The Potential Use of the CRISPR-Cas System for HIV-1 Gene Therapy by Gabriela De Nardi Sanches-da-Silva, Luiza Fonseca Sales Medeiros, Fabio Mitsuo Lima

“…The virus carrier can develop severe immunodeficiency since CD4+ T lymphocytes are the main target, leading to acquired immunodeficiency syndrome (AIDS). …”
Get full text

Pancreatic Inflammatory Pseudotumor-Like Follicular Dendritic Cell Tumor by Madison Mograbi, Michael S. Stump, David T. Luyimbazi, Mohammad H. Shakhatreh, Douglas J. Grider

“…Follicular dendritic cell sarcoma (FDCS) is a rare and underdiagnosed malignant neoplasm which characteristically presents as a solitary, slow-growing mass with no discrete symptoms. Histologically, lymphocytes and spindle cells featuring large nucleoli in a whorled pattern are usually seen. …”
Get full text

A mathematical model of HTLV-I infection with two time delays by Xuejuan Lu, Lulu Hui, Shengqiang Liu, Jia Li

“…In this paper, we include two time delays in a mathematical model for the CD8$^+$ cytotoxicT lymphocytes (CTLs) response to the Human T-cell leukaemia virus type I (HTLV-I) infection,where one is the intracellular infection delay and the other is the immune delay to account for aseries of immunological events leading to the CTL response. …”
Get full text

Immature Dendritic Cell Therapy Confers Durable Immune Modulation in an Antigen-Dependent and Antigen-Independent Manner in Nonobese Diabetic Mice by Jeannette Lo, Chang-Qing Xia, Ruihua Peng, Michael J. Clare-Salzler

“…Of interest, DCs pulsed with SD or ID appeared to provide better protection. T lymphocytes from DC-treated mice acquired spontaneous proliferating capability during in vitro culture, which could be largely eliminated by IL-2 neutralizing antibodies. …”
Get full text

S1P Lyase Regulation of Thymic Egress and Oncogenic Inflammatory Signaling by Ashok Kumar, Jesus Zamora-Pineda, Emilie Degagné, Julie D. Saba

“…S1P chemotactic gradients are essential for lymphocyte egress and other aspects of physiological cell trafficking. …”
Get full text

Regulation of Stress-Induced Immunosuppression in the Context of Neuroendocrine, Cytokine, and Cellular Processes by Evgenii Balakin, Ksenia Yurku, Mark Ivanov, Alexander Izotov, Valeriya Nakhod, Vasiliy Pustovoyt

“…A significant portion of the data confirms that the activation of the hypothalamic–pituitary–adrenal (HPA) axis and subsequent elevation of cortisol levels exert substantial immunosuppressive effects on immune cells, particularly macrophages and lymphocytes, leading to the suppression of innate and adaptive immune responses. …”
Get full text

Primary Bone Marrow B-Cell Lymphoma Undetected by Multiple Imaging Modalities That Initially Presented with Hypercalcemia by Jin Sae Yoo, Juwon Kim, Hyeong Ju Kwon, Jung Soo Lim

“…As a result, the pathology of bone marrow confirmed the presence of atypical lymphocytes that stained positive for the CD20 marker, which is consistent with BCL involving the bone marrow. …”
Get full text

Nutritional Status and Immune Functions in Maintenance Hemodialysis Patients by Hayriye Sayarlioglu, Reha Erkoc, Cengiz Demir, Ekrem Dogan, Mehmet Sayarlioglu, Ahmet Faik Oner, Imdat Dilek

“…In all patients serum urea, creatinine, albumin, iron, cholesterol, triglyceride, CRP, IgG, IgM, IgA, CD4, CD8, CD19, CD16-56 lymphocytes were measured. Kt/V values were calculated according to DOQI guideline. …”
Get full text

Why Does Pnemococcus Kill? by Yves Bergeron, Michel G Bergeron

“…These steps involve the successive recruitment of polymorphonuclear neutrophils (PMNs). monocytes and lymphocytes; the pulmonary and/or systemic release of inflammatoty mediators that characterize the prebacteremic and bacteremic phases of infection; and the participation of parenchymal cells in the host response. …”
Get full text

Serum amyloid A protein as a predictor of severity in coronavirus disease 2019-infected Egyptian patients by Dalia A.E.M.A.E.R. Negm, Wafaa M.A.E.-W. Elzefzafy, Sabah E.A. El Raheem, Nessren M.B. El Deen

“…There was a high statistically significant decrease in the number of lymphocytes in COVID-19 patient groups compared with the control group. …”
Get full text

Pancytopenia in a 70-Year-Old African-American Male: An Unusual Presentation of a Rare Disease by Aibek E. Mirrakhimov, Alaa M. Ali, Aram Barbaryan, Nwabundo Anusim, Raya Saba, Shawn G. Kwatra, Nasir Hussain, Teresita Zdunek, Alan D. Gilman

“…Hairy cell leukemia is a rare lymphoid neoplasm arising from mature B-lymphocytes. Clinically, the disease presents with splenomegaly and abdominal discomfort, frequent infections, fatigue and bleeding because of related cytopenias. …”
Get full text

The Utility of Endoscopic Biopsies in Patients with Normal Upper Endoscopy by Anouar Teriaky, Abdullah AlNasser, Carolyn McLean, James Gregor, Brian Yan

“…The most frequent abnormality was reflux esophagitis in 16% of esophageal biopsies, chronic gastritis in 23% of gastric biopsies, and increased intraepithelial lymphocytes in 6% of duodenal biopsies. The additional cost for taking biopsies in a normal upper GI tract for a diagnosis of eosinophilic esophagitis was $2963 Canadian (CAD), H. pylori associated gastritis was $1404 CAD, and celiac disease was $3024 CAD. …”
Get full text

Kounis Syndrome Secondary to Medicine-Induced Hypersensitivity by Parackrama Karunathilake, Udaya Ralapanawa, Thilak Jayalath, Shamali Abeyagunawardena

“…Kounis syndrome is mediated by mast cells that interact with macrophages and T-lymphocytes, causing degranulation and inflammation with cytokine release. …”
Get full text

Cutaneous adverse drug reaction associated with topical use of benzyl benzoate in a dog by Fabiana Wurster Strey, Marinara Macelai Leite, Jéssica Vargas, Bruno Leite Anjos

“…Interface dermatitis with a predominance of lymphocytes in the hair follicle region, multifocal areas of mild spongiosis, mild vacuolar degeneration of keratinocytes and sub-corneal pustule was also identified. …”
Get full text

Efficiency of pH-Sensitive Fusogenic Polymer-Modified Liposomes as a Vaccine Carrier by Shinobu Watarai, Tana Iwase, Tomoko Tajima, Eiji Yuba, Kenji Kono

“…When sera were analyzed for isotype distribution, OVA-specific IgG1 antibody responses were noted in mice immunized with OVA-containing polymer-unmodified liposomes, whereas immunization with OVA-containing SucPG-modified liposomes resulted in the induction of OVA-specific IgG1, IgG2a, and IgG3 Ab responses. In spleen lymphocytes from mice immunized with OVA-containing SucPG-modified liposomes, both IFN-γ-(Th1-type-) and IL-4-(Th2 type-) specific mRNA were detected. …”
Get full text

Utility of MYD88 in the Differential Diagnosis and Choice of Second-Line Therapy in a Case of Nonsecretory Lymphoplasmacytic Lymphoma versus Free Light Chain Waldenstrom’s Macroglo... by D. Kazmierski, M. L. Palomba, C. Barsigian

“…Bone marrow biopsy revealed 95% monoclonal B-lymphocytes with lymphoplasmacytic differentiation favoring a diagnosis of LPL/WM over MZL, with a favorable response to chemotherapy. …”
Get full text

MHC class II of different non-professional antigen-presenting cells mediate multiple effects of crosstalk with CD4+T cells in lung diseases by Ming-Yan Wang, Yu Qiao, Shan-Jie Wei, Zhao-Liang Su, Zhao-Liang Su, Hong-Yan Lu

“…Professional APCs engulf foreign microorganisms and display their peptides to T lymphocytes using MHC molecules. MHC II on their cell surface and potentially present antigen to CD4+T cells. …”
Get full text

Influence of Natural Honey on Biochemical and Hematological Variables in AIDS: A case study by Noori S. Al-Waili, Thia N. Al-Waili, Ali N. Al-Waili, Khelod S. Saloom

“…Natural honey decreased prostaglandins levels, and elevated NO-end product, percentage of lymphocytes, platelet count, and serum protein, albumin and copper levels. …”
Get full text

Incompletely closed HIV-1CH040 envelope glycoproteins resist broadly neutralizing antibodies while mediating efficient HIV-1 entry by Durgadevi Parthasarathy, Stephanie Pickthorn, Shamim Ahmed, Dmitry Mazurov, Jeffy Jeffy, Rajni Kant Shukla, Amit Sharma, Alon Herschhorn

“…We detected robust in vitro spread of SHIV CH040 in pig-tailed macaque lymphocytes that was comparable to efficient spread of other SHIVs. …”
Get full text

Histopathological Study of Gallbladder Associated with Gallstone Disease by Seerwan Raheem, Ismail Kakey

“…The tissue section showed infiltration of some inflammatory cells, lymphocytes, and plasma cells, and some types of macrophages of the gallbladder mucosa with chronic inflammatory cells associated with epithelial hyperplasia, bleeding in blood vessels was frequently occurring. …”
Get full text