MDTR: a knowledge-guided interpretable representation for quantifying liver toxicity at transcriptomic level by Inyoung Sung, Sangseon Lee, Dongmin Bang, Dongmin Bang, Jungseob Yi, Sunho Lee, Sun Kim, Sun Kim, Sun Kim, Sun Kim

“…Despite accumulating drug-induced transcriptome data such as LINCS, analyzing such transcriptome data upon drug treatment is a challenging task because the perturbation of expression is dose and time dependent. In addition, the mechanisms of drug toxicity are known only as literature information, not in a computable form.MethodsTo address these challenges, we propose a Multi-Dimensional Transcriptomic Ruler (MDTR) that quantifies the degree of DILI at the transcriptome level. …”
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A Generic AI-Based Technique for Assessing Student Performance in Conducting Online Virtual and Remote Controlled Laboratories by Ahmed M. Abd El-Haleem, Mohab Mohammed Eid, Mahmoud M. Elmesalawy, Hadeer A. Hassan Hosny

“…The performance evaluation module is designed to automatically detect the student performance during the experiment run time and triggers the LLMS virtual assistant service to provide struggling students with the appropriate help when they need it. …”
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The intestinal microbial community and function of Riptortus pedestris at different developmental stages and its effects on development by Yanbin Wang, Rong Li, Chunjing Wang, Ting Sun, Hongjuan Zhang, Fang Zhao, Jiehui Liu, Yuqiong Hao, Xiansheng Xie

“…Excitingly, Burkholderia bacteria eliminated by antibiotic treatment were unable to molt normally, and their lifespan was shortened in nymphs, indicating that the gut microbiota had a significant effect on nymph development.ConclusionIn summary, our results, for the first time, systematically illustrate the abundance and function across the gut microbiota from the different developmental stages of R. pedestris and demonstrate that the genera Burkholderia are crucial during the development of R. pedestris. …”
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Advancing <i>Glycyrrhiza glabra</i> L. Cultivation and Hairy Root Transformation and Elicitation for Future Metabolite Overexpression by Negin Afsharzadeh, Renate Paltram, Arne Jungwirth, Leila Tabrizi, Vahideh Nazeri, Hadi Kalantari, Heidi Halbwirth, Leila Samiei, Hester Sheehan, Majid Shokrpour

“…Hairy root cultures grown in blue light and in blue and red light combined had higher growth rates than those grown in red light only or in control conditions (dark). FRAP increased over time under all light treatments, including the control, and those cultures exposed to blue and red light combined had higher FRAP than the control. …”
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Serum Inflammatory Cytokines and Growth Factors in Patients with Sjögren’s Syndrome and Diabetes Mellitus by Yalçın Karaküçük, Sema Yilmaz, Ali Unlu, Banu Bozkurt, Şule Nur Acar Duyan

“…After detailed ophthalmological examination, Schirmer test, tear break-up time (TBUT) and Ocular Surface Disease Index (OSDI) scores were measured. …”
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Effects of Different Rates of Poultry Manure and Split Applications of Urea Fertilizer on Soil Chemical Properties, Growth, and Yield of Maize by Aruna Olasekan Adekiya, Oluwaseyi Iyabo Ogunboye, Babatunde Sunday Ewulo, Adeniyi Olayanju

“….), it is necessary to investigate the best time to apply UF that will optimize soil chemical properties, growth, and yield of maize. …”
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Construction of a Real-Scene 3D Digital Campus Using a Multi-Source Data Fusion: A Case Study of Lanzhou Jiaotong University by Rui Gao, Guanghui Yan, Yingzhi Wang, Tianfeng Yan, Ruiting Niu, Chunyang Tang

“…Finally, the 3D model is visualized on the web using Cesium, which enables functionalities such as real-time data loading, perspective switching, and spatial data querying. …”
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Air Particle Abrasion in Dentistry: An Overview of Effects on Dentin Adhesion and Bond Strength by Andreea Kui, Smaranda Buduru, Anca Labuneț, Sorina Sava, Dalia Pop, Iris Bara, Marius Negucioiu

“…Optimal APA parameters were identified as 50 μm particle size, 60 psi (4 bar) air pressure and 5 s exposure time. Longer exposure times provided no additional benefit. …”
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Semi-field experiments reveal contrasted predation and movement patterns of aquatic macroinvertebrate predators of Anopheles gambiae larvae by Hudson Onen, Emmanuel W. Kaindoa, Joel Nkya, Alex Limwagu, Martha A. Kaddumukasa, Fredros O. Okumu, Jonathan K. Kayondo, Anne M. Akol, Frédéric Tripet

“…The larval predation rates of predacious diving beetle, backswimmer and dragonfly nymphs were stable over time at a mean of 3.2, 7.0 and 9.6 larvae consumed each day. …”
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In-situ probing of the Fischer-Tropsch reaction on Co single crystal surfaces up to 1 bar by Patrick Lömker, David Degerman, Christopher M. Goodwin, Mikhail Shipilin, Peter Amann, Gabriel L. S. Rodrigues, Fernando Garcia-Martinez, Raffael Rameshan, Jörgen Gladh, Hsin-Yi Wang, Markus Soldemo, Alexander Holm, Steffen Tober, Jan-Christian Schober, Leon Jacobse, Vedran Vonk, Robert Gleißner, Heshmat Noei, Zoltan Hegedues, Andreas Stierle, Christoph Schlueter, Anders Nilsson

“…Furthermore, we demonstrate that the intermediate surface species are highly dynamic, appearing and disappearing with time delays after rapid changes in the reactants’ composition.…”
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Physiological Properties of Dietary Ellagitannin-Rich Preparations Obtained from Strawberry Pomace Using Different Extraction Methods by Juśkiewicz Jerzy, Król Bogusław, Kosmala Monika, Milala Joanna, Zduńczyk Zenon, Żary-Sikorska Ewa

“…It could be concluded that more efficient acetone extraction of strawberry pomace increased the content of both ellagitannins and proanthocyanidins in the polyphenolic preparation, which caused a stronger inhibiting effect on caecal fermentation processes and at the same time lowered blood triacylglycerols and glucose level. …”
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Impact of A1 segment asymmetry on hemodynamic conditions around the circle of Willis and anterior communicating artery aneurysm formation by Joonho Lee, Seul-Ki Jeong, Ji Man Hong, Ji Man Hong

“…BackgroundThis study aims to investigate how A1 segment asymmetry—also known as A1 dominancy—influences the development of the anterior communicating artery aneurysm (AcomA) as it affects hemodynamic conditions within the circle of Willis (COW). Using time-of-flight magnetic resonance angiography (TOF-MRA), the research introduces a novel approach to assessing shear stress in A1 segments to uncover the hemodynamic factors contributing to AcomA formation.MethodAn observational study was conducted over 6 years at a tertiary university hospital’s outpatient clinic. …”
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Assessment of multidecadal precipitation seasonality in the panama canal watershed by István Gábor Hatvani, Nayara Azevedo de Castro Souza, Russell S. Harmon, Jorge A. Espinosa, Zoltán Kern

“…New Hydrological Insights for the Region: Three spatial domains of similar patterns of seasonal and geographical distribution of rainfall were delineated in PCW by clustering the precipitation-seasonality time series. Stations in the northeastern and northwestern domains of the PCW experience higher average daily precipitation, influenced by the interplay of the annual movement of the ITCZ33 Intertropical Convergence Zone across Panama and weather systems over the Caribbean Sea. …”
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Tailor-Made, Linear, and “Comb-Like” Polyester-Based Copolymers: Synthesis, Characterization, and Thermal Behavior of Potential 3D-Printing/Electrospinning Candidates by Franco L. Redondo, Mario D. Ninago, Augusto G. O. de Freitas, Cristiano Giacomelli, Andrés E. Ciolino, Marcelo A. Villar

“…For both sets of copolymers, the decrease in the resulting melting temperatures and the increase in the half-life crystallization time values might be useful processing parameters, particularly if these copolymers are planned for using as an alternative source of 3D printing or electrospinning materials.…”
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2D SnSe2 micro-flower decorated with 0D In2O3 nanoparticles for low-temperature low-concentration TEA detection by Li Wang, Jianpeng Li, Cheng Xu, Ziqin Yang, Xiangyun Tan, Zhihu Dong, Li Xu, Dongwei Zhang, Chunqing He

“…In this study, we report the facile hydrothermal and ultrasonic treatment synthesis of 2D SnSe2 micro-flower modified with 0D In2O3 nanoparticles to form SnSe2/In2O3 heterojunctions for the first time. The SnSe2/In2O3 sensor has a response value of 4.86 for 10 ​ppm TEA gas at 120 ​°C, with response and recovery times of 18 ​s and 79 ​s respectively, and detection limits as low as 100 ​ppb. …”
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Effectiveness and safety of human placenta hydrolysate injection into subacromial space in patients with shoulder impingement syndrome: a single-blind, randomized trial by Du Hwan Kim, Myung Woo Park, Hyun Iee Shin, Byung Chan Lee, Don-Kyu Kim, Chul-Hyun Cho, Ye-Ji Kim

“…Results Significant differences were noted in the VAS (p < 0.001) during daily activity, SPADI total score (p < 0.001), and EQ-5D-5L utility index (p < 0.001) nine weeks after the last injection between the hPH group and placebo group. Significant time effects were observed for all outcome measurements (all p < 0.001) in the hPH group but not in the placebo group. …”
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Efficient Method for Robust Backdoor Detection and Removal in Feature Space Using Clean Data by Donik Vrsnak, Marko Subasic, Sven Loncaric

“…Secondly, it reduces the memory footprint and the computation time by at least an order of magnitude compared to other methods, which allows FEAT-IN to be used practically in real-world scenarios. …”
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Effect of home-based interventions on basic activities of daily living for patients who had a stroke: a systematic review with meta-analysis by Ping Qin, Canxin Cai, Xuan Chen, Xijun Wei

“…Future research is needed to investigate the effectiveness of home-based rehabilitation in groups with stratification by stroke severity and time since stroke onset, with elaboration of details of the home-based and the control interventions. …”
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Digital screening tool for the assessment of cognitive impairment in unsupervised setting—digiDEM-SCREEN: study protocol for a validation study by Elmar Graessel, Nikolas Dietzel, Hans-Ulrich Prokosch, Peter L Kolominsky-Rabas, Peter Heuschmann, Michael Zeiler, Klaus Kammerer, Ulrich Frick, Rüdiger Pryss

“…Digital screening tools, in particular, provide the advantage of being accessible without spatial or time restrictions. The study aims to validate a digital cognitive screening test (digiDEM-SCREEN) as an app in the German language.Methods and analysis This is a multicentre study in Bavaria. …”
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Effect of the High-FODMAP Diet on Bowel Preparation for Colonoscopy: A Multicenter, Prospective Cohort Study by Peng Cheng, Ruijun Ma, Shuling Wang, Jun Fang, Zhengrong Zhong, Yu Bai, Xiangjun Meng, Zhaoshen Li

“…Patients in the high-FODMAP-diet group showed poor bowel cleansing efficacy: BBPS≥6 in 76.8% vs. 90.3% (P<0.01) and bubble scores of 2.42±1.69 vs. 1.32±1.63 (P<0.001). The intubation time was significantly longer in the high-FODMAP-diet group (7.07±5.18 vs. 5.46±3.05 min; P=0.002). …”
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