NKAPL facilitates transcription pause-release and bridges elongation to initiation during meiosis exit by Zhenlong Kang, Chen Xu, Shuai Lu, Jie Gong, Ruoyu Yan, Gan Luo, Yuanyuan Wang, Qing He, Yifei Wu, Yitong Yan, Baomei Qian, Shenglin Han, Zhiwen Bu, Jinwen Zhang, Xian Xia, Liang Chen, Zhibin Hu, Mingyan Lin, Zheng Sun, Yayun Gu, Lan Ye

Get full text

“Subtype-precise” therapy leads diagnostic and therapeutic innovations: a new pattern for precision treatment of breast cancer by ZHANG Siwei, MA Ding, JIANG Yizhou, SHAO Zhimin

“…They deeply analyzed the molecular characteristics of TNBC, leading to the development of a “Fudan subtype” closely related to clinical outcomes: luminal androgen receptor subtype (LAR), which can be targeted with anti-HER2 and CDK4/6 inhibitors; the immunomodulatory subtype (IM), suitable for immunotherapy; basal-like immune-suppressed subtype (BLIS), which can be treated with platinum-based drugs or poly (ADP-ribose) polymerase (PARP) inhibitors; and mesenchymal-like subtype (MES), which can be treated with anti-cancer stem cell and anti-angiogenic therapies. The team then extended the concept of “subtype-precise” to luminal breast cancer, the subtype with the largest number, the highest proportion and the risk of recurrence for decades. …”
Get full text

PlaceField2BVec: A bionic geospatial location encoding method for hierarchical temporal memory model by Zugang Chen, Shaohua Wang, Kai Wu, Guoqing Li, Jing Li, Jian Wang

“…To solve the problem, based on the research from neuroscience about place cell, we proposed a new geospatial location encoding method called PlaceField2BVec. …”
Get full text

Inhibition of p70 Ribosomal S6K1 Protects the Myocardium against Ischemia/Reperfusion-Induced Necrosis through Downregulation of RIP3 by Hui Shang, Jinjin Shi, Jun Zhu, Yunfeng Guo, Xiaoyan Wang

“…Background: Myocardial ischemia-reperfusion (I/R) injury refers to cell damage that occurs as a consequence of the restoration of blood circulation following reperfusion therapy for cardiovascular diseases, and it is a primary cause of myocardial infarction. …”
Get full text

Variation in a single allele drives divergent yield responses to elevated CO2 between rice subspecies by Yunlong Liu, Siyu Zhang, Haoyu Qian, Chengbo Shen, Shuijin Hu, Weijian Zhang, Yong Wang, Shan Huang, Songhan Wang, Zhenghui Liu, Ganghua Li, Xiangdong Fu, Yanfeng Ding, Shan Li, Kees Jan van Groenigen, Yu Jiang

Get full text

Prevalensi Kanker Serviks Berdasarkan Paritas di RSUP. Dr. M. Djamil Padang Periode Januari 2011- Desember 2012 by Septia Haryani, Defrin Defrin, Yenita Yenita

“…Distribution cervical cancer by the age of majority in the age group >50 years old were 27 cases (42,9%), based on kind of payment is mostly used jamkesmas were 21 cases (38,1%), based on histopathology of majority on squamous cell carcinoma is 46 cases (73%) and based on the highest number of parity is the parity group 3-5 were 40 cases (63,5%). …”
Get full text

Delta Neutrophil Index in Coronary Artery Bypass Surgery: An Innovation in Postoperative Mortality Assessment by Bilgiç A, Toprak B, Kaya H

“…Traditional markers such as C-reactive protein (CRP) and white blood cell (WBC) counts are commonly used but have limitations in specificity and prognostic value. …”
Get full text

An ensemble machine learning-based performance evaluation identifies top In-Silico pathogenicity prediction methods that best classify driver mutations in cancer by Subrata Das, Vatsal Patel, Shouvik Chakravarty, Arnab Ghosh, Anirban Mukhopadhyay, Nidhan K. Biswas

“…This study aims to develop an ensemble machine learning approach to evaluate the performance (rank) of pathogenic and conservation scoring algorithms (PCSAs) based on their ability to distinguish pathogenic driver mutations from benign passenger (non-driver) mutations in head and neck squamous cell carcinoma (HNSC). Methods The study used a dataset from 502 HNSC patients, classifying mutations based on 299 known high-confidence cancer driver genes. …”
Get full text

Nomogram model and risk score predicting overall survival and guiding clinical decision in patients with Hodgkin’s lymphoma: an observational study using SEER population-based data... by Yue Yang, Shang Li, Xiao Zhu, Yi Kong, Mingtao Zhang, Xiangping Liang, Zherui Zhang, Shuzhen Tan, Yingqi Li, Yueyuan Zhong, Yingqi Shao, Jiayi Xu, Zesong Li

Get full text

Lymphadenopathies: A Retrospective Study of Epidemiology, Characteristics, Diagnosis and Treatment Outcomes of Patients in a Tertiary Hospital in Mogadishu-Somalia by Kıratlı K, Bulut M, Ali MA, Aysin M, Ali AM, Mohamed Hirsi I, Bashir AM

“…It was determined that benign conditions, including tuberculosis were more common in pediatric group and younger adults (p< 0.001), and weight loss was a significant in terms of malignancy and tuberculosis (p< 0.001). White blood cell value (p< 0.001), erythrocyte sedimentation rate (p< 0.001), and C-reactive protein (p:0.001) revealed differences across the diagnostic groups.Conclusion: Almost two-thirds of patients were diagnosed with tuberculosis lymphadenitis. …”
Get full text

Préférence manuelle chez les gibbons by Luca Morino, Makiko Uchikoshi, Fred Bercovitch, William D Hopkins, Tetsuro Matsuzawa

“…Un des problèmes est le manque de données chez certaines espèces-clés comme notamment au sein des hylobatidés, alors que ce taxon est particulièrement intéressant dans ce contexte : 1. ils sont très proches de l’homme et partagent un répertoire vocal complexe, ils pourraient donc partager certaines voies neurologiques pour leur vocalisation complexe ; 2. leur adaptation à l’arboricolie s’associe à des contraintes posturales uniques ; 3. il y a peu de données sur leur latéralité, et celles-ci sont contradictoires. Pour essayer de clarifier la situation, nous avons testé la préférence manuelle de 22 siamangs (Symphalangus syndactylus) et 20 gibbons (8 Hylobates lar, 4 H. agilis, 4 H. muelleri, 3 H. pileatus, 1 Nomascus leucogenys), vivant en captivité au Japon. …”
Get full text

Altered functional brain connectivity in Dyt1 knock-in mouse models by R. Z. Adury, B. J. Wilkes, P. Girdhar, Y. Li, D. E. Vaillancourt, D. E. Vaillancourt, D. E. Vaillancourt

“…However, how TorsinA dysfunction in specific cell types affects network connectivity and dystonia-related pathophysiology remains unclear. …”
Get full text

Prognostic evaluation of non-muscle invasive bladder cancer with P-CRP and its nomogram by Junyun Wu, Zhixuan Deng, Xu Lei, Zhiyao Xu, Chenxi Tan, Yunqiao Tang, Xi Sheng, Ning Yang

Get full text

Possible linking and treatment between Parkinson’s disease and inflammatory bowel disease: a study of Mendelian randomization based on gut–brain axis by Beiming Wang, Xiaoyin Bai, Yingmai Yang, Hong Yang

“…Among 60 protein-coding druggable targets over tier 2, 18 overlapped with pleiotropic genes and enriched in mitochondria, antigen presentation, processing and immune cell regulation pathways. Three druggable genes (LRRK2, RAB29 and HLA-DQA2) passed colocalization analysis. …”
Get full text

IDH-mutant gliomas in children and adolescents - from biology to clinical trials by Louise Evans, Sarah Trinder, Sarah Trinder, Andrew Dodgshun, Andrew Dodgshun, David D. Eisenstat, David D. Eisenstat, David D. Eisenstat, James R. Whittle, James R. Whittle, James R. Whittle, Jordan R. Hansford, Jordan R. Hansford, Jordan R. Hansford, Santosh Valvi, Santosh Valvi, Santosh Valvi

Get full text

UNEMPLOYMENT AND POVERTY IN THE DANUBE DELTA SETTLEMENTS. TERRITORIAL DISPARITIES by NICOLETA DAMIAN

“…L’enquête au terrain effectuée en plusieurs localités du delta du Danube y indique une situation beaucoup plus grave du chômage par rapport à celle suggérée par la statistique officielle. L’Agence départementale d’occupation de la main d’oeuvre de Tulcea essaie de spécialiser une part des habitants du delta du Danube dans des activités liées an tourisme. …”
Get full text

Platelet-derived HMGB1 induces NETosis, exacerbating brain damage in the photothrombotic stroke model by Sang-A. Oh, Song-I. Seol, Dashdulam Davaanyam, Seung-Woo Kim, Ja-Kyeong Lee

“…Abstract Following cerebral ischemia, neutrophil extracellular traps (NETs) contribute significantly to brain damage by exacerbating delayed immune cell infiltration and vascular injury. They are detected both in brain tissue and within blood vessels. …”
Get full text

La mort de l’auteur selon Friedrich Kittler by Emmanuel Guez, Frédérique Vargoz

“…La « mort de l’auteur », énoncée par Roland Barthes et Michel Foucault, est ainsi en réalité pour Friedrich Kittler celle de l’auteur de ce qu’il appelle le système d’inscription 1800, c’est-à-dire le réseau institutionnel et technique déterminant les modalités selon lesquelles les données peuvent être, à cette époque, adressées, stockées et traitées. …”
Get full text

Deciphering Regulatory Networks Governing Seedling Emergence in Deep-Sown Direct-Seeded Rice Cultivation by Jasneet Singh, Nitika Sandhu, Aman Kumar, Om Prakash Raigar, Sutej Bains, Gaurav Augustine, Muskan Gupta, Ekta Kharche, Anu Kalia, Navtej Singh Bains, Arvind Kumar

“…Among these, two genes (LOC_Os04g51460 and LOC_Os02g45450) contribute to cell wall remodelling and membrane stability, while three genes (LOC_Os04g48484, LOC_Os06g04399, and LOC_Os07g15440) play key roles in mitigating abiotic stress. …”
Get full text

Preventing epileptogenesis by interaction between inositol isomers and proteins by Lia Tsverava, Luka Kharkhelauri, Vincenzo Lagani, Giorgi Gamkrelidze, Veriko Bokuchava, Tamar Kiguradze, Merab Kokaia, Revaz Solomonia

“…Myo‐inositol (MI), the most prevalent isomer, functions as an osmolyte and mediates cell signal transduction. Other notable isomers include Scyllo‐inositol (SCI) and D‐Chiro‐inositol (DCHI). …”
Get full text