Serial Paediatrics Omics Tracking in Myalgic Encephalomyelitis (SPOT-ME): protocol paper for a multidisciplinary, observational study of clinical and biological markers of paediatr... by Adam Scheinberg, Natalie Thomas, Katherine Huang, Paul R Gooley, Elisha K Josev, Tracey Chau, Darcy Tantanis, Sarah J Knight, Christopher W Armstrong

“…Data generated will be compared with controls and over several time points within each patient to potentially develop a biomarker signature of the disease, identify subsets or clusters of patients, and to unveil the pathomechanisms of the disease.Methods and analysis This protocol paper outlines a comprehensive, multilevel, longitudinal, observational study in paediatric ME/CFS. …”
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Long-Term Effect of Half-Fluence Photodynamic Therapy on Fundus Autofluorescence in Acute Central Serous Chorioretinopathy by Martin Stattin, Stefan Hagen, Daniel Ahmed, Eva Smretschnig, Florian Frommlet, Katharina Krepler, Siamak Ansari-Shahrezaei

“…To evaluate normalized short-wavelength fundus autofluorescence (SW-FAF) imaging changes over time as a predictive parameter for the retinal pigment epithelium (RPE) function in eyes compromised by acute central serous chorioretinopathy (CSCR) after indocyanine green angiography-guided verteporfin (Visudyne®, Novartis Pharma, Basel, Switzerland) photodynamic therapy (PDT) with a half-fluence rate (25 J/cm2). …”
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Inflammatory Markers and Obstructive Sleep Apnea in Obese Children: The NANOS Study by Alex Gileles-Hillel, María Luz Alonso-Álvarez, Leila Kheirandish-Gozal, Eduard Peris, José Aurelio Cordero-Guevara, Joaquin Terán-Santos, Mónica Gonzalez Martinez, María José Jurado-Luque, Jaime Corral-Peñafiel, Joaquin Duran-Cantolla, David Gozal

“…Results. 204 children were enrolled in the study; 75 had OSA, defined by an obstructive respiratory disturbance index (RDI) of 3 events/hour total sleep time (TST). BMI, gender, and age were similar in OSA and no-OSA children. …”
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The Impact of EGDT on Sepsis Mortality in a Single Tertiary Care Center in Lebanon by Christopher El Khuri, Gilbert Abou Dagher, Ali Chami, Ralph Bou Chebl, Tarek Amoun, Rana Bachir, Batoul Jaafar, Nesrine Rizk

“…Protocol patients received more fluids at 6 and 24 hours (3.8 ± 1.7 L and 6.1 ± 2.1 L) compared to the control group (2.7 ± 2.0 L and 4.9 ± 2.8 L p=<0.001). Time to and duration of vasopressor use, choice of appropriate antibiotics, and length of ED stay were not significantly different between the two groups. …”
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Spatiotemporal Dynamics of Drought in the Huai River Basin (2012–2018): Analyzing Patterns Through Hydrological Simulation and Geospatial Methods by Yuanhong You, Yuhao Zhang, Yanyu Lu, Ying Hao, Zhiguang Tang, Haiyan Hou

“…On the other hand, we identified a time–lag relationship among meteorological, agricultural, and hydrological droughts, uncovering interactions and propagation mechanisms across different drought types in this basin. …”
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Photobiomodulation preconditioning for oral mucositis prevention and quality of life improvement in chemotherapy patients: a randomized clinical trial by Marwa Khalil, Omar Hamadah, Maher Saifo

“…This trial aims to study the effect of preconditioning with photobiomodulation in preventing oral mucositis and xerostomia in cancer patients undergoing chemotherapy alone for the first time, and to examine its role in improving patients’ quality of life. …”
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Recipient sex and donor leukemic cell characteristics determine leukemogenesis in patient-derived models by Anna MP. Stanger, Marlon Arnone, Pauline Hanns, Lucca M. Kimmich, Jessica Kübler, Sarah Gekeler, Elsa S. Görsch, Lea Kramer, Marcelle Baer, Jan C. Schroeder, Taylor S. Mills, Martina Konantz, Saskia S. Rudat, Claudia Lengerke

“…Testosterone may be the more important player since, strikingly, better engraftment was seen in castrated versus control male recipients, while ovariectomy did not significantly impair engraftment in females. Shorter time-to-engraftment and mouse survival were observed with adverse molecular risk, and respectively with high FLT3-ITD ratio mutated AML cells. …”
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Cool Neighbors: Combining Artificial Intelligence and Citizen Science to Chart the Sun’s Cosmic Neighborhood by Aaron Meisner, Dan Caselden, Austin Humphreys, Grady Robbins, Eden Schapera, J. Davy Kirkpatrick, Adam Schneider, L. Clifton Johnson, Marc Kuchner, Jacqueline Faherty, Sarah Casewell, Federico Marocco, Adam Burgasser, Daniella Bardalez Gagliuffi

“…Through analysis of more than 10 million total Zooniverse classifications from the combination of Cool Neighbors and Backyard Worlds: Planet 9, among other results, we find (1) Cool Neighbors volunteers perform ~3x more classifications per unit of time invested than Backyard Worlds: Planet 9 volunteers, and (2) each registered Cool Neighbors participant performs ~2–5x more classifications than each registered Backyard Worlds: Planet 9 participant. …”
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EXPLORING THE INFLUENCES ON DISPLACED CITIZENS' DECISION TO REPATRIATE: A CLASSIFICATION OF POSITIVE AND NEGATIVE FACTORS by Volodymyr Filippov, Iryna Bashynska, Elvin Yangulov

“…Positive factors include the improvement in the security situation, government programmes for displaced persons and the prospects for economic growth in the country as it begins to recover. At the same time, negative factors include continued military aggression, uncertainty about infrastructure reconstruction and a lack of social guarantees. …”
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Efficacy analysis of drug-eluting beads transcatheter arterial chemoembolization combining systemic chemotherapy and immune checkpoint inhibitors in unresectable intrahepatic chola... by Liu Song, Wang Qingdong, Yin Shunhang, Li Long, Zhao Guangsheng, Yu Guangji, Wang Dong

“…Conclusions Compared with systemic therapy alone (systemic chemotherapy + immune checkpoint inhibitor), combined DEB-TACE improves the tumor control rate of patients with unresectable intrahepatic cholangiocarcinoma, extends the survival time and without increasing treatment-related adverse effects, which is a safe and feasible treatment modality.…”
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TCR Gene Transfer: MAGE-C2/HLA-A2 and MAGE-A3/HLA-DP4 Epitopes as Melanoma-Specific Immune Targets by Trudy Straetemans, Mandy van Brakel, Sabine van Steenbergen, Marieke Broertjes, Joost Drexhage, Joost Hegmans, Bart N. Lambrecht, Cor Lamers, Pierre van Der Bruggen, Pierre G. Coulie, Reno Debets

“…Further development of TCR gene therapy requires the implementation of T-cell target epitopes that prevent “on-target” reactivity towards healthy tissues and at the same time direct a clinically effective response towards tumor tissues. …”
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Side-Stream Based Marine Solubles From Atlantic Cod (Gadus morhua) Modulate Appetite and Dietary Nutrient Utilization in Atlantic Salmon (Salmo salar L.) and can Replace Fish Meal by Hanne Jorun Sixten, Ivar Rønnestad, André S. Bogevik, Tone Aspevik, Åge Oterhals, Ana S. Gomes, Floriana Lai, Ingvill Tolås, Virginie Gelebard, Marie Hillestad, Katerina Kousoulaki

“…However, in the brain, a short-time upregulation of agouti-related protein-1 (agrp1), corresponded to higher cumulative feed intake (FI) for the FM10 diet supporting notions that this may be a candidate biomarker for appetite in salmon. …”
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Silent witnesses: unveiling the epidemic of femicides in North-west Tshwane, South Africa – a decade of analysis by Yaseen Bismilla, K. K. Hlaise, C. Van Wyk

“…Objectives The study had four main objectives: to analyse the demographics and incidence rates of femicides in the North-west Tshwane area, to examine the circumstances surrounding femicides (including the time, location, and demographic risk factors), to identify the causes and pathological characteristics of femicides; and to observe trends in femicide rates over the ten-year study period. …”
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Analysis of Perceptions of Milk Consumption and Customer Service in the City of Riobamba, Province of Chimborazo by O. Parada Gutiérrez, J. Vasco, C. Delgado

“…Similarly, it was found that there are decisions that the consumer makes unconsciously based on memories and past experiences that influence their present behavior at the time of consumption. The study also revealed the need to improve the level of service. …”
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Molecular Alterations of KIT Oncogene in Gliomas by Ana L. Gomes, Jorge S. Reis-Filho, José M. Lopes, Olga Martinho, Maryou B. K. Lambros, Albino Martins, Fernando Schmitt, Fernando Pardal, Rui M. Reis

“…KIT activating gene mutations (exons 9, 11, 13 and 17) and gene amplification analysis, as defined by chromogenic in situ hybridization (CISH) and quantitative real-time PCR (qRT-PCR) were performed in CD117 positive cases. …”
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Low skeletal muscle mass as a proxy marker of sarcopenia is a risk factor for major complications in older patients undergoing curative colon resections for colon cancer by İsmail Tırnova, Maya Gasimova, Hatice Akay, Çağla Sarıtürk, Aslıhan Güven Mert, Özlem Yenidünya, Feza Yarbuğ Karakayalı

“…Univariate and multivariate analyses were performed to investigate the factors related to the postoperative complications, OS and DFS.ResultsIn total, 98 cases (mean age 75.2 ± 6.9, 55.1% male) were included in the study. The median follow-up time was 38.3 (0.5–113) months. There were 64 patients (65.3%) in the Low SMMI group and 34 patients (34.7%) in the Normal SMMI group. …”
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Development of the PRECIOUS Short-Form (PRECIOUS-SF) quality of care measure for children with serious illnesses by Felicia Jia Ler Ang, Yin Bun Cheung, Mihir Gandhi, Rahul Malhotra, Truls Ostbye, Chetna Malhotra, Cristelle Chu-Tian Chow, Poh Heng Chong, Zubair Amin, Teresa Shu Zhen Tan, Eric Finkelstein

“…Methodology PRECIOUS was administered by parents of children living with serious illnesses at two time-points (baseline and two weeks) in an online survey. …”
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A consort‐guided randomized, blinded, controlled clinical trial on the effects of 6 weeks training on heart rate variability in thoroughbred horses by Emma Santosuosso, Renaud Léguillette, Sierra Shoemaker, Ryan Baumwart, Sierra Temple, Kaneesha Hemmerling, Tessa Kell, Warwick Bayly

“…Changes in HRV variables over time (ANOVA), and correlation with V̇O2max (Pearson's chi‐squared test) were tested (P < .05 significance). …”
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The Class III PI3K/Beclin-1 Autophagic Pathway Participates in the mmLDL-Induced Upregulation of ETA Receptor in Mouse Mesenteric Arteries by Xi Xie, Chen Chen, Cang-Bao Xu, Jie Lin, Lei Cao, Gen Chen, Jie Li

“…The dose-effect curve of endothelin-1- (ET-1-) induced mesenteric artery contraction was measured using myography, while ETA receptor mRNA expression was detected using real-time polymerase chain reactions, and the protein levels of the ETA receptor, class III PI3K, Beclin-1, LC3 II/I, p62, NF-κB, and p-NF-κB were observed using Western blot analysis. mmLDL significantly strengthened ET-1-induced contraction (the Emax value increased from 184.87 ± 7.46% in the NS group to 319.91 ± 20.31% in the mmLDL group (P<0.001), and the pEC50 value increased from 8.05 ± 0.05 to 9.11 ± 0.09 (P<0.01). …”
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qBiCo: a method to assess global DNA conversion performance in epigenetics via single-copy genes and repetitive elements by Faidra Karkala, Roy B. Simons, Floor Claessens, Vivian Kalamara, Manfred Kayser, Athina Vidaki

“…Conclusions Overall, with the present study, we offer researchers in the epigenetic field a novel long-awaited QC tool that for the first time allows them to measure key quality and quantity parameters of the most popular DNA conversion process. …”
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