Preserved Expression of Skin Neurotrophic Factors in Advanced Diabetic Neuropathy Does Not Lead to Neural Regeneration despite Pancreas and Kidney Transplantation by František Saudek, Monika Cahová, Terezie Havrdová, Klára Zacharovová, Helena Daňková, Luděk Voska, Věra Lánská, Nurcan Üçeyler, Claudia Sommer

“…Compared to DM and HC groups, we found a significantly higher (p < 0.05–0.001) expression of NGF (nerve growth factor), NGFR (NGF receptor), NTRK1 (neurotrophic receptor tyrosine kinase 1), GDNF (glial cell-derived neurotrophic factor), GFRA1 (GDNF family receptor alpha 1), and GFAP (glial fibrillary acidic protein) in both transplant groups (Tx1 and Tx2). …”
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Sustainable Skincare Innovation: Cork Powder Extracts as Active Ingredients for Skin Aging by Ana Silva, Cláudia Pinto, Sara Cravo, Sandra Mota, Liliana Rego, Smeera Ratanji, Clara Quintas, Joana Rocha e Silva, Carlos Afonso, Maria Elizabeth Tiritan, Honorina Cidade, Teresa Cruz, Isabel F. Almeida

“…Antioxidant potential was screened by DPPH method and the bioactivity and safety of extracts were further explored using cell-based assays. <b>Results</b>: All extracts exhibited a reduction in age-related markers, including senescence-associated beta-galactosidase (SA-β-gal) activity. …”
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Microtubule inhibition as a proposed mechanism for the anthelmintic effect of phytochemicals isolated from Cicerbita alpina by Mark James Horgan, Ines Sigg, Ioanna Poulopoulou, Francisco J. Rodriguez-Mejias, Eva Albertini, Pietro Fusani, Florian Fischer, Eftychia Martinidou, Daniela Schuster, Stefan Martens, Pidder Jansen Dürr, Matthias Gauly, Hermann Stuppner, Alexander Weiss, Veronika Temml, Bianka Siewert

“…Additionally, the BuOH fraction was non-cytotoxic to human cell-lines. Subsequent FCC and SEC derived subfractions were submitted to the anthelmintic assay workflow and the enriched subfractions B1 and E3.8, phytochemically assigned as 11-β,13-dihydrolactucin and luteolin, demonstrated bioactivity against the embryo phenotype (B1 | 58% ED | c = 1.8 µM and E3.8 | 46% ED | c = 1.7 µM) within range of the flubendazole control. …”
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Hsp70/Bmi1-FoxO1-SOD Signaling Pathway Contributes to the Protective Effect of Sound Conditioning against Acute Acoustic Trauma in a Rat Model by Guoxia Zhu, Yongxiang Wu, Yang Qiu, Keyong Tian, Wenjuan Mi, Xinqin Liu, Yuanyuan Chen, Jinwen Jia, Jiasheng Luo, Lianjun Lu, Jianhua Qiu

“…Moreover, the auditory brainstem responses (ABRs) and electron microscopy revealed that SC could protect against acute acoustic trauma (AAT) based on a significant reduction of hearing impairment and visible reduction in outer hair cell loss as well as ultrastructural changes in OHCs and SGNs. …”
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Clinical Practice Guideline for the Treatment of Traumatic Shock Patients from the Korean Society of Traumatology by Pil Young Jung, Byungchul Yu, Chan-Yong Park, Sung Wook Chang, O Hyun Kim, Maru Kim, Junsik Kwon, Gil Jae Lee, Korean Society of Traumatology (KST) Clinical Research Group

“…The ratio of plasma to red blood cell concentration should be at least 1:2 for trauma patients requiring massive transfusion (1B). …”
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miRNAs and Hematological Markers in Non-Alcoholic Fatty Liver Disease—A New Diagnostic Path? by Agata Michalak, Małgorzata Guz, Joanna Kozicka, Marek Cybulski, Witold Jeleniewicz, Ilona Telejko, Karolina Szczygieł, Ewa Tywanek, Halina Cichoż-Lach

“…The assessment of hematological parameters concerned: mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), red blood cell distribution width (RDW), MPV to platelet (PLT) ratio (MPR), RDW to PLT ratio (RPR), neutrophil to lymphocyte (LYM) ratio (NLR), PLT to LYM ratio (PLR) and RDW to LYM ratio (RLR). …”
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Development of a recombinant infectious bronchitis virus vaccine expressing infectious laryngotracheitis virus multiple epitopes by Guanming Shao, Jun Fu, Yun Pan, Shiying Gong, Chaoyi Song, Sheng Chen, Keyu Feng, Xinheng Zhang, Qingmei Xie

“…In this study, we designed a multi-epitope cassette (gD-T/B) containing multiple T and B cell epitopes of ILTV gD protein. The genetic stability of the full-length gD gene and the gD-T/B multi-epitope cassette replacing non-essential genes in IBV was systematically analyzed. …”
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Unveiling <i>DENND2D</i> as a Novel Prognostic Biomarker for Prostate Cancer Recurrence: From Gene to Prognosis by Chi-Fen Chang, Lih-Chyang Chen, Yei-Tsung Chen, Chao-Yuan Huang, Chia-Cheng Yu, Victor C. Lin, Te-Ling Lu, Shu-Pin Huang, Bo-Ying Bao

“…Emerging evidence suggests a critical role for differentially expressed in normal and neoplastic cell (<i>DENN</i>) domain-containing genes in oncogenesis; however, their implications in prostate cancer and BCR risk remain underexplored. …”
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Lipoxin A4 yields an electrophilic 15-oxo metabolite that mediates FPR2 receptor-independent anti-inflammatory signaling by Adolf Koudelka, Gregory J. Buchan, Veronika Cechova, James P. O’Brien, Emily R. Stevenson, Crystal E. Uvalle, Heng Liu, Steven R. Woodcock, Steven J. Mullett, Cheng Zhang, Bruce A. Freeman, Stacy L. Gelhaus

“…The enzymatic oxidation of arachidonic acid is proposed to yield trihydroxytetraene species (termed lipoxins) that resolve inflammation via ligand activation of the formyl peptide receptor, FPR2. While cell and murine models activate signaling responses to synthetic lipoxins, primarily lipoxin A4 (LXA4), there are expanding concerns about the reported biological formation, detection, and signaling mechanisms ascribed to LXA4 and related di- and tri-hydroxy ω-6 and ω-3 fatty acids. …”
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Effects and Mechanisms of Cutting Upper Thoracic Sympathetic Trunk on Ventricular Rate in Ambulatory Canines with Persistent Atrial Fibrillation by Jie Cai, Min Tang, Hao Liu, Shiao Ding, Rongxin Lu, Wei Wang, Nan Ma, Ju Mei, Zhaolei Jiang

“…Compared with the control group, both left stellate ganglion (LSG) and right stellate ganglion (RSG) of the experimental group caused neural remodeling characterized by decreased ganglionic cell density and reduced TH staining. TH-positive component was significantly decreased in the left atrium of the experimental group compared with the control group. …”
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Pediatric bacterial meningitis in southern China: analysis of 838 cases by Lianfeng Chen, Wen-Lin Wu, Yuanyuan Gao, Xiaojing Li, Sida Yang, Huici Liang, Kelu Zheng, Yani Zhang, Haixia Zhu, Yang Tian, Bingwei Peng, Haisheng Lin, Xiuying Wang, Shuyao Ning, Yinyan Gan, Chi Hou, Yinting Liao, Huiling Sheng, Wen-Xiong Chen, Wen-Xiong Chen

“…Most patients initially exhibited typical cerebrospinal fluid (CSF) changes of BM, including elevated white blood cell count, increased protein levels, and decreased glucose concentration. …”
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Optimizing Energy and Spectral Efficiency in Mobile Networks: A Comprehensive Energy Sustainability Framework for Network Operators by Luis Mata, Marco Sousa, Pedro Vieira, Maria Paula Queluz, Antonio Rodrigues

“…The framework can be flexibly applied at the location (site), BS (cell), or equipment type (hardware) levels. Notably, the implemented ML and XAI model achieved an F1-Score of 0.78 for 5G scenarios and 0.83 for 4G scenarios in predicting the Energy Sustainability Class, relying on a reduced set of indicators encompassing the most influential factors. …”
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Polymorphism of genes associated with infectious lung diseases in Northern Asian populations and in patients with community-acquired pneumonia by S. V. Mikhailova, L. V. Shcherbakova, N. I. Logvinenko, I. I. Logvinenko, M. I. Voevoda

“…It is responsible for invader recognition, immune-cell recruitment, adaptive-immunity activation, and regulation of inflammation intensity. …”
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The role of ultrasound combined with water bath in the establishment of animal models of rat urethral stricture by Xiaojian Ye, Xianjing Lin, Yehui Chen, Rongquan Xu, Jiawei Zhou

“…The surgical groups underwent urethral injury induced by recombinant transforming growth factor-β1 (TGF-β1) solution, followed by the random selection of one surgical group (n = 6) to receive treatment with mesenchymal stem cell (MSC) exosomes. High-frequency ultrasonography using a GE E10 device combined with a water bath method was employed to evaluate the urethral conditions of all rats. …”
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c-FLIP and microRNA 708-5p gene expression in newly diagnosed and chemotherapy in acute myeloid leukemia of Iraqi patient by Jaafar Sadiq Jaafar, Hiba Muneer Abdual Hassan Al-Kafagi, Israa Hussein Hamzah

“…BACKGROUND: C-FLICE-like inhibitory protein (c-FLIP) is a protein that does not merely block apoptosis signaling but also adjusts further pathways of cell death. Acute myeloid leukemia (AML), a nonhomogeneous hematologic malignancy, is the highly common form of AML among adults and is described through the clonal enlargement of myeloid blasts in the bone marrow (BM), peripheral blood, and/or else tissues. …”
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An Improved Bio-Inspired Material Generation Algorithm for Engineering Optimization Problems Including PV Source Penetration in Distribution Systems by Mona Gafar, Shahenda Sarhan, Ahmed R. Ginidi, Abdullah M. Shaheen

“…Lastly, the PV parameters estimation problem is successfully solved via IMGO, considering the commercial RTC France cell. Comparative studies demonstrate that the IMGO algorithm not only achieves significant energy loss reduction but also contributes to environmental sustainability by reducing emissions, showcasing its overall effectiveness in practical energy optimization applications. …”
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Development and validation of a prediction model for acute kidney injury following cardiac valve surgery by Xiaotong Jia, Jun Ma, Zeyou Qi, Dongni Zhang, Junwei Gao

“…Based on multivariate analysis, advanced age (OR: 1.855; p = 0.011), preoperative hypertension (OR: 1.91; p = 0.017), coronary heart disease (OR: 6.773; p &lt; 0.001), preoperative albumin (OR: 0.924; p = 0.015), D-Dimer (OR: 1.001; p = 0.038), plasma creatinine (OR: 1.025; p = 0.001), cardiopulmonary bypass (CPB) duration (OR: 1.011; p = 0.001), repeat CPB (OR: 6.195; p = 0.010), intraoperative red blood cell transfusion (OR: 2.560; p &lt; 0.001), urine volume (OR: 0.406 p &lt; 0.001) and vasoactive–inotropic score (OR: 1.135; p = 0.009) were independent risk factors for AKI. …”
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Biofabrication of copper oxide nanoparticles using Dalbergia sisso leaf extract for antibacterial, antibiofilm and antioxidant activities by Muhammad Hussnain Siddique, Maimona Sadia, Saima Muzammil, Muhammad Saqalein, Asma Ashraf, Sumreen Hayat, Saba Saba, Arif Muhammad Khan, Abeer Hashem, Graciela Dolores Avila-Qezada, Elsayed Fathi Abd-Allah

“…The effect of different concentrations of nanoparticles on cell membrane disruption was also investigated and a significant increase (p < 0.05) in the leakage of cellular content such as DNA, proteins and reducing sugar was measured. …”
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DigiLoCS: A leap forward in predictive organ-on-chip simulations. by Manoja Rajalakshmi Aravindakshan, Chittaranjan Mandal, Alex Pothen, Stephan Schaller, Christian Maass

“…The methodology integrated quantitative Organ-on-Chip (OoC) and cell-based assay analyses of drug depletion kinetics and is further enhanced by incorporating an OoC-digital twin model to simulate drug depletion kinetics in humans. …”
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Butterfly Pea and Roselle Combination Extracts Reduce V-CAM, ICAM, and IL-6 Levels in High Fat Atherogenic Diet Rats by Karnirius Harefa, Ahmad Hafizullah Ritonga, Riri Safitri, Barita Aritonang, Rahmad Gurusinga, Irmayani Irmayani, Sri Wulan

“…While their individual effects on cardiovascular health have been studied, no studies have explored the combined impact on atherosclerosis biomarkers, including vascular cell adhesion molecules (VCAM)-1, intercellular adhesion molecule (ICAM)-1, and interleukin (IL)-6. …”
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