Antibody-induced erythrophagocyte reprogramming of Kupffer cells prevents anti-CD40 cancer immunotherapy-associated liver toxicity by Florence Vallelian, Marc Pfefferlé, Irina L Dubach, Raphael M Buzzi, Elena Dürst, Nadja Schulthess-Lutz, Livio Baselgia, Kerstin Hansen, Larissa Imhof, Sandra Koernig, Didier Le Roy, Thierry Roger, Rok Humar, Dominik J Schaer

“…An effective prophylactic treatment for liver immune-related adverse events that does not suppress specific antitumor immunity remains to be found.Methods We used different mouse models and time-resolved single-cell RNA-sequencing to characterize the pathogenesis of anti-CD40 mAb induced liver toxicity. …”
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11 Key Strategies in Using AI Chat GPT to Develop HOTS-Based Entrepreneurship Questionnaires by Almaida Vebibina, Rusijono Rusijono, Andi Mariono, Ahsan Muafa, Dydik Kurniawan, Ragil Sugeng Dewantoro, Dian Noer Asyari, Sussi Widiastuti, Jarot Suseno

“… Developing entrepreneurship assessment questions that measure higher-order thinking skills (HOTS) is a challenge that requires time and in-depth analysis. Artificial intelligence such as Chat GPT is here to simplify the process. …”
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Randomised feasibility study of an intestinal adsorbent in acute diarrhoea in The Gambia by Elena Markaryan, Matthew Dodd, Stephen Allen, Carol Howell, Angela Allen, Paul Rahden, Abdoulie Fatty, Momodou Lamin Jobarteh, Abdoulwahab Sallah, Ebrahim Jaiteh, Doreen Umoh, Fanta Bass, Radovan Hnatič

“…There were no major protocol deviations although patient-held diaries did not collect reliable information. Time from randomisation to the last watery stool (primary outcome) was shorter in the intervention than control arm (mean difference −19.3 hours, 95% CI −30.9 to −7.8). …”
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A Hybrid Fuzzy Wavelet Neural Network Model with Self-Adapted Fuzzy c-Means Clustering and Genetic Algorithm for Water Quality Prediction in Rivers by Mingzhi Huang, Di Tian, Hongbin Liu, Chao Zhang, Xiaohui Yi, Jiannan Cai, Jujun Ruan, Tao Zhang, Shaofei Kong, Guangguo Ying

“…The results indicate that the FWNN made effective use of the self-adaptability of NN, the uncertainty capacity of FL, and the partial analysis ability of WT, so it could handle the fluctuation and the nonseasonal time series data of water quality, while exhibiting higher estimation accuracy and better robustness and achieving better performances for predicting water quality with high determination coefficients R2 over 0.90. …”
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Running trends in Switzerland from 1999 to 2019: An exploratory observational study. by Anja Witthöft, Thimo Marcin, Mabliny Thuany, Volker Scheer, Pantelis T Nikolaidis, Matthias Wilhelm, Katja Weiss, Thomas Rosemann, Beat Knechtle

“…The running trends in a whole country covering a longer period of time and several race distances are missing so far.…”
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Electrocardiographic Changes in Pregnant Patients With Congenital Heart Disease by Maria A. Pabon, Amrit Misra, Kimberlee Gauvreau, Madeline E. Duncan, Ava Conklin, Katherine E. Economy, Fred M. Wu, Thomas Tadros, Anne Marie Valente, For the STORCC Investigators

“…EKG parameters were measured in all available EKGs by two investigators, blinded to diagnosis and time of gestation. Results One hundred and seventy pregnant patients were included. …”
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Redox-dependent purine degradation triggers postnatal loss of cardiac regeneration potential by Yuichi Saito, Yuki Sugiura, Akane Sakaguchi, Tai Sada, Chihiro Nishiyama, Rae Maeda, Mari Kaneko, Hiroshi Kiyonari, Wataru Kimura

“…Here, we conducted interspecies multi-omic comparisons between the mouse heart and that of the opossum, which have different postnatal time-windows for cardiomyocyte cell cycle withdrawal. …”
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System of Administrative and Legal Regulation of the Status of the Cabinet of Ministers of Ukraine in the Field of Scientific, Research and Technical Activity in Ukraine by V. S. Tarasenko

“…Administrative and legal status in the system of administrative and legal regulation is considered as a structural element, an integral part of it. At the same time, it is part of the subject of legal regulation by the rules of administrative law. …”
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Rethinking Conservation and Restoration Strategies of Endangered and Key Medicinal Clavicarpa Plants in Yunnan‐Kweichow Plateau's Karst Areas Under Climate Change by Chao Luo, Baiyang He, Yulu Wu, Yuteng Xue, Huang Deng, Shanman Li, Xianghong Dong, Litang Lu

“…The EC‐Earth3‐Veg, MRI‐ESM2‐0, and MPI‐ESM1‐2‐HR models were utilized for conservation status assessment and project future distributions for four time periods: the present, 2030s, 2050s, and 2070s. …”
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Novel transparent high-entropy sesquioxide ceramics with high physicochemical plasma etching resistance by Yu-Bin Shin, Su Been Ham, Ha-Neul Kim, Mi-Ju Kim, Jae-Woong Ko, Jae-Wook Lee, Young-Jo Park, Jung-Hyung Kim, Hyo-Chang Lee, Young Hwa Jung, Jung Woo Lee, Ho Jin Ma

“…An evaluation of the plasma-etching resistance of high-entropy ceramics revealed for the first time a low etching rate of 8 nm/h compared with that of conventional plasma-resistant materials. …”
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Gene Expression Signatures of Peripheral Blood Mononuclear Cells during the Early Post-Transplant Period in Patients Developing Cardiac Allograft Vasculopathy by Khurram Shahzad, Martin Cadeiras, Sarfaraz Memon, Barry Zeeberg, Tod Klingler, Anshu Sinha, Esteban G. Tabak, Sreevalsa Unniachan, Mario C. Deng

“…We corroborated our findings by retrospective analysis of PBMC real-time PCR data from 33 patients. Results. Over 300 genes were differentially expressed (FDR < 5%), and 18 GO-categories including “macrophage activation”, “Interleukin-6 pathway”, “NF-KappaB cascade”, and “response to virus” were enriched by these genes (FDR < 5%). …”
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Antibacterial activity and impact on keratinocyte cell growth of Cutibacterium acnes bacteriophages in a Cutibacterium acnes IA1- colonized keratinocyte model by Juan C Farfán-Esquivel, María Victoria Gutiérrez, Alejandro Ondo-Méndez, John M González, Martha J Vives-Flórez

“…Nevertheless, IA1 caused a higher impact on cell doubling time by increasing it 1.8 times more than cell growth control group. …”
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New Insights Into the Reservoir Landslide Deformation Mechanism From InSAR and Numerical Simulation Technology by Guoshi Liu, Bin Wang, Qian Sun, Jun Hu, Lei-Lei Liu, Wanji Zheng, Liye Zou

“…The complete deformation time series reveals three independent components of landslide movement and their trigger factors geometrically. …”
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Reengineering of the organizational structure and business processes of investment and construction activities. Their place in the general system of corporate regulation by S. B. Sborshikov, N. V. Lazareva

“…On this basis it will help to gain competitive advantages, among other things through the wider use of technical means, employees meeting higher requirements of scientific and technical progress and capable of solving complex problems of investment and construction activities, arising at the present stage, in the shortest possible time.Materials and methods. The theoretical basis of the research was a system approach, logistics of regulatory impacts, structural and functional analysis, methods of investment design, strategic and operational management. …”
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Determination of geometry of cutting tool for smallsize machining of parts made of titanium alloys by D. S. Rechenko, D. G. Balova, A. K. Aubakirova, R. U. Kamenov, D. E. Levin

“…Requirements for the quality of manufacturing implants made of titanium alloys used in medicine are quite high. At the same time existing processing methods in their manufacture do not always provide the required quality of the treated surfaces, characterized by roughness and surface layer defects of the final part. …”
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Asymmetric ion transport through heterogeneous bilayers of covalent organic frameworks by Xiaopeng Zhang, Shixian Xin, Qin Qian, Xiaoyi Xi, Munan Fang, Zhifei Sun, Yunyang Wang, Yulong Li, Yue Wang, Xingtao Tian, Yuntong Li, Siyu Wang, Jinlei Yang, Zhiyong Tang, Lianshan Li

“…Using an electric field as a driving force, rectified ion transport was observed for the first time. Notably, this ionic current rectification property could be modulated by the salt concentration and the structural composition of the membrane, and it was universal for various COF heterojunctions with different chemical ingredients. …”
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In Situ Classification of Original Rocks by Portable Multi-Directional Laser-Induced Breakdown Spectroscopy Device by Mengyang Zhang, Hongbo Fu, Huadong Wang, Feifan Shi, Saifullah Jamali, Zongling Ding, Bian Wu, Zhirong Zhang

“…Laser-induced breakdown spectroscopy (LIBS) is particularly well-suited for in situ online analysis due to its rapid response time and minimal sample preparation requirements. …”
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ROS-mediated M1 polarization-necroptosis crosstalk involved in Di-(2-ethylhexyl) phthalate-induced chicken liver injury by Guangxing Li, Menglin Wu, Kaiting Chen, Yue Xu, Xiandan Zhang, Yang Chen, Hong Zhang, Ruili Zhang, Xiaodan Huang

“…With increasing dose and time, DEHP decreased body weight, increased liver coefficient, raised activities of liver function indicators and caused pathological liver damage in chickens. …”
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From Waste to Value: Optimization of Ultrasound-Assisted Extraction of Anthocyanins and Flavonols from <i>Pistacia lentiscus</i> L. Oilcakes by Lucrezia Muti, Luana Beatriz dos Santos Nascimento, Giulia Goracci, Cassandra Detti, Cecilia Brunetti, Anna Rita Bilia, Francesco Ferrini, Antonella Gori

“…The optimal extraction conditions found were to be an extraction time of 15 min with 70% ethanol as the solvent and a liquid-to-solid ratio of 0.012 L g⁻¹, which resulted in a maximum extraction yield of 19.78 mg g⁻¹ dry extract for the Total Flavonol Content and over 25.4 mg g⁻¹ dry extract for the Total Flavonol and Anthocyanin Content. …”
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Parthenolide Is Neuroprotective in Rat Experimental Stroke Model: Downregulating NF-κB, Phospho-p38MAPK, and Caspase-1 and Ameliorating BBB Permeability by Lipeng Dong, Huimin Qiao, Xiangjian Zhang, Xiaolin Zhang, Chaohui Wang, Lina Wang, Lili Cui, Jingru Zhao, Yinxue Xing, Yanhua Li, Zongjie Liu, Chunhua Zhu

“…PN administered intraperitoneally immediately after cerebral ischemia and once daily on the following days. At time points after MCAO, neurological deficit, infarct volume, and brain water content were measured. …”
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