Human Mast Cells (HMC-1 5C6) Enhance Interleukin-6 Production by Quiescent and Lipopolysaccharide-Stimulated Human Coronary Artery Endothelial Cells by Damandeep S. Walia, Mukut Sharma, Vineesh V. Raveendran, Jianping Zhou, Ram Sharma, Daniel J. Stechschulte, Kottarappat N. Dileepan

“…We examined the effect of intact human mast cells (HMC-1 5C6) and their selected mediators on interleukin-6 (IL-6) production and bone morphogenetic protein-2 (BMP-2) expression in human coronary artery endothelial cells (HCAEC) in the presence and absence of lipopolysaccharide (LPS). …”
Get full text

Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8+ T-cell antitumor activity via the non-canonical P53/STING pathway by Jing Chen, Jie Wu, Xiang Chen, Qian Tao, Nian Liu, Cong Peng, Can Lu, Qiuqiu Li

“…This resulted in apoptosis, pyroptosis, and immunogenic cell death in tumor cells by Clo. Furthermore, Clo-induced GSDME-mediated pyroptosis partly assists in activating T cell immunity via CCL5 and CXCL10. …”
Get full text

Metastatic Renal Cell Carcinoma Presenting as Prolonged Pyrexia and Stauffer’s Syndrome: Can a Routine Ultrasound Scan Fail to Detect a Renal Cell Carcinoma? by C. L. Fonseka, A. G. T. A. Kariyawasam, S. A. G. L. Singhapura, C. M. de Silva, T. E. Kanakkahewa, I. G. T. M. Senarathna, C. K. Bodinayake

“…Prolonged pyrexia and weight loss are recognised paraneoplastic manifestations of renal cell carcinoma (RCC). Stauffer’s syndrome is a rarely described paraneoplastic manifestation, which is described early in the course of RCC. …”
Get full text

Efficient Acquisition of Fully Human Antibody Genes against Self-Proteins by Sorting Single B Cells Stimulated with Vaccines Based on Nitrated T Helper Cell Epitopes by Liangliang Jiang, Tao Jiang, Jianhua Luo, Yanliang Kang, Yue Tong, Xiaoda Song, Xiangdong Gao, Wenbing Yao, Hong Tian

“…Single B cell antibody technology is a method for isolating antigen-specific B cells from human peripheral blood and obtaining antibody genes in developing antibody drugs. …”
Get full text

The Average IFN-γ Secreting Capacity of Specific CD8+ T Cells Is Compromised While Increasing Copies of a Single T Cell Epitope Encoded by DNA Vaccine by Yanmin Wan, Jing Wang, Haizhu Zhou, Zhidong Hu, Xiaonan Ren, Jianqing Xu

“…We found that frequencies of specific CD8+ T cell could be improved by multiplying epitope copies, while the MFI of IFN-γ secreted by epitope-specific CD8+ T cells decreased synchronously. …”
Get full text

Anlotinib Inhibits Cisplatin Resistance in Non-Small-Cell Lung Cancer Cells by Inhibiting MCL-1 Expression via MET/STAT3/Akt Pathway by Lile Wang, Lu Xu, Shuhua Han, Xiaoli Zhu

“…However, the underlying molecular mechanism of anlotinib mediates cisplatin (DDP) resistance in NSCLC remains unclear. Methods. Cell viability was assessed by the cell counting kit 8 assay. …”
Get full text

Activated CD27+PD-1+ CD8 T Cells and CD4 T Regulatory Cells Dominate the Tumor Microenvironment in Refractory Celiac Disease Type II by Tessa Dieckman, Mette Schreurs, Ciska Lindelauf, Ahmed Mahfouz, Caroline R. Meijer, Louise Pigeaud, Vincent van Unen, Gerd Bouma, Frits Koning

Subjects: Get full text

Bone Formation by Sheep Stem Cells in an Ectopic Mouse Model: Comparison of Adipose and Bone Marrow Derived Cells and Identification of Donor-Derived Bone by Antibody Staining by Kristian Kjærgaard, Chris H. Dreyer, Nicholas Ditzel, Christina M. Andreasen, Li Chen, Søren P. Sheikh, Søren Overgaard, Ming Ding

“…Stem Cells International…”
Get full text

Revealing the heterogeneity of treatment resistance in less‐defined subtype diffuse large B cell lymphoma patients by integrating programmed cell death patterns and liquid biopsy by Wei Hua, Jie Liu, Yue Li, Hua Yin, Hao‐Rui Shen, Jia‐Zhu Wu, Yi‐Lin Kong, Bi‐Hui Pan, Jun‐Heng Liang, Li Wang, Jian‐Yong Li, Rui Gao, Jin‐Hua Liang, Wei Xu

“…Abstract Precision medicine in less‐defined subtype diffuse large B‐cell lymphoma (DLBCL) remains a challenge due to the heterogeneous nature of the disease. …”
Get full text

Correlation of Interleukin-17-Producing Effector Memory T Cells and CD4+CD25+Foxp3 Regulatory T Cells with the Phosphate Levels in Chronic Hemodialysis Patients by Cheng-Lin Lang, Min-Hui Wang, Kuan-Yu Hung, Sung-Hao Hsu, Chih-Kang Chiang, Kuo-Cheng Lu

“…Interleukin-17-producing CD4+ effector memory T (Th17) cells and CD4+CD25+Foxp3 regulatory T (Treg) cells both play critical roles in immune activation and inflammation. …”
Get full text

Editorial: Impact of the innate and adaptive immune system in driving type 1 inflammatory skin disease by Mark Mellett, Judit Danis, Barbara Meier-Schiesser

Subjects: “…tissue-resident memory T cells (TRM cells)…”
Get full text

Fibroblastic reticular cell tumor of eyelid: Rare case report and review of literature by Pragnya P. Mishra, K Madan, Siddhartha Biswas, Anuradha Calicut Kini Rao

Subjects: “…dendritic cells…”
Get full text

Decrease of NAD+ Inhibits the Apoptosis of OLP T Cells via Inducing Mitochondrial Fission by Zhang ZY, Wang F, Zhou G

Subjects: Get full text

Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence by Nicola Alessio, Tiziana Squillaro, Giovanni Di Bernardo, Giovanni Galano, Roberto De Rosa, Mariarosa AB Melone, Gianfranco Peluso, Umberto Galderisi

Subjects: “…mesenchymal stromal cells…”
Get full text

The role and underlying mechanism of dental pulp stem cell-derived exosomal miR-31 in the treatment of osteoarthritis by targeting mTOR to enhance chondrocyte autophagy levels by Guanglei Zhao, Jinyang Lyu, Xin Huang, Gangyong Huang, Feiyan Chen, Yibing Wei, Siqun Wang, Jun Xia, Jie Chen, Jingsheng Shi

Subjects: Get full text

Dual Role of α-MSH in Colitis Progression: Mediating Neutrophil Differentiation via Bone Marrow by Liao X, Liu H, Li Y, Zhang W, Dai Q, Wei H, Zhou J, Xie X, Zhou H

Subjects: Get full text

Abcb1 is involved in the efflux of trivalent inorganic arsenic from brain microvascular endothelial cells by Man Lv, Ziqiao Guan, Jia Cui, Xinbo Ma, Kunyu Zhang, Xinhua Shao, Meichen Zhang, Yanhui Gao, Yanmei Yang, Xiaona Liu

Subjects: “…Brain microvascular endothelial cells…”
Get full text

Is the myonuclear domain ceiling hypothesis dead? by Ferdos Aman, Eman El Khatib, Alanood AlNeaimi, Ahmed Mohamed, Alya Sultan Almulla, Amna Zaidan, Jana Alshafei, Omar Habbal, Salma Eldesouki, Rizwan Qaisar

Subjects: Get full text

Primordial Germ Cells Quality of Chicken Embryo from Post Cryopreservation Blood Samples by Nurul Azizah, Tatan Kostaman, Yuli Arif Tribudi, Diana Andrianita Kusumaningrum, Suyatno Suyatno, Zultinur Muttaqin, Eko Koswara, Muhammad Gunawan

Subjects: Get full text

Mechanism of triptolide regulating proliferation and apoptosis of hepatoma cells by inhibiting JAK/STAT pathway by Wang Guanglian, Zhu Zhenxin, Sun Zhengang, Yang Zhiqi

Subjects: Get full text