Codon optimized influenza H1 HA sequence but not CTLA-4 targeting of HA antigen to enhance the efficacy of DNA vaccines in an animal model by Dito Anurogo, Chia-Yuan Chen, Chu-Chi Lin, Jeanne Adiwinata Pawitan, Daniel W. Qiu, J. Timothy Qiu

“…In the investigation here, protein expression was enhanced via codon optimization and then mouse cytotoxic T-lymphocyte antigen 4 (CTLA-4) was harnessed as a modulatory adjunct to bind directly to antigen-presenting cells. …”
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White blood cell traits and lung cancer risk: a two-sample mendelian randomization analysis by Kaijun Long, Zhengfeng Zhu, Xinzhe Zheng, Gang Xu, Cheng Chen, Xixian Ke

“…We conducted a two-sample MR analysis using genome-wide association study (GWAS) summary statistics for the both exposure traits (eosinophil count, neutrophil count, lymphocyte count, monocyte count, basophil count, and total white blood cell count) and outcome traits (lung cancer and its subtypes). …”
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Phase II Study of Personalized Peptide Vaccination with Both a Hepatitis C Virus-Derived Peptide and Peptides from Tumor-Associated Antigens for the Treatment of HCV-Positive Advan... by Shigeru Yutani, Kazuomi Ueshima, Kazumichi Abe, Atsushi Ishiguro, Junichi Eguchi, Satoko Matsueda, Nobukazu Komatsu, Shigeki Shichijo, Akira Yamada, Kyogo Itoh, Tetsuro Sasada, Masatoshi Kudo, Masanori Noguchi

“…Peptide-specific cytotoxic T lymphocyte (CTL) and IgG responses were measured before and after vaccination. …”
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The effects of intermittent fasting on antioxidant and inflammatory markers and liver enzymes in postmenopausal, overweight and obese women with rheumatoid arthritis: a randomized... by Aryan Tavakoli, Camellia Akhgarjand, Hastimansooreh Ansar, Hirad Houjaghani, Amirhossein Khormani, Kurosh Djafarian, Abdolrahman Rostamian, Mahsa Ranjbar, Gholamreza Mohammadi Farsani

“…The IF group showed significant decreases in serum malondialdehyde (MDA) levels (P = 0.02) and neutrophil-to-lymphocyte ratio (P = 0.018) and increased catalase levels (P = 0.004) compared to the control group. …”
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Evidence of Helicobacter spp. in Saliva and Gastric Mucosa of Domestic Dogs in the Central Region of Rio Grande do Sul, Brazil by Daniel D. Guerra Segundo, Camila B. E. Mello, Juliana F. Cargnelutti, Mariana M. Flores, Luís F. Pedrotti, Bernardo N. Antunes, Vanessa Milech, Omar G. Velasquez, Letícia R. Martins, Saulo T. L. Pinto Filho

“…Respectively, eight, 15, and nine dogs had mild, moderate, and severe colonisation. Lymphocytic-plasmacytic infiltrate was the main gastric lesion. …”
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Association of haplotypes for SNPs in the LTR regions of bovine leukemia virus with hematological indices of cattle by N. V. Blazhko, S. Kh. Vyshegurov, A. S. Donchenko, K. S. Shatokhin, T. I. Krytsyna, V. A. Ryabinina

“…We performed the total count of white blood cells (WBC), lymphocyte (lymf), granulocyte (gran), monocyte (mon), red blood cell (RBC), hemoglobin (HGB), hematocrit (HTC), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red blood cell distribution width (RDW), platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and platelet crit count (PCT). …”
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Severe Cutaneous Adverse Drug Reactions at a Tertiary Care Center in Saudi Arabia by Mohammed I. AlJasser

“…More importantly, thorough studies of HLA associations and lymphocyte transformation tests among Arabs with SCARs are likely to further improve patient care in the Arabian Gulf region.…”
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Global research trends on biomarkers for cancer immunotherapy: Visualization and bibliometric analysis by Yuan Qiao, Dong Xie, Zhengxiang Li, Shaohua Cao, Dong Zhao

“…The research on biomarkers mainly concentrated upon the following aspects: PD-1/PD-L1, CTLA-4, gene expression, adverse events, total mutational burden (TMB), body mass index (BMI), gut microbiota, cd8(+)/cd4(+) t-cells, and blood-related biomarkers such as lactate dehydrogenase (LDH), neutrophil–lymphocyte ratio (NLR), cytokines. Furthermore, “artificial intelligence” and “machine learning” have become the most important research hotspot over the last 2 y, which will help us to identify useful biomarkers from complex big data and provide a basis for precise medicine for malignant tumors.…”
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Proliferating CLL cells express high levels of CXCR4 and CD5 by Daniel Friedman, Drshika P. Mehtani, Jennifer B. Vidler, Piers E. M. Patten, Robbert Hoogeboom

“…Abstract Chronic lymphocytic leukemia (CLL) is an incurable progressive malignancy of CD5+ B cells with a birth rate between 0.1% and 1% of the entire clone per day. …”
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Patient and provider experiences with active surveillance: A scoping review. by Claire Kim, Frances C Wright, Nicole J Look Hong, Gary Groot, Lucy Helyer, Pamela Meiers, May Lynn Quan, Robin Urquhart, Rebecca Warburton, Anna R Gagliardi

“…Among 344 full-text articles, 73 studies were eligible: 2 ductal carcinoma in situ (DCIS), 4 chronic lymphocytic leukemia (CLL), 6 renal cell carcinoma (RCC) and 61 prostate cancer. …”
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Identification of GBN5 as a molecular biomarker of pan-cancer species by integrated multi-omics analysis by Qian Guo, Xinxin Zhong, Zihan Dang, Baiquan Zhang, Zixin Yang

“…We also demonstrated that GBN5 expression was significantly associated with immunomodulatory molecules and biomarkers of lymphocyte subpopulation infiltration. Methylation levels of GBN5 expression were significantly negatively correlated in a variety of tumors, and GBN5 missense mutations were the predominant SNP type in pan-cancer. …”
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Potential Health Implications of the Consumption of Thermally-Oxidized Cooking Oils – a Review by Falade Ayodeji Osmund, Oboh Ganiyu, Okoh Anthony Ifeanyi

“…Furthermore, several in vivo studies had suggested that consumption of thermally-oxidized cooking oils might not be healthy as it might negatively influence the lipid profile (increased low density lipoprotein (LDL), decreased high density lipoprotein (HDL) and elevated cholesterol level), haematological system (alteration in concentration of heamoglobin (Hb), packed cell volume (PCV), white blood cell (WBC) count, neutrophil and lymphocyte counts), kidney function, and induce lipid peroxidation and oxidative stress which have been associated with the pathogenesis of various degenerative diseases. …”
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Use of Chitosan to Prevent Aeromonas hydrophila Infection on Catfish Clarias sp. by . Sukenda, L. Jamal, D. Wahjuningrum, A. Hasan

“…Results showed that total count of eritrocyte, leucocyte,  level of hematocrite, haemoglobin and phagocytic index higher at fish injected with chitosan previously compared with control as well as lymphocyte, neutrophile, monocyte, and trombocyte.  …”
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Elotuzumab Enhances CD16-Independent NK Cell-Mediated Cytotoxicity against Myeloma Cells by Upregulating Several NK Cell-Enhancing Genes by Yan-Hua Wang, Shotaro Hagiwara, Hiroshi Kazama, Yuki Iizuka, Norina Tanaka, Junji Tanaka

“…Elotuzumab (Elo) is an immune-stimulatory antibody that targets the signaling lymphocytic activation molecule family 7 (SLAMF7) expressed on the surface of MM and NK cells. …”
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Bioinformatic Analysis Reveals Central Role for Tumor-Infiltrating Immune Cells in Uveal Melanoma Progression by Mieszko Lachota, Anton Lennikov, Karl-Johan Malmberg, Radoslaw Zagozdzon

“…Therefore, we propose further investigations of IDO1 and metalloproteinases as novel targets for immunotherapy in lymphocyte-rich metastatic UM patients.…”
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Successful Treatment of Linear Psoriasis With the IL-17a-Antagonist Ixekizumab: A Case Report by Christov S, Ohm F, Augustin M, Wagner JN

“…The histopathological findings showed psoriasiform epidermal hyperplasia with alternating ortho- and parakeratosis, subepidermal capillary dilatation, and perivascular lymphocytic infiltrates, confirming the diagnosis. Ixekizumab, a IL-17A antagonist, was administered leading to a rapid and significant reduction in disease severity within the first 16 weeks. …”
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Association between the systemic immune-inflammation index and sarcopenia in older adults: a cross-sectional study by Esra Cataltepe, Eda Ceker, Ayse Fadiloglu, Fatih Gungor, Nermin Karakurt, Zekeriya Ulger, Hacer Dogan Varan

“…To determine the SII, we used the formula: Platelet count (109/mm3)×Neutrophil count (109/mm3) / Lymphocyte count (109/mm3). Results The average age of the participants was 74.8 ± 6.4, and 62.3% (n = 394) were female. …”
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A study on processes of some haematological parameters in growing male and female japanese quails (coturnix coturnix japonica) by Ercan Keskin, Zafer Durgun, Mehmet Kocabatmaz

“…The RBC was significantly higher in males (3 65x 10⁶) than females (3 28x 10⁶) at 8 week of age (P<0,05), The white blood cell (WBC) and thrombocyte counts did not show evidently changes, whereas WBC in females (24-28x 10³) were found slightly higher than males (21-26 x 10³) at all weeks, in the percentage of leucocyte types were not determined any differences between sexes during eight weeks and the lymphocyte percentages (57-70%) were drastically higher than heterophils (24-36%) in both groups There was no differences between sexes in respect to the blood cell sizes where as RBC sizes were bigger in females than males at either 1 st and 8 th weeks. …”
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The combined therapy of chronic hepatitis with pegilated interferon <i>a</i>-2а and ribavirin in patients with HIV-infection and patients with HCV monoinfection by N. D. Yuschuk, S. L. Maximov, L. M. Ivanova, Ye. K. Klimova, O. O. Znoyko, A. V. Kravchenko

“…During treatment significant decrease of CD4+ lymphocyte number took place, however no clinical signs of HIV-infection progression has been found.Conclusions. …”
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Exploring the Dynamics of Sleep Deprivation: Insights into Complete Blood Count and Coagulation Parameters in a Case-Control Study by Abd Elhadi Agena, Leena Mirghani, Abdirasak Ali Mude

“…The case group had a substantial drop in lymphocyte counts on day 3 (p=0.016). The third day showed significant differences in neutrophil and eosinophil levels (p=0.003 and 0.000, respectively). …”
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