An association between type A porcine endogenous retrovirus copy number and hematological parameters and gender in miniature pigs by R. B. Aitnazarov, S. V. Nikitin, G. V. Kontsevaya, M. I. Voevoda, N. S. Yudin

“…Reference values for eighteen blood parameters of miniature pigs were determined, including white blood cell count (WBC), red blood cell count (RBC), platelet count (PLT), absolute (LYM#) and relative (LYM%)  lymphocyte counts, absolute (MID#) and relative (MID%) monocyte, basophil and eosinophil counts, absolute (GRA#) and relative (GRA%) granulocyte counts, hematocrit (HCT) and thrombocrit (PCT), mean cell volume (MCV) and mean platelet volume (MPV). …”
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Some haematological parameters in partridges (allectoris gracea) bred in konya by Ercan Keskin, Ramazan Çöl, Tufan Keçeci, Hüdai İpek, Feyyaz Önder

“…On the other hand, although the white blood cell count, mean corpuscular volume and mean corpuscular hemoglobin of the chicks and the lymphocyte percentage of the adult were lower. Ihe red blood cell count of the chicks was higher amount when compared to the same values of young partridges. …”
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STING agonist-based treatment promotes vascular normalization and tertiary lymphoid structure formation in the therapeutic melanoma microenvironment by Walter J Storkus, Ronald J Fecek, Manoj Chelvanambi, Jennifer L Taylor

“…Enhancement of tumor infiltrating lymphocyte (TIL) is a critical element of efficacious therapy and one that may be achieved via administration of agents that promote tumor vascular normalization (VN) and/or induce the development of tertiary lymphoid structures (TLS) within the tumor microenvironment (TME).Methods Low-dose stimulator of interferon genes (STING) agonist ADU S-100 (5 µg/mouse) was delivered intratumorally to established subcutaneous B16.F10 melanomas on days 10, 14 and 17 post-tumor inoculation. …”
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hCTLA4-Gene-Modified Human Bone Marrow-Derived Mesenchymal Stem Cells (hBMMSCs) Maintain POSTN Secretion to Enhance the Migration Capability of Allogeneic hBMMSCs through the Integ... by Lei Song, Fei Zhang, Rui Zhou, Jun Xiao, Lei He, Fei Dai

“…Cytotoxic T-lymphocyte-associated protein 4- (CTLA4-) modified human bone marrow-derived mesenchymal stem cells (hBMMSCs) might be promising seed cells for bone tissue engineering. …”
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Changes in Techno-Functional Characteristics of Cow Colostrum Powder Prepared by Freeze Drying by Anamika Das, Raman Seth, Ayon Tarafdar, Swarnima Dey, Yogesh Kumar, Ranjna Sirohi

“…BCWP exhibited lower phagocytic activity as well as lymphocyte proliferation index as compared to BSCP which was carried out in vitro. …”
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Multidimension Analysis of the Prognostic Value, Immune Regulatory Function, and ceRNA Network of LY6E in Individuals with Colorectal Cancer by Ting Li, Weidong Liu, Chun Wang, Man Wang, Wenjia Hui, Jiajie Lu, Feng Gao

“…Background. Lymphocyte antigen 6 complex, locus E (LY6E) is abnormally expressed in several cancers and is associated with poor outcomes. …”
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The Effectiveness of Rapamycin Combined with Eltrombopag in Murine Models of Immune-Mediated Bone Marrow Failure by Shaoxue Ding, Xiaowei Liang, Tian Zhang, Rong Fu

“…In this study, an immune attack-mediated AA mouse model was constructed by total body irradiation (TBI) and allo-lymphocyte infusion. In our study, we tested the efficacy of Rapa combined with Elt as a new treatment in mouse models of immune-mediated bone marrow failure. …”
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Combining systemic inflammation biomarkers with traditional prognostic factors to predict surgical site infections in elderly hip fracture patients: a risk factor analysis and dyna... by Yuhui Guo, Chengsi Li, Haichuan Guo, Peiyuan Wang, Xuebin Zhang

“…Multivariable analysis identified traditional prognostic factors older age (OR = 1.08, 95% CI 1.04–1.12), ASA class III-IV (OR = 2.46, 95% CI 1.32–4.56), surgical delay ≥ 6 days (OR = 3.59, 95% CI 1.36–9.47), surgical duration > 180 min (OR = 2.72, 95% CI 1.17–6.35), and systemic inflammation biomarkers Platelet-to-lymphocyte ratio (PAR) ≥ 6.6 (OR = 2.25, 95% CI 1.17–4.33) and Systemic Immune-Inflammation Index (SII) ≥ 541.1 (OR = 2.24, 95% CI 1.14–4.40) as independent predictors of SSI. …”
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Low Systemic Inflammation Response Index Predicts Good Prognosis in Locally Advanced Pancreatic Carcinoma Patients Treated with Concurrent Chemoradiotherapy by Erkan Topkan, Huseyin Mertsoylu, Ahmet Kucuk, Ali Ayberk Besen, Ahmet Sezer, Duygu Sezen, Yasemin Bolukbasi, Ugur Selek, Berrin Pehlivan

“…The SIRI was defined as: SIRI=neutrophil×monocyte/lymphocyte counts. Ideal SIRI cutoff(s) influencing overall survival (OS) and progression-free survival (PFS) results were sought by using receiver operating characteristic (ROC) curve analysis. …”
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Relationship of monocyte to high-density lipoprotein ratio (MHR) and other inflammatory biomarkers with sarcopenia: a population-based study by Zhiwei Xue, Jian Cao, Jianhui Mou, Rui Wang, Peng Liu

“…Abstract Objectives In previous studies, several inflammatory biomarkers derived from complete blood cell counts (CBC), such as systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and non‑high‑density lipoprotein cholesterol to high‑density lipoprotein cholesterol ratio (NHHR) have been identified as predictors of sarcopenia. …”
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Unsupervised machine learning clustering approach for hospitalized COVID-19 pneumonia patients by Nuttinan Nalinthasnai, Ratchainant Thammasudjarit, Tanapat Tassaneyasin, Dararat Eksombatchai, Somnuek Sungkanuparph, Viboon Boonsarngsuk, Yuda Sutherasan, Detajin Junhasavasdikul, Pongdhep Theerawit, Tananchai Petnak

“…Cluster 3 (N = 141) was characterized by older age, diabetes mellitus, higher chest x-ray scores, more severe vital signs, higher creatinine levels, lower hemoglobin levels, lower lymphocyte counts, higher C-reactive protein, higher D-dimer, and higher LDH levels. …”
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Invasive fungal diseases in patients with autoimmune diseases: a case series from the French RESSIF network by Vincent Poindron, Benjamin Terrier, François Maillot, Jean-Pierre Gangneux, Nassim Kamar, Valéry Salle, Lilia Hasseine, François Danion, Lilia Merabet, Guillaume Desoubeaux, Éric Bailly, Milène Sasso, Antoine Néel, Simon Galmiche, Benjamin Thoreau, Stéphane Bretagne, Alexandre Alanio, André Paugam, Valérie Letscher-Bru, Sophie Cassaing, Hélène Guegan, Loïc Favennec, Alida Minoza, Florent Morio, Julie Bonhomme, Odile Eloy, Laurence Millon, Anne-Pauline Bellanger, Philippe Poirier, Maxime Moniot, Taieb Chouaki, Antoine Huguenin, Frédéric Dalle, Bernard Bouteille, Muriel Nicolas, Nicole Desbois-Nogard, Marie-Elisabeth Bougnoux, Karine Boukris-Sitbon, Fanny Lanternier, Caroline Mahinc, Marc Pihet, Magalie Demar, Céline Damiani, Marie-Fleur Durieux, Elena Charpentier, Cécile Nourrisson, Benoit Suzon

“…We studied association of AID-specific treatments with 30-day mortality. We analysed total lymphocyte and CD4-T cell counts in patients with Pneumocystis jirovecii pneumonia (PCP).Results From 2012 to 2018, 549 individuals with IFD and AID were included, mainly with PCP (n=227, 41.3%), fungemia (n=167, 30.4%) and invasive aspergillosis (n=84, 15.5%). …”
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Hyperglycemia and Correlated High Levels of Inflammation Have a Positive Relationship with the Severity of Coronavirus Disease 2019 by Wen Zhang, Chuanwei Li, Yu Xu, Binfeng He, Mingdong Hu, Guoqiang Cao, Li Li, Shuang Wu, Xia Wang, Chun Zhang, Jianping Zhao, Jungang Xie, Zihui Xu, Qi Li, Guansong Wang

“…Compared with patients without diabetes (n=366), patients with diabetes (n=95) had a higher leucocyte count, neutrophil count, neutrophil to lymphocyte ratio (NLR), and erythrocyte sedimentation rate (ESR). …”
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INBRX-120, a CD8α-targeted detuned IL-2 that selectively expands and activates tumoricidal effector cells for safe and durable in vivo responses by Jason Ho, Chelsie Macedo, Garrett Cyprus, Rajay Pandit, Anya Polovina, Nadja Kern, Abrahim Hussain, Sae Jeong Ahn, William Crago, Emily Rowell, Florian J Sulzmaier, John C Timmer, Brendan P Eckelman

“…Background As a major driver of lymphocyte proliferation and activation interleukin 2 (IL-2) is a crucial mediator for antitumor responses. …”
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Comprehensive Sepsis Risk Prediction in Leukemia Using a Random Forest Model and Restricted Cubic Spline Analysis by Kou Y, Tian Y, Ha Y, Wang S, Sun X, Lv S, Luo B, Yang Y, Qin L

“…Key predictors of sepsis identified by SHAP analysis included C-reactive protein (CRP), procalcitonin (PCT), neutrophil count (Neut), lymphocyte count (Lymph), thrombin time (TT), red blood cell count (RBC), total bile acid (TBA), and systolic blood pressure (SBP). …”
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Prolonged ICU Stay in Severe and Critically-Ill COVID-19 Patients Who Received Convalescent Plasma Therapy by Bambang Pujo Semedi, Nadya Noor Ramadhania, Betty Agustina Tambunan, Siprianus Ugroseno Yudho Bintoro, Soedarsono Soedarsono, Cita Rosita Sigit Prakoeswa

“…Factors that confounded mortality were obesity (aOR = 14.1; 95% CI (1.25, 166.7); p=0.032), mechanical ventilation (aOR = 333; 95% CI (4.5,1,000); p<0.001), higher neutrophil-to-lymphocyte ratio (NLR) (aOR = 7.32; 95% CI (1.82, 29.4); p=0.005), and lower P/F ratio (aOR = 7.70; 95% CI (2.04, 29.4); p=0.003). …”
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Quantifying the tumour vasculature environment from CD-31 immunohistochemistry images of breast cancer using deep learning based semantic segmentation by Tristan Whitmarsh, Wei Cope, Julia Carmona-Bozo, Roido Manavaki, Stephen-John Sammut, Ramona Woitek, Elena Provenzano, Emma L. Brown, Sarah E. Bohndiek, Ferdia A. Gallagher, Carlos Caldas, Fiona J. Gilbert, Florian Markowetz

“…The model also segments the vascular smooth muscle, benign epithelium, adipose tissue, stroma, lymphocyte clusters, nerves and CD-31 positive leukocytes, and we applied it to an additional 21 images from 15 patients. …”
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Ly6E on tumor cells impairs anti-tumor T-cell responses: a novel mechanism of tumor-induced immune exclusion by Lan Hailin, Chen Yiting, Wu Yue, Li Lijun, Zhang Renlu, Chen Yunhan, Zhu Yanyang, Zhang Qiuyu

“…Abstract Background Lymphocyte antigen 6 complex, locus E (Ly6E) has been initially demonstrated to involve in T cell activity and impair viral infectivity. …”
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Solid Self-Microemulsifying Drug Delivery System for Improved Oral Bioavailability of Relugolix: Preparation and Evaluation by Li ZL, Deng GX, Fang CZ, Zhao YQ, Yuan J, Chen L, Zhong HJ, Guo F

“…The optimized RLGL-S-SMEDDS were evaluated in terms of particle size, zeta potential, morphology analysis, thermodynamic stability, drug release, flow properties, transporter pathways in Caco-2 cells, the influence of excipients on the intestinal transporters, transport within Caco-2 cell monolayers and transport in lymphocyte. In vivo pharmacokinetic study and toxicological study were also conducted.Results: The optimum formulation for self-microemulsifying drug delivery system (SMEDDS) consists of Ethyl Oleate (26% of the weight), Solutol HS15 (49% of the weight), Transcutol HP (25% of the weight) and loaded relugolix (4.8 mg/g). …”
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The evolving landscape of COVID-19: factors associated with in-hospital COVID-19 related mortality during the 2023–2024 phase of JN.1 subvariant dominance by Drieda Zaçe, Albiana Çekrezi, Christopher Jones, Ludovica Ferrari, Giuseppe De Simone, Elisabetta Teti, Vincenzo Malagnino, Marco Iannetta, Loredana Sarmati, Anna Maria Geretti

“…Baseline factors associated with mortality were neutrophil-lymphocyte ratio > 8, D-dimer ≥ 1800 ng/mL, procalcitonin ≥ 1.0 ng/mL, and albumin < 3.2 g/dL; during admission, nasopharyngeal SARS-CoV-2 antigen positivity persisting for > 12 days, hospitalisation for ≥ 10 days, higher oxygen requirements with the resulting corticosteroid use, and healthcare-associated bacteraemia were associated with increased odds of mortality. …”
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