LFA-1: A potential key player in microglia-mediated neuroprotection against oxygen-glucose deprivation in vitro. by Robin Jansen, Marc Pawlitzki, Michael Gliem, Sven G Meuth, Stefanie Schreiber, Michael-W Görtler, Jens Neumann

“…Our present study reveals the relevance of a β2 integrin, lymphocyte function-associated antigen-1 (LFA-1), as a potential key player in protecting neuronal cell death after oxygen-glucose deprivation in organotypic hippocampal cell cultures. …”
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Differential diagnosis of hypertrophic pachymeningitis: literature review by G. Makarevičius, J. Grigaitė, M. Jokubaitis, A. Klimašauskienė

“…Idiopathic HP can be only diagnosed when secondary causes of HP are ruled out and dural biopsy confirms that there are only unspecific findings: lymphocytic-plasmacytic infiltration and fibrosis. In this article, we review the literature regarding HP and discuss clinical and radiological features of both, idiopathic and secondary HP, and their differential diagnosis. …”
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Distinguishable Immunologic Characteristics of COVID-19 Patients with Comorbid Type 2 Diabetes Compared with Nondiabetic Individuals by Ruxing Zhao, Yujing Sun, Yongyuan Zhang, Weili Wang, Shouyu Wang, Chuang Wang, Jinbo Liu, Ling Gao, Zhao Hu, Jianchun Fei, Xinguo Hou, Huizhen Zheng, Li Chen

“…An abnormal increase in neutrophil count and a decrease in lymphocyte subpopulations may represent risk factors of COVID-19 severity. …”
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Reinforcing cancer immunotherapy with engineered porous hollow mycobacterium tuberculosis loaded with tumor neoantigens by Jie Jiang, Feng-Ying Huang, Shu-Zhen Dai, Guang-Hong Tan, Ming-Hui Chen, Hengyu Chen, Wu-Ping Zheng, Ri-Hong Wu, Weijing Xie

“…Vaccines formulated with phMTb facilitated DC maturation, activation, cross-presentation of tumor neoantigens, and promoted migration of phMTb-laden DCs to lymph nodes, enhancing effector and memory CD8+ T lymphocyte function. In murine tumor models, immunization with phMTb-formulated neoantigen vaccines elicited a robust tumor-specific cytotoxic T lymphocyte immune response with minimal adverse effects. …”
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Mitoxantrone Therapy for Acute Posterior Multifocal Placoid Pigment Epitheliopathy with Cerebral Vasculitis by Hélène Massé, Jean-Laurent Guyomard, Dominique Baudet, Jean-François Pinel, Gilles Edan, Jean-François Charlin

“…A relapse of APMPPE was diagnosed, complicated with lymphocytic meningitis and cerebral ischemia. Intravenous therapy with mitoxantrone was performed in combination with methylprednisolone. …”
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Mediators of Inflammation in Topical Therapy of Skin Cancers by Vlad Mihai Voiculescu, Cristina Victoria Lisievici, Mihai Lupu, Cristina Vajaitu, Carmen Cristina Draghici, Alexandra Victoria Popa, Iulia Solomon, Teona Ioana Sebe, Maria Magdalena Constantin, Constantin Caruntu

“…Currently, various associations have shown a superior success rate than monotherapy, such as systemic acitretin and topical IMQ, topical 5-FU with tretinoin cream, or IMQ with checkpoint inhibitor cytotoxic T lymphocyte antigen 4. Novel therapies targeting Toll-like receptor-7 (TLR-7) with higher selectivity than IMQ are also of great interest.…”
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Investigation of Viral, Bacterial and Parasitic Zoonotic Diseases in Rodents in Turkey by Mehmet Ozkan Timurkan, Esin Guven, Seyda Cengiz, Hakan Aydın, Ridvan Kirman, Hamza Avcioglu

“…Objectives The aim of this study was to investigate the presence of viral lymphocytic choriomeningitis and hantavirus infections, bacterial tularaemia and leptospirosis, and parasitic leishmaniasis and toxoplasmosis in rodents that are likely to carry and spread zoonotic agents, by using molecular methods. …”
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A Subgroup of First-Degree Relatives of Crohn's Disease Patients Shows a Profile of Inflammatory Markers in the Blood Which Is More Typical of Crohn's Disease Patients Than of Norm... by Broide Efrat, Goren Iris, Hongbin Wang, Scapa Eitan, Keisari Yona

“…All hematological parameters were significantly different in CD patients compared to controls, with significantly higher levels of CRP, WBC, PMN, MONO, and PLT and lower Hb and lymphocyte count. The hematological profile of FDRs showed values between the controls and CD patients with ten FDRs that their parameters matched those of CD patients and significantly different from other FDRs. …”
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Combination Immunotherapy with 4-1BBL and CTLA-4 Blockade for the Treatment of Prostate Cancer by Kuang Youlin, Zhang Li, Weng Xiaodong, Liu Xiuheng, Zhu Hengchen

“…Interruption of immune regulatory pathways via activation of 4-1BB or cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) blockade appears to be a promising strategy for cancer immunotherapy. …”
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Irinotecan Plus S-1 Followed by Hepatectomy for a Patient with Initially Unresectable Colorectal Liver Metastases, Who Showed Severe Drug Rash with Oxaliplatin Plus 5-FU and Leucov... by Hiroyuki Komori, Toru Beppu, Yasuo Sakamoto, Yuji Miyamoto, Hiromitsu Hayashi, Katsunori Imai, Hidetoshi Nitta, Masayuki Watanabe, Hideo Baba

“…Although she reported no prior history of adverse reactions to tegafur-uracil, a drug lymphocyte stimulation test showed an allergic response to 5-FU. …”
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Infiltration of the liver by cells of innate and adaptive immunity and their destruction in development of experimental immune concanavalin-A-induced hepatitis by S. I. Pavlovich, T. M. Bryzgina, N. V. Makogon, L. I. Aleksyuk, T. V. Martynova, R. I. Yanchy, I. N. Alekseyeva

“…Infiltration by leukocytes in the liver was increased, initially essentially grew neutrophilic, and then - lymphocytic. In the early terms after ConA injection destruction of thymic cells was amplified mainly by apoptotic pathway, and spleen cells – by necrotic pathway.Conclusions. …”
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Human Herpesvirus 6 is Associated with Status Epilepticus and Hyponatremia after Umbilical Cord Blood Transplantation by Fernanda Leite de Souza Franceschi, Jaime Green, Zuzan Cayci, Evan Mariash, Mustapha Ezzeddine, Veronika Bachanova, Celalettin Ustun

“…The authors report a case involving a 65-year-old man with nonconvulsive status epilepticus 34 days after umbilical cord blood transplantion for chronic lymphocytic leukemia. Cerebrospinal fluid and serum were positive for human herpesvirus 6 (HHV6). …”
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Tumor cells escape immunosurveillance by hampering LFA-1 by Shishir Upadhyay, Lewis Murugu, Lena Svensson, Lena Svensson

“…Integral to this process is the integrin Lymphocyte Function-Associated Antigen 1 (LFA-1). LFA-1 facilitates adhesion during leukocyte migration and helps establish stable cell-to-cell contacts between leukocytes and their targets. …”
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High-resolution mapping of cell cycle dynamics during steady-state T cell development and regeneration in vivo by Heike Kunze-Schumacher, Nikita A. Verheyden, Zoe Grewers, Michael Meyer-Hermann, Victor Greiff, Philippe A. Robert, Andreas Krueger

“…Summary: Control of cell proliferation is critical for the lymphocyte life cycle. However, little is known about how stage-specific alterations in cell cycle behavior drive proliferation dynamics during T cell development. …”
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Inflammatory Markers and Severity in COVID-19 Patients with Clostridioides Difficile Co-Infection: A Retrospective Analysis Including Subgroups with Diabetes, Cancer, and Elderly by Teodor Cerbulescu, Flavia Ignuta, Uma Shailendri Rayudu, Maliha Afra, Ovidiu Rosca, Adrian Vlad, Stana Loredana

“…We collected baseline demographics, comorbidities, and laboratory parameters including C-reactive protein (CRP), Interleukin-6 (IL-6), ferritin, neutrophil and lymphocyte counts, albumin, platelet counts, and calculated indices (C-reactive protein to Albumin Ratio (CAR), Neutrophil-to-Lymphocyte Ratio (NLR), Prognostic Nutritional Index (PNI), SII). …”
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Evaluation of a Telemedicine System for the Transmission of Morpho/Immunological Data Aiming at the Inclusion of Patients in a Therapeutic Trial by Jean-François Lesesve, Richard Garand

“…We present one of the first approaches of the use of telehaematology for the inclusion of patients in the GOELAMS chronic lymphocytic leukaemia 98 trial. The advantages were (1) the creation of a unique, protected, stable data bank that could be remotely consulted, (2) the use of digitized pictures which made expertise on identical documents possible, (3) the facility of computer exchanges between experts, in terms of reception as well as replying time delays. …”
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Penile Livedoid Vasculopathy: First Reported Case by Ahmad Hallak, William Bennett, Mohammed Adib Tanbir, Supriya R. Donthamsetty, Bethaney Vincent

“…Due to diagnostic uncertainty, a biopsy was performed which revealed hyaline thrombi within the lumens of small vessels within the upper to mid dermis, fibrinoid material in the walls of these blood vessels and within the perivascular stroma with overlying and adjacent epidermal spongiosis, and mild perivascular lymphocytic infiltrate with a few scattered neutrophils most consistent with livedoid vasculitis. …”
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Hyper IgG4-Related Disease Presenting with Orbital Tumor and Immune Deficiency by Caroline G. Olson, Nancy Y. Olson

“…Orbital mass biopsy showed polyclonal lymphocytic infiltration and increased IgG4 plasma cells. …”
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Immune response in virus model structured by cell infection-age by Cameron Browne

“…This paper concerns modeling the coupled within-host population dynamics of virus and CTL (Cytotoxic T Lymphocyte) immune response. There is substantial evidence that the CTL immune response plays a crucial role in controlling HIV in infected patients. …”
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A review on the potential of Bruton’s tyrosine kinase (Btk) inhibitor – Ibrutinib for treatment of Multiple Myeloma (MM) by Sze-Ting Bong, Lydia Ngiik-Shiew Law, Jodi Woan-Fei Law

“…Ibrutinib is a highly selective irreversible Btk inhibitor commonly used as treatment for B-cell malignancies such as Mantle Cell Lymphoma (MCL) and Chronic Lymphocytic Leukemia (CLL). With reference to the potential involvement of Btk in MM and current treatment of MCL and CLL using ibrutinib, researchers have begun to examine the effect of ibrutinib treatment on MM. …”
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