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49121
Transcatheter Atrial Septal Defect Closure in Children with and without Fluoroscopy: A Comparison
Published 2019-01-01“…There was no significant difference in number of defects or characteristics of ASD rims. Median procedure time was shorter in group 2 [60min (47-86) versus 34min (28-44)]. …”
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49122
p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment
Published 2025-01-01“…Using genetically engineered mice, we show that Trp53 deficiency in Pten-null prostatic epithelial cells (PECs) does not impact early cell proliferation and neoplasia formation, nor growth arrest and senescence entry at a later time. However, Trp53-deficiency enhances invasive adenocarcinoma development and promotes metastatic cell dissemination. …”
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49123
Effect of cooling rate on metallurgical and mechanical properties in continuous wave laser welding of hot-dip galvanised steel-to-aluminium sheets in a zero part-to-part gap lap jo...
Published 2025-06-01“…Results revealed that active cooling influences Zn vapours and IMCs differently; faster cooling reduced total IMCs and Fe2Al5 phase and increased joint strength; however, it exacerbated spattering and weld discontinuity due to insufficient time for outgassing the Zn vapours from the molten pool. …”
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49124
“Inclisiran: Early LDL-C target achievement in a real-life population”
Published 2025-03-01“…Blood samples were collected before the inclisiran administration and at week and one month afterward with the aim toevaluate achievement of LDL-C targets at these time intervals (primary endpoint) and reduction in LDL-C levels (secondary endpoint). …”
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49125
A BERT-Based Classification Model: The Case of Russian Fairy Tales
Published 2024-12-01“…Traditional classification methods including stylometric and parametric algorithms, however, are not only labour-intensive and time-consuming, but they are also struggling with identifying corresponding classifying discriminants. …”
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49126
Twelve barriers to COPD diagnosis in France: a comparative qualitative study
Published 2025-01-01“…The article respects the consolidated criteria for reporting qualitative research guidelines.Results Three phases in the patients’ clinical pathway to diagnosis and 12 barriers were found: Phase 1 (symptoms before consultation; n=4), lack of COPD knowledge, symptom denial, fear of lung cancer, and delayed general practice consultations; Phase 2 (primary care; n=3), letting bronchitis become chronic, priority to diseases with similar symptoms and/or more serious diseases, lack of COPD screening devices, time and curative treatments; Phase 3 (specialised medicine; n=5), treatment before diagnosis, late referral to pulmonologists, difficulty in accessing specialists and examination results, patient’s reluctance to undergo further examinations, and need for additional tests to confirm a diagnosis.Conclusion People unaware of their COPD condition can encounter up to 12 barriers, which may combine before obtaining a formal diagnosis. …”
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49127
The Neutrophil-to-Monocyte Ratio and Platelet-to-White Blood Cell Ratio Represent Novel Prognostic Markers in Patients with Pancreatic Cancer
Published 2021-01-01“…In univariate analysis, the survival time of NMR>48 and PWR≤6 was shorter than that of NMR≤48 and PWR>6 in patients with pancreatic cancer (P<0.001). …”
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49128
Multimodality Imaging Probe for Positron Emission Tomography and Fluorescence Imaging Studies
Published 2014-05-01“…., Woodbridge, CT) and imaged (Λ ex : 465 nm, Λ em : 535 nm, time: 8 seconds, Xenon Light Source, Kodak). The same mouse was then placed under an Inveon microPET scanner (Siemens Medical Solutions, Knoxville, TN) injected (intravenously) with 25 μCi of 18 F and after a half-hour (to allow sufficient bone uptake) was imaged for 30 minutes. …”
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49129
慢病毒介导靶向PRL-3 基因的siRNA 抑制肝癌细胞的侵袭性
Published 2010-01-01“…【目的】 探讨肝再生磷酸酶-3(PRL-3)的表达对肝癌细胞侵袭能力的影响65377;【方法】 设计65380;合成4对针对PRL-3 基因siRNA 的寡核苷酸序列,分别构建质粒,转染293T 细胞,据其对PRL-3 的抑制率,筛选最有效的PRL-3 基因RNAi 靶序列,设计并合成其siRNA 的双链DNA Oligo,与含绿色荧光蛋白(GFP)编码基因的pGCL-GFP 线性化载体连接产生重组慢病毒质粒LV-PRL3-SiRNA,并行PCR 和测序鉴定65377;将LV-PRL3-SiRNA,pHelper 1.0 和pHelper 2.0三种质粒DNA共转染293T细胞,包装产生慢病毒,以293T细胞GFP蛋白的表达水平经孔稀释法测定病毒滴度65377;重组慢病毒感染肝癌SMCC7721 细胞,行real time-PCR和western-blot验证PRL-3基因的沉默效果65377;用Transwell侵袭试验检测SMCC7721细胞体外侵袭力的改变65377;【结果】 成功构建PRL-3 基因RNA干扰慢病毒载体并获得相应的慢病毒,浓缩病毒悬液的滴度为6 × 108 Tu/mL65377;和对照组相比,RNA 干扰组SMMC7721 细胞PRL-3 基因的mRNA 水平和蛋白水平的抑制率分别为75%和63%;其穿过人工基底膜的平均数(14.2 ± 0.8)明显少于空白对照组(33.0 ± 1.6)及非特异性siRNA感染组(31.2 ± 0.8),侵袭抑制率为58% (P < 0.01)65377;【结论】 降低PRL-3 的表达可抑制肝癌细胞的侵袭能力65377;…”
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49130
Neurotransmitters crosstalk and regulation in the reward circuit of subjects with behavioral addiction
Published 2025-01-01“…Behavioral addictive disorders (BADs) have become a significant societal challenge over time. The central feature of BADs is the loss of control over engaging in and continuing behaviors, even when facing negative consequences. …”
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49131
Removal of the Tumor Thrombus from the Right Atrium without Extracorporeal Circulation: Emphasis on the Displacement of the Tumor Apex
Published 2020-01-01“…Specific complications associated with the access to the right atrium from the abdominal cavity (paresis of the right phrenic nerve, pneumothorax, and mediastinitis) were not detected in any case. The average clamping time of the supradiaphragmatic inferior vena cava (IVC) was 6.3 ± 4.6 min. …”
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49132
Siphon-type hydroelectric plants: application for power generation in a low head dam in southern Brazil
Published 2024-01-01“…Continuing to leverage the hydroelectric sector is even more challenging today, because there is a growing world demand for energy, at the same time that the most attractive places from an economic point of view have already been benefited. …”
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49133
Effect of Cluster Acupuncture of Scalp-point combined with Rehabilitation Training for Daily Living Ability of Patients with Parkinson's Disease
Published 2020-04-01“…The control group was given simple rehabilitation training, loosening-up activities for 10 min a time first, and 30 minutes'Pavel rehabilitation training in preparation period,3 times a week, continuous training for two weeks. …”
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49134
Evaluation of the long-term effects of COVID-19 on pulmonary functions in recovered patients
Published 2024-12-01“…Conclusions: Patients with COVID-19 pneumonia, which required oxygen, especially severe disease at the time of hospitalization, had a higher rate of abnormal spirometry than patients with mild symptoms. …”
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49135
Participant Contributions to Person-Generated Health Data Research Using Mobile Devices: Scoping Review
Published 2025-01-01“…Reporting completeness for data ownership and participants’ access to data after contribution worsened over time. ConclusionsOur work depicts the reporting practices in publications about research involving PGHD from mobile devices. …”
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49136
Machine Learning Based Modeling of Thermospheric Mass Density
Published 2024-05-01“…Further tests have been made by checking the MBiLE model prediction deviations in relation to magnetic local time, day of year, solar flux level, and magnetic activities. …”
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49137
Chemical Vapour Deposition of MWCNT on Silica Coated Fe3O4 and Use of Response Surface Methodology for Optimizing the Extraction of Organophosphorus Pesticides from Water
Published 2019-01-01“…The factors influencing the extraction efficiency such as pH, contact time, and adsorbent dosage were investigated and optimized by response surface methodology (RSM) and desirability function. …”
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49138
Effect of healthy lifestyle score trajectory on all-cause mortality in the late middle-aged and older population: Finding from 17-year retrospective cohort study
Published 2025-02-01“…However, as HLS may fluctuate over time, there is increasing focus on monitoring HLS trends. …”
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49139
Efficacy and safety of upadacitinib in the treatment of moderate-to-severe atopic dermatitis: A systematic review.
Published 2024-01-01“…<h4>Methods</h4>PubMed, Medline, Embase, Web of Science, Clinical Trials Website, and Cochrane Library databases were searched from the time of establishment until January 6, 2024, to compile a list of all randomized controlled trials (RCTs) including upadacitinib in the treatment of moderate-to-severe AD. …”
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49140
Digital modeling of soil-borne fusarium’s nutritional: Investigating microbiological and microecological dynamics in Moroccan agroecosystems
Published 2024-01-01“…Any similar outbreak over time poses a serious threat to the long-term sustainability of these oases. …”
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