丙酮酸乙酯抑制脓毒症时HMGB1释放的分子机制

“…激光共聚焦显微镜观察培养细胞内p-p38MAPK?NF-κB和CBP的变化;Real-time PCR检测培养细胞HMGB1的mRNA水平,ELISA检测培养上清HMGB1的蛋白含量?…”
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Association between serum total bilirubin levels and 28-day all-cause mortality after intracerebral hemorrhage by Dachang Qiu, Guangwei Li, Yongfei Dong, Yongfei Dong

“…The effect of serum TBIL levels on survival time and rate in the 28-day period was analyzed using Kaplan–Meier curves and restricted mean survival times. …”
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Survival Status and Predictors of Mortality among Newborns Admitted with Neonatal Sepsis at Public Hospitals in Ethiopia by Samuel Dessu, Aklilu Habte, Tamirat Melis, Mesfin Gebremedhin

“…The Kaplan-Meier survival curve together with log-rank test was used to estimate the survival time of the neonates. Variables which had p value < 0.05 in multivariable analysis using the cox proportional hazard model were declared as statistically significant predictors of mortality. …”
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Analiza troškova kvalitete odabranih građevinskih radova by Ksenija Tijanić, Diana Car-Pušić, Zlata Dolaček-Alduk

“…Pored toga, kad se radnoj operaciji pristupa s potrebnom pozornošću, smanjuje se i mogućnost pogreške, potreban dodatni rad, a time i dodatni troškovi za kvalitetu.…”
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Cell Wall Protein 2 as a Vaccine Candidate Protects Mice Against <i>Clostridioides difficile</i> Infection by Shaohui Wang, Joshua Heuler, Jessica Bullock, Junling Qin, Soumyadeep Chakraborty, Agbendeh Lubem Nathaniel, Shifeng Wang, Xingmin Sun

“…Conclusions: Our report demonstrates for the first time the potential of Cwp2_A as an effective vaccine candidate against CDI in mice.…”
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Identifying freshwater wetland suitable habitat through a hydrological-biological connectivity framework: A case study of Naoli River wetlands, China by Daiji Wan, Jian Yang, Xuan Liu, Qiwei Liu, Baolong Chen, Yanhui Chen, Dandan Zhao, Jiping Liu

“…The results showed that (1) the hydrological connectivity of wetlands within the Naoli River Reserve showed a fluctuating and decreasing trend, and the maximum distance difference between the high and low connectivity periods was 26 km. (2) Waterbirds and macroinvertebrates had a larger area of suitable habitat at moderate hydrological connectivity. At the same time, fish and phytoplankton showed a decrease in the area of suitable habitat with decreasing hydrological connectivity. (3) Hydrological connectivity significantly regulates a high-suitability habitat, and suitable hydrological connectivity increases habitat area by about 35 %. (4) The restoration of hydrological connectivity and suitable habitats should be emphasized in the Trans-Qixing River area, and wetland biodiversity should be maintained according to the hydrological connectivity status in the mainstream area of the Naoli River and the Inner-Qixing River area.…”
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The trajectory of changes in cognitive frailty and factors influencing it in elderly patients with cerebral infarction by Shengnan Xu, Qin Liang, Li Zhang, Shihua Liu

“…[Objective] The trajectory of cognitive frailty in elderly patients with cerebral infarction was analyzed, and the influencing factors were discussed. [ Methods] A total of 100 elderly patients with cerebral infarction hospitalized in Suzhou Hospital of Anhui Medical University from January to September in 2023 were selected for the study.Clinical data were collected on the patients, and cognitive frailty was assessed using the Frailty Screening Scale and the Montreal Cognitive Assessment Questionnaire (MoCA) at the time of admission and 1, 3, 6 months after treatment.Failty score ≥3 scores and MoCA <26 scores were defined as cognitive fraily.Potential categories of cognitive frailty change trajectories were identified by latent category growth modeling, and multifactorial logistic regression analyzed the factors influencing patients' cognitive frailty change trajectories. [ Results] The trajectory of cognitive frailty change in elderly patients with cerebral infarction identified by model fitting can be categorized into a group with a persistently low level of frailty (30 cases), a group with a slow rise in frailty (52 cases), and a group with a persistently high level of frailty (18 cases).Multifactorial logistic regression analysis showed that older age, poor sleep quality, and the number of comorbid chronic diseases > 4 were all risk factors for the development of persistent low levels of cognitive frailty into a slow rise in cognitive decline in elderly patients with cerebral infarction (P<0.05), Higher body mass index and high self-care ability were both protective factors for the development of persistent low levels of cognitive decline into a slow rise in cognitive decline in elderly patients with cerebral infarction (P<0.05).Older age, poor sleep quality and the number of comorbid chronic diseases >4 were risk factors for the progression of persistent low levels of cognitive decline to persistent high levels of cognitive decline in elderly patients with cerebral infarction (P < 0.05), and higher self-care ability were protective factors for the progression of persistent low levels of cognitive decline to persistent high levels of cognitive decline in elderly patients with cerebral infarction (P < 0.05). …”
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Systematic Search for Long-term Trends in Fermi-LAT Jetted Active Galactic Nuclei by P. Peñil, A. Domínguez, S. Buson, M. Ajello, S. Adhikari, A. Rico

“…Additionally, a novel type of variability has emerged in jetted AGN light curves, specifically, the observation of a long-term trend characterized by a linear increase of the flux with time in blazars such as PG 1553+113, which is among the objects most likely to display periodic behavior. …”
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A comparative study on the efficacy of over-the-counter wax solvents versus distilled water for managing ear cerumen by Syed. Mohd. Ahmad, Rajesh Kumar Suman, Simran Kaur Pal, Ayush Agrawal

“…Furthermore, five subjects in group A developed otitis externa, compared with three in group B. The average time required for ear suctioning to visualize the tympanic membrane was 9.24 ± 2.50 min in group A and 9.68 ± 2.18 min in group B. …”
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Allograft tolerance after adult living donor liver transplantation: a case-control study by Mohamed S. Habl, Moataz Maher Emara, Reham A. Zayed, Ahmed M. Sultan, Ahmed Elsabagh, Ahmed Marwan Elsaid, Ehab E. Abdel-khalek, Mohamed M. El-Saadany, Mohamed Abdel Wahab, Ahmed Shehta

“…Age was significantly higher in Group 1. The median time for tolerance among the study recipients was 60 months (36–168). …”
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Wetland elevation change following beneficial use of dredged material nourishment by Brian D. Harris, Aleksandra Ostojic, Lenore P. Tedesco, Keith VanDerSys, Susan Bailey, Justin L. Shawler, Navid H. Jafari, Monica Chasten

“…Multispectral surveys were performed to document the revegetation of the nourished island over time.ResultsThe placement of dredged material smothered the vegetation, but the site experienced significant revegetation (low of 22% cover in August 2021 to 52% in September 2023) after three full growing cycles. …”
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Lymphocyte Oxidative Stress/Genotoxic Effects Are Related to Serum IgG and IgA Levels in Coke Oven Workers by Meili Gao, Yongfei Li, Aqun Zheng, Xiaochang Xue, Lan Chen, Yu Kong

“…Significant differences were observed in biomarkers, including 1-hydroxypyrene levels, employment time, percentages of alcohol drinkers, MDA, 8-OHdG levels, CTL levels and CTM, MN, CA frequency, and IgG, IgA levels between the control and exposed groups. …”
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Custom-Made Computer-Aided-Design/Computer-Aided-Manufacturing Biphasic Calcium-Phosphate Scaffold for Augmentation of an Atrophic Mandibular Anterior Ridge by Francesco Guido Mangano, Piero Antonio Zecca, Ric van Noort, Samvel Apresyan, Giovanna Iezzi, Adriano Piattelli, Aldo Macchi, Carlo Mangano

“…The scaffold closely matched the shape of the defect: this helped to reduce the time for the surgery and contributed to good healing. …”
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Immortalized Mesenchymal Stem Cells: A Safe Cell Source for Cellular or Cell Membrane-Based Treatment of Glioma by Yuxuan Zhang, Jie Liu, Yunzhao Mo, Zetao Chen, Taoliang Chen, Yan Li, Yaofeng Zheng, Shaokang Deng, Xiangdong Xu, Huajian Chen, Haoqi He, Jiansheng Chen, Tao Jin, Xinlin Sun, Yiquan Ke, Jihui Wang

“…In this study, we focused on the safety of immortalized mesenchymal stem cells (im-MSCs) and, for the first time, studied the feasibility of im-MSCs as candidates for the treatment of glioma. …”
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Clinical outcomes of dogs with high-grade cutaneous mast cell tumors by Siew Mei Ong, Siew Mei Ong, Charly McKenna, Christopher Pinard, Christopher Pinard, Christopher Pinard, Christopher Pinard, Danielle Richardson, Michelle L. Oblak

“…Surgically treated dogs had significantly prolonged survival and were 6.88 times more likely to survive beyond 5.5 months. The presence of metastasis at initial staging was strongly associated with poorer outcomes, as dogs without metastasis at initial staging had 6.94 times higher odds of surviving beyond 2 years. …”
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Smad2/3 Upregulates the Expression of Vimentin and Affects Its Distribution in DBP-Exposed Sertoli Cells by Xi Zhang, Xiaogang Wang, Taixiu Liu, Min Mo, Lin Ao, Jinyi Liu, Jia Cao, Zhihong Cui

“…We hypothesized that Smad2/3 affects the distribution of vimentin by regulating its expression and that there is cross talk between Smad2/3 and PPARα. The real-time PCR and ChIP-qPCR results showed that SB431542 (an inhibitor of Smad2/3) could significantly attenuate the expression of vimentin induced by DBP in SCs. …”
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Research advance of Bacillus velezensis: bioinformatics, characteristics, and applications by Ting Su, Biao Shen, Xingjuan Hu, Yue Teng, Peifang Weng, Zufang Wu, Lianliang Liu

“…In addition, B. velezensis can shorten the fermentation time as well as improve the nutritional value and f lavor of fermented food. …”
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Возможности применения Опросника «7х7» (7 симптомов за 7 дней) для оценки динамики симптомов функциональной диспепсии и синдрома раздраженного кишечника... by V. T. Ivashkin, A. A. Sheptulin, Ye. A. Poluektova, D. V. Reykhart, A. V. Belostotsky, A. A. Drozdova, V. S. Arnautov

“…During Visit 2, according to attending physician examination (General clinical impression scale), in 40% of patients symptoms have improved. At the same time during Visit 2 according to the «7×7» Questionnaire most of the patients (48%) estimated their state as borderline disorder. …”
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Optimization of Black Garlic Protein Extraction Process and Exploration of Its Properties and Functions with Enzymatic Hydrolysis Products by Jian Liu, Yuanyuan Wang, Bo Wang, Wei Zhang, Xiaoyu Ren, Youchuang Zhang, Lijun Jiang, Chunming Dong, Guihong Zhao

“…The optimal extraction conditions were determined as a solid-to-liquid ratio of 1:50, an extraction time of 100 min, an extraction temperature of 30 °C, and an alkaline extraction pH of 9.0. …”
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Nutritional and Flavor Characteristics of Lactobacillus rhamnosus Fermented Goji Berry Juice and Its Antioxidant Activity and in Vitro Inhibition of Xanthine Oxidase Activity by Xin AN, Tongtong LI, Jiaxue HU, Huiyan LIU, Haitian FANG, Xiaobo WEI

“…The results showed that the optimal fermentation process for the fermentation of goji berry juice by Lactobacillus rhamnosus was 28 h of fermentation time, 34 ℃ of fermentation temperature and 4% of inoculum. …”
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