Disrupting the network of co-evolving amino terminal domain residues relieves mitochondrial calcium uptake inhibition by MCUb by Danielle M. Colussi, Ryan Grainger, Megan Noble, Taylor Lake, Murray Junop, Peter B. Stathopulos

“…The regulatory mechanisms of the mitochondrial calcium uniporter complex (mtCU), the predominant channel mediating calcium (Ca2+) flux into the matrix, are critical for bioenergetics and cell fate. The pore-forming components of mtCU are the mitochondrial Ca2+ uniporter (MCU) subunit and the MCU dominant-negative beta (MCUb) subunit. …”
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Signatures of H3K4me3 modification predict cancer immunotherapy response and identify a new immune checkpoint-SLAMF9 by Tao Fan, Chu Xiao, Ziqin Deng, Shuofeng Li, He Tian, Yujia Zheng, Bo Zheng, Chunxiang Li, Jie He

“…The mice melanoma model showed Slamf9 knockdown remarkably restrained cancer progression and enhanced the efficacy of anti-CTLA-4 and anti-PD-L1 therapies by elevating CD8 + T cell infiltration. This study provided a new H3K4me3-associated biomarker system to predict tumor immunotherapy response and suggested the preclinical rationale for investigating the roles of SLAMF9 in cancer immunity regulation and treatment.…”
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Leveraging Autofluorescence for Tumor Detection, Diagnosis, and Accurate Excision with Surgical Margin Assessment in Tumor Excision by Antonis Perdiou, Ramona Dumitrescu, Daniela Jumanca, Octavia Balean, Ruxandra Sava-Rosianu, Serban Talpos, Dacian Virgil Lalescu, Atena Galuscan

“…A double analysis was conducted: a primary analysis of the full cohort and a subgroup analysis focusing on squamous cell carcinoma (control: <i>n</i> = 19; experimental: <i>n</i> = 24). …”
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Associations between brominated flame retardants exposure and non-alcoholic fatty liver disease: Mediation analysis in the NHANES by Yulan Cheng, Jingyi Su, Xiangdong Wang, Ruiyao Huang, Zixuan Zhao, Kai Tian, Tianxiang Gu, Xiaoke Wang, Lin Chen, Xinyuan Zhao

“…Additionally, mediation analysis showed that absolute neutrophil cell count (ANC) and lymphocyte count (LC) (inflammation markers) have significantly mediated influences on the correlations of PBB153, PBDE85, and PBDE28 with N AFLD risk. …”
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Cadmium and polyvinyl chloride microplastics induce mitochondrial damage and apoptosis under oxidative stress in duck kidney by Hui Zou, Jie Song, Xianzu Luo, Waseem Ali, Sifan Li, Ling Xiong, Yan Chen, Yan Yuan, Yonggang Ma, Xishuai Tong, Zongping Liu

“…These injuries can induce mitochondrial damage and eventually lead to renal cell apoptosis. To sum up, these evidence show that Cd or PVC-MPs can induce kidney oxidative damage, trace element metabolism disorder, mitochondrial damage and apoptosis.…”
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ApWD40a, a Member of the WD40-Repeat Protein Family, Is Crucial for Fungal Development, Toxin Synthesis, and Pathogenicity in the Ginseng Alternaria Leaf Blight Fungus <i>Alternari... by Jinling Lan, Shengjie Mei, Yingxue Du, Meili Chi, Jiayi Yang, Shuliu Guo, Mingliang Chu, Ronglin He, Jie Gao

“…The Δ<i>Apwd40a</i> mutant showed increased sensitivity to osmotic stress and metal ion stress induced by sorbitol, NaCl, and KCl, but decreased the sensitivity to a cell wall stress factor (SDS) and oxidative stress factors (paraquat and H₂O₂). …”
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Molecular genetic diagnosis and surgical management in a cohort of children with 46,XY disorders/differences of sex development by Yuenshan Sammi Wong, Yuenshan Sammi Wong, Ho Ming Luk, Ho Chung Yau, Lap Ming Wong, Sarah Wing Yiu Poon, Joanna Yuet Ling Tung, Yuk Him Tam, Yuk Him Tam

“…A total of 5/21 had germ cell neoplasms in one or both gonads. A total of 8/10 patients with gonadal dysgenesis had comorbidities involving other systems. …”
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Effects of Extraction Temperature on Physicochemical Properties and Antioxidant and Immunomodulatory Activities of Polysaccharides from Lycium ruthenicum Murr. by Bing LIU, Jingyu MA, Ting LI, Jun ZHU, Meipeng ZHU, Lihua WU, Xia CHEN, Xinguo ZHANG, Ping ZHAO

“…The effect of extraction temperature on the immunomodulatory activity of LRPs was investigated by analyzing the effect of LRPs on RAW264.7 cell viability and cytokine secretion. Different extraction temperatures could affect the physicochemical properties of LRPs as well as their antioxidant and immunomodulatory activities. …”
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The promotion effect of FeS2 on Sb2S3 bioleaching and Sb speciation transformation by Xing-fu Zheng, Xing-fu Zheng, Xing-fu Zheng, Jin-lan Xia, Jin-lan Xia, Zhen-yuan Nie, Zhen-yuan Nie, Hong-peng Cao, Hong-peng Cao, Rui-Jia Hu, Yu-ting Liang, Hong-chang Liu, Hong-chang Liu

“…The electrochemical results revealed that after FeS2 was mixed, a FeS2-Sb2S3 galvanic cell formed, which promoted the electron transfer efficiency and redox reaction of Sb2S3. …”
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Intratumoral oncolytic virus OH2 injection in patients with locally advanced or metastatic sarcoma: a phase 1/2 trial by Lu Zhang, Shu Li, Jing Huang, Yan Wu, Liang Han, Tian Gao, Qingxia Fan, Suxia Luo, Binlei Liu, Lixin Zhou, Xinyu Wang, Ling Jia, Jianhua Shi, Zhichao Tan, Zhengfu Fan, Sijuan Ding, Chujie Bai, Ruifeng Xue, Jiayong Liu

“…A clear increase in CD8+cell density in the tumor microenvironment was observed in the patients’ post-treatment specimens compared with baseline.Conclusions Intratumoral injection of oncolytic virus OH2 is well tolerable in patients with sarcoma. …”
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Evaluation of the antidiabetic and antinephritic effects of Pueraria tuberosa and Pterocarpus santalinus extracts co-encapsulated in nanostructured lipid carriers in streptozotocin... by Gyamcho Tshering Bhutia, Asit Kumar De, Manas Bhowmik, Pavia Bera, Tanmoy Bera

“…It restored the kidney hypertrophy index, stabilized biochemical parameters, enhanced histopathological outcomes, and increased beta-cell count. Additionally, (PTE+PSE)-NLC led to a 30.53-fold more significant reduction in blood glucose levels than free (PTE+PSE) extracts. …”
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Prevalence of Autoimmune Thyroiditis and Other Autoimmune Diseases in Relation to Serum BAFF/APRIL Levels in Prolactinoma Patients by Özlem Kanburoğlu Meletli, Alev Altınova, Başak Bolayır, Resul Karakuş, Meriç Coşkun, Mehmet Muhittin Yalçın, Müjde Aktürk, İlhan Yetkin, Füsun Saadet Toruner

“…The aim of this study was to investigate the prevalence of thyroid and non-thyroid autoimmune diseases, serum B-cell activating factor (BAFF), and proliferation- inducing ligand (APRIL) levels as indicators of increased autoimmunity, quality of life, depression, and anxiety in patients with prolactinoma. …”
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Multi-omics unveils strain-specific neuroactive metabolite production linked to inflammation modulation by Bacteroides and their extracellular vesicles by Basit Yousuf, Walid Mottawea, Galal Ali Esmail, Nazila Nazemof, Nour Elhouda Bouhlel, Emmanuel Njoku, Yingxi Li, Xu Zhang, Zoran Minic, Riadh Hammami

“…We used CRISPR/Cas12a-based gene engineering to create a knockout mutant lacking the glutamate decarboxylase gene (gadB) to demonstrate the specific contribution of Bacteroides finegoldii-derived GABA in modulating intestinal homeostasis. Cell-free supernatants from wild-type (WT, GABA+) and ΔgadB (GABA-) provided GABA-independent reinforcement of epithelial membrane integrity in LPS-treated Caco-2/HT29-MTX co-cultures. …”
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Coagulation Profile of Convalescent Plasma Donors and Recipients by Hanna H Pitkänen MD, PhD, Tuukka Helin MD, PhD, Tamim Khawaja MD, Jukka-Pekka Pietilä MD, Mikael Kajova MD, Hanna Välimaa MD, PhD, DDS, Tero Vahlberg MSc, Jarkko Ihalainen MD, Antti Vierikko MD, Olli Vapalahti MD, PhD, Anu Kantele MD, PhD, Riitta Lassila MD, PhD

“…CP donors had normal blood cell counts and coagulation profiles, without differences between LCP and HCP donors at the baseline. …”
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Hydrogen Sulfide Promotes Functional Endometrium Recovery via Regulating Pyroptosis in Severe Endometrial Injury: A Prospective Laboratory Based Randomized Control Trial by Haiyan Shan, Mingyuan Xu, Jie Ni, Ling Zhou, Mengchun Xue, Jun Xue, Xiaohuan Yuan, Luyang Tao, Mingyang Zhang, Hong Zhang

“…Pyroptosis, a form of programmed cell death associated with inflammation, is initiated by the cleavage of gasdermin family proteins by caspase, which has been implicated in endometrial injury. …”
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Ozone Therapy on Rats Submitted to Subtotal Nephrectomy: Role of Antioxidant System by José Luis Calunga, Zullyt B. Zamora, Aluet Borrego, Sarahí del Río, Ernesto Barber, Silvia Menéndez, Frank Hernández, Teresita Montero, Dunia Taboada

“…Ozone increases the endogenous antioxidant defense system, preserving the cell redox state. The aim of this study is to evaluate the effect of ozone/oxygen mixture in the renal function, morphology, and biochemical parameters, in an experimental model of CRF (subtotal nephrectomy). …”
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Transcriptomic analysis of melatonin on the mechanism of embryonic gonadal development in female Jilin white geese by Jin Yu, Ichraf Mabrouk, Qiuyuan Liu, Yuxuan Zhou, Yupu Song, Jingyun Ma, Fengshuo Liu, Xiangman Hu, Zhiyi Yang, Yuxia Zeng, Jingtao Hu, Yongfeng Sun

“…These DEGs were enriched in Gene Ontology (GO) terms related to the microtubule cytoskeleton, cytoskeleton, cell adhesion, and biological adhesion and the KEGG enrichment analysis suggested that the DEGs were mainly enriched in “MAPK signaling pathway”, “Wnt signaling pathway”, “Calcium signaling pathway”, “Focal adhesion”, “Neuroactive ligand-receptor interaction”, “Melanogenesis”, “mTOR signaling pathway”, “ECM-receptor interaction”, and “TGF-beta signaling pathway” in the two comparison groups. …”
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EGR1 mRNA expression levels and polymorphisms are associated with slaughter performance in chickens by Mao Ye, Xiaohuan Chao, Chutian Ye, Lijin Guo, Zhexia Fan, Xuerong Ma, Aijun Liu, Weiming Liang, Shuya Chen, Cheng Fang, Xiquan Zhang, Qingbin Luo

“…We used various experimental methods, including RT-qPCR, Cell Counting Kit 8, 5-ethynyl-2′-deoxyuridine, western blot, flow cytometry, and immunofluorescence, to validate EGR1’s role in chicken primary myoblasts. …”
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Angelica sinensis polysaccharide as potential protectants against recurrent spontaneous abortion: focus on autophagy regulation by Yeli Sun, Guohua Li, Mengwen Kong, Junyuan Li, Shuyun Wang, Yuan Tan

“…Functional assays revealed that ASP enhances trophoblast cell proliferation, migration, and invasion.ConclusionIn summary, our findings demonstrate diminished autophagy activity in RSA patients, while ASP appears to restore autophagy and regulate key metabolic pathways, including glycolysis/gluconeogenesis. …”
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A Potential Protective Effect of Alcohol Consumption in Male Genital Lichen Sclerosus: A Case-Control Study by Joey El Khoury, Jessica Andraos, Anthony Kanbar, Rami Halabi, Serge Assaf, Anthony Mina, Sabine El Breidi, Charbel Dabal, Charbel El Hachem, Rodrigue Saad, Antoine Kassis, Maher Abdessater, Raghid El Khoury

“…The etiologies and exact pathophysiology are not well-known; however, LSc can be considered a precursor to male genital squamous cell carcinoma. We aim, through this case-control study, to potentially associate genital LSc with risk factors and certain patient characteristics in Lebanese adult males. …”
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