Pharmacological Inhibition of Glutaminase 1 Normalized the Metabolic State and CD4+ T Cell Response in Sjogren’s Syndrome by Jiayao Fu, Yiping Pu, Baoli Wang, Hui Li, Xiujuan Yang, Lisong Xie, Huan Shi, Zhijun Wang, Junhao Yin, Tianle Zhan, Yanxiong Shao, Changyu Chen, Qi Luo, Jiabao Xu, Zirui Zong, Xindi Wei, Wanwen Xiao, Chuangqi Yu, Lingyan Zheng

“…Histological and qRT–PCR analyses showed that this concentration of BPTES attenuated lymphocytic infiltration and the numbers of PCNA-positive cells and CD4+ T cells. …”
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Effect of Multiradiance Low-Level Laser Therapy and Topical Silver Sulfadiazine on Healing Characteristics of Dermal Wounds in Marine Toads (Rhinella marina) by Kate E. Archibald, Tara Harrison, Brigid Troan, Dustin Smith, Larry J. Minter

“…Toads were euthanized at one of five timepoints (day 4, 7, 13, 19, or 28) to permit scoring of histologic criteria, including lymphocytic inflammation, granulomatous inflammation, heterophilic inflammation, granulation tissue, fibrosis, and reepithelialization. …”
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Cross-species comparisons between pigs and mice reveal conserved sex-specific intraspinal inflammatory responses after spinal cord injury by Reena Kumari, Gabrielle V. Hammers, Robert H. Hammons, Andrew N. Stewart, Steven M. MacLean, Tracy Niedzielko, Lonnie E. Schneider, Candace L. Floyd, John C. Gensel

“…Immunohistological evaluations of spinal cord tissue at 2 days and 6 weeks post-injury revealed intraspinal microglia/macrophage (IBA-1, CD68) and lymphocyte responses (T-cells (CD3) and B-cells (CD79a)) consistent with observations in rodents and humans. …”
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A Nomogram for Predicting Overall Survival in Primary Central Nervous System Lymphoma: A Retrospective Study by Ling Y, Miao X, Zhou X, Ma J, Lin Z, Li Q, Zhang M, Ma Y, Chen B

“…Additionally, Kaplan-Meier survival curves were plotted to show the stratification ability of the risk groups.Results: Eastern Cooperative Oncology Group performance status (ECOG-PS), albumin, and two inflammatory biomarkers D-Dimer, and neutrophil-to-lymphocyte ratio (NLR)—were independent predictors of inferior OS. …”
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Kinetic-pharmacodynamic model to predict post-rituximab B-cell repletion as a predictor of relapse in pediatric idiopathic nephrotic syndrome by Ziwei Li, Qian Shen, Hong Xu, Zhiping Li

“…Monte Carlo simulation was conducted to explore a mini-dose regimen with larger intervals.ResultsNomogram contained 7 predictors of relapse including neutrophil-to-lymphocyte ratio, duration of B-cell depletion, duration of disease, urine immunoglobulin G to creatinine ratio, urine transferrin, duration of maintenance immunosuppressant and hemoglobin. …”
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Application Value of NT-proBNP Combined with NLR in Evaluation of Major Adverse Cardiac Events in Elderly Patients with Chronic Heart Failure by Zhiyong Li, Hui Rong, Wenxun Wu, Ting Huang, Jun Xu

“…To explore the application value of N-terminal pro-B type natriuretic peptide (NT-proBNP) combined with neutrophil-to-lymphocyte ratio (NLR) in evaluation of major adverse cardiac events (MACEs) in elderly patients with chronic heart failure (CHF). …”
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TMEM147 Correlates with Immune Infiltration and Serve as a Potential Prognostic Biomarker in Hepatocellular Carcinoma by Sheng Cheng, Jutang Li, Ming Xu, Qun Bao, Jiaoxiang Wu, Peng Sun, Bo Han

“…Mechanistic studies revealed that high TMEM147 expression was linked to the B lymphocyte, antigen response, IL6 signaling pathway, cell cycle, Kirsten rat sarcoma viral oncogene homolog (KRAS) signaling pathway, and myelocytomatosis oncogene (MYC) targets. …”
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Predictive value of epicardial fat thickness for left ventricular reverse remodeling after radiofrequency ablation in atrial fibrillation patients with left ventricular hypertrophy by Ke Hu, Wenhui Wang, Junping Zhen, Chunsong Kang

“…[Results] A total of 28 patients who did not achieve reverse remodeling were included in the control group, and 22 patients who achieved reverse remodeling were included in the reverse remodeling group.There were significant differences in age, atrial fibrillation classification, duration of atrial fibrillation, left atrial diameter (LAD), left ventricular end-diastolic diameter, left ventricular end-diastolic diameter index (LVEDI), neutrophil to lymphocyte ratio (NLR), high-sensitivity C-reactive protein (hsCRP), platelet distribution width(PDW), red cell distribution width, fibrinogen to albumin ratio (FAR) and EFT between the two groups (P<0.05).Multivariate logistic regression analysis showed that EFT, LAD, LVEDI, NLR, hsCRP, PDW and FAR were independent factors for left ventricular reverse remodeling(P<0.05).The cut-off value of EFT for predicting postoperative left ventricular reverse remodeling was 0.848, sensitivity was 95.5%, specificity was 89.3%, and AUC was 0.937 (95% CI: 0.868-0.983). …”
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Misdiagnosis of Leprosy with Severe Reversal Reaction as Psoriatic Arthritis: A Case Report and Literature Review by Gunawan H, Hidayah RMN, Ruchiatan K, Pangastuti M, Usman HA, Amalia F

“…Slit-skin smear examinations from anesthetic lesions on the left arm showed bacterial index 3+, and skin biopsies from anesthetic lesions on the left thigh revealed a granulomatous reaction with epithelioid cells, Langhans giant cells, and lymphocyte infiltration. The patient was diagnosed as mid-borderline leprosy with severe reversal reaction, then received multidrug therapy–multibacillary and prednisone. …”
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Effectiveness of Sambiloto (Andrographis paniculata) Supplementation on Antibody Titers of Newcastle Disease, Avian Influenza and Infectious Bursal Disease in Broilers by Madi Hartono, Muhammad Mirandy Pratama Sirat, Purnama Edy Santosa, Ratna Ermawati

“…The content of andrographolide and flavonoids are thought to act as immunostimulants for specific and non-specific immune functions through the production of NK cells, macrophages, cytokine induction, IL-2 production, and lymphocyte proliferation. The conclusions of this study were supplementation of Sambiloto (Andrographis paniculata) liquid extract at a dose of 6 mg/kg BW in broiler drinking water could increase antibody titers against Newcastle Disease and Infectious Bursal Disease and at a dose of 24 mg/kg BW in broiler drinking water could increase antibody titres against Avian Influenza.…”
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Frequency and Predictors of Pneumonia After Isolated Coronary Artery Bypass Grafting (CABG): A Single-Center Study by Ozgur Baris, Tugba Asli Onyilmaz, Huseyin Kaya

“…In patients with POP, diabetes mellitus (<i>p</i> = 0.03) and chronic kidney disease (<i>p</i> = 0.048) prevalence was higher, cardiopulmonary bypass (CPB) (<i>p</i> = 0.01) and cross-clamp time (<i>p</i> = 0.003) was longer, LDH levels (<i>p</i> = 0.017) were higher, hemoglobin (<i>p</i> = 0.012) and albumin (<i>p</i> = 0.015) levels were lower, and lymphocyte % (<i>p</i> = 0.04) was lower; prevalence of COPD and length of stay (LOS) in hospital tended to be higher (both <i>p</i> < 0.06). …”
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STAT3 Expression and Its Correlation with PD-L1 Expression in Non-Hodgkin’s Lymphoma and Hodgkin’s Lymphoma at Dr. Saiful Anwar Regional Public Hospital in Malang, Indonesian Popul... by Ailen Oktaviana Hambalie, Eviana Norahmawati, Agustina Tri Endharti, Diah Prabawati Retnani, Nayla Rahmadiani

“…Lymphomas are malignant lymphocyte neoplasms that globally account for 10% of cancers in individuals aged <20 years. …”
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The Immunosuppressant Fingolimod (FTY720) for the Treatment of Mechanical Force-Induced Abnormal Scars by Masayo Aoki, Akatsuki Kondo, Noriko Matsunaga, Azusa Honda, Yuri Okubo, Kazuaki Takabe, Rei Ogawa

“…On the other hand, FTY720 tended to reduce white blood cells and significantly reduced the lymphocyte frequencies in the blood. Conclusion. Topical FTY720 induces M2 predominance and impairs angiogenesis. …”
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EXamining the feasibility of exerCisE to manage symptoms of Lupus (EXCEL): a protocol for a randomised controlled pilot study by John Reynolds, Katie Hesketh, Matthew Cocks, Megan Quickfall, Alex J Wadley, Scott Green, Jet Veldhuijzen Van Zanten

“…Measures of feasibility and acceptability will be reported, and peripheral blood will be collected at weeks 0, 12 and 18 to explore whether the frequency, phenotype and metabolic profile of lymphocyte subsets has changed. Biomarkers of SLE activity, and self-reported measures of fatigue, sleep quality and health-related quality of life will also be monitored at these timepoints. …”
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Co-dynamics of hepatitis B and C viruses under the influence of CTL immunity by A.M. Elaiw, GH.S. Alsaadi, A.A. Raezah, A.D. Hobiny

“…Understanding the cytotoxic T lymphocyte (CTL) immune response against hepatitis B virus (HBV) and hepatitis C virus (HCV) infections is crucial, as these infections can lead to liver cirrhosis and cancer. …”
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Clinical Characteristics and Outcome of Kidney Transplant Recipients Infected with COVID-19: A Retrospective Observational Study by Manzoor Ahmad Parry, Rayees Yousuf Sheikh, Raja Kaamil Qadri, Muzafar Maqsood Wani, Imtiyaz Wani, Mohammad Ashraf Bhat

“…The median neutrophil-to-lymphocyte ratio was 4.2 (interquartile range [IQR] 3.0–6.8) for mild cases, 6.5 (IQR: 5.0–10.8) for moderate cases, and 19 (IQR: 7.0–24.7) for severe cases (P = 0.008). …”
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Exploring Clec9a in dendritic cell-based tumor immunotherapy for molecular insights and therapeutic potentials by Zubair Hussain, Yueteng Zhang, Lu Qiu, Shanshan Gou, Kangdong Liu

“…This review specifically highlights the C-type lectin receptor family 9 member A (Clec9a or DNGR-1), which is exclusively expressed on cDC1s and plays a pivotal role in augmenting antigen cross-presentation and cytotoxic T lymphocyte (CTL) responses while simultaneously mitigating off-target effects. …”
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Receipt of specialized palliative care and health care utilization at the end of life in hematological cancer patients – the Stockholm experience by Lena von Bahr, Peter Strang, Torbjörn Schultz, Per Fürst

“…Results: Of the 2,858 included patients (mean age 76 years, 41% women), 38% had myeloid malignancies, 41% lymphocytic malignancies, and 21% had myeloma. During the last 3 months of life, 56% received SPC, with an overrepresentation of women, aOR 1.35 (1.16–1.58, p < 0.0001), whereas persons with risk of frailty (HFRS) were underrepresented, aOR 0.74 (0.63–0.86, p < 0.0001). …”
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Prevalence of Autoimmune Diseases in Patients Treated With Immune Checkpoint Inhibitors: An Epidemiological Study Using A Global Network of Health Care Organizations by Pushti Khandwala, Devashish Desai, Arthur Lau

“…Subgroup analysis was done to evaluate risk of ACs in patients receiving cytotoxic T‐lymphocyte‐associated protein 4 inhibitor (CTLA4i) versus program cell death protein 1 inhibitor (PD1i) and program death ligand 1 inhibitor (PDL1i) inhibitors and combination treatment (CT) (CTLA4 + PD1i/PDL1i) versus PD1i/PDL1i. …”
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Relationship between systemic immune-inflammation index and depression among individuals with and without cardiovascular disease by Dan Liu, Chaojie He, Xinguo Luo

“…SII was calculated as the platelet count × neutrophil count/lymphocyte count. In order to determine the relationships between SII and depressive symptoms in participants with and without CVD, binary logistic regression model and smooth curve fitting were used. …”
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