Programmed cell death 1 inhibitor alone or combined with chemotherapy for patients with locally advanced or metastatic urothelial carcinoma: a single-center experience by Xing Huang, Chupeng Sun, Peng Zhang, Lei Wang

“…Eastern Cooperative Oncology Group (ECOG) performance status (PS) and neutrophil-lymphocyte ratio (NLR) were identified as prognostic factors. …”
Get full text

Daclatasvir and Sofosbuvir Therapy Enhance Monocyte Phenotypic Changes in Naive Chronic Hepatitis C Patients: A Prospective Cohort Study by Hanan M. Fayed, Ali A. Ghweil, Mona M. AbdelMeguid

“…CHC patients had significantly lower albumin, higher ALT, AST, alkaline phosphatase, and increased fibrosis scores [Fib-4 (1.85±0.98) and AST to platelet ratio index (APRI) (0.6±0.35)], higher monocyte and eosinophil counts and lowered neutrophil to monocyte ratio (NMR), and lymphocyte to monocyte ratio (LMR) compared to week 12 and control. …”
Get full text

Relationship between PLR and Clinicopathological Characteristics of Patients with Advanced NSCLC and Its Predictive Value for the Efficacy of Chemotherapy and Prognosis by Jianming Zhao, Yiping Pan, Yu Sheng, Jun Sun

“…To investigate the relationship between blood platelet-to-lymphocyte ratio (PLR) and clinicopathological characteristics of patients with advanced non-small cell lung cancer (NSCLC) and evaluate the value of PLR for predicting the efficacy of chemotherapy and prognosis. …”
Get full text

Aspartate aminotransferase to platelet ratio correlates with poor prognosis and metabolic alterations in Dabie bandavirus infection by Chunxia Guo, Ruixue Li, Xia Wang, Xiulan Peng

“…Receiver operating characteristic analysis showed the predictive performance of APRI for SFTS prognosis is 0.77, with a 95% CI of 0.73–0.80, which was superior to NLR (area under the curve (AUC): 0.65), platelet-to-lymphocyte ratio (AUC: 0.54), and systemic immune-inflammation index (AUC: 0.58). …”
Get full text

The clinical features and outcomes of diabetes patients infected with COVID-19: a systematic review and meta-analysis comprising 192,693 patients by Kai Liu, Shu Liu, Ting-ting Xu, Hong Qiao

“…We discovered that white blood cell count, neutrophil count, inflammatory marker levels, D-dimer, urea, precursor of the brain natriuretic peptide (Pro-BNP) increased and lymphocyte count, estimated glomerular filtration rate (eGFR), albumin decreased significantly in the diabetic group in laboratory test results. …”
Get full text

Steatotic liver disease in people with HIV at Tshepong Hospital: A post-mortem analysis by Aqeela Moosa, Ebrahim Variava, Alistair D. Calver, Gajendra Chita, Nadia Sabet, Sharol Ngwenya, Maria Papathanasopoulos, Tanvier Omar

“…Factors associated with SLD were: CD4 T-lymphocyte count 200 cells/µL (odds ratio [OR]: 3.69; 95% confidence interval [CI]: 1.19–11.44), female sex (OR: 8.5; 95% CI: 2.57–28.17), hypertension (OR: 6.5; 95% CI: 2.05–21.00), and being normal or overweight (OR: 6.75; 95% CI: 1.12–40.56). …”
Get full text

HPK1 kinase inhibitor: a sufficient approach to target HPK1 to modulate T cell activation in cancer immunotherapy compared with degraders by Qin Wang, Xinyi Zhu, Jing Li, Sanjia Xu, Ali Wang, Xinwen Zhang, Xingxing Wang, Xiaopeng Cai, Haimei Xing, Ye Liu, Xuesong Liu, Zhiwei Wang, Lai Wang, Lai Wang, Xi Yuan

“…However, whether kinase inhibition is sufficient to eliminate the immunosuppressive function of HPK1, particularly in T cells, remains elusive.MethodsIn this study, genetic tools were used to edit the human T lymphocyte cell line Jurkat. The activation of HPK1-null cells, HPK1-wildtype cells and HPK1-kinase-inactive cells was compared through ectopic expression of HPK1 in HPK1 knockout cells or direct HPK1 mutation. …”
Get full text

Assessing the effect of beta-propiolactone inactivation on the antigenicity and immunogenicity of cluster 2.1 duck Tembusu virus by Kanana Rungprasert, Wikanda Tunterek, Phornphisut Areeraksakul, Duangduean Prakairungnamthip, Chalida Sri-in, Navapon Techakriengkrai, Wijit Banlunara, Christine A. Jansen, Teerawut Nedumpun, Aunyaratana Thontiravong

“…This was evidenced by the absence of clinical signs and the robust induction of DTMUV-specific neutralizing antibodies and T helper lymphocyte responses in immunized ducks. Overall, these findings suggest that a 1:4000 dilution of BPL with 24 h of incubation is the optimal condition for complete inactivation of cluster 2.1 DTMUV without significant loss of antigenicity and immunogenicity. …”
Get full text

The association of lipid accumulation product with inflammatory parameters and mortality: evidence from a large population-based study by Yi Chi, Yiqing Zhang, Huang Lin, Shanshan Zhou, Genlin Jia, Wei Wen

“…Mediation analysis revealed that Systemic Inflammatory Response Index (SIRI), Monocyte-to-HDL ratio (MHR), and Neutrophil-to-Lymphocyte ratio (NLR) mediated 27.15%, 35.15%, and 16.55%, respectively, of the association between AVI and all-cause mortality.ConclusionAVI is positively associated with all-cause mortality in older adults with hypertension, and this association appears to be partially mediated by inflammatory parameters.…”
Get full text

Hypofractionated radiotherapy combined with a PD-1 inhibitor, granulocyte macrophage-colony stimulating factor, and thymosin-α1 in advanced metastatic solid tumors: a multicenter P... by Jiamin Yu, Li Yin, Wenjie Guo, Qiang Wang, Juying Liu, Lansheng Zhang, Hongxun Ye, Jianhong Xia, Youyou Xia, Jianfeng Wu, Wanwei Wang, Yanguang Yang, Dan Zong, Xia He, Lijun Wang, Hong Jiang

“…The group with a lower baseline neutrophil–lymphocyte ratio had a significantly lower risks of distant metastasis and death( P = 0.024). …”
Get full text

The Feature of Distribution and Clonality of TCR γ/δ Subfamilies T Cells in Patients with B-Cell Non-Hodgkin Lymphoma by Liang Wang, Meng Xu, Chunyan Wang, Lihua Zhu, Junyan Hu, Shaohua Chen, Xiuli Wu, Bo Li, Yangqiu Li

“…Four newly diagnosed B-NHL cases, including three with diffuse large B-cell lymphoma (DLBCL) and one with small lymphocytic lymphoma (SLL), were enrolled. The restrictive expression of TCR Vγ/Vδ subfamilies with different distribution patterns could be detected in PB, BM, or LN from all of four patients, and partial subfamily T cells showed clonal proliferation. …”
Get full text

Donor-derived cell-free DNA for detection of acute rejection in lung transplant recipients by Gökce Yavuz, Julia Walter, Julia Walter, Kaimo Hirv, Oliver Wachter, Andrea Dick, Julia Kovacs, Julia Zimmermann, Olaf M. Glueck, Maximilian Vorstandlechner, Nicole Samm, Jan M. Fertmann, Wulf Sienel, Sebastian Michel, Sebastian Michel, Michael Irlbeck, Nikolaus Kneidinger, Nikolaus Kneidinger, Nikolaus Kneidinger, Rudolf Hatz, Rudolf Hatz, Jürgen Behr, Jürgen Behr, Christian Schneider, Christian Schneider, Teresa Kauke, Teresa Kauke

“…Using blood samples collected sequentially post-transplant from a cohort of 81 LTR, we compared median levels of %ddcfDNA in patients with acute cellular rejection (ACR), antibody-mediated rejection (AMR), infection, or decline in pulmonary function (FEV1).ResultsMedian %ddcfDNA levels were significantly higher in groups with ACR (1.92% [0.70%, 2.30%], p=0.0006), AMR (1.27% [0.34%, 2.29%], p=0.0009), isolated lymphocytic bronchiolitis (0.54% [0.23%, 2.18%], p=0.03), and infection or prolonged ventilation over 30 days (0.50% [0.22%, 2.35%], p=0.005) versus stable allograft function group (0.26% [0.09%, 0.60%]). …”
Get full text

Preoperative prediction of lymph node metastasis in intrahepatic cholangiocarcinoma: an integrative approach combining ultrasound-based radiomics and inflammation-related markers by Yu-ting Peng, Jin-shu Pang, Peng Lin, Jia-min Chen, Rong Wen, Chang-wen Liu, Zhi-yuan Wen, Yu-quan Wu, Jin-bo Peng, Lu Zhang, Hong Yang, Dong-yue Wen, Yun He

“…The combined model, which incorporates the optimal radiomics score, clinical N stage, and platelet-to-lymphocyte ratio (PLR), achieved an AUC of 0.882 in the validation cohort, significantly outperforming the clinical model with an AUC of 0.687 (P = 0.009). …”
Get full text

Serum and tear autoantibodies from NOD and NOR mice as potential diagnostic indicators of local and systemic inflammation in Sjögren’s disease by Shruti Singh Kakan, Sara Abdelhamid, Sara Abdelhamid, Yaping Ju, Yaping Ju, J. Andrew MacKay, J. Andrew MacKay, J. Andrew MacKay, Maria C. Edman, Indu Raman, Chengsong Zhu, Prithvi Raj, Sarah F. Hamm-Alvarez, Sarah F. Hamm-Alvarez

“…BackgroundSjögren’s Disease (SjD) is an autoimmune disease characterized by lymphocytic infiltration of salivary and lacrimal glands (LG). …”
Get full text

Potential Toxicity of the Essential Oil from Minthostachys mollis: A Medicinal Plant Commonly Used in the Traditional Andean Medicine in Peru by Juan Pedro Rojas-Armas, Jorge Luis Arroyo-Acevedo, José Manuel Ortiz-Sánchez, Miriam Palomino-Pacheco, Hugo Jesus Hilario-Vargas, Oscar Herrera-Calderón, Julio Hilario-Vargas

“…In the lung, inflammatory infiltrate was observed, predominantly lymphocytic with severe hemorrhage and presence of macrophages with hemosiderin. …”
Get full text

Th1/Th2 Cells and Associated Cytokines in Acute Hepatitis E and Related Acute Liver Failure by Jian Wu, Yurong Guo, Xuan Lu, Fen Huang, Feifei Lv, Daqiao Wei, Anquan Shang, Jinfeng Yang, Qiaoling Pan, Bin Jiang, Jiong Yu, Hongcui Cao, Lanjuan Li

“…There was no significant difference in viral load and HEV RNA in the AHE and HEV-ALF groups (both P>0.05). The Th lymphocyte levels (CD3+, CD4+) in the AHE and HEV-ALF groups were significantly higher than those in the HC group (both P<0.05), but there was no significant difference between the AHE and HEV-ALF groups (P>0.05). …”
Get full text

Genomic, transcriptomic, and T cell receptor profiling in stratifying response to first-line chemoradiotherapy or radiotherapy for esophageal squamous cell carcinoma by Xiaqin Zhang, Jianhong Lian, Fukun Chen, Kai Wang, Haoyuan Xue, Sufang Jia, Weili Wang, Zhongkang Li, Hua Liang, Hongwei Li

“…The chromosomal copy number variation (CNV) burden of the neutrophil-to-lymphocyte ratio (NLR)-high group appeared to be higher than that of the NLR-low group, and the StromalScore in the NLR-low group was significantly higher. …”
Get full text

Pathogen community composition and co-infection patterns in a wild community of rodents by Abbate, Jessica L., Galan, Maxime, Razzauti, Maria, Sironen, Tarja, Voutilainen, Liina, Henttonen, Heikki, Gasqui, Patrick, Cosson, Jean-François, Charbonnel, Nathalie

“…Rodents were screened for virus exposure (hantaviruses, cowpox virus, Lymphocytic choriomeningitis virus, Tick-borne encephalitis virus) using antibody assays. …”
Get full text

Anti-NMDAR-Positive Small-Cell Lung Cancer Paraneoplastic Limbic Encephalitis: A Case Report and Literature Review by Raman Sohal, Steven H. Adams, Vishal Phogat, Abha Harish, Carlos Ynigo D. Lopez, Michael P. A. Williams, Kamal K. Khurana, Basel Abuzuaiter, Nia Jagroop, Bhavya Narapureddy

“…Lumbar puncture was performed which showed lymphocytic pleocytosis, a nonspecific inflammatory change. …”
Get full text

Real-world clinical outcome of unresectable locally advanced & de-novo metastatic pancreatic ductal adenocarcinoma: a multicentre retrospective study by Mohamed Aseafan, Ali H. Alfakeeh, Emad Tashkandi, Mervat Mahrous, Mohammed Alghamdi, Bader Alshamsan, Marwan Al-Hajeili, Safwan Bakhsh, Kanan Alshammari, Fahad A. Almugbel, Abdulhameed H. Alfagih, Ahmed Allehebi, Mohamed Montaser, Mohamed Hamdy Elsafty, Khaled Abd Elaziz Elnaghi, Ibrahim Issa, Eesa Bakshi, Sadeem AlSubaie, Bandar AlMutairi, Hoda Mokhtar, Mohamed Aboelatta, Nedal Bukhari, Ali M. Alzahrani, Tusneem Elhassan, Ali Alqahtani, Shouki Bazarbashi

“…Independent prognostic factors for PFS and OS included performance status, first-line regimen, and neutrophil-lymphocyte ratio (NLR). Among patients tested, 7.1% had deficient mismatch repair (d-MMR), and 5.8% harbored BRCA mutations. …”
Get full text