Nursing of a pediatric patient with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (1例罕见IPEX综合征患儿的护理) by ZHU Huiyun (朱慧云), WANG Suling (王苏玲)

“…Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a rare, fatal autoimmune disorder caused by mutations in the FOXP3 gene leading to the disruption of signaling pathways involved in regulatory T-lymphocyte function. This paper reviewed the clinical data of an IPEX child with respiratory and gastrointestinal symptoms as main symptoms, and summarized treatment and nursing experience. …”
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CXCL1-Triggered Interaction of LFA1 and ICAM1 Control Glucose-Induced Leukocyte Recruitment during Inflammation In Vivo by Kirsten Buschmann, Lutz Koch, Natascha Braach, Hanna Mueller, David Frommhold, Johannes Poeschl, Peter Ruef

“…Experiments with functional or genetic inhibition of the chemokine receptor CXCR2, intercellular adhesion molecule 1 (ICAM1), and lymphocyte function antigen 1 (LFA1) suggest that keratino-derived-chemokine CXCL1-triggered interactions of ICAM1 and LFA1 are crucially involved in the trauma model of inflammation. …”
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Immunotherapeutic Potential of Lactobacillus Species as Immune Checkpoint Inhibitors in Cancer Immunotherapy by Renukadevi J, Sam Helinto J, Prena D

“…This review explores the immunotherapeutic potential of Lactobacillus species via adjuvant therapy with immune checkpoint inhibitors (ICIs), such as programmed cell death protein-1, programmed death ligand-1, and cytotoxic T-lymphocyte antigen-4 inhibitors, which have revolutionized cancer treatment by enhancing T-cell-mediated antitumor immunity. …”
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Hyperleukocytosis in a neuroblastoma patient after treatment with natural killer T cells expressing a GD2-specific chimeric antigen receptor and IL-15 by Xin Xu, Shantan Reddy, Saleh Bhar, Frederic D Bushman, Amy N Courtney, Gabriel A Barragán, Gengwen Tian, Erica J Di Pierro, Leonid S Metelitsa, Antonino Montalbano, Hangjin Yu, Claudia Martinez Amador, Nisha Ghatwai, Michael S Wood, Deborah Schady, Aoife M Roche, David de la Cerda, Donald Williams Parsons, Andras Heczey

“…We report that the use of aAPCs instead of PBMCs for CAR-NKT restimulation contributed to a hyperproliferative state associated with distinct gene expression that possibly led to explosive lymphocyte expansion and uncontrolled toxicity in the patient. …”
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Blockade of ICAM-1 Improves the Outcome of Polymicrobial Sepsis via Modulating Neutrophil Migration and Reversing Immunosuppression by Yan-jun Zhao, Wen-jing Yi, Xiao-jian Wan, Jun Wang, Tian-zhu Tao, Jin-bao Li, Jia-feng Wang, Xiao-ming Deng

“…Its influence on neutrophil migration and infiltration, as well as lymphocyte status, in thymus and spleen was also investigated. …”
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Significance of Preoperative Systemic Immune Score for Stage I Gastric Cancer Patients by Jun Lu, Long-long Cao, Ping Li, Jian-wei Xie, Jia-bin Wang, Jian-xian Lin, Qi-yue Chen, Mi Lin, Ru-hong Tu, Chang-ming Huang, Chao-hui Zheng

“…The patient score was 1 for either a pretreatment hypoalbuminemia or elevated derived neutrophil-lymphocyte ratio (dNLR) and was 0 otherwise. The SIS served as an independent prognostic factor for reduced OS. …”
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B cells enhance IL-1 beta driven invasiveness in triple negative breast cancer by Nicole J. Toney, Lynn M. Opdenaker, Lisa Frerichs, Shirin R. Modarai, Aihui Ma, Holly Archinal, Grace O. Ajayi, Jennifer Sims-Mourtada

“…Abstract Triple-negative breast cancer (TNBC) is an aggressive subtype often characterized by high lymphocyte infiltration, including tumor-infiltrating B cells (TIBs). …”
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Gain-of-Function Mutations in STAT1: A Recently Defined Cause for Chronic Mucocutaneous Candidiasis Disease Mimicking Combined Immunodeficiencies by Sanem Eren Akarcan, Ezgi Ulusoy Severcan, Neslihan Edeer Karaca, Esra Isik, Guzide Aksu, Mélanie Migaud, Ferda Evin Gurkan, Elif Azarsiz, Anne Puel, Jean-Laurent Casanova, Necil Kutukculer

“…She had hypergammaglobulinemia; IgE level, percentages of lymphocyte subgroups, and in vitro T-cell proliferation responses were normal. …”
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Detection of t(14;16)(q32;q22) and Monosomy 13 by FISH Analysis in a Patient with Multiple Myeloma Associated with Sjögren’s Syndrome: The First Case Report from India by Rupesh R. Sanap, Arundhati S. Athalye, Prochi F. Madon, Boman N. Dhabhar, Mahendra B. Sute, Amit A. Mahabale, Dhanashree J. Warang, Firuza R. Parikh

“…Sjögren’s syndrome (SS) is a chronic slowly progressive autoimmune disorder characterized by symptoms of oral and ocular dryness, exocrine dysfunction, and lymphocytic infiltration of exocrine glands. Multiple myeloma (MM) is a bone-marrow-based malignant neoplasm of plasma cells associated with serum/urine monoclonal paraproteins and lytic skeletal lesions. …”
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Pre-transplant T-cell clonal analysis identifies CD8+ donor reactive clones that contribute to kidney transplant rejection by Jes M. Sanders, Barbara L. Banbury, Erika L. Schumacher, Jie He, Yuvaraj Sambandam, Paul A. Fields, Lorenzo Gallon, Lorenzo Gallon, James M. Mathew, James M. Mathew, James M. Mathew, Joseph R. Leventhal, Joseph R. Leventhal

“…We defined a set of donor reactive T-cell clones (DRTC) with the goal to elucidate signatures of kidney allograft rejection.MethodsDRTC were identified pretransplant using an anti-donor mixed lymphocyte reaction assay: CFSE-diluting CD4+ and CD8+ DRTC were flow-sorted, and the TCR sequences were identified using Adaptive Immunosequencing. …”
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Evaluation of Serum Vascular Adhesion Protein-1 as a Potential Biomarker in Thyroid Cancer by Zhigang Hu, Pengxin Zhao, Kaili Zhang, Leilei Zang, Haiying Liao, Weiyuan Ma

“…Vascular adhesion protein-1 (VAP-1) is a glycoprotein that mediates tissue-selective lymphocyte adhesion. The prognostic value of VAP-1 has been determined in gastric cancer. …”
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Effect of cyclosporin A on inflammatory cytokine production by U937 monocyte-like cells by Juan E. Losa Garcia, María Rosa Martín de Cabo, Fernando Mateos Rodríguez, Jesús Pérez Losada, Antonio Jiménez López, José Luis Pérez Arellano

“…In some of them the inhibition of T-lymphocyte activation does not suitably account for the observed beneficial effect, suggesting that CsA could act on other types of cells. …”
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Normal Thymic Size and Low Rate of Infections in Human Donor Milk Fed HIV-Exposed Uninfected Infants from Birth to 18 Months of Age by Dorthe Lisbeth Jeppesen, Annette Kjær Ersbøll, Tine Ursula Hoppe, Susanne Dam Nielsen, Niels Henrik Valerius

“…Ultrasound-obtained thymic index (Ti), T-lymphocyte subsets, and the number of infections were examined from birth to 18 months of age in 18 HIV-EU infants. …”
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Relationship between Indicators of Nutritional Status and the Development of Pneumonia Associated with Ischemic Stroke by Alexis Suárez Quesada, Alexis Álvarez Aliaga, Julia Matilde Pupo Jiménez, Joel Berdú Saumell, Marta Elena Hernández Galano

“…The 39.1 % of the patients presented a certain degree of nutritional risk upon admission, the main factors identified were the global lymphocyte count 7 mmol / l and aspartate- aminotransferase> 25 U / L. …”
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Impact of Organ Donor Pretreatment With Anti-Thymocyte Globulin in a Murine Model of Allogenic Kidney Transplantation by An He, An He, Yiren Yang, Katja Kotsch, Arne Sattler

“…Anti-thymocyte globulin (ATG) has a history as lymphocyte-depleting, immunosuppressive drug for treating rejection episodes post transplantation. …”
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Development of Safe and Non-Self-Immunogenic Mucosal Adjuvant by Recombinant Fusion of Cholera Toxin A1 Subunit with Protein Transduction Domain by Byoung-Shik Shim, In Su Cheon, Eugene Lee, Sung-Moo Park, Youngjoo Choi, Dae-Im Jung, Eunji Yang, Jung-ah Choi, June Young Chun, Jae-Ouk Kim, Cheol-Heui Yun, Cecil Czerkinsky, Man Ki Song

“…Moreover, in vivo cytotoxic T lymphocyte activity elicited by TCTA1T was significantly higher than that elicited by a mutant TCTA1T (TmCTA1T) lacking ADP-ribosyltransferase function. …”
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Alkylresorcinols as a New Type of Gut Microbiota Regulators Influencing Immune Therapy Efficiency in Lung Cancer Treatment by Aleksandr V. Shestopalov, Oleg I. Kit, Anastasia A. Zabolotneva, Elena Y. Zlatnik, Aleksey Yu Maksimov, Inna A. Novikova, Alexander B. Sagakyants, Sofya V. Timofeeva, Anna S. Goncharova, Anastasia V. Galina, Svetlana A. Appolonova, Pavel A. Markin, Valentin V. Makarov, Sergey M. Yudin, Anton A. Keskinov, Sergei A. Roumiantsev, Oleg I. Meshkov

“…Quantitative analysis of AR levels, as well as other microbial metabolites in blood serum and faeces, was performed using gas chromatography with mass spectrometric detection; estimation of lymphocyte subsets was performed by flow cytometry; faecal microbiota transplantation (FMT) from lung cancer patients after ICI therapy to germ-free mice was performed to explore whether the intestinal microbiota could produce AR molecules. …”
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Exclusive Cutaneous and Subcutaneous Sarcoidal Granulomatous Inflammation due to Immune Checkpoint Inhibitors: Report of Two Cases with Unusual Manifestations and Review of the Lit... by Narciss Mobini, Rummit Dhillon, Jason Dickey, Jordan Spoon, Kaviyon Sadrolashrafi

“…The primary target antigens are cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), a downregulator of T-cell activation, and programmed cell death-1 receptor (PD-1), a regulator of T-cell proliferation. …”
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Ethyl Caffeate Ameliorates Collagen-Induced Arthritis by Suppressing Th1 Immune Response by Shikui Xu, Aixue Zuo, Zengjun Guo, Chunping Wan

“…Methods. In vitro, lymphocyte proliferation assay was measured by CCK-8 kit. …”
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Maltoma of Thyroid: A Rare Thyroid Tumour by Navisha Latheef, Vijendra Shenoy, M. Panduranga Kamath, Mahesh Chandra Hegde, A. Raghavendra Rao

“…Thyroid profile was within normal limits. FNAC showed lymphocytic thyroiditis. The patient underwent a right hemithyroidectomy. …”
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