breast cancer cell line) infected with oHSV-1 and non-infected cells.ResultsThe results of our data analysis indicated notable disparities in the genes associated with the proteasome pathway between infected and non-infected cells. …”
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Lipoprotein Particle Predictors of Arterial Stiffness after 17 Years of Follow Up: The Malmö Diet and Cancer Study by Jacob Hartz, Ronald M. Krauss, Mikael Göttsater, Olle Melander, Peter Nilsson, Michele Mietus-Snyder

“…Associations between c-fPWV and lipoprotein particles were determined with multiple linear regression, controlling for sex, presence of diabetes, waist-to-hip circumference, and smoking status at baseline, as well as heart rate (measured at the carotid artery), mean arterial pressure, antihypertensive and lipid-lowering medications, C-reactive protein (CRP), and age at the time of c-fPWV measurement. Results. The results confirm that triglycerides (TG) and high-density lipoprotein cholesterol (HDL-c) but not low-density lipoprotein cholesterol (LDL-c) predict c-fPWV. …”
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The endocannabinoid system’s genetic polymorphisms in sickle cell anemia patients by Amanda Cristina Meneguetti Berti, Vanessa da Silveira Ramos de Castro, Gabriela Silva Arcanjo, Aderson da Silva Araujo, Antonio Roberto Lucena-Araujo, Marcos André Cavalcanti Bezerra, Lucas Gazarini, Danilo Grünig Humberto da Silva, Edis Belini-Júnior

“…We observed a lower frequency of -α3.7kb-thalassemia mutation in patients with priapism than in patients without this complication (p < 0.001), and in adjusted multivariate analyses TT-CC genotype of CNR2 rs35761398 was associated with a lower chance of developing priapism (OR = 0.386 [0.175–0.854], p = 0.019) and a lower risk of it over time (HR = 0.634 [0.402–0.987], p = 0.049). The SCA ischemic priapism is related to unbalanced vasodilation/vasoconstriction pathways, such as decreased RhoA/Rho-kinase (ROCK) signaling. …”
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Protective Effects of Two Safflower Derived Compounds, Kaempferol and Hydroxysafflor Yellow A, on Hyperglycaemic Stress-Induced Podocyte Apoptosis via Modulating of Macrophage M1/M... by Yuanping Li, Dan Zheng, Dayue Shen, Xilan Zhang, Xiaoyun Zhao, Hui Liao

“…The expressions of inducible nitric oxide synthase (iNOS), tumor necrosis factor- (TNF-) α, mannose receptor (CD206), and arginase- (Arg-) 1 were quantified by Western blotting and real-time quantitative PCR. The collected supernatants from macrophage were named as (NG) MS, (HG) MS, (Ka) MS, and (HSYA) MS. (2) The podocyte survival rate was assessed by Bromodeoxyuridine assay, while TNF-α and interleukin- (IL-) 1β levels were evaluated by Elisa. …”
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3D-Printed Tablets of Nifurtimox: In Vitro and In Vivo Anti-<i>Trypanosoma cruzi</i> Studies by Giselle R. Bedogni, Ana Luiza Lima, Idejan P. Gross, Tatiana Prata Menezes, Andre Talvani, Marcilio Cunha-Filho, Claudio J. Salomon

“…This work aimed for the first time to formulate tablets of nifurtimox by hot melt extrusion coupled with 3D printing as a strategy to increase drug dissolution and the production of tablets with dosage on demand. …”
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Identification of a novel immunogenic cell death-related classifier to predict prognosis and optimize precision treatment in hepatocellular carcinoma by Dongjing Zhang, Bingyun Lu, Qianqian Ma, Wen Xu, Qi Zhang, Zhiqi Xiao, Yuanheng Li, Ren Chen, An-jiang Wang

“…High ICD score indicated an immune-excluded TME phenotype, with lower anticancer immunity and shorter survival time. In contrast, low ICD score corresponded to abundant immune cell infiltration, high sensitivity to immunotherapy and a positive prognosis, indicating an “immune-hot” phenotype. …”
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Hubungan Lama Penggunaan Obat Anti Nyamuk Bakar dengan Kadar Kolinesterase Darah pada Masyarakat Kelurahan Jati Rumah Gadang Padang by Amelia ., Yustini Alioes, Sofina Rusdan

“…<br />Kata kunci: obat anti nyamuk bakar, kolinesterase, insektisida</p><p> </p><p>Abstract<br />In this time, pesticide is not only used by agriculture sector but also used by household sector to eradicate insects and disease agents, one of them is anti mosquito fuel which contain insecticide. …”
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Characterizing Telehealth Barriers and Preferences to Promote Acceptable Implementation Strategies in Central Uganda: Multilevel Formative Evaluation by Michael Kizito, Erina Nabunjo Mugabi, Sabrina Ford, Bree Holtz, Kelly Hirko

“…Although 89% (n=81) of patients reported saving time with telehealth approaches, 33.3% (n=30) of patients reported that telehealth made them feel uncomfortable, and 43.8% (n=39) reported concerns about confidentiality. …”
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Evolution and Recent Radiation Therapy Advancement in Uganda: A Precedent on How to Increase Access to Quality Radiotherapy Services in Low- and Middle-Income Countries by Awusi Kavuma, Solomon Kibudde, Daniel Kanyike, Joseph Kigula-Mugambe, Tianyu Zhao, Hiram Gay, Baozhou Sun, Jackson Orem

“…These advancements improved the efficiency/precision of treatments and the time patients spent undergoing therapy. Around the second decade of radiotherapy services, about 600 new patients with cancer were annually treated compared with about 2,600 in 2023. …”
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Self-administered active versus sham acupressure for diarrhea predominant irritable bowel syndrome: a nurse-led randomized clinical trial by Maha Gamal Ramadan Asal, Ahmed Abdelwahab Ibrahim El-Sayed, Samira Ahmed Alsenany, Zahraa Hassan Ramzy, Rasha Fathy Ahmed Dawood

“…Conclusion Active acupressure is an effective nursing intervention for alleviating symptoms of IBS-D, particularly when applied consistently over time. It improves both physical and psychological outcomes, offering a valuable non-pharmacological treatment option. …”
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A headspace-gas chromatography method for isopropanol determination in warfarin sodium products as a measure of drug crystallinity by Rahman Ziyaur, Akhtar Sohail, Siddiqui Akhtar, Ciavarella Anthony B., Nguyenpho Agnes, Faustino Patrick J., Khan Mansoor A.

“…Chromatographic parameters (retention time, IPA/NPA area ratio, tailing factor, theoretical plates, USP symmetry, capacity factor, selectivity and resolution) were consistent over three days of validation. …”
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A roadmap to implementing machine learning in healthcare: from concept to practice by Adam Paul Yan, Adam Paul Yan, Lin Lawrence Guo, Jiro Inoue, Santiago Eduardo Arciniegas, Emily Vettese, Agata Wolochacz, Nicole Crellin-Parsons, Brandon Purves, Steven Wallace, Azaz Patel, Medhat Roshdi, Karim Jessa, Karim Jessa, Bren Cardiff, Lillian Sung, Lillian Sung, Lillian Sung

“…Its goal was to develop, deploy, evaluate and maintain clinical ML models to improve pediatric patient outcomes using electronic health records data.ObjectiveTo provide examples from the PREDICT experience illustrating how common challenges with clinical ML deployment were addressed.Materials and methodsWe present common challenges in developing and deploying models in healthcare related to the following: identify clinical scenarios, establish data infrastructure and utilization, create machine learning operations and integrate into clinical workflows.ResultsWe show examples of how these challenges were overcome and provide suggestions for pragmatic solutions while maintaining best practices.DiscussionThese approaches will require refinement over time as the number of deployments and experience increase.…”
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Nootkatone Derivative Nootkatone-(E)-2-iodobenzoyl hydrazone Promotes Megakaryocytic Differentiation in Erythroleukemia by Targeting JAK2 and Enhancing JAK2/STAT3 and PKCδ/MAPK Cro... by Yang Pan, Feng Xiao, Chaolan Pan, Hui Song, Peng Zhao, Meijun Chen, Liejun Huang, Jue Yang, Xiaojiang Hao

“…Our results demonstrate that the nootkatone derivative nootkatone-(E)-2-iodobenzoyl hydrazone (N2) significantly inhibited erythroleukemia cell proliferation in a concentration- and time-dependent manner. More importantly, N2 induced megakaryocytic differentiation, as evidenced by significant morphological changes, and upregulation of megakaryocytic markers CD41 and CD61. …”
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The incidence of and risk factors for axillary web syndrome with limited shoulder movement after surgery for breast cancer, and the effect of early physical therapy intervention by Ya-Hui Chou, Su-Fen Liao, Dar-Ren Chen, Shou-Tung Chen, Wei-Te Wang

“…The incidence of AWS with shoulder movement limitation was 18%, and the time to diagnosis was 26.3 days. In a subsequent multivariate analysis, younger age (OR = 0.95; 95% CI = 0.91–0.99; p = 0.019), higher number of removed lymph nodes (OR = 1.09; 95% CI = 1.03–1.16; p = 0.007) and receiving neoadjuvant chemotherapy (NAC) (OR = 2.96; 95% CI = 1.25–6.98; p = 0.013) were associated with an increased risk of developing AWS with shoulder movement limitation. …”
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