Developing an Effective Therapeutic HPV Vaccine to Eradicate Large Tumors by Genetically Fusing Xcl1 and Incorporating IL-9 as Molecular Adjuvants by Zhongjie Sun, Zhongyan Wu, Xuncheng Su

“…Therapeutic vaccines mount a HPV-specific CD8+ cytotoxic T lymphocyte response, thus clearing HPV-infected cells. …”
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On an Impulsive Conformable M1 Oncolytic Virotherapy Neural Network Model: Stability of Sets Analysis by Gani Stamov, Ivanka Stamova, Cvetelina Spirova

“…The proposed model extends some existing mathematical models that describe the dynamics of the concentrations of normal cells, tumor cells, nutrients, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>M</mi><mn>1</mn></mrow></semantics></math></inline-formula> viruses and cytotoxic T lymphocyte (CTL) cells to the impulsive conformable setting. …”
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Inflammatory Characteristics of Stenotic Aortic Valves: A Comparison between Rheumatic and Nonrheumatic Aortic Stenosis by Lars Wallby, Thora Steffensen, Lena Jonasson, Mats Broqvist

“…The RAS valves revealed a lower degree of T lymphocyte infiltration compared with the NRAS valves. …”
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The real-world safety of Ofatumumab: a pharmacovigilance analysis based on the FDA adverse event reporting system by Yue Zhou, Yutong Wu, Xiao Zhao, Lingxu Xu, Mingguang Sun, Zhaoyou Meng

“…It was approved by the FDA in 2020 for the treatment of relapsing multiple sclerosis (RMS) in adult patients, and in 2009 for the treatment of Chronic Lymphocytic Leukemia (CLL). With the escalating clinical application of Ofatumumab, comprehending its safety profile within actual healthcare environments is of considerable importance.MethodsThis study compiled a dataset derived from the FAERS database, which included real-world safety data on Ofatumumab from Q4 2009 to Q2 2024. …”
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Intracellular Cytokine Flow Cytometry to Differentiate between Active and Latent Tuberculosis through Assessment of Tuberculosis-specific Cytokines by Sindhura Lakshmi Koulmane Laxminarayana, Sushma Belurkar, Kavitha Saravu, Shilna Muttickal Swaminathan

“…METHODS: A prospective study of adult patients with MTB, LTBI, and healthy controls was performed over 1 year. QFT, ICCFC, and lymphocyte subsets were tested. The diagnostic performance of the ICCFC in detecting LTBI and MTB in comparison with the QFT was analyzed. …”
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Revolution of blood cancer treatment in the oral cavity: Breakthroughs in nanotherapy by Pavithra Bharathy, Elizabeth Rani E, Punniyakoti V. Thanikachalam

“…Clinical trials and research findings have demonstrated the potential of nanotherapy for improving outcomes in patients with acute myeloid leukemia, chronic lymphocytic leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma, and multiple myeloma. …”
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Selective Immunoglobulins deficiency in relatives antibody deficiency patient by Yralys Naranjo Herrera, María del Carmen Chávez Alfonso, Valia Concepción Ulloa, Cándido Marcos León Márquez, Grace Alicia De Lara García, Ernesto Gabriel Caraballosa Yero

“…Results: decreased IgA and IgG values were found only in some first-degree relatives and all showed IgM and CD3+CD4+T lymphocyte numbers within normal parameters. Female patients, adults and the mother as a predominated relative, most of them being asymptomatic. …”
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Two Case Reports of Neuroinvasive West Nile Virus Infection in the Critical Care Unit by Edgardo M. Flores Anticona, Hadeel Zainah, Daniel R. Ouellette, Laura E. Johnson

“…Cerebrospinal fluid (CSF) analysis revealed pleocytosis with lymphocyte predominance. WNV serology was positive in the CSF. …”
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Notch/CXCR4 Partnership in Acute Lymphoblastic Leukemia Progression by Georgia Tsaouli, Elisabetta Ferretti, Diana Bellavia, Alessandra Vacca, Maria Pia Felli

“…These two receptor pathways intersect other critical signals in the proliferative, differentiation, and metabolic programs of lymphocyte transformation. Also, the identification of the crosstalks in leukemia-stroma interaction within the tumor microenvironment may unveil new targetable mechanisms in disease relapse. …”
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Antiproliferative and genotoxic potential of xanthen-3-one derivatives by Veljović Elma, Špirtović-Halilović Selma, Muratović Samija, Osmanović Amar, Haverić Sanin, Haverić Anja, Hadžić Maida, Salihović Mirsada, Malenica Maja, Šapčanin Aida, Završnik Davorka

“…Analyses of cytotoxic and genotoxic potential of the trifluormethyl derivative were performed with cytokinesis-block micronucleus cytome assay in human lymphocyte culture and revealed no genotoxic and cytotoxic effects. …”
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Uncovering the significance of CBX3 as an up-and-coming biomarker in cardio-vascular health by Muhammad Aamir Wahab, Nunzio Del Gaudio, Biagio Gargiulo, Vincenzo Quagliariello, Nicola Maurea, Michele Grieco, Rosaria Benedetti, Angela Nebbioso, Lucia Altucci, Mariarosaria Conte

“…However, the broader im- pact of CBX3 on endothelial function, as well as its effects on monocyte/macro- phage and lymphocyte infiltration and function within the arterial wall, remain poorly understood. …”
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Characteristic TARC/CCL17 expression in the salivary gland of IgG4-related disease: potential diagnostic utility and insights into pathogenesis by Nanako Kikuchi, Sae Hatanaka, Terufumi Kubo, Ryuta Kamekura, Masatoshi Kanda, Takuya Kakuki, Takashi Sasaya, Kengo Mita, Hiroki Kobayashi, Hajime Ikai, Kenta Sasaki, Naoki Shijubou, Kenji Murata, Takayuki Kanaseki, Tomohide Tsukahara, Yoshihiko Hirohashi, Tadashi Hasegawa, Akihiro Miyazaki, Hiroki Takahashi, Ken-ichi Takano, Toshihiko Torigoe

“…Immunoglobulin G4-related disease (IgG4-RD) is a chronic inflammatory condition of unknown etiology characterized by lymphocytic infiltration, fibrosis, and infiltration of IgG4-positive plasma cells. …”
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Gastric Adenocarcinoma of the Fundic Gland Type Treated by Endoscopic Mucosal Resection: A Case Report and Review of the Literature by Eleanor Lewin, Philip Daroca, Sanjay Sikka, Tong Wu, Yukihiro Nakanishi

“…The tumor invaded the submucosa with complete disruption of the muscularis mucosae and mild lymphocytic and fibroblastic stromal reaction. No necrosis, mitosis, or lymph-vascular invasion was identified. …”
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Congenital T-cell activation impairs transitional-to-follicular B-cell maturation in humans by Hugues Allard-Chamard, Kirsty Hillier, Michelle L. Ramseier, Alice Bertocchi, Naoki Kaneko, Katherine Premo, Grace Yuen, Marshall Karpel, Vinay S. Mahajan, Christina Tsekeri, Joseph S. Hong, Jean Vencic, Rory Crotty, Anish V. Sharda, Sara Barmettler, Emma Westermann-Clark, Jolan E. Walter, Musie Ghebremichael, Alex K. Shalek, Jocelyn R. Farmer, Shiv Pillai

“…Abstract: Patients with cytotoxic T-lymphocyte–associated protein 4 (CTLA4) deficiency exhibit profound humoral immune dysfunction, yet the basis for the B-cell defect is not known. …”
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Central Role of Gimap5 in Maintaining Peripheral Tolerance and T Cell Homeostasis in the Gut by Mehari Endale, H. Ibrahim Aksoylar, Kasper Hoebe

“…Here, we discuss how defects in Gimap5 function impair immunological tolerance and lymphocyte survival and ultimately drive the development of CD4+ T cell-mediated early-onset colitis.…”
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Neo-BCV: A Novel Bacterial Liquid Complex Vaccine for Enhancing Dendritic Cell-Mediated Immune Responses Against Lung Cancer by Zilong Zhu, Zhuze Chu, Fei Fei, Chenxi Wu, Zhengyue Fei, Yuxia Sun, Yun Chen, Peihua Lu

“…Results: We have demonstrated that Neo-BCV can promote Dendritic cells (DCs) maturation and induce DCs differentiation into pro-inflammatory subgroups, significantly enhancing cytotoxic T lymphocyte (CTL)-mediated anti-tumor responses. Transcriptome sequencing revealed that Neo-BCV exerts its effects by specifically inhibiting the JAK2-STAT3 signaling pathway, a crucial regulator of cancer progression, metabolism, and inflammation. …”
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Thyroidectomy for Painful Thyroiditis Resistant to Steroid Treatment: Three New Cases with Review of the Literature by Enrico Mazza, Francesco Quaglino, Adolfo Suriani, Nicola Palestini, Cristina Gottero, Renzo Leli, Stefano Taraglio

“…Conversely, in the first patient, thyroid histology showed features of granulomatous thyroiditis, typical of SAT, without fibrosis or lymphocytic infiltration, typical of HT/PHT, coupled to undetectable serum anti-thyroid antibodies. …”
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Bioinformatic characterization of STING expression in hematological malignancies reveals association with prognosis and anti-tumor immunity by Xiang-mei Wen, Xiang-mei Wen, Xiang-mei Wen, Zi-jun Xu, Zi-jun Xu, Zi-jun Xu, Ji-chun Ma, Ji-chun Ma, Ji-chun Ma, Min-jie Zhang, Min-jie Zhang, Min-jie Zhang, Ye Jin, Ye Jin, Jiang Lin, Jiang Lin, Jiang Lin, Jun Qian, Jun Qian, Yuan-yuan Fang, Yuan-yuan Fang, Yuan-yuan Fang, Shu-yu Luo, Shu-yu Luo, Shu-yu Luo, Zhen-wei Mao

“…Cytolytic score and STING expression were positively correlated in some hematological tumors, especially chronic lymphocytic leukemia and mantle cell lymphoma. Interestingly, STING expression was negatively correlated with TIDE biomarkers in AML, suggesting that AML patients with a high STING expression level may benefit from immunologic treatment. …”
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Evaluation of the Ability of Miltefosine Associated with Topical GM-CSF in Modulating the Immune Response of Patients with Cutaneous Leishmaniasis by Fábio Peixoto, Maurício T. Nascimento, Rúbia Costa, Juliana Silva, Gaby Renard, Luiz Henrique Guimarães, Gerson Penna, Manoel Barral-Netto, Lucas P. Carvalho, Paulo R. L. Machado, Edgar M. Carvalho

“…Mononuclear cells were stimulated with soluble Leishmania antigen (SLA) on day 0 and day 15 of therapy, and cytokine levels were determined in supernatants by ELISA. The lymphocyte proliferation and oxidative burst were evaluated by flow cytometry, and the degree of infection and Leishmania killing by optical microscopy. …”
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Monomorphic Ventricular Tachycardia as a Presentation of Giant Cell Myocarditis by Michael H. Chiu, Cvetan Trpkov, Saman Rezazedeh, Derek S. Chew

“…It is a rare disorder which involves T lymphocyte-mediated myocardial inflammation. Diagnosis is challenging and requires a high index of suspicion since therapy may improve an otherwise uniformly fatal prognosis. …”
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