Putative effects of moringa oil or its nano-emulsion on the growth, physiological responses, blood health, semen quality, and the sperm antioxidant-related genes in ram by Rehab F. S. A. Ismail, Wael A. Khalil, Sara I. Grawish, Karima Gh. M. Mahmoud, Sameh A. Abdelnour, Alaa M. A. Gad

“…Serum and seminal interstitial-cell-stimulating hormone (ICSH) levels were significantly improved (P < 0.0001) in the NMO group. …”
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Characterization of the bioaccumulation and toxicity of copper pyrithione, an antifouling compound, on juveniles of rainbow trout by Bourdon, Charlotte, Cachot, Jérôme, Gonzalez, Patrice, Couture, Patrice

“…The expression of genes involved in the antioxidant response (sod1, sod2, gpx), detoxification (cyp1a, mt1x, mt2x), Cu transport (ctr1, ctr2, slc11a2), energy metabolism (AcoAc, cox, 12S) and cell cycle regulation (bax) strongly decreased at Day 8 in the gills and at Day 16 in the liver of CuPT-exposed fish in comparison to controls at the same time point. …”
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First Indonesian Nasopharyngeal Cancer Whole Epigenome Sequencing Identify Tumour Suppressor CpG Methylation by Handoko, Adham M, Rachmadi L, Tobing DL, Asmarinah A, Fadilah F, Dai W, Lee AWM, Gondhowiardjo SA

“…Aberrant methylation, particularly at CpG sites, can silence tumour suppressor genes, promoting uncontrolled cell growth. This study aims to analyse the methylation patterns in Indonesian NPC patients through whole-epigenome sequencing.Methods: Seven clinical nasopharyngeal cancer samples were collected and confirmed histopathologically. …”
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Identification of Potential Diagnostic Biomarkers of Carotid Atherosclerosis in Obese Populations by Wu X, Pan J, Pan X, Kang J, Ren J, Huang Y, Gong L, Li Y

“…PLCB2, PRKCB, and PLCG2 were identified as key genes in the calcium signaling pathway associated with immune cell infiltration. In vivo experiments showed that MMP9, PLA2G7, CD52, SPP1, FYB, and PLCB2 mRNA levels were up-regulated in adipose, aortic tissues and serum of OB and AS model mice, CLEC5A was up-regulated in aorta and serum, and PRKCB was up-regulated in adipose and serum.Conclusion: MMP9, PLA2G7, CD52, CLEC5A, SPP1, and FYB may serve as potential diagnostic biomarkers for CAS in obese populations. …”
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Modulatory effects of Lactiplantibacillus plantarum on chronic metabolic diseases by Lei Tian, Ruixiang Zhao, Xinyi Xu, Zhiwei Zhou, Xiaofang Xu, Dongmei Luo, Zhiqiang Zhou, Yu Liu, Ariel Kushmaro, Robert S. Marks, András Dinnyés, Qun Sun

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Periodontal Indices as Predictors of Cognitive Decline: Insights from the PerioMind Colombia Cohort by Catalina Arévalo-Caro, Diego López, Jose Antonio Sánchez Milán, Cristina Lorca, María Mulet, Humberto Arboleda, Sergio Losada Amaya, Aida Serra, Xavier Gallart-Palau

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TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa in patients with advanced solid tumors: a first-in-human, phase 1, dose-escalation trial by Wei Gao, Ping Hu, Aung Naing, Meredith McKean, Anthony Tolcher, Lillian L Siu, Keyvan Tadjalli-Mehr, Anja Victor, Emilia Richter, Marco A F Nogueira Filho, Thomas Kitzing, Stephan Gleicher, Daniel Holland

“…Background M6223 is an intravenous (IV), Fc-competent, fully human, antagonistic, anti-T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domains (TIGIT) antibody. …”
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Evaluation and refinement of thresholds for early migration of total knee replacements as an estimator of late aseptic loosening: an updated systematic review of RSA and survival s... by Raymond Puijk, Jiwanjot Singh, Rowan H Puijk, Elise K Laende, José W M Plevier, Peter A Nolte, Bart G C W Pijls

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Giardiose et oesophagostomose nodulaire au parc national de Taï : risque zoonotique ? by Roland Wa Yao Kouassi, William Scott McGraw, Bassirou Bonfoh, Julie Brunet, Sylvie Perroteye, Ermanno Candofi, Eliezer Kouakou N’goran

“…Parallèlement, le gène de la TPI a été identifié dans 63 % des selles humaines et 43 % des selles de singes et le gène de la Gdh détecté dans 37 % des selles humaines et 87 % de celles des singes. Par ailleurs, des œufs d’Oesophagostomum ont été observés au microscope dans 10 % des selles humaines et 32 % des prélèvements simiens. …”
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Hubungan Karakteristik Penderita dengan Gambaran Sitopatologi pada Kasus Karsinoma Paru yang Dirawat di RSUP Dr. M. Djamil Padang by Metha Arsilita Hulma, Masrul Basyar, Henny Mulyani

“…Results of univariate analysis showed patients with lung carcinoma mostly are male (71.1%), &gt; 40 years age group (85.2%), background in basic educated people (49.2 %), had occupation contacted carcinogenic compound (53,9%), the greatest frequency was found in patients with severe Brikman Index (49.2%), active smokers (66.4%), and most of cytopathology cell type are adenocarcinoma (47.7 %). Results of bivariate analysis showed there are significant relationship between sex and smoking history with the overview of cytopathology (p=0,022 dan p=0,000). …”
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Comprehensive analysis of full genome sequence and Bd-milRNA/target mRNAs to discover the mechanism of hypovirulence in Botryosphaeria dothidea strains on pear infection with BdCV1... by Wangcheng Hu, Hui Luo, Yuekun Yang, Qiong Wang, Ni Hong, Guoping Wang, Aiming Wang, Liping Wang

“…WEGO analysis revealed involvement of the differentially expressed Bd-milRNA-targeted genes in metabolic process, catalytic activity, cell process and response to stress or stimulus. …”
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Clinicopathological and molecular characteristics of papillary thyroid carcinoma in adolescent and young adult patients by Van Phu Thang Nguyen, Hirokazu Kurohama, Yuko Akazawa, Thi Ngoc Anh Nguyen, Katsuya Matsuda, Yuki Matsuoka, Zhanna Mussazhanova, Kenichi Yokota, Shinya Satoh, Hiroyuki Yamashita, Thi Nhung Nguyen, Yerkerzhan Sailaubekova, Masahiro Nakashima

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Impaired pulmonary function increases the risk of gout: evidence from a large cohort study in the UK Biobank by Zijian Kang, Jianzheng Zhang, Chen Zhu, Ying Zhu, Hanlei Jiang, Qiang Tong, Sheng-Ming Dai

“…The association might be partially mediated by biomarkers including urate levels, inflammatory markers, and immune cell counts.…”
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Biological Characteristics and Whole-Genome Analysis of a Porcine <i>E. coli</i> Phage by Shenghui Wan, Nana Li, Sajid Habib, Pei Zheng, Yanfang Li, Yan Liang, Yonggang Qu

“…The optimal MOI for phage Psq-1 was 0.1, with a latent period of 25 min, an exponential growth period of 25 min, and a lysis yield of 44.21 PFU/cell. Its activity remains stable at temperatures between 40 °C and 60 °C and from pH 4.0 to pH 13.0. …”
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Polyethylene microplastic exposure adversely affects oocyte quality in human and mouse by Qiaoling Wang, Fengli Chi, Yingdong Liu, Qiurong Chang, Siyu Chen, Pengcheng Kong, Wanli Yang, Wenqiang Liu, Xiaoming Teng, Yan Zhao, Yi Guo

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Correction: Cancer care in German centers of excellence during the first 2 years of the COVID-19 pandemic by Volker Arndt, Daniela Doege, Stefan Fröhling, Peter Albers, Hana Algül, Ralf Bargou, Carsten Bokemeyer, Martin Bornhäuser, Christian H. Brandts, Peter Brossart, Sara Yvonne Brucker, Tim H. Brümmendorf, Hartmut Döhner, Norbert Gattermann, Michael Hallek, Volker Heinemann, Ulrich Keilholz, Thomas Kindler, Cornelia von Levetzow, Florian Lordick, Ulf Peter Neumann, Christoph Peters, Dirk Schadendorf, Stephan Stilgenbauer, Thomas Zander, Daniel Zips, Delia Braun, Thomas Seufferlein, Gerd Nettekoven, Michael Baumann

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Impact of mango peel pectin and Bacillus iranensis on growth, immunity, and gene expression in Nile tilapia (Oreochromis niloticus) by Anisa Rilla Lubis, Nguyen Vu Linh, Khambou Tayyamath, Supreya Wannavijit, Punika Ninyamasiri, Chanagun Chitmanat, Wanaporn Tapingkae, Einar Ringø, Hien Van Doan, Maria Ángeles Esteban

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Protective Mechanism of Electroacupuncture Combined with Enriched Rehabilitative Training on Hippocampal Neurons in Rats with Cerebral Ischemia-Reperfusion Injury by Li GONG, Wei TANG, Zhen QIU, Mengxing LI

“…Western blot was used to detect the expression of protein kinase-like endoplasmic reticulum kinase (PERK), CCAAT/enhancer binding protein homologous protein (CHOP), B-cell lymphoma-2(Bcl-2), Bcl-2 associated X-protein (Bax), protein kinase B(Akt), and phosphory lated protein kinase B(p-Akt).Results:Compared withthenormalgroupandshamgroup, learning and memory ability of rats in the model group were decreased (<italic>P</italic>&lt; 0.01), and cerebral infarction volume, apoptosis index, protein expression of PERK, CHOP, Bcl-2 and Bax in hippocampus of rats in the model group were significantly increased (<italic>P</italic>&lt; 0.01). …”
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Comparison of Clinical Characteristics and Mortality Outcome in Critical COVID-19 Patients Infected with Alpha and Omicron Variants by Cheng HI, Chang KW, Wu BC, Teo MY, Hung WS, Wu HM, Huang ACC, Lin CW, Lin TY, Lin HC, Chiu CH, Lin SM

“…The Alpha group had a higher body mass index, had a longer ICU stay, and included more patients with acute respiratory distress syndrome, and the Omicron group included more active smokers, had more comorbidities, had worse initial laboratory data (including higher white blood cell counts, prothrombin time [PT], activated partial prothrombin time, blood urine nitrogen levels, and creatine levels), and had higher in-hospital mortality rates (40.6% vs 15.2%, p = 0.004). …”
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Growth performance of 7-g Anguilla bicolor bicolor at different density by Eko Harianto, Tatag Budiardi, Agus Oman Sudrajat

“…Blood profile in form of hemoglobin, hematocrit, red blood cell and differential leukocytes showed no significant differences except for the leukocyte parameters with the highest rate was achieved at the stocking density of 4 g/L (2.70±0.001x105 sel/mm3). …”
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