Development and validation of a nomogram to predict recurrence in epithelial ovarian cancer using complete blood count and lipid profiles by Xi Tang, Jingke He, Qin Huang, Yi Chen, Ke Chen, Jing Liu, Yingyu Tian, Hui Wang

“…Grade, International Federation of Gynecology and Obstetrics (FIGO) stage, platelet-to-lymphocyte ratio, red blood cell distribution width-coefficient of variation, triglycerides, and human epididymal protein 4 were identified as independent prognostic factors. …”
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Human inborn errors of immunity underlying Talaromyces marneffei infections: a multicenter, retrospective cohort study by Huifeng Fan, Zhiyong Yang, Yuhui Wu, Xiulan Lu, Tian Li, Xuyang Lu, Gen Lu, Liming He, Guoping Lu, Li Huang

“…Elevated levels of IgE were detected in five cases, and six cases exhibited decreased T lymphocyte absolute counts. Four children were diagnosed with hyperimmunoglobulin M syndrome (HIGM) due to CD40LG mutations, three cases had severe combined immunodeficiency (SCID), and five were diagnosed with hyper-IgE syndrome (HIES). …”
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Inflammatory-Related Clinical and Metabolic Outcomes in COVID-19 Patients by Maria Martinez-Urbistondo, Alberto Mora-Vargas, Esther Expósito-Palomo, Raquel Castejón, M. Jesús Citores, Silvia Rosado, Carmen de Mendoza, Isolina Baños, Ana Fernández-Cruz, Lidia Daimiel, Rodrigo San-Cristóbal, Juan Antonio Vargas, J. Alfredo Martinez

“…A total of 165 patients diagnosed with COVID-19 pneumonia were examined for medical features and inflammatory markers such as blood IL-6, CRP, ferritin, LDH, neutrophil/lymphocyte index (NLI), D-Dimer, and Red Cell Distribution Width (RDW). …”
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B-CLL with negative 18F-FDG PET/CT and intensive solitary lesion on PSMA PET/CT mimicking prostate cancer bone metastases by Theresa Jung, Daniel Neureiter, Gregor Schweighofer-Zwink, Gundula Rendl, Christian Pirich, Mohsen Beheshti

“…We report a case of 82-year-old male presented with prostate and history of oesophageal cancer and B-cell chronic lymphocytic leukemia (B-CLL). Both 68Ga-PSMA-11 and 2-(3-(1-carboxy-5-((6-(18f)fluoro-pyridine-3-carbonyl)-amino)-pentyl)-ureido)-pentanedioic acid (18F-DCFPyL) PET/CT, which were performed for prostate cancer staging and re-staging in about 1 year interval, showed focal uptake in the primary prostate tumor as well as an intense focal lesion in L2, suggestive of bone metastasis. 18F-FDG PET/CT scans performed before and after PSMA PET/CT examinations showed no abnormal uptake related to oesophageal and/or B-CLL. …”
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The liver’s dilemma: sensing real danger in a sea of PAMPs: the (arterial) sinusoidal segment theory by Andrea Henriques-Pons, Natália Vacani-Martins, Carina de Lima Pereira dos Santos, Marcelo Meuser-Batista

“…In the liver, dendritic, Kupffer (KC), liver sinusoidal endothelial cells (LSECs), and even hepatocytes express PD-L1, a T lymphocyte downregulatory molecule. Most cells express Fas-L, IL-10, TGF-β, low levels of co-stimulatory molecules, lack of or have low levels of MHC-I and/or MHC-II expression. …”
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Great Tit (Parus major) Nestlings Have Longer Telomeres in Old‐Growth Forests Than in Young Forests by Ronalds Krams, Dina Cīrule, Maris Munkevics, Sergejs Popovs, Priit Jõers, Jorge Contreras Garduño, Indrikis A. Krams, Tatjana Krama

“…Since insect larvae are the preferred food for great tit nestlings, the shortage of food may divert energy resources away from growth, which can show up as physiological stress, often raising the heterophil/lymphocyte (H/L) ratio. The H/L ratio revealed a significant difference in stress levels, being the highest in great tit nestlings developing in young‐managed pine forests. …”
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Prognostic Role of Monocytic Myeloid-Derived Suppressor Cells in Advanced Non-Small-Cell Lung Cancer: Relation to Different Hematologic Indices by Asmaa M. Zahran, Helal F. Hetta, Zeinab Albadry M. Zahran, Alaa Rashad, Amal Rayan, Dalia O. Mohamed, Zeinab Ahmed Abd Elhameed, Salah M. Khallaf, Gaber El-Saber Batiha, Yasir Waheed, Khalid Muhammad, Hanaa Nafady-Hego

“…Furthermore, these cells accumulated significantly in stage IV compared to stage III (p=0.006) and correlated negatively with overall survival (r=−0.471, p=0.002), lymphocyte to monocyte ratio (r=−0.446, p=0.004), and mean platelet volume to platelet count ratio (MPV/PC) (r=−0.464, p=0.003), patients with Mo‐MDSCs<13% had significantly better survival than those with Mo‐MDSCs≥13% (p=0.041). …”
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Effect of a Yogic Breathing Technique on Immune Parameters among Healthcare Workers: A Randomized Controlled Pilot Study by Archana Balasubramanian, Priyathersini Nagarajan, Mathangi Damal Chandrasekar, Kaviraja Udupa, Emmanuel Bhaskar, Divya Kanchibotla, Saumya Subramanian

“…Pro-inflammatory markers such as erythrocyte sedimentation rate, C-reactive protein and neutrophil-to-lymphocyte ratio showed a decrease in mean values after 12 weeks in both groups, which was not statistically significant. …”
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Effect of Preoperative Nutritional Risk Screening on Postoperative Recovery in Patients with Laparoscopic-Assisted Radical Resection for Colorectal Cancer by Xiaolong Wang, Jianlin Wu, Sen Lei, Feng Tian, Ce Cao, Guangfeng Shi

“…There were statistically significant differences in BMI, albumin, total cholesterol, and lymphocyte count between patients from the two groups (all P<0.05). …”
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FAN score predicts prognosis after platinum-based first-line chemotherapy in patients with metastatic urothelial carcinoma by Yu Ishizuya, Atsunari Kawashima, Yuki Horibe, Akinaru Yamamoto, Masaru Tani, Akihiro Yoshimura, Liu Yutong, Sassi Nesrine, Toshiki Oka, Yohei Okuda, Toshihiro Uemura, Gaku Yamamichi, Takuji Hayashi, Yoshiyuki Yamamoto, Taigo Kato, Koji Hatano, Norio Nonomura

“…Abstract We have reported that the FAN score, which consists of the fibrosis-4 (Fib-4) index, albumin–bilirubin (ALBI) score, and neutrophil–lymphocyte ratio (NLR), is a prognostic marker for patients receiving pembrolizumab for mUC. …”
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Clinico-pathological profile of patients with HIV and tuberculosis co-infection by Cheryl Sarah Philipose, Sinchana KM, Haritha Haridas, John Ramapuram, Sharada Rai

“…The age of the patients ranged from 18 to 65 years. The mean CD4+ T lymphocyte count was 164.7 cells/μl. Pulmonary TB was diagnosed in 59 patients (73.8%), while extra-pulmonary TB was detected in 21 (26.2%) cases. …”
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Targeting the NLRP3 inflammasome abrogates cardiotoxicity of immune checkpoint blockers by Ping Li, Zhen Qin, Yang Lu, Jiamin Gao, Zhenwei Wang, Ge Zhang, Han Yang, Yachen Hou, Dashuai Wang, Pengchong Du, Yunzhe Wang, Quanzhou Chen, Zhaowei Sun, Jinying Zhang, Junnan Tang

“…In addition, MCC950 attenuated cardiotoxicity induced by dual programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) immunotherapy and promoted tumor regression, and showed efficacy in treating established cardiotoxicity.Conclusions Our findings provide a promising clinical approach for preventing and treating cardiotoxicity induced by ICIs, dissociating the antitumor efficacy of ICI-based therapies from their cardiotoxic side effects.…”
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Ruxolitinib and oHSV combination therapy increases CD4 T cell activity and germinal center B cell populations in murine sarcoma by Ravi Dhital, Yeaseul Kim, Doyeon Kim, Ilse Hernandez-Aguirre, Jack Hedberg, Alexia Martin, Kevin A. Cassady

“…Beyond the cytotoxic T lymphocyte (CTL) and regulatory T cell (Treg) changes reported in our earlier studies, RUX+oHSV treatment modulates myeloid and other lymphoid compartments, including germinal center B cell populations with enhanced activation. …”
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Worst pattern of invasion: A prognostic indicator in early-stage oral tongue cancer: A single-center cohort study by Bhargav Ram, LM Chandra Sekara Rao S, Daphne Fonseca, Sravan Kumar Ch, Johnathan Gondi, Anil Kumar Akula, Hemantkumar Nemade

“…The study included only pathologically proven early-stage tongue squamous cell carcinoma (pathological T1-T2) with node-negative (N0) and complete histological details such as WPOI, Lymphocyte host response (LHR), Perinueral invasion (PNI), and Lymphovascular invasion (LVI). …”
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Mitigation of PFOA/PFOS toxicity in zebrafish (Danio rerio) by oxidative stress modulation and gut microbial metabolism through the use of aquatic probiotic Lactobacillus rhamnosus by Chun Wang, Guanyi Li, Sibao Chen, Ruixuan Li, Mengyan Wang, Xia Wang, Ning Ding, Yingxue Sun

“…Additionally, L. rhamnosus exhibited significant reparative effects on damaged intestinal tissues, as evidenced by the restoration of damaged intestinal villi and an increase in lymphocyte count. Furthermore, it was capable of enhancing the abundance of thick-walled phylum and actinomycetes phylum within the zebrafish gut microbiota. …”
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Association of Immune Nutrition Indices with the Risk of All-Cause Mortality and Cardiovascular Mortality in Patients with Heart Failure in the NHANES (1999–2018) by Feifei Zhang, Yuetao Xie, Litian Liu, Huiliang Liu, Ohua Feng, Yingxiao Li, Yi Dang

“…Novel indicators emerge as immune nutrition indices, including the prognostic nutritional index (PNI), neutrophil-to-lymphocyte ratio (NLR), Controlling Nutritional Status (CONUT) score, and cholesterol-modified prognostic nutritional index (CPNI). …”
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Seroprevalence of SARS-CoV-2 Infection Among People Living with HIV in Libreville, Gabon by Samira Zoa-Assoumou, Hervé M’boyis-Kandem, Pelagie Saphou-Damon, Davy Ulrich Leger Mouangala, Guy-Francis Nzengui, Marina Mbani-Okoumba, Claudine Kombila-Koumavor, Gael Mourembou, Brama Ibrahim, Angelique Ndjoyi-Mbiguino

“…History of SARS-CoV-2 diagnosis, ART treatment, and TCD4 lymphocyte count were not found to be associated with the presence of antibodies against SARS-CoV-2 among the study participants. …”
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Risk Factors and Changes of Peripheral NK and T Cells in Pulmonary Interstitial Fibrosis of Patients with Rheumatoid Arthritis by Na-Lin Lai, Wen Jia, Xia Wang, Jing Luo, Guang-Ying Liu, Chong Gao, Xiao-Feng Li, Jian-Fang Xie

“…To investigate the clinical risk factors, especially the changes of lymphocyte subsets, in RA-ILD in order to make early diagnosis and achieve prevention of the pulmonary interstitial lesions. …”
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New Echocardiographic Findings Correlate with Intramyocardial Inflammation in Endomyocardial Biopsies of Patients with Acute Myocarditis and Inflammatory Cardiomyopathy by Felicitas Escher, Mario Kasner, Uwe Kühl, Johannes Heymer, Ursula Wilkenshoff, Carsten Tschöpe, Heinz-Peter Schultheiss

“…LSR and LS correlate significantly with lymphocytic infiltrates (for CD3 r=0.7, P<0.0001, and LFA-1 r=0.8, P<0.0001). …”
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Influence of Dietary Chromium and Vitamin E Supplementation on Performance, Metabolism, and Physiology of Broilers Subjected to Cyclic Heat Stress by ML X Júnior, RD Bernardes, CH Oliveira, KMM Dias, BF Almeida, SO Borges, FS Dalólio, KM Gomes, CJ Rodrigues, AA Calderano

“…Performance, glucose levels, thyroid hormone levels, heterophil-to-lymphocyte (H:L) ratio, malondialdehyde (MDA) in muscle, relative weight of lymphoid organs, and HSP70 mRNA expression were measured. …”
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