Characteristics of Hepatitis C Virus Infection in HIV-Infected People by Curtis L Cooper, Andrew D Badley, Jonathan B Angel

“…Plasma HCV RNA levels are higher in matched HIV-infected people than in HIV-seronegative control subjects and are inversely correlated with CD4+ T lymphocyte counts. HCV genotype does not appear to influence this value. …”
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The Transcribed-Ultraconserved Regions: A Novel Class of Long Noncoding RNAs Involved in Cancer Susceptibility by Paola Scaruffi

“…Most recent studies show that they are significantly altered in adult chronic lymphocytic leukemias, carcinomas, and pediatric neuroblastomas, leading to the hypothesis that UCRs may play a role in tumorigenesis and promising innovative future T-UCR—based therapeutic approaches.…”
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Role of Endoscopy in the Investigation of Upper Gastrointestinal Symptoms in HIV-Infected Patients by C Mel Wilcox

“…By tailoring the use of endoscopy to the presenting symptoms and CD4 lymphocyte count, the diagnostic benefit can be increased.…”
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Granulocytic Sarcoma by AML M4eo (inv16) after Allogeneic Stem Cell Transplantation without Bone Marrow Involvement by Stephan Zaenker, Stefan Schweyer, Justin Hasenkamp, Lorenz Truemper, Gerald Wulf

“…The patient underwent the withdrawal of immunosuppression, hysterectomy, and local irradiation at first relapse, as well as systemic chemotherapy and donor lymphocyte infusions at second recurrence, inducing a second and third complete remission, respectively. …”
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Subtle‐but‐smouldering myocardial injury after immune checkpoint inhibitor treatment accompanied by amyloid deposits by Mizuki Ida, Shiro Nakamori, Shinya Yamamoto, Seimi Watanabe, Kyoko Imanaka‐Yoshida, Masaki Ishida, Hajime Sakuma, Keiichi Yamanaka, Kaoru Dohi

“…However, histological examination revealed the deposition of transthyretin amyloid fibrils with only minimal T‐lymphocyte infiltration and no myocyte necrosis, suggesting transthyretin cardiac amyloidosis rather than ICI myocarditis. …”
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Dynamics of Graft Function Measured by DNA-Technology in a Patient with Severe Aplastic Anemia and Repeated Stem Cell Transplantation by Anna Karastaneva, Christian Urban, Herwig Lackner, Wolfgang Schwinger

“…A subsequent attempt to support the graft by antithymocyte globulin (ATG) and a peripheral stem cell boost resulted in transitory autologous recovery of hematopoiesis followed by mixed chimerism, supported by donor lymphocyte infusions (DLIs) and finally graft rejection with relapse of SAA. …”
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Nivolumab and Ipilimumab Combination Immunotherapy for Patients with Metastatic Collecting Duct Carcinoma by Tetsuya Danno, Shohei Iwata, Fusako Niimi, Sachi Honda, Haruka Okada, Takeshi Azuma

“…Recently, immune checkpoint inhibitors (ICI), anti-programmed death-1 (PD-1) antibody, and anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) antibody were approved for use against metastatic renal cell carcinoma. …”
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Crystal Structures of Tcl1 Family Oncoproteins and Their Conserved Surface Features by John M. Petock, Ivan Y. Torshin, Yuan-Fang Wang, Garrett C. Du Bois, Carlo M. Croce, Robert W. Harrison, Irene T. Weber

“…The sequences and crystal structures of three Tcl1 proteins were analyzed in order to understand their interactions with Akt/PKB and the implications for lymphocyte malignancies. Tcl1 proteins are ~15 kD and share 25—80% amino acid sequence identity. …”
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Hypoxanthine Derivatives in Experimental Infections by Claudio De Simone, Edoardo Arrigoni Martelli, Pietro Foresta, Giuseppe Famularo, Roberto Giacomelli, Emilio Jirillo, Vito Ruggiero, Giorgio Tonietti

“…In fact, only the treatment with ST 789 resulted in a clear enhancement of the primary antibody production as well as macrophage phagocytic activity, whereas T lymphocyte responsiveness to mitogens and both macrophage- and natural killer-dependent cytotoxicity were not significantly affected. …”
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Belatacept and regulatory T cells in transplantation: synergistic strategies for immune tolerance and graft survival by Gil-Ran Kim, Kyung-Ho Nam, Je-Min Choi

“…Belatacept, a modified version of cytotoxic T lymphocyte antigen-4 immunoglobulin with increased binding affinity for its ligand, has emerged as a viable alternative to traditional CNIs due to its lower toxicity profile. …”
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Towards the Application of Atorvastatin to Intensify Proapoptotic Potential of Conventional Antileukemic Agents In Vitro by Jolanta D. Żołnierczyk, Arleta Kaźmierczuk, Paweł Hikisz, Barbara Cebula-Obrzut, Ewa Wawrzyniak, Jerzy Z. Błoński, Małgorzata Misiewicz, Paweł Robak, Piotr Smolewski, Zofia M. Kiliańska

“…It has been previously revealed that statins used at high concentrations display antileukemic potential towards chronic lymphocytic leukemia (CLL) cells. However, their usage alone in clinical practice may be limited due to possible side effects of high doses of these drugs. …”
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Leptomeningeal Enhancement due to Neurosarcoidosis Mimicking Malignancy by Sahara N. Saltijeral, Horiana B. Grosu, Henriette De La Garza, Barbara O’Brien, Gloria Iliescu

“…The cerebrospinal fluid analyses demonstrated lymphocytic pleocytosis, hypoglycorrhachia, and hyperproteinorrachia but no other abnormalities. …”
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T Cell Costimulatory Molecules in Anti-Viral Immunity: Potential Role in Immunotherapeutic Vaccines by Tania H Watts, Edward M Bertram, Jacob Bukczynski, Tao Wen

“…T lymphocyte activation is required to eliminate or control intracellular viruses. …”
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Peripheral blood immunoinflammatory biomarkers: prospective predictors of postoperative long-term survival and chronic postsurgical pain in breast cancer by Baoli Li, Li Che, Huixian Li, Fangdi Min, Bolun Ai, Linxin Wu, Taihang Wang, Peixin Tan, Bingbing Fu, Jiashuo Yang, Yi Fang, Hui Zheng, Tao Yan

“…Optimal cut-off values for preoperative immunoinflammatory biomarkers, including the preoperative systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), neutrophil-to-lymphocyte ratio (NLR), and pan-immune-inflammation value (PIV), were established via receiver operating characteristic (ROC) curves. …”
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The value of inflammation-related indicators in chemotherapy efficacy and disease-free survival of triple-negative breast cancer by Jie Zhu, Jiale Cheng, Yuyuan Ma, Ying Wang, Zhonghua Zou, Wenjie Wang, Haihua Shi, You Meng

“…Levels of interleukin-6 (IL-6) were detected by enzyme-linked immunosorbent assays (ELISAs). Platelet-to-lymphocyte ratio (PLR) and immune inflammatory index (SII) were obtained from blood routine. …”
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Clustering patients with COVID-19 according to respiratory support requirements, and its impact on short- and long-term outcome (RECOVID study) by Rosario Menéndez, Raúl Méndez, Ana Latorre, Paula González-Jiménez, Germán Peces-Barba, María Molina-Molina, Pedro Pablo España, Estela García, Angélica Consuegra-Vanegas, Marta María García-Clemente, Carolina Panadero, Juan Marco Figueira-Gonçalves, David De la Rosa-Carrillo, Oriol Sibila, María Dolores Martínez-Pitarch, Nuria Toledo-Pons, Cecilia López-Ramírez, Wanda Almonte-Batista, Abigail Macías-Paredes, Mercedes Villamon, Marisol Domínguez-Álvarez, Eli Nancy Pérez-Rodas, Javier Lázaro, Sarai Quirós, Rosa Cordovilla, Irene Cano-Pumarega, Antoni Torres

“…C3 presented higher comorbidities and elevated lymphocyte count, SpO2/FiO2 and low C-reactive protein (CRP). …”
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Comparison between traditional logistic regression and machine learning for predicting mortality in adult sepsis patients by Hongsheng Wu, Biling Liao, Tengfei Ji, Keqiang Ma, Yumei Luo, Shengmin Zhang

“…Model validation and comparison with the Sequential Organ Failure Assessment (SOFA) and the Acute Physiology and Chronic Health Evaluation (APACHE) scores were performed using receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA) curves in the validation set.ResultsUnivariate analysis was employed to assess 17 variables, namely gender, history of coronary heart disease (CHD), systolic pressure, white blood cell (WBC), neutrophil count (NEUT), lymphocyte count (LYMP), lactic acid, neutrophil-to-lymphocyte ratio (NLR), red blood cell distribution width (RDW), interleukin-6 (IL-6), prothrombin time (PT), international normalized ratio (INR), fibrinogen (FBI), D-dimer, aspartate aminotransferase (AST), total bilirubin (Tbil), and lung infection. …”
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Breast Cancer Conditioned Media Modulate the Expression of Immune Checkpoints and Adhesion Molecules in Endothelial Cells by İpek Türkdönmez, Emel Şahin, Mehmet Şahin

“…Materials and Methods: In this study, the expression levels of some immune checkpoints, including lymphocyte-activation-protein 3 (LAG-3), V-domain Ig suppressor of T-cell activation (VISTA), Indoleamine-2,3-dioxygenase (IDO), IDO-2, programmed cell death 1 ligand (PD-L1), PD-L2, Cytotoxic T-lymphocyte associated protein 4, (CTLA-4), and some adhesion molecules, including E-cadherin, VE-cadherin, E-selectin, platelet EC adhesion molecule-1 (PECAM-1), vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), were measured using quantitative real-time polymerase chain reaction in HUVEC ECs preincubated with the conditioned media (CM) collected from normal (CRL-4010) and carcinoma cells (CRL-2329 and MDA-MB-231). …”
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Chlorambucil-Induced Acute Interstitial Pneumonitis by Hammad Shafqat, Adam J. Olszewski

“…Chlorambucil is an alkylating agent commonly used in treatment of chronic lymphocytic leukemia (CLL). We report a case of interstitial pneumonitis developing in an 83-year-old man 1.5 months after completing a six-month course of chlorambucil for CLL. …”
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Application of Bionanomaterials in Tumor Immune Microenvironment Therapy by Jiawei Wang, Yan Bao, Yandan Yao

“…In this review, we will summarize the most current researches on bionanomaterials for targeted regulation of tumor-associated macrophages, myeloid-derived suppressor cells, dendritic cells, T lymphocyte cells, and cancer-associated fibroblasts and summarize the prospects and challenges of cell-targeted therapy and clinical translational potential in a tumor immune microenvironment in cancer treatment.…”
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