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47921
Evaluation of Leea rubra Leaf Extract for Oxidative Damage Protection and Antitumor and Antimicrobial Potential
Published 2021-01-01“…The oxidative hemolysis caused by AAPH in human erythrocytes was inhibited by EAF extract in a time-dependent manner, and the production of malondialdehyde (MDA) was significantly reduced, which indicates the prevention of lipid peroxidation. …”
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47922
Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis
Published 2016-01-01“…To test this, allergen and diluent challenged CD4+ T cells from healthy controls and patients from different time points were analyzed. The initial experiments focused on signature genes of the pathway and found complex changes following immunotherapy, which were consistent with our hypothesis. …”
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47923
Barlow Twins deep neural network for advanced 1D drug–target interaction prediction
Published 2025-02-01“…Abstract Accurate prediction of drug–target interactions is critical for advancing drug discovery. By reducing time and cost, machine learning and deep learning can accelerate this laborious discovery process. …”
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47924
Effect of Biofloc Culture on the Daily Rhythmicity of the Activity and Expression of Digestive Enzymes in Tilapia, Oreochromis niloticus
Published 2025-01-01“…During 60 days, fish were feed three times a day (zeitgeber time, ZT: 0, 4, and 8) with a fishmeal-based diet containing 32% of crude protein and 5% of lipid, where molasses was added as a carbon source in BFT. …”
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47925
Aroma profile of two commercial truffle species from Yunnan and Sichuan, China: inter- and intraspecific variability and shared key compounds
Published 2021-03-01“…A large number of volatiles identified in T. indicum and T. pseudohimalayense are reported here for the first time for these truffles. While more than 50% of identified VOCs were produced by both truffle species, considerable differences were present in the aroma profiles of fruiting bodies collected at various maturation stages, revealing a dynamic pattern in the biosynthesis of VOCs. …”
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47926
The clinical journey of belantamab mafodotin in relapsed or refractory multiple myeloma: lessons in drug development
Published 2025-02-01“…It considers how incorporating longer follow-up in DREAMM-3 may have better captured the clinical benefits of belantamab mafodotin, particularly given its multimodal, immune-related mechanism of action with responses deepening over time. A non-inferiority hypothesis may have been more appropriate rather than superiority in the context of a monotherapy versus an active doublet therapy. …”
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47927
A Method and Engineering Practice for a Fully Mechanized Caving Coalface to Rapidly Pass Through a Large Fault
Published 2025-01-01“…The results of engineering practice show that it took only 23 days for this coalface to pass through fault F<sub>6</sub>, about one month shorter than the time required by traditional methods (e.g., proactively taking a detour). …”
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47928
Clinical Characteristics, Intraoperative Findings, and Surgical Outcomes of Canalicular Laceration Repair with Monocanalicular Stent in Asia
Published 2019-01-01“…Subgroup classification revealed 64.6% of patients (n=31) were categorized in the deep laceration group, and lower anatomical and functional outcomes were noted in deep laceration. The mean follow-up time was 14.5 months. Overall, the anatomical success rate was 87.5%, and the functional success rate was 91.7% after stent removal. …”
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47929
Efficacy of high-dose steroids versus low-dose steroids in the treatment of immune checkpoint inhibitor-associated myocarditis: a case series and systematic review
Published 2025-02-01“…This group also demonstrated lower incidences of biomarker rebound and maintained lower levels over time. Additionally, the clinical treatment process was more straightforward in the high-dose group, with treatment efficacy surpassing that observed in patients who received an initial methylprednisolone (mPSL) dose of less than 1 g/day. …”
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47930
Pregnancy entails a U-shaped trajectory in human brain structure linked to hormones and maternal attachment
Published 2025-01-01“…The U-shaped trajectory is predominantly linked to gestational factors, as it only presents in gestational mothers and correlates with fluctuations in estrogens over time. Finally, the mother’s mental health status mediates the relationship between postpartum GM volume recovery and maternal attachment at 6 months postpartum. …”
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47931
Comparative testing of vaccines based on viruses of genetic lineages G1 and Y280 for their potency against low pathogenic avian influenza H9N2
Published 2021-08-01“…The level of inhibition (reduction) of the virulent LPAI virus genome synthesis in vaccinated birds following their challenge with H9N2 virus of genetic lineage G1 was higher in birds following homologous vaccination, while the time periods of the genome detection in the biomaterial samples were the same. …”
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47932
Effect of Preservation Methods on Physicochemical Quality, Phenolic Content, and Antioxidant Activity of Stevia Leaves
Published 2021-01-01“…In addition, the storage time increased the amounts of polyphenols and DPPH scavenging activity. …”
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47933
Factors associated with in-hospital mortality of newborns admitted to a special care newborn unit of a tertiary care hospital in southern Bangladesh: a retrospective cohort study
Published 2024-12-01“…Factors significantly associated with shorter survival time and increased in-hospital mortality included low birth weight (p=0.004), preterm delivery (p=0.022) and respiratory distress syndrome (RDS) (p=0.002). …”
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47934
A multi-level meta-analysis of the relationship between decision-making during birth and postpartum mental health
Published 2025-12-01“…A higher percentange of planned cesarean sections in a sample and longer time lags between birth and post-effect measurement were identified as moderating variables.Conclusions Ineffective decision-making is a significant contributing factor to the development of adverse postpartum mental health problems outcomes. …”
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47935
Can Orthodontic Treatment Be Stable 20 Years after the End of the Treatment Scheme? Treatment of a Class 2, Division 1 Malocclusion with Severe Skeletal Discrepancy and Its 20-Year...
Published 2021-01-01“…The maintenance of a stable orthodontic result over time is the result not only of a correct and physiological occlusion but also and above all of a correct diagnosis and correct identification of problems that can cause the malocclusion itself. …”
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47936
Relationship between klotho, neurotrophic factors (BDNF, NGF, GDNF) and cognitive functions in patients with bipolar disorder
Published 2025-01-01“…Klotho and NGF were predictors of Weshler 40-min test results (adjusted R2 = 0.467), and Klotho and BDNF were predictors of Stroop test colour word reading time (adjusted R2 = 0.391) with other variables. …”
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47937
Characterization of vortex-shedding regimes and lock-in response of a wind turbine airfoil with two high-fidelity simulation approaches
Published 2025-01-01“…By running the 3D static simulation for a sufficiently long time, the vortex shedding is found to have intermittent periods of different characteristics, including different Strouhal numbers. …”
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47938
Second law efficiency and thermal entropy generation of 30:70% of glycerol + water based SiO2 nanofluids in a thermosyphon flat plate collector: Experimental and Bayesian artificia...
Published 2025-01-01“…The research was conducted between 09:00 and 16:30 hours, with volume loadings varying from 0.25 to 1.0%. The time intervals of period-1 (09:00 to 13:00 hours) and period-2 (13:00 to 16:30 hours) were considered for clarity. …”
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47939
An in-vivo herb-drug interaction study of IME-9 and glimepiride in nicotinamide-STZ-induced diabetic rats
Published 2025-05-01“…This led to a reduction in Vd and CL together with an increase in t1/2 and mean residence time. Notably, the combination treatment (GP+IME-9) significantly decreased FBGL, TC and TG levels compared to individual therapy groups, suggesting synergistic pharmacodynamic effects. …”
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47940
An Economic Model Evaluating Competitive Wheat Genotypes for Weed Suppression and Yield in a Wheat and Canola Rotation
Published 2025-01-01“…The model applied a local weather sequence and predicted wheat production potential, costs and benefits over time. An early vigour wheat genotype was compared to commercial wheat cultivars for weed control, yield and actual production cost. …”
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