Elite Alleles of EPE1 Identified via Genome-wide Association Studies Increase Panicle Elongation Length in Rice by Hao Sun, Qiqi Yao, Mei Hai, Tianhu Li, Jinghan Sun, Zhengbo Liu, Yang Ang, Yingying Zhao, Yanan Zhang, Xianping Cheng, Tao Huang, Yinping Chang, Mingyu Du, Erbao Liu

“…We characterize one gibberellin (GA)-related gene, LOC_Os02g41954 (OsGA2ox9), which encodes gibberellin 2-beta-dioxygenase 7 located in the cell membrane and nucleus. Gibberellin 2-oxidase (GA2ox) has been reported to control GA levels by inactivating GA via 2-β hydroxylation. …”
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Oral human papillomavirus (HPV) prevalence and genotyping among healthy adult populations in the United States and Europe: results from the PROGRESS (PRevalence of Oral hpv infecti... by Laia Alemany, Marisa Felsher, Anna R. Giuliano, Tim Waterboer, Haitham Mirghani, Hisham Mehanna, Craig Roberts, Ya-Ting Chen, Núria Lara, Mark Lynam, Mayara Torres, Montse Pedrós, Emilio Sanchez, Jacque Spitzer, Bradley Sirak, Beatriz Quirós, Gema Carretero, Sonia Paytubi, Edith Morais, Miquel Angel Pavón

“…Summary: Background: HPV-related oropharyngeal squamous cell carcinoma (OPSCC) is increasing in incidence, yet there are few well-designed oral HPV epidemiology studies in general populations. …”
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Cyclophilin–CD147 interaction enables SARS-CoV-2 infection of human monocytes and their activation via Toll-like receptors 7 and 8 by Gabor Tajti, Laura Gebetsberger, Gregor Pamlitschka, Katharina Aigner-Radakovics, Judith Leitner, Peter Steinberger, Hannes Stockinger, Anna Ohradanova-Repic

“…By employing THP-1 and Jurkat NF-κB::eGFP reporter cell lines expressing specific TLRs, various TLR ligands and blocking antibodies, we determined that surface TLRs, including TLR2/1, TLR2/6 and TLR4 do not play a major role in SARS-CoV-2 sensing. …”
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UV-fs-LA-ICP-MS Analysis of CO2-Rich Fluid Inclusions in a Frozen State: Example from the Dahu Au-Mo Deposit, Xiaoqinling Region, Central China by Wei Jian, Moritz Albrecht, Bernd Lehmann, Jingwen Mao, Ingo Horn, Yanhe Li, Huishou Ye, Zongyan Li, Guanguan Fang, Yongsheng Xue

“…The recently developed technique of ultraviolet femtosecond laser ablation inductively coupled plasma mass spectrometry (UV-fs-LA-ICP-MS) combined with a freezing cell is expected to improve the analysis of CO2-rich fluid inclusions by decreasing their internal pressure and avoiding the common problem of uncontrolled explosive fluid release on ablation. …”
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On the substrate turnover rate of NBCe1 and AE1 SLC4 transporters: structure-function considerations by Alexander Pushkin, Liyo Kao, Hristina R. Zhekova, Rustam Azimov, Natalia Abuladze, Xuesi M. Shao, D. Peter Tieleman, Ira Kurtz, Ira Kurtz

“…Knowledge of a transporter’s TOR allows comparison of the transport capacity of various transporters at the molecular level as well as the total transport per cell and whole organ levels. Despite this, there is currently a very limited number of transporters, for which TOR has been determined experimentally. …”
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Identifying health risk determinants and molecular targets in patients with idiopathic pulmonary fibrosis via combined differential and weighted gene co-expression analysis by Abu Tayab Moin, Md. Asad Ullah, Jannatul Ferdous Nipa, Mohammad Sheikh Farider Rahman, Afsana Emran, Md. Minhazul Islam, Swapnil Das, Tawsif Al Arian, Mohammad Mahfuz Enam Elahi, Mukta Akter, Umme Sadea Rahman, Arnab Halder, Shoaib Saikat, Mohammad Jakir Hosen

“…These genes exhibited distinct expression patterns across tissues and were associated with pathways such as extracellular matrix organization, collagen fibril formation, and cell adhesion. Co-expression analysis revealed DEG modules correlated with varying IPF severity phenotypes. …”
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Study on improving yield and antioxidant enzyme activities in millet by rationing molybdenum and nitrogen by Yuan Zhao, Guoliang Wang, Min Liu, HongTao Xue, PeiYue Zhao, BaiShu Han, HuiPing Fan, Rui Wang, LiXia Wang, ErHu Guo, AiYing Zhang, AiYing Zhang

“…The application of appropriate nitrogen and molybdenum fertilizer can improve the growth and development of plants, increase photosynthetic efficiency, regulate active oxygen metabolism in vivo, maintain the oxidation balance required for normal cell growth, enhance the activity of crop antioxidant enzymes and dry matter accumulation, so as to increase crop yield. …”
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Treatment outcomes and its associated factors among neonates admitted with sepsis in Hiwot Fana Comprehensive Specialized University Hospital, Harar, Ethiopia by Betelhem Gezahegn, Ahmed Abdella, Fentahun Meseret, Ahmed Mohammed, Mulualem Keneni, Tesfaye Asfaw, Diribsa Tizazu, Assefa Desalew

“…In the multivariable logistic regression analysis, low white blood cell (WBC) count [adjusted odds ratio (AOR) = 4.24, 95% CI: 1.5–12.5], desaturation (aOR = 3.00, 95% CI: 1.6–5.5), pre-term birth (aOR = 2.14, 95% CI: 1.1–4.0), lack of maternal antenatal care (ANC) follow-up (aOR = 2.4, 95% CI: 1.2–4.7), and chorioamnionitis (aOR = 2.8, 95% CI: 1.2–6.5) were significantly associated with neonatal sepsis mortality.ConclusionApproximately one-quarter of patients with neonatal sepsis died. …”
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Molecular mechanisms of aflatoxin neurotoxicity and potential neuroprotective agents by Chongshan Dai, Erjie Tian, Hui Li, Subhajit Das Gupta, Zhihui Hao, Zhanhui Wang, Tony Velkov, Jianzhong Shen

“…Several signaling pathways, including gasdermin D, toll like receptor 2 (TLR2), TLR4, Akt, NF-κB, ERK/MAPK, protein kinase C (PKC), and mitochondrial apoptotic pathways have been shown to participate in AFB1-induced neuronal or astrocyte cell death. Targeting these pathways by small molecules (e.g., quercetin, curcumin, and gallic acid, and dimethyl fumarate), Chinese herbal extracts (e.g., Artichoke leaf extract, Chelidonium majus ethanolic extract, pumpkin extract, and Crocus sativus L. tea), and probiotic supplements could effectively improve AFB1-induced neurobehavioral abnormalities and neurotoxicity. …”
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Hepatitis associated with immune checkpoint inhibitors-based combinations of other therapies: A real-world pharmacovigilance analysis based on the FDA adverse event reporting syste... by Zhaohui Li, Zixiang Zhou, Nan Zhang, Binhe Tian, Xiangqi Chen, Haitao Zhao, Hanping Wang

“…Abstract Background The combination regimen with immune checkpoint inhibitors (ICIs) and other therapies has been widely applied for patients with non-small-cell lung cancer (NSCLC). To date, no literature has systematically addressed the risk of hepatitis associated with the combination therapy. …”
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Research on screening key proteins related to the pathogenesis of sepsis associated encephalopathy based on DIA proteomics technology by Wu Shuhui, Hu Hongjie, Lu Yuru, Zhu Wei

“…These proteins were involved in signaling pathways such as Mitogen-Activated Protein Kinase （MAPK） signaling, focal adhesion and phospholipase D signaling pathways, and were involved in biological processes such as cell adhesion, signaling, macromolecular modification, etc. …”
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Peripheral blood immunoinflammatory biomarkers: prospective predictors of postoperative long-term survival and chronic postsurgical pain in breast cancer by Baoli Li, Li Che, Huixian Li, Fangdi Min, Bolun Ai, Linxin Wu, Taihang Wang, Peixin Tan, Bingbing Fu, Jiashuo Yang, Yi Fang, Hui Zheng, Tao Yan

“…The relationships among the perioperative neutrophil count (NEU), monocyte count (MONO), lymphocyte count (LYM), platelet count (PLT), SII, SIRI, NLR, PIV, dynamic changes in peripheral blood cell counts, and CPSP were further assessed using logistic regression analysis.ResultsKaplan−Meier curves revealed a considerable prolongation of disease-free survival (DFS) and overall survival (OS) in the low preoperative SII, SIRI, NLR, and PIV groups. …”
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Computer-guided identification of novel inhibitors of apoptosis-signaling kinase 1 from Spondia mombim bioactive compounds against colorectal cancer by Olusola Olalekan Elekofehinti, Hannah Oluwaseun Popoola, Adedotun Olayemi Oluwatuyi, Opeyemi Iwaloye, Moses Orimoloye Akinjiyan, Oluwamodupe Cecilia, Frank Abimbola Ogundolie, Olalekan Isaac Olatunde, Oussama Abchir, Samir Chtita, Joao Batista Texeira Rocha

“…It mediates inflammation and apoptosis and promotes cell proliferation through the transcription of cyclin D1. 5-Fluorouracil remains one of the primary recommended drugs to manage colorectal cancer. …”
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Multi-Omics Analysis in Mouse Primary Cortical Neurons Reveals Complex Positive and Negative Biological Interactions Between Constituent Compounds of <i>Centella asiatica</i> by Steven R. Chamberlin, Jonathan A. Zweig, Cody J. Neff, Luke Marney, Jaewoo Choi, Liping Yang, Claudia S. Maier, Amala Soumyanath, Shannon McWeeney, Nora E. Gray

“…Treatment effects on the cell transcriptome (18,491 genes) and metabolome (192 metabolites) relative to vehicle control were evaluated using RNAseq and metabolomic analyses, respectively. …”
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Screened of long non-coding RNA related to wool development and fineness in Gansu alpine fine-wool sheep by Zhaohua He, Fangfang Zhao, Hongxian Sun, Jiang Hu, Jiqing Wang, Xiu Liu, Mingna Li, Zhiyun Hao, Zhidong Zhao, Bingang Shi, Feiyan Liu, Shaobin Li

“…Utilizing functional enrichment analysis on the target genes, we successfully identified a number of target genes might be associated with the improvement of wool fineness, such as FOXN1, LIPK, LOC101116068, LOC101106296, KRTAP5.4, KRT71, KRT82, DNASE1L2, which are related to hair follicle development, histidine metabolism, epidermal cell differentiation, oxidative phosphorylation and hair cycle process. …”
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Genome-wide association study of the antibody response to <i>Corynebacterium pseudotuberculosis</i> in sheep by J. Kyselová, L. Tichý, J. Marková, A. Gurgul, Z. Sztankóová, K. Vališ, S. Šlosárková, K. Kavanová, M. Beinhauerová, T. Szmatola, T. Szmatola

“…These include antigen processing and presentation of exogenous peptides via major histocompatibility complex (MHC) class I and II, Th17 mucosal cell differentiation, cellular autophagy, and phagosome-related mechanisms. …”
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Adaptive clinical trial of AZD7442 and SARS-CoV-2 vaccination in immunosuppressed patients highly vulnerable to infection with SARS-CoV-2 virus (RAPID-PROTECTION): protocol for a m... by Ernest Choy, Kerenza Hood, Emma Thomas-Jones, Eleanor Barnes, Keith Wilson, Christian H Ottensmeier, Debbie Harris, Adrian Hill, Mark Tuthill, Richard Adams, Catherine Porter, Katie Ewer, Sian Griffin, Rebecca Tangney, Joanne Euden, Shirley Pringle, Lawrence Raisanen, Ruby Ray, Lisette Sheena Nixon, Melanie Varley, Craig Bodman, Paola Cicconi, Vivien Dagley, Steven Knapper

“…Participant samples will be taken at baseline and at multiple timepoints after the administration of AZD7442.Analysis The participant samples will be analysed to measure the function and magnitude of SARS-CoV-2 specific antibody and T-cell responses at baseline and at multiple timepoints after the administration of AZD7442. …”
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APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology by Kristine M. Tran, Nellie E. Kwang, Claire A. Butler, Angela Gomez-Arboledas, Shimako Kawauchi, Cassandra Mar, Donna Chao, Rocio A. Barahona, Celia Da Cunha, Kate I. Tsourmas, Zechuan Shi, Shuling Wang, Sherilyn Collins, Amber Walker, Kai-Xuan Shi, Joshua A. Alcantara, Jonathan Neumann, Duc M. Duong, Nicholas T. Seyfried, Andrea J. Tenner, Frank M. LaFerla, Lindsay A. Hohsfield, Vivek Swarup, Grant R. MacGregor, Kim N. Green

“…We used immunohistochemical and biochemical analysis along with single-cell spatial omics and bulk proteomics to explore the impact of the ApoeCh variant on AD pathological development and the brain’s response to plaques and tau. …”
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Parasitic infection prevalence in tuberculosis patients and their household contacts in the Littoral Region of Cameroon by Lucy Cho Nchang, Chefor Magha, Patience Agwa Fonong, Narcisse Victor Tchamatchoua Gandjui, Nancielle Mbiatong Tchatat, Desmond Akumtoh Nkimbeng, Frank Noel Nietcho, Juluis Visnel Foyet, Fanny Fri Fombad, Tatiana Djikeussi Katcho, Jerome Fru Cho, Achim Hoerauf, Manuel Ritter, Samuel Wanji

“…Background: Parasitic infections are known to suppress the cell mediated immunity that protects against tuberculosis. …”
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Exercise-induced anxiety impairs local and systemic inflammatory response and glucose metabolism in C57BL/6J mice by I. Gálvez, M.C. Navarro, S. Torres-Piles, L. Martín-Cordero, M.D. Hinchado, E. Ortega

“…Exercise strongly modulates the immune system, inducing a plethora of dynamic responses involving the innate immune cell function and inflammatory processes that contribute to both potential health benefits and harmful side effects. …”
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