Brain neurons internalise polymeric micron-sized capsules: Insights from in vitro and in vivo studies by Olga Kopach, Olga A. Sindeeva, Kaiyu Zheng, Eleanor McGowan, Gleb B. Sukhorukov, Dmitri A. Rusakov

“…This internalisation was time-dependent, correlated with particle size and mediated by a macropinocytosis mechanism that appears to bypass lysosomal formation. …”
Get full text

Secular trends of epidemiologic patterns of chronic kidney disease over three decades: an updated analysis of the Global Burden of Disease Study 2019 by Jing Liu, Xue Li, Yongping Liu, Xiaodong Sun, Xiaojin Feng, Ningning Hou, Zhenna Chen

“…Objectives To assess the characteristics of the global death burden imposed by chronic kidney disease (CKD) and the attributable risk factors from 1990 to 2019 to help inform a framework for policy discussions, resource allocation and research priorities.Design A population-based observational study.Setting The death data and relative risk factors were obtained from the Global Burden of Disease (GBD) Study 2019 database.Main outcome measures Based on the GBD database, we estimated the death burden attributable to CKD stratified by sociodemographic index (SDI), geographic location, sex, age group, time period and risk factors from 1990 to 2019.Results Over three decade study period, the global number of CKD-related deaths increased from 0.60 million (95% uncertainty interval (UI): 0.57–0.63 million) in 1990 to 1.43 million (95% UI: 1.31–1.52 million) in 2019. …”
Get full text

Statin prescriptions and progression of advanced fibrosis risk in primary care patients with MASLD by Andrew D Schreiner, William P Moran, Jingwen Zhang, Patrick D Mauldin, Justin Marsden, Mulugeta Gebregziabher, Chelsey A Petz, David G Koch, Chloe Bays

“…We developed Cox regression models for the time to a high-risk FIB-4 score with statin therapy as the primary covariate and adjusting for baseline fibrosis risk, demographic and comorbidity variables.Results The cohort of 1238 patients with MASLD was followed for a mean of 3.3 years, with 47% of patients receiving a prescription for a statin, and 18% of patients progressing to a high-risk FIB-4. …”
Get full text

Prevalence of childhood mental disorders in high-income countries: a systematic review and meta-analysis to inform policymaking by Charlotte Waddell, Christine Schwartz, Jenny Lou Barican, Donna Yung, Yufei Zheng, Katholiki Georgiades

“…Among children with mental disorders, only 44.2% (95% CI 37.6% to 50.9%) received any services for these conditions.Conclusions An estimated one in eight children have mental disorders at any given time, causing symptoms and impairment, therefore requiring treatment. …”
Get full text

Study on seismic performance of high-strength steel earthquake-resilient beam-column joint with double damage elements by Hongchao Guo, Dongdong Zheng, Jing Lu, Xudong Zhou, Wenqi Wang, Yunhe Liu

“…The research findings show a significant time sequence in the joint double damage element, with both components dissipating over 90% of energy. …”

The Analysis of Estrogen-Degrading and Functional Metabolism Genes in Rhodococcus equi DSSKP-R-001 by Kejian Tian, Fanxing Meng, Qi Meng, Yan Gao, Lili Zhang, Le Wang, Yuqing Wang, Xue Li, Hongliang Huo

“…In this study, the metabolic mechanisms by which Rhodococcus equi R-001 degrades various estrogens were analyzed for the first time. A new pollutant metabolism system is outlined, providing a starting point for the construction of engineered estrogen-degrading bacteria.…”
Get full text

Germline Mutation in KIF1Bβ Gene Associated with Loss of Heterozygosity: Usefulness of Next-Generation Sequencing in the Genetic Screening of Patients with Pheochromocytoma by Giuseppina De Filpo, Elisa Contini, Viola Serio, Andrea Valeri, Massimiliano Chetta, Daniele Guasti, Daniele Bani, Massimo Mannelli, Elena Rapizzi, Michaela Luconi, Mario Maggi, Tonino Ercolino, Letizia Canu

“…Our results underline the usefulness of next-generation sequencing in the presence of multiple tumor predisposition genes and how, at the same time, its use may result challenging for the clinicians. …”
Get full text

Effects of Food on the Pharmacokinetics and Safety of HA121-28 Tablet, a Novel Multi-Targeting Tyrosine Kinase Inhibitor, in Healthy Chinese Subjects: A Phase I Clinical Trial by Liu Y, Li X, Zhang M, Men Y, Wang Y, Zhu X, Zheng L

“…The geometric mean ratios (GMRs) for the peak concentration in plasma (Cmax), area under the curve from zero to the time point (AUClast), and area under the curve from zero to infinite (AUCinf) postprandially versus fasted were 108.45% (98.51% – 119.40%), 105.23% (100.25% – 110.47%), and 104.14% (97.41% – 111.34%), respectively. …”
Get full text

Association between triglyceride/high density lipoprotein ratio and incidence risk of Parkinson’s disease: a population-based cohort study by Yoonkyung Chang, Ju-young Park, Tae-Jin Song

“…Considering the multivariable time-dependent Cox proportional hazard model with repeated measures of average TG/HDL cholesterol ratio, a per unit increase in TG/HDL cholesterol ratio significantly increased the risk of PD in the entire cohort (hazard ratio (HR), 1.010; 95% confidence interval (CI), 1.001–1.020). …”
Get full text

Soluble Receptor for Advanced Glycation End Products: A Protective Molecule against Intramyocardial Lipid Accumulation in Obese Zucker Rats? by Elena Dozio, Elena Vianello, Francesco Bandera, Erika Longhi, Stefano Brizzola, Manuela Nebuloni, Massimiliano M. Corsi Romanelli

“…Heart RAGE expression was explored by real-time RT-PCR and Western blot analyses. Serum levels of sRAGE (total and endogenous secretory form (esRAGE)) were quantified by ELISA. …”
Get full text

Reactivation of Denervated Schwann Cells by Embryonic Spinal Cord Neurons to Promote Axon Regeneration and Remyelination by Xinyu Fang, Chaofan Zhang, Chongjing Zhang, Yuanqing Cai, Zibo Yu, Zida Huang, Wenbo Li, Wenming Zhang

“…The results showed that at different times after transplantation, the cells could survive and generate neurons. …”
Get full text

Antifungal efficacy of chitosan-mediated fenugreek nanocomposite incorporated in tissue conditioner by Mohika Damle, Ponsekar Abraham Anandapandian, B. Eswaran, Swapnaneel Pradhan, Silvin Joe C J, Shreyas Dhumke

“…Kruskal-Wallis test showed significant effects over time, with 2.5 % group showing lowest fungal growth at 521 CFU/mL, followed by 2 % group at 587 CFU/mL, while the 1.5 % nanocomposite group still displayed considerable fungal growth. …”
Get full text

Characterization and functional analysis of chicken hnRNP protein by Ke Wang, Manzi Huang, Qinghua Zeng, Huansheng Wu

“…In summary, our findings reveal for the first time that multiple chicken hnRNPs interact with viral dsRNA, modulate IFN-β production, and specifically, that chicken hnRNPA3 promotes IBDV replication. …”
Get full text

Transgenerational effect of prenatal stress on behavior and lipid peroxidation in brain structures of female rats during the estral cycle by A. V. Vyushina, A. V. Pritvorova, S. G. Pivina, N. E. Ordyan

“…If both F1 parents were prenatally stressed, female F2 rats retained interstage differences similar to the control pattern, while their locomotor-exploratory activity and time spent in the center of an “open field” decreased in absolute values. …”
Get full text

Diagnostic Value of Dynamics Serum sCD163, sTREM-1, PCT, and CRP in Differentiating Sepsis, Severity Assessment, and Prognostic Prediction by Longxiang Su, Lin Feng, Qing Song, Hongjun Kang, Xingang Zhang, Zhixin Liang, Yanhong Jia, Dan Feng, Changting Liu, Lixin Xie

“…Both sCD163 and SOFA scores are risk factors impacting the survival time. Conclusion. With regard to sepsis diagnosis and severity, sTREM-1 is more ideal and constitutes a risk factor. sCD163 is of a positive value in dynamic prognostic assessment and may be taken as a survival-impacting risk factor.…”
Get full text

Socioeconomic environment and survival in patients after ST-segment elevation myocardial infarction (STEMI): a longitudinal study for the City of Vienna by Christian Roth, Michael Kühn, Rudolf Berger, Sonja Spitzer, Vanessa di Lego

“…SEE is proxied via mean individual gross income from employment in each municipal district.Results Results are based on Kaplan-Meier survival probability estimates, Cox proportional hazard regressions and competing risk models, always using age as the time scale. Descriptive findings suggest a socioeconomic gradient in the age at death after STEMI. …”
Get full text

Exploring the gender difference in type 2 diabetes incidence in a Swiss cohort using latent class analysis: an intersectional approach by Julien Vaucher, Michael Amiguet, Carole Clair, Joelle Schwarz, Jeanne Marie Barbier, Aurélie M Lasserre

“…Over a median follow-up time of 14.5 years, 255 (7.5%) participants developed type 2 diabetes, of which 158 men (62.0%). …”
Get full text

A Study on Canopy Volume Measurement Model for Fruit Tree Application Based on LiDAR Point Cloud by Na Guo, Ning Xu, Jianming Kang, Guohai Zhang, Qingshan Meng, Mengmeng Niu, Wenxuan Wu, Xingguo Zhang

“…However, existing methods for measuring canopy volume fail to satisfy the high precision and real-time requirements necessary for accurate variable-rate applications in fruit orchards. …”
Get full text

Estimation of median LC50 and toxicity of environmentally relevant concentrations of thiram in Labeo rohita by Sana Alam, Gulnaz Afzal, Riaz Hussain, Hafiz Muhammad Ali, Amtul Sami, Rabbiah Manzoor Malik, Raheela Jabeen, Farid Shokry Ataya, Kun Li

“…In this study, firstly LC50 value of thiram has been determined as 0.744 mg/L for the first time in Labeo rohita and then, the fish were exposed to different sub-lethal concentrations of thiram (40 μg/L, 80 μg/L and 120 μg/L) to evaluate the effects on tissue growth, oxidative stress, anti-oxidant enzymes and histo-pathological parameters at days-20, 40 and 60 of the experiment. …”
Get full text

Intertransverse process block versus subcostal transversus abdominis plane block in patients undergoing laparoscopic radical gastrectomy: a prospective randomized controlled trial by Qian Chen, Xinyue Zhou, Fang Wang, Yang Zeng, Bin Qian, Haiyun Du

“…The ITPB group showed lower intraoperative opioid use, and statistical significantly lower scores at rest and coughing at 6, 24 h postoperatively. The time to first requiring rescue analgesia was longer in the ITPB group than the subcostal TAPB group (median [IQR]): 8.0 [8.0] vs 6.0 [6.0] h, P = 0.009. …”
Get full text