Comparative analysis of clinical characteristics and outcomes between carbapenem-resistant and carbapenem-sensitive Klebsiella pneumoniae infections: insights from a tertiary hospi... by Bu Wang, Bu Wang, Wei Zhang, Hongxia Zhang, Maochen Li, Zhihua Zhang, Xiaocui Peng, Na Wang, Ning Song

“…CRKP patients had significantly higher body temperature, white blood cell counts, and inflammatory markers, while showing lower diastolic blood pressure and oxygen saturation (p < 0.05). …”
Get full text

Phytocompounds from Indonesia Medicinal Herbs as Potential Apelin Receptor Agonist for Heart Failure Therapy: An In-silico Approach by Muhamad Rizqy Fadhillah, Wawaimuli Arozal, Muhammad Habiburrahman, Somasundaram Arumugam, Heri Wibowo, Suci Widya Primadhani, Aryo Tedjo, Surya Dwira, Nurul Gusti Khatimah

“…The Apelin Receptor (APR), a class A (rhodopsin-like) G-Protein Coupled Receptor (GPCR), is one of the cell membrane receptors that potentially become a specific target of heart failure therapy when activated. …”
Get full text

Comprehensive analysis of mRNA and miRNA differential expression profiles in the hypothalamus-pituitary-gonadal axis in laying and broodiness period of Wanxi white geese by Xinwei Tong, Xiaojin Li, Yuhua Wang, Fei Xie, Ruidong Li, Man Ren, Qianqian Hu, Shenghe Li

“…Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analysis showed that differentially expressed genes (DEGs) and differentially expressed miRNAs (DEMs) were significantly enriched in hormone level regulation, cell communication, calcium signaling pathway, GnRH signaling pathway, MAPK signaling pathway, Wnt signaling pathway, and other processes. …”
Get full text

Recent trends in research on the role of cholesterol in leukemia: a bibliometric and visualization study by Huijuan Lv, Ke Lu, Ximing Wang, Yanfang Zhang, Mengqi Zhuang, Jing Li, Keli Su, Wen Gao

“…BackgroundCholesterol metabolism significantly impacts leukemia pathophysiology, affecting tumor cell survival, proliferation, and treatment resistance. …”
Get full text

A case of de novo neuroendocrine prostate cancer presented with elevated level of serum CEA carrying BRCA2 mutation: case report and literature review by Weizhe Han, Nihati Rexiati, Fang Yu, Yongzhi Wang, Yueli Tian, Jianyuan Wu, Gang Wang, Tao Liu, Zhonghua Yang

“…Biopsy of prostate revealed mixed carcinoma including small cell neuroendocrine carcinoma (SCNEC) and adenocarcinoma (Gleason score of 4 + 5). …”
Get full text

The Relationship of Tumor-infiltrating Lymphocyte Ratio with Histopathological Parameters and Effect on Survival in Colorectal Cancers by İsra Serda Oğuz, Sinan Koca, Seval Ay Ersoy, Özgecan Dülgar, Ayşenur Toksöz, Mahmut Gümüş

“…Introduction: Tumor lymphocyte infiltration demonstrates a positive effect on patient survival in breast cancer, melanoma, renal cell carcinoma, and lung cancer. This study aimed to elucidate the relationship between tumor-infiltrating lymphocyte (TIL) ratio and disease-free survival (DFS) and overall survival (OS) by considering localization, clinical and pathological features, microsatellite instability (MSI) status, mutation status, and demographic data. …”
Get full text

Alarmins HMGB1, IL-33, S100A7, and S100A12 in Psoriasis Vulgaris by Pavel Borsky, Zdenek Fiala, Ctirad Andrys, Martin Beranek, Kvetoslava Hamakova, Andrea Malkova, Tereza Svadlakova, Jan Krejsek, Vladimir Palicka, Lenka Borska, Vit Rehacek

“…They are the markers of cell destructive processes. Objective. The aim of the present study was to evaluate the suitability of selected alarmins (HMGB1, IL-33, S100A7, and S100A12) as potential biomarkers of severity of psoriasis and to explore possible relationships between these proteins for the purpose of better understanding their roles in the immunopathology of psoriasis. …”
Get full text

Fatal toxoplasmic encephalitis triggered by anti-TNF therapy by Rodrigo A. Montoro, Michael Moran, Katherine A. Overmyer, Andrew Periaccante, Joshua J. Coon, Swapnil Lanjewar, Laura J. Knoll, Rob Striker

“…First, in addition to her rheumatoid arthritis pathology, there is evidence of loss of immune resilience and abnormal T cell subsets. Second, some strains of T. gondii are more virulent than others. …”
Get full text

Identification of novel pQTL‐SNPs associated with lung adenocarcinoma risk: A multi‐stage study by Yutong Wu, Huiwen Xu, Liping Mao, Rongrong Zhao, Junfeng Chu, Lili Huang, Wendi Zhang, Yiran Liu, Qiong Chen, Xiaobo Tao, Siqi Li, Shenxuan Zhou, Anhui Ning, Zhenyu Li, Tian Tian, Lei Zhang, Jiahua Cui, Guangyu Tian, Minjie Chu

“…In addition, the expression of NRP1 and APOH were significant decreased in LUAD cell lines and validated in plasma of LUAD patients. …”
Get full text

Mortality Predictors using Chest Computed Tomography Findings in COVID-19 Patients by Ali Yavuz Uzun, Yılmaz Üçüncü, Nur Hürsoy, Fatma Beyazal Çeliker, Zihni Yazıcı

“…Elevated values of white blood cell count (p=0.018), aspartate aminotransferase (p<0.001), lactate dehydrogenase (p<0.001) and C-reactive protein (p<0.001) were found to be associated with high mortality rates. …”
Get full text

REGENERATIVE MEDICINE IN BURN INJURY: A BIBLIOMETRIC ANALYSIS AND LITERATURE REVIEW by Naufal Aminur Rahman, Santi Devina, Muhammad Yusuf Billiant Pradana, Godwin Emeka Ozokolie, Lanre Peter Daodu, Shreya Pandey

“…Researchers primarily focused on four main areas: materials and techniques, injury management, cell-based therapies, and wound healing strategies. …”
Get full text

PRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands by Vasudha Mishra, Alka Singh, Michael Korzinkin, Xiangying Cheng, Claudia Wing, Viktoria Sarkisova, Ashwin L. Koppayi, Alexandra Pogorelskaya, Oksana Glushchenko, Manu Sundaresan, Venkat Thodima, Jack Carter, Koichi Ito, Peggy Scherle, Anna Trzcinska, Ivan Ozerov, Everett E. Vokes, Grayson Cole, Frank W. Pun, Le Shen, Yuxuan Miao, Alexander T. Pearson, Mark W. Lingen, Bruce Ruggeri, Ari J. Rosenberg, Alex Zhavoronkov, Nishant Agrawal, Evgeny Izumchenko

“…Identifying protein arginine methyl transferase 5 (PRMT5) as a putative candidate with the top-scored druggability, we next determined the applicability of PRMT5 inhibitors (PRT543 and PRT811) using ACC cell lines, organoids, and patient derived xenograft (PDX) models. …”
Get full text

Xpert Bladder Cancer Detection in Emergency Setting Assessment (XESA Project): A Prospective, Single-centre Trial by Federica Sordelli, Antonio Desai, Filippo Dagnino, Roberto Contieri, Sofia Giuriolo, Marco Paciotti, Vittorio Fasulo, Stefano Mancon, Davide Maffei, Pier Paolo Avolio, Giorgio Da Rin, Federica Maura, Elena Vanni, Davide Federico, Piergiuseppe Colombo, Giovanni Lughezzani, Nicolò Maria Buffi, Paolo Casale, Alberto Saita, Massiomo Lazzeri, Rodolfo Hurle, Antonio Voza

“…We found that for patients visiting the emergency department because of blood in their urine, use of this test could save time and money over urine cell analysis (UCA) for ruling out or diagnosing bladder cancer. …”
Get full text

Collection of microorganisms of ICG SB RAS as a genetic resource for biotechnology by A. V. Bryanskaya, Y. E. Uvarova, A. S. Rozanov, N. M. Slynko, V. N. Shlyakhtun, K. V. Starostin, E. A. Demidov, E. V. Lazareva, O. P. Taran, S. E. Peltek

“…The particular qualities of growing of strains on different substrates have been established, the study of cell morphology has been carried out. The physiological characteristics of the strains of the collection have been established: the attitude to oxygen, the type of nutrition, the range of temperature and pH, the attitude to NaCl and others. …”
Get full text

Guttiferone K Exerts the Anti-inflammatory Effect on Mycobacterium Tuberculosis- (H37Ra-) Infected Macrophages by Targeting the TLR/IRAK-1 Mediated Akt and NF-κB Pathway by Qingwen Zhang, Jinxia Sun, Yan Fu, Weigang He, Yinhong Li, Hongsheng Tan, Hongxi Xu, Xin Jiang

“…Guttiferone K could also suppress the NLRP3 inflammasome activity and induce autophagy by inhibiting the protein kinase B (p-Akt) and mammalian target of rapamycin (mTOR) phosphorylation at Ser473 and Ser2448 in both cell lines. Thus, Guttiferone K possesses significant anti-inflammatory effect, alleviating Mtb-induced inflammation with an underlying mechanism that targeting on the TLR/IRAK-1 pathway and inhibiting the downstream NF-κB and Akt/mTOR signaling pathways. …”
Get full text

Optimization of the extraction methods and evaluation of the hypoglycemic effect of Adhatoda Zeylanica extracts on artificially induced diabetic mice by Md Fahim Ahmed, Khalid Hasan Raby, Nishat Tasnim, Md Tariful Islam, Mahbub Chowdhury, Zarin Tasnim Juthi, Md Ashik Mia, Lubna Jahan, A.K.M. Zakir Hossain, Shoeb Ahmed

“…Additionally, therapeutic doses of A. zeylanica leaf extract exhibited low cytotoxicity (cell survival rate >89 %), highlighting its potential as a safe and effective source of antidiabetic agent.…”
Get full text

Mechanistic study on the mitigation of cadmium accumulation in Ligusticum sinense cv. Chuanxiong through plant growth-promoting rhizobacteria Arthrobacter sp. CX-2 by Shu-qi Niu, Ting Li, Lin Liu, Xiu-wen Bao, Xing-mao Yang, Hao-ran Song, Yang Li, Jing Bai, Li-ying He, Qing-he Wang, Si-jing Liu, Jin-lin Guo

“…Chuanxiong were not affected by the addition of CX-2, which was confirmed through cell experiments. For rhizosphere soil, CX-2 significantly decreased the exchangeable Cd content by 36.84 % and enhanced the availability of nutrients. …”
Get full text

Melatonin induces drought stress tolerance by regulating the physiological mechanisms, antioxidant enzymes, and leaf structural modifications in Rosa centifolia L by Muhammad Ahsan, Adnan Younis, Aftab Jamal, Mohammed O. Alshaharni, Uthman Balgith Algopishi, Abeer Al-Andal, Mateen Sajid, Muhammad Naeem, Jawad Ahmad Khan, Emanuele Radicetti, Mohammad Valipour, Gulzar Akhtar

“…Furthermore, leaf cortex (51 %), vascular bundle area (76 %), palisade cell area (59 %), and lamina thickness (42 %) were remarkably increased with melatonin foliar sprays in water-deficit plants. …”
Get full text

Differences in soil Cd immobilization and blockage of rice Cd uptake by biochar derived from crop residue and bone − A 2-year field experiment by Zhongjun Xue, Fengfeng Sui, Yanjie Qi, Siyu Pan, Ning Wang, Rongjun Bian, Stephen Joseph, Xuhui Zhang, Lianqing Li, Genxing Pan

“…Higher Si content in rice root in RHB treatment may promote complexation and deposition of Si hemicellulose-bound Cd in the root cell walls. This study reveals the important role of biochar's elemental composition and properties in soil Cd immobilization and the mitigation of rice Cd uptake.…”
Get full text

Integrating machine learning and structure-based approaches for repurposing potent tyrosine protein kinase Src inhibitors to treat inflammatory disorders by Muhammad Waleed Iqbal, Muhammad Shahab, Zakir ullah, Guojun Zheng, Irfan Anjum, Gamal A. Shazly, Atrsaw Asrat Mengistie, Xinxiao Sun, Qipeng Yuan

“…Abstract Tyrosine-protein kinase Src plays a key role in cell proliferation and growth under favorable conditions, but its overexpression and genetic mutations can lead to the progression of various inflammatory diseases. …”
Get full text