Asthma in Children and Adults: A Shared Biological and Molecular Basis by Paolo M Renzi

“…Signs of cellular activation and increased production of lymphokines of the type 2 helper T lymphocyte, which can increase IgE levels and affect eosinophils, are also found in every age group. …”
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The mcpC mutant of Salmonella enteritidis exhibits attenuation and confers both immunogenicity and protective efficacy in mice by Lu Zhang, Li Chen, Xuqiang Zhang, Yang Li, Qingfeng Zheng, Yun Li, Ning Li, Qiumei Shi, Yanying Zhang, Tonglei Wu

“…Immunization with ΔmcpC induced the production of specific IgG and SIgA antibodies, enhanced lymphocyte proliferation, upregulated cytokine expression, and achieved a 100% survival rate in immunized mice. …”
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Development and validation of a nomogram for predicting immune-mediated colitis in lung cancer patients treated with immune checkpoint inhibitors: a retrospective cohort study in C... by Qianjie Xu, Xiaosheng Li, Yuliang Yuan, Guangzhong Liang, Zuhai Hu, Wei Zhang, Ying Wang, Haike Lei

“…Conversely, a higher white blood cell (WBC) count, CD4/CD8 ratio, and platelet−lymphocyte ratio (PLR) were identified as factors associated with a reduced risk of IMC development (all P < 0.05). …”
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Impact of White Blood Cell Count After Percutaneous Coronary Intervention on Long-Term Prognosis in Patients with Unstable Angina Pectoris: A Single-Center Retrospective Observatio... by Zhang Z, Wang H, Wang R, She Z, Liang X, Liu H, Kou X, Wang S

“…The Kaplan–Meier method and COX proportional regression model were used to evaluate the association between the incidence of 5-year endpoint events and post-PCI leukocytosis.Results: Leukocytosis and neutrocytosis within 24 hours after PCI were observed in majority of patients with UA, while lymphocyte count significantly decreased after PCI in those patients. …”
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Clinical Features of COVID‐19 Associated Pulmonary Aspergillosis: A Multicenter, Retrospective Study by Yasheng Zhan, Guojun He, Cheng Zhong, Yake Yao, Jiangying Zhou, Tong Li, Hua Zhou

“…All seven patients were diagnosed with CAPA without neutropenia, four with lymphopenia, seven with decreased CD4+ T lymphocyte, and five with decreased CD8+ T lymphocyte. …”
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Late Onset Combined Immunodeficiency Presenting with Recurrent Pneumocystis jiroveci Pneumonia by Ilias Papakonstantinou, Ioannis G. Baraboutis, Lazaros Karnesis

“…Late onset combined immunodeficiency (LOCID) is a recently described variant of common variable immunodeficiency (CVID), involving adult patients presenting with opportunistic infections and/or low CD4+ lymphocyte counts. A 36-year-old male with unremarkable past medical history presented with fever, respiratory failure, and lymphocytopenia. …”
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The mitochondria as an emerging target of self-renewal in T-cell acute lymphoblastic leukemia by Majd A. Al-Hamaly, Evelyn Winter, Jessica S. Blackburn

“…Acute lymphocytic leukemia (ALL) is the most common leukemia in children, with the T-cell subtype (T-ALL) accounting for 15% of those cases. …”
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Hepatic Lamp2a deficiency promotes inflammation of murine autoimmune cholangitis via affecting bile acid metabolism by Qingling Fan, Guanya Guo, Yinan Hu, Yi Lu, Rui Su, Jiaqi Yang, Erzhuo Xia, Shuoyi Ma, Miao Zhang, Jingbo Wang, Ting Li, Ying Han

“…Mechanistically, the loss of Lamp2a in hepatocytes contributed to the abnormal accumulation of Acot8, thus altered the bile acid components, thereby enhancing the lymphocyte activities, and ultimately promoting the inflammatory phenotype of model mice. …”
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Beneficial effects of baicalein on a model of allergic rhinitis by Liu Tao, Xu Jing, Wu Yungang, Li Xiaoxia, Ding Detao, Ma Dengdian, Yao Mengwei, Wei Wenzhong, Zhang Wei, Wang Shaohua, Yao Jing, Li Xiaoyu

“…Infiltrations of eosinophils, lymphocyte, and neutrophils were decreased in baicalein-administered rats. …”
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Immunomodulatory Effects of Tigecycline in Balb/C Mice by Elhayek Shada Y., Fararjeh Mohammad A., Assaf Areej M., Abu-Rish Eman Y., Bustanji Yasser

“…It was found that tigecycline enhanced lymphocyte proliferation and significantly increased cellular infiltration within the footpad, as based on DTH testing, but reduced the hemagglutination titer. …”
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Severe Combined Immunodeficiency Disorder due to a Novel Mutation in Recombination Activation Gene 2: About 2 Cases by Ibtihal Benhsaien, Fatima Ailal, Khadija Elazhary, Jalila El bakkouri, Abdallah Badou, Ahmed Aziz Bousfiha

“…The first case is a girl diagnosed with SCID at birth based on her family history and lymphocyte subpopulation typing. The second case is a 4-month-old boy with a history of recurrent opportunistic infections, BCGitis, and failure to thrive, and the immunology workup confirms a SCID phenotype. …”
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Myelodysplastic Syndrome with Transfusion Dependence Treated with Venetoclax by Waqas Jehangir, Alexander Karabachev, Taimoor Jahangir, Elvira Umyarova

“…Venetoclax, an inhibitor of the antiapoptotic protein BCL-2 used to treat chronic lymphocytic leukemia, is currently being evaluated in clinical trials as a monotherapy in high-risk myelodysplastic syndromes/acute myeloid leukemia. …”
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Unveiling immune resistance mechanisms in nasopharyngeal carcinoma and emerging targets for antitumor immune response: tertiary lymphoid structures by Huilin Wang, Yuting Zhan, Jiadi Luo, Weiyuan Wang, Songqing Fan

“…The presence of intense lymphocytic infiltration and elevated expression of programmed cell death ligand 1(PD-L1) in NPC highlights its potential for immunotherapy, yet current treatment outcomes remain suboptimal. …”
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Experimental and Density Functional Theory Characteristics of Ibrutinib, a Bruton’s Kinase Inhibitor Approved for Leukemia Treatment by Ali I. Ismail

“…Ibrutinib, a Bruton’s tyrosine kinase that plays an essential role in the B-cell development and cancer cells, has been recently approved to treat chronic, lymphocytic, and other types of leukemia. This study focused on investigating ibrutinib by its electronic transitions, vibrational frequencies, and electrospray mass spectra. …”
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Histopathology of Infectious Colitis by Christina M. Surawicz

“…In IBD, in contrast, crypt architecture is often abnormal nd the inflammatory infiltrate in the lamina propria in both acute and chronic, ie, polymorphonuclear cells, plasma cells ,and lymphocyte are present in increased numbers. Second, biopsy may give a clue to the specific infection. …”
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Correlation analysis of recurrent factors in borderline ovarian tumors undergoing fertility preservation surgery by Yichi Xie, Dandan Wang, Ningning Zhang, Qing Yang

“…The results of multivariate analysis showed that the pathological features of micro papillary structure, intra operative as cites, bilateral tumors, and the increased ratio of neu tro phil to lymphocyte before surgery are independent risk factors for the recurrence of borderline ovarian tumors.ConclusionThe prognosis of women of childbearing age with borderline ovarian tumors undergoing conservation function surgery is good. …”
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Immune Optimization as a Preventive and Therapeutic Adjunct for the Management of Renin–Angiotensin–Aldosterone System Dysfunction Diseases: A Review by Michael T. Okafor, Queenet C. Onyebuchukwu, Germaine A. Okafor, Samuel C. Niteh, Chikere A. Anusiem

“…We reviewed articles with keywords, such as Renin Angiotensin Aldosterone System, Immune-Mediated Inflammatory Diseases, Immune Dysfunction, T lymphocyte activation/dysfunction, cytokines, RAAS Dysfunction, RAAS blockers, therapeutic adjunct, and prevention. …”
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Research progress of HIF-1a on immunotherapy outcomes in immune vascular microenvironment by Shaoyan Shi, Xuehai Ou, Chao Liu, Hao Wen, Jiang Ke

“…HIF-1α regulates critical pathways, including the expression of vascular endothelial growth factor and immune checkpoint upregulation, leading to tumor-infiltrating lymphocyte dysfunction and recruitment of immunosuppressive cells like regulatory T cells and myeloid-derived suppressor cells. …”
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Diagnosis of feline infectious peritonitis by immunohistochemistry and histopathology methods: a case report based on diagnostic approach by Mehmet Burak Ateş, Gökhan Akçakavak, Zeynep Çelik, Özgür Özdemir

“…Microscopically, inflammatory cell infiltration and fibrin exudation, consisting mainly of macrophage, lymphocyte and plasma cells, were determined around small and medium-sized vessels in the tunica serosa layer of the intestines. …”
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Genetic Factors in Animal Models of Intestinal Inflammation by R Balfour Sartor

“…The dominant role of genetic background in induction of intestinal inflammation is further documented by spontaneous colitis which develops in spontaneously mutant mice, cotton-top tamarins, human leukocyte antigen-B27/ β2 microglobulin transgenic rats and mice with targeted deletions of certain immunoregulatory cytokine and T lymphocyte genes. Identification of the immunological mechanisms of host genetic susceptibility and the genetic basis of spontaneous colitis should provide new insights into the pathogenesis of human inflammatory bowel disease.…”
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