Immunotherapeutic Approaches in Triple-Negative Breast Cancer: State of the Art and Future Perspectives by Karima Oualla, Loay Kassem, Lamiae Nouiakh, Lamiae Amaadour, Zineb Benbrahim, Samia Arifi, Nawfel Mellas

“…Chemotherapy remains the mainstay of treatment in the absence of effective targets, but the good understanding of immune tumor microenvironment, the identification of immune-related targets, and the role of tumor-infiltrating lymphocytes (TILs) in TNBC has allowed to develop promising immunotherapeutic strategies for this unique subset of breast cancer. …”
Get full text

Trichostatin A Promotes the Generation and Suppressive Functions of Regulatory T Cells by Cristian Doñas, Macarena Fritz, Valeria Manríquez, Gabriela Tejón, María Rosa Bono, Alejandra Loyola, Mario Rosemblatt

“…Regulatory T cells are a specific subset of lymphocytes that suppress immune responses and play a crucial role in the maintenance of self-tolerance. …”
Get full text

Saccharomyces Boulardii and Saccharomyces Cerevisiae Improve Immunity in Broilers Vaccinated Against Pasteurella Multocida and Salmonella Gallinarum by C Von Mühlen, NL Conrad, AP Roll, RC Dias, FPL Leite, CD Corcini, AS Varela Junior, VFB Roll

“…S. boulardii supplementation increased lymphocytes (p = 0.003) and decreased heterophils (p=0.004), while S. cerevisiae had no significant effect. …”
Get full text

Effect of Probiotics and Herbal Products on Intestinal Histomorphological and Immunological Development in Piglets by Daiga Gāliņa, Līga Ansonska, Anda Valdovska

“…Probiotics increased p<0.05 the number of intraepithelial lymphocytes (IELs), density of CD3+ cells in Peyer’s patches (PPs), and lamina propria (LP). …”
Get full text

Epidermal growth factor and remarkable correlations in a case series COVID-19 by Héctor José Pérez Hernández

“…Variables included: Age, sex, comorbidities, respiratory rate, heart rate, hospital stay, neutrophils, lymphocytes, neutrophil-lymphocyte index. Summary measures: Absolute frequency, percentage, and the arithmetic mean were used. …”
Get full text

Ways to promote the efficiency of herpetic stomatitis treatment by R.V. Lutsenko, N.V. Moisieieva, A.H. Sydorenko, H.Yu. Ostrovska, A.A. Kapustianska

“…The drug suppresses the synthesis of the virus due to the structure of inosinic acid in the polyribosomes of the cell affected by the virus, and also helps to eliminate the deficiency or dysfunction of immunity that occurred in the case of herpetic stomatitis, it affects the activity of T-cytotoxic lymphocytes and natural killers, enhances the action of neutrophil granulocytes, chemotaxis and phagocytosis of monocytes and macrophages, increases the synthesis of interleukins IL-1 and IL-2, affects the number of Ig G immunoglobulins. …”
Get full text

Tumor microenvironment and immunotherapy for triple-negative breast cancer by Zijie Guo, Ziyu Zhu, Xixi Lin, Shenkangle Wang, Yihong Wen, Linbo Wang, Lili Zhi, Jichun Zhou

“…The high presence of tumor-infiltrating lymphocytes and immune checkpoint proteins in TNBC indicates the potential of immunotherapeutic strategies. …”
Get full text

Immunoinformatic approach to the design of a novel multi-epitope vaccine against Leishmania major fused to human IgG-Fc by Mahmood Fadaie, Zabihollah Shahmoradi, Hossein Khanahmad

“…Immune simulation results showed significant increases in IgM and IgG antibody levels following three vaccinations, along with enhanced activation of B cells, helper T cells, and cytotoxic T lymphocytes. Conclusion and implications: These findings provide novel insights for developing effective candidates for cutaneous leishmaniasis vaccines. …”
Get full text

New Tools in HCV Diagnosis, in Light of the Enhanced Awareness and the New Drugs for Treatment: SMARTube and Stimmunology by Svetlana Gorodin, Serhat Unal, Youchun Wang, Mikhail I. Mikhaylov, Ludmila Bigbulatova, Tamar Jehuda-Cohen

“…Blood samples were tested for anti-HCV antibodies before and after incubation in the SMARTube, which promotes the in vitro stimulation of in vivo HCV primed lymphocytes, thus enhancing levels of anti-HCV antibodies. …”
Get full text

Comprehensive Analysis of the Role of SLC2A3 on Prognosis and Immune Infiltration in Head and Neck Squamous Cell Carcinoma by Manru Chu, Ke Zheng, Xiaojie Li, Zhiqiang Luo, Xin Yang, Changbo Wei

“…Furthermore, SLC2A3 expression strongly correlated with tumor-infiltrating lymphocytes in HNSCC. Conclusion. SLC2A3 could serve as a potential prognostic biomarker for tumor immune infiltration in HNSCC.…”
Get full text

Pregnant Women with Type 2 Diabetes Mellitus and Hypertension: A Physiological Overview by Muhsin Hmeadi Ubeid

“…However, there is no difference observed in the proportion of high-type neutrophils in diabetes pregnant patients. The lymphocytes of pregnant T2DM patients who are dependent on insulin consumption do not demonstrate any relevance. …”
Get full text

The Beneficial Effect of IL-12 and IL-18 Transduced Dendritic Cells Stimulated with Tumor Antigens on Generation of an Antitumor Response in a Mouse Colon Carcinoma Model by Jagoda Mierzejewska, Katarzyna Węgierek-Ciura, Joanna Rossowska, Agnieszka Szczygieł, Natalia Anger-Góra, Bożena Szermer-Olearnik, Magdalena Geneja, Elżbieta Pajtasz-Piasecka

“…Administration of DCs transduced for production of IL-12 alone and in combination with IL-18 increased the inflow and activity of CD4+ and CD8+ T lymphocytes in the tumor microenvironment and tumor-draining lymph nodes. …”
Get full text

Human Liver Stem Cells Suppress T-Cell Proliferation, NK Activity, and Dendritic Cell Differentiation by Stefania Bruno, Cristina Grange, Marta Tapparo, Chiara Pasquino, Renato Romagnoli, Ennia Dametto, Antonio Amoroso, Ciro Tetta, Giovanni Camussi

“…The aim of the present study was to evaluate the immunogenicity and the immunomodulatory properties of HLSCs on T-lymphocytes, natural killer cells (NKs), and dendritic cells (DCs) in allogeneic experimental settings. …”
Get full text

Level of adaptative stress of the organism and cellular reactivity of patients with acute festering-inflammatory diseases of the kidneys and paranephral tissues by V. Stepan, R. Sydorchuk, A. Iftodiy, N. Stepan, L. Sydorchuk

“…In patients with APIDKPT, the absolute number of leukocytes increases by 66.72%, due to an increase in the relative number of neutrophils by 15.83%, which is due to an increase in the relative number of rod-shaped cells by 3.39 times, the relative number of eosinophils increases by 16.39%, the absolute number of lymphocytes by 25.14%. The overall level of adaptive stress in patients with APIDKPT is 14.29% higher than this indicator in practically healthy individuals. …”
Get full text

Cancer vaccines: platforms and current progress by Wanting Lei, Kexun Zhou, Ye Lei, Qiu Li, Hong Zhu

“…Preventive cancer vaccines, like those against HPV and HBV, reduce the incidence of virus-associated cancers, while therapeutic cancer vaccines aim to activate dendritic cells and cytotoxic T lymphocytes for durable anti-tumor immunity. Recent advancements in vaccine platforms, such as synthetic peptides, mRNA, DNA, cellular, and nano-vaccines, have enhanced antigen presentation and immune activation. …”
Get full text

A Precocious Cerebellar Ataxia and Frequent Fever Episodes in a 16-Month-Old Infant Revealing Ataxia-Telangiectasia Syndrome by Luigi Nespoli, Annapia Verri, Silvia Tajè, Francesco Paolo Pellegrini, Maddalena Marinoni

“…Other investigations showed leukocytopenia with lymphopenia, reduced IgG2 and IgA levels, and low titers of specific postimmunization antibodies against tetanus toxoid and Haemophilus B polysaccharide. Peripheral lymphocytes subsets showed reduction of T cells with a marked predominance of T cells with a memory phenotype and a corresponding reduction of naïve T cells; NK cells were very increased (41%) with normal activity. …”
Get full text

CXCR6 Expression Is Important for Retention and Circulation of ILC Precursors by Sylvestre Chea, Cécilie Possot, Thibaut Perchet, Maxime Petit, Ana Cumano, Rachel Golub

“…We show that adult intestinal ILC subsets have heterogeneous expression pattern of CXCR6, integrin α4β7, CD62L, CD69, and CD44, with ILC1 and ILC3 being more likely tissue resident lymphocytes. Intestinal ILC subsets were unchanged in percentages and numbers in both mice. …”
Get full text

ANORECTAL PATHOLOGIES IN THE COURSE OF ACUTE LEUKAEMIAS: PREDICTIVE PARAMETERS by Fatma Yılmaz, Bugra Saglam, Ufuk Gorduk, Ugur Kalan, Hacer Berna Afacan Öztürk, Ahmet Kursad Gunes, Murat Albayrak

“…In the group of patients with anorectal pathology, WBC, lymphocytes, monocytes, LDH were significantly (p<0.05) higher and platelets, MPV, PCT were significantly (p<0.05) lower. …”
Get full text

Amyloid β-Related Angiitis Causing Coma Responsive to Immunosuppression by Shennan A. Weiss, David Pisapia, Stephan A. Mayer, Joshua Z. Willey, Kiwon Lee

“…Serum and cerebrospinal fluid studies showed a lymphocytic leukocytosis in the cerebrospinal fluid (CSF), but no other evidence of infection, and the patient underwent a brain biopsy. …”
Get full text

T Cell Histiocyte Rich Large B Cell Lymphoma Presenting as Hemophagocytic Lymphohistiocytosis: An Uncommon Presentation of a Rare Disease by Uroosa Ibrahim, Gwenalyn Garcia, Amina Saqib, Shafinaz Hussein, Qun Dai

“…T cell histiocyte rich large B cell lymphoma (THRLBCL) is a rare subtype of non-Hodgkin’s lymphoma characterized by malignant B cells with reactive T lymphocytes. The pathophysiology is thought to involve cytokine-mediated evasion of T cell immune response by malignant B cells. …”
Get full text