Statin-Associated Necrotizing Autoimmune Myositis Complicated by an Uncommon Adverse Effect to Treatment by Brian M. Fung, Emil R. Heinze, Andrew L. Wong

“…Statin-associated necrotizing autoimmune myositis (NAM) is an autoimmune condition characterized by severe acute-onset proximal muscle weakness, a very high creatinine kinase (CK) level, and prominent myofiber necrosis and minimal lymphocytic infiltration on muscle biopsy. Unlike self-limited statin myopathy, this condition usually requires aggressive immunomodulation therapy to assist recovery and prevent future disability. …”
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Is There a Correlation between New Scoring Systems and Systemic Inflammation in Stable Bronchiectasis? by Hikmet Coban, Adil Can Gungen

“…The correlations between mean scores and CRP levels, leukocyte count, and neutrophil/lymphocyte ratio were investigated. Findings. Mean BSI and FACED scores were 7.2 ± 5.2 and 2.1 ± 1.8, respectively. …”
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Case Report: Atypical post-COVID Cogan's syndrome [version 2; peer review: 2 approved] by Sayhi Sameh, Chaima Zitouni, Mayssa Bouzidi, Wafa Sleimi, Sameh Mezri

“…One month later, she presented with lymphocytic meningitis and high intracranial pressure, which improved under treatment. …”
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A Man with an Umbilicated Papule of the Hand: What Is Your Diagnosis? by Deba P. Sarma, Meredith Cox, Paige Walter, William Crisler, Christopher Huerter

“…Marked edema, capillary proliferation and extensive lymphocytic infiltration was also present. One red intranuclear inclusion was identified in an epidermal keratinocyte. …”
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Human Brain Microvascular Endothelial Cells and Umbilical Vein Endothelial Cells Differentially Facilitate Leukocyte Recruitment and Utilize Chemokines for T Cell Migration by Shumei Man, Eroboghene E. Ubogu, Katherine A. Williams, Barbara Tucky, Melissa K. Callahan, Richard M. Ransohoff

“…Only THBMECs utilized abluminal CCL5 to facilitate T-lymphocyte migration in vitro although both THBMECs and HUVECs employed CCL3 to facilitate T cell migration. …”
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A Case of Chemotherapy-Refractory “THRLBCL like Transformation of NLPHL” Successfully Treated with Lenalidomide by Mamatha Siricilla, Lydia Irwin, Andres Ferber

“…Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a subtype of nonclassical Hodgkin lymphoma (HL). …”
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MicroRNAs as Haematopoiesis Regulators by Ram Babu Undi, Ravinder Kandi, Ravi Kumar Gutti

“…Aberrant expression of miRNAs was observed in hematological malignancies including chronic myelogenous leukemia, chronic lymphocytic leukemia, multiple myelomas, and B cell lymphomas. …”
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Deep and Machine Learning for Acute Lymphoblastic Leukemia Diagnosis: A Comprehensive Review by Mohammad Faiz, Bakkanarappa Gari Mounika, Mohd Akbar, Swapnita Srivastava

“…The medical condition known as acute lymphoblastic leukemia (ALL) is characterized by an excess of immature lymphocyte production, and it can affect people across all age ranges. …”
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Thrombin Cleavage of Osteopontin Modulates Its Activities in Human Cells In Vitro and Mouse Experimental Autoimmune Encephalomyelitis In Vivo by Elena Boggio, Chiara Dianzani, Casimiro Luca Gigliotti, Maria Felicia Soluri, Nausicaa Clemente, Giuseppe Cappellano, Erika Toth, Davide Raineri, Benedetta Ferrara, Cristoforo Comi, Umberto Dianzani, Annalisa Chiocchetti

“…Interestingly, thrombin cleavage of osteopontin unmasks a cryptic domain of interaction with α4β1 integrin that is the main adhesion molecule involved in lymphocyte transmigration to the brain and is the target for natalizumab, the most potent drug preventing relapses. …”
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Helicobacter pylori and T Helper Cells: Mechanisms of Immune Escape and Tolerance by Tiziana Larussa, Isabella Leone, Evelina Suraci, Maria Imeneo, Francesco Luzza

“…In this review we discuss the current findings underlying the mechanisms implemented by H. pylori to alter the T helper lymphocyte proliferation, thus facilitating the development of chronic infections and allowing the survival of the bacterium in the human host.…”
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Is the BCG Vaccine Safe for Undernourished Individuals? by Larissa Lumi Watanabe Ishikawa, Larissa Camargo da Rosa, Thais Graziela Donegá França, Raphael Sanches Peres, Fernanda Chiuso-Minicucci, Sofia Fernanda Gonçalves Zorzella-Pezavento, Alexandrina Sartori

“…These animals received 70% of the amount of food consumed by the healthy control group and exhibited physiological alterations compatible with malnutrition, including body weight loss, reduced levels of triglycerides and glucose, and reduced lymphocyte numbers. Undernourished mice were immunized with BCG, and the mycobacterial loads in lymph nodes, spleen, liver, lungs, and thymus were determined. …”
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An Unusual Initial Presentation of Lupus Nephritis as a Renal Mass by Remi Goupil, Annie-Claire Nadeau-Fredette, Virginie Royal, Alexandre Dugas, Jean-Philippe Lafrance

“…The mass effect was apparently due to a dense interstitial lymphocytic infiltrate resulting in a pseudotumor. Further investigation revealed microscopic hematuria with a normal kidney function and no significant proteinuria. …”
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A Case of Immunotherapy-Induced Colitis Complicated by Perforation and Treated with Infliximab Postoperatively by Lukas Delasos, Aakash Desai, Nerea Lopetegui Lia, Nikhila Kethireddy, Carolyn Ray

“…Severe colitis has been reported in approximately 5% of patients treated with cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) inhibitors, such as ipilimumab. …”
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Varicella zoster virus triggering Henoch–Schonlein Purpura in an adult: A case report by Kevin Chung, Natasha Priya Dyal, Sandhya Nagarakanti

“…CSF testing showed lymphocytic pleocytosis and elevated protein levels, and PCR testing confirmed varicella zoster virus (VZV) infection. …”
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The Effects of Forodesine in Murine and Human Multiple Myeloma Cells by Liesbeth Bieghs, Jo Caers, Elke De Bruyne, Els Van Valckenborgh, Fiona Higginbotham, Karin Vanderkerken, Eline Menu

“…Recently forodesine, a purine nucleoside phosphorylase inhibitor, was found to induce apoptosis in leukemic cells of chronic lymphocytic leukemia patients by increasing the dGTP levels. …”
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Deep visual proteomics reveals DNA replication stress as a hallmark of signet ring cell carcinoma by Sonja Kabatnik, Xiang Zheng, Georgios Pappas, Sophia Steigerwald, Matthew P. Padula, Matthias Mann

“…Additionally, we observed substantial enrichment of immune-related proteins, reflecting high levels of cytotoxic T lymphocyte infiltration and elevated PD-1 expression. …”
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Utility of [18F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Scan in Inflammatory Myopathies: Case Report and Literature Review by Juan Pablo Rivas-de Noriega, Javier Andrés Galnares-Olalde, Javier Zúñiga-Varga, Juan Pablo Herrera-Félix, Marco Antonio Alegría-Loyola, Alonso Turrent-Carriles

“…A biopsy was performed revealing lymphocytic predominant infiltrates and myonecrosis. …”
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Biomarkers in metastatic castration-resistant prostate cancer for efficiency of immune checkpoint inhibitors by Zixi Wu, Junbiao Zhang, Le Li, Zhihua Wang, Chunguang Yang

“…However, while immune checkpoint inhibitor monotherapy or combination therapy targeting cytotoxic T lymphocyte antigen 4 (CTLA-4) and/or programmed cell death-1 (PD-1)/PD-1 ligand 1 (PD-L1) axis has been regarded as the standard therapy in many solid tumours, mCRPC as ‘cold’ tumours are considered to be relatively resistant to ICB treatment. …”
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Deep Neck Infections: The Effectiveness of Therapeutic Management and Bacteriological Profile by Geanina Bandol, Mihail Dan Cobzeanu, Mihaela Moscalu, Octavian Dragos Palade, Liliana Moisii, Florentina Severin, Emilia Patrascanu, Florin Mocanu, Andrei Ionut Roman, Bogdan Mihail Cobzeanu

“…<i>Results</i>: Reduced lymphocyte percentages and increased neutrophil-to-lymphocyte ratios (NLRs) were significantly associated with complications (<i>p</i> < 0.001 and <i>p</i> = 0.0041, respectively). …”
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Predictive Immunological, Virological, and Routine Laboratory Markers for Critical COVID-19 on Admission by Mercedes García-Gasalla, Juana M. Ferrer, Pablo A. Fraile-Ribot, Adrián Ferre-Beltrán, Adrián Rodríguez, Natalia Martínez-Pomar, Luisa Ramon-Clar, Amanda Iglesias, Inés Losada-López, Francisco Fanjul, Joan Albert Pou, Isabel Llompart-Alabern, Nuria Toledo, Jaime Pons, Antonio Oliver, Melchor Riera, Javier Murillas

“…Blood tests to measure neutrophil/lymphocyte ratio (NLR) and levels of ferritin, CRP, D-dimer, complement components (C3 and C4), cytokines, and lymphocyte subsets, as well as SARS-Cov-2 RT-PCR tests, were performed in COVID-19-confirmed cases within 48 hours of admission. …”
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