Identification of the Hub Genes Involved in Stem Cell Treatment for Intervertebral Disc Degeneration: A Conjoint Analysis of Single-Cell and Machine Learning by Jianfeng Chen, Fuwei Qi, Guanshen Li, Qiaosong Deng, Chenlin Zhang, Xiaojun Li, Yafeng Zhang

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Genetic Mutations of Tim-3 Ligand and Exhausted Tim-3+ CD8+ T Cells and Survival in Diffuse Large B Cell Lymphoma by Tingting Zhang, Tianyuan Ren, Zheng Song, Jing Zhao, Lei Jiao, Zhenzhen Zhang, Jin He, Xianming Liu, Lihua Qiu, Lanfang Li, Shiyong Zhou, Bin Meng, Qiongli Zhai, Xiubao Ren, Zhengzi Qian, Xianhuo Wang, Huilai Zhang

“…Furthermore, we defined a novel subtype of exhausted T cells, named as exhausted Tim-3+ CD8+ T cells, and found that patients with exhausted Tim-3+ CD8+ T cells (median survival, 62.8 months, 95% CI: 50.0–75.6) exhibited shorter survival than those with nonexhausted Tim-3- CD8+ T cells (median survival, 82.5 months, 95% CI: 72.0–92.9; p=0.034). …”
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Laminin as a Potent Substrate for Large-Scale Expansion of Human Induced Pluripotent Stem Cells in a Closed Cell Expansion System by Fernanda C. Paccola Mesquita, Camila Hochman-Mendez, Jacquelynn Morrissey, Luiz C. Sampaio, Doris A. Taylor

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Response Gene to Complement 32 is associated with poor patient survival and an inflamed tumor-immune microenvironment in clear cell renal cell carcinoma by Lingling Li, Xiaocui Bu, Shuhui Wang, Yan Liu, Chongdao Chen, Wei Zhang, Peng Zhao

“…It has been well established that tumor-infiltrating lymphocytes (TILs) play a critical role in the pathogenesis and progression of clear cell renal cell carcinoma (ccRCC). However, the mechanism on the interactions between TILs and tumor cells in the tumor-immune microenvironment remains unclear. …”
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Gastrospheres as a Model of Gastric Cancer Stem Cells Skew Th17/Treg Balance toward Antitumor Th17 Cells by Alaleh Rezalotfi, Ghasem Solgi, Marzieh Ebrahimi

“…Finally, the cytotoxic potential of induced immune cells was measured by examining the secretion of lactate dehydrogenase from target cells. …”
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LINC01355 Contributes to Malignant Phenotype of Oral Squamous Cell Carcinoma and Cytotoxic T Cell Infiltration via Activating Notch Signaling Pathway by Chen Zou, Siyuan Wu, Haigang Wei, Hailing Luo, Zhe Tang, Xia Li, Xiaozhi Lv, Yilong Ai

“…Firstly, we found that the results indicated LINC01355 was increased in OSCC cells. Knockdown of LINC01355 repressed OSCC cell proliferation, migration, and invasion. …”
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Lipid Peroxidation-Mediated Inflammation Promotes Cell Apoptosis through Activation of NF-κB Pathway in Rheumatoid Arthritis Synovial Cells by Geng Yin, Ying Wang, Xiao-min Cen, Min Yang, Yan Liang, Qi-bing Xie

“…In the present study, we proposed to determine whether enhanced inflammations may lead to cell apoptosis in rheumatoid arthritis synoviocytes. …”
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Epigenomic exploration of disease status of EGFR‐mutated non‐small cell lung cancer using plasma cell‐free DNA hydroxymethylomes by Yong Peng, Jason Karpus, Jyoti D. Patel, Everett E. Vokes, Marina Chiara Garassino, Kirsteen Lugtu, Zhou Zhang, Wei Zhang, Mengjie Chen, Chuan He, Christine M. Bestvina

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Kupffer Cells Promote the Differentiation of Adult Liver Hematopoietic Stem and Progenitor Cells into Lymphocytes via ICAM-1 and LFA-1 Interaction by Deping Meng, Yuhong Qin, Nan Lu, Keke Fang, Yuan Hu, Zhigang Tian, Cai Zhang

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Elevated Circulating Angiogenic Progenitors and White Blood Cells Are Associated with Hypoxia-Inducible Angiogenic Growth Factors in Children with Sickle Cell Disease by Solomon F. Ofori-Acquah, Iris D. Buchanan, Ifeyinwa Osunkwo, Jerry Manlove-Simmons, Feyisayo Lawal, Alexander Quarshie, Arshed A. Quyyumi, Gary H. Gibbons, Beatrice E. Gee

“…Hemoglobin SS subjects had at least twice as many mononuclear cell colonies and more circulating progenitor cell than Control subjects. …”
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Bundle sheath cell-dependent chloroplast movement in mesophyll cells of C4 plants analyzed using live leaf-section imaging by Yuta Kato, Takao Oi, Yoshikatsu Sato, Mitsutaka Taniguchi

“…Abstract C4 plants have C4 photosynthetic cycle, a CO2-concentrating pump that functions across mesophyll (M) and bundle sheath (BS) cells. M chloroplasts aggregate toward BS cells in response to environmental stress, which would contribute to adjustment in C4 photosynthetic cycle. …”
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Early T-Cell Precursor Leukemia Has a Higher Risk of Induction-Related Infection among T-Cell Acute Lymphoblastic Leukemia in Adult by Kangyu Huang, Min Dai, Qiuli Li, Nannan Liu, Dainan Lin, Qiang Wang, Xuan Zhou, Zhixiang Wang, Ya Gao, Hua Jin, Xiaoli Liu, Qifa Liu, Hongsheng Zhou

“…Of 97 patients with T-ALL enrolled in the trial, 46 were early T-cell precursor (ETP) ALL and 51 were non-ETP ALL. …”
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MicroRNA-Based Markers of Oral Tongue Squamous Cell Carcinoma and Buccal Squamous Cell Carcinoma: A Systems Biology Approach by Setareh Shojaei, Pouya Menbari, Shokoofeh Jamshidi, Amir Taherkhani

“…Objective. Oral tongue squamous cell carcinoma (OTSCC) and buccal squamous cell carcinoma (BSCC) are the first and second leading causes of oral cancer, respectively. …”
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Hair Follicle Dermal Cells Support Expansion of Murine and Human Embryonic and Induced Pluripotent Stem Cells and Promote Haematopoiesis in Mouse Cultures by Jun Liu, Claire A. Higgins, Jenna C. Whitehouse, Susan J. Harris, Heather Crawford, Angela M. Christiano, Majlinda Lako, Nicholas Hole, Colin A. B. Jahoda

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Ly6E on tumor cells impairs anti-tumor T-cell responses: a novel mechanism of tumor-induced immune exclusion by Lan Hailin, Chen Yiting, Wu Yue, Li Lijun, Zhang Renlu, Chen Yunhan, Zhu Yanyang, Zhang Qiuyu

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Therapeutic potential and mechanisms of umbilical cord mesenchymal stem cells differentiating into tendon cells and promotion of rotator cuff tendon-bone healing by Youliang Shen, Yuelei Wang, Yidan Xu, Jie Wang, Chuqiang Yin, Zengshuai Han, Feng Shen, Ting Wang

“…In vitro experiments were performed to explore the mechanism of differentiation of umbilical cord mesenchymal stem cells (UCMSCs) to tendon cells and to evaluate their potential in promoting rotator cuff injury repair. …”
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Cartilage Defect Treatments: With or without Cells? Mesenchymal Stem Cells or Chondrocytes? Traditional or Matrix-Assisted?... by Zhantao Deng, Jiewen Jin, Jianning Zhao, Haidong Xu

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Concurrent B Cell Acute Lymphoblastic Lymphoma/Leukemia and Monoclonal B Cell Lymphocytosis: A Case Report with Extensive Molecular Analysis by Maryam Mehdipour Dalivand, Parastou Tizro, Julie Partain, Anita Aggarwal, Jack Lichy, Francisco Mot Ara, Victor E. Nava

“…Although acute lymphoblastic leukemia (ALL) and monoclonal B cell lymphocytosis (MBL) are common neoplasia, a simultaneous presentation is very unusual. …”
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Theileria annulata infects B-cells in sheep, which display lower dissemination potential compared to T. lestoquardi-infected ovine B-cells by Shahin Tajeri, Perle Latré de Laté, Johanneke D. Hemmink, Christina Vrettou, Gordon Langsley, W. Ivan Morrison

“…This revealed that T. annulata sporozites target ovine B-cells, whereas T. lestoquardi sporozoite infection was not restricted to ovine B-cells. …”
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HuR Plays a Positive Role to Strengthen the Signaling Pathways of CD4+ T Cell Activation and Th17 Cell Differentiation by Shiguang Yu, Morgan Tripod, Ulus Atasoy, Jing Chen

“…After antigen and/or different cytokine stimulation, CD4+ T cells activated and differentiated into distinct T helper (Th) cells via differential T cell signaling pathways. …”
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