Synthesis and antitumor activity of some novel thiophene, pyrimidine, coumarin, pyrazole and pyridine derivatives by Albratty Mohammed, El-Sharkawy Karam Ahmed, Alam Shamsher

“…Some of these compounds showed promising inhibitory effects on three different cell lines. However, fused pyrimidine acetonitrile derivatives 6a and 6b exerted the highest inhibitory effect, comparable to that of doxorubicin.…”
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First Report on Microbial-Derived Polydeoxyribonucleotide: A Sustainable and Enhanced Alternative to Salmon-Based Polydeoxyribonucleotide by Doobyeong Chae, Sae-Woong Oh, Yoon-Seo Choi, Dae-Jung Kang, Chun-Woong Park, Jongsung Lee, Won-Sang Seo

“…In wound-healing assays, L-PDRN demonstrated superior efficacy in promoting cell migration and wound closure, even under inflammatory conditions induced by tumor necrosis factor (TNF-α). …”
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Curcumin nanoparticles alleviate brain mitochondrial dysfunction and cellular senescence in γ-irradiated rats by Omnia A. Moselhy, Nahed Abdel-Aziz, Azza El-bahkery, Said S. Moselhy, Ehab A. Ibrahim

“…Abstract Despite the diverse applications of γ radiation in radiotherapy, industrial processes, and sterilization, it causes hazardous effects on living organisms, such as cellular senescence, persistent cell cycle arrest, and mitochondrial dysfunction. …”
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Enhancing postharvest quality of bananas: comparative study on the use ZnO and Ag2O nanoparticles and ZnO/Ag2O composites by Noluthando Noxolo Aruwajoye, Isaac Adeyemi Sanusi, Gabriel Sanjo Aruwajoye, Asanda Mditshwa, Samson Zeray Tesfay

“…Remarkably, the Ag2O + ZnO composite formulation showed the most significant positive effects on total acidity, pH, and stomatal cell integrity toward improving banana quality. This study highlights the potential of ZnO/Ag2O composites as effective postharvest treatments to enhance banana quality and extend shelf life, providing a promising approach to reduce postharvest losses and ensure fruit quality during storage and transportation.…”
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HACE1 protects against myocardial ischemia–reperfusion injury via inhibition of mitochondrial fission in mice by Bang-Xia Liu, Juan Zheng, Zhan-Wei Tang, Lei Gao, Meng Wang, Ying Sun, Chen Chen, Heng-Chen Yao

“…Conclusion Collectively, our data show that myocardial I/RI is associated with HACE1 downregulation and Drp1 activation, causing cardiomyocytes to undergo cell death. Therefore, HACE1 could be a promising therapeutic target for the treatment of myocardial I/RI.…”
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THE DEVELOPMENT OF SCIENCE AND THE FATE OF A SCIENTIST (FOLLOWING GENETICS) by Jonas Rubikas

“…The beginners and the levels are as follows: 1) G. Mendel, 1865, "The Cell–The Feature"; 2) T. H. Morgan, 1911, "The Chromosome–The Feature"; 3) O. …”
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Prognostic factors for head and neck cancer of unknown primary including the impact of human papilloma virus infection by Lars Axelsson, Jan Nyman, Hedda Haugen-Cange, Mogens Bove, Leif Johansson, Shahin De Lara, Anikó Kovács, Eva Hammerlid

“…The medical records were reviewed, and only patients with squamous cell carcinoma or undifferentiated carcinoma treated with curative intent were included. …”
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Heterogeneity in Fluorescence-Stained Sperm Membrane Patterns and Their Dynamic Changes Towards Fertilization in Mice by Momoka Hirai, Satoshi Kishigami

“…Methods: Sperm were collected from the cauda epididymis or testis of Institute of Cancer Research (ICR) male mice and stained with MemBright dye (commercial name: MemGlow™-560, MG-560), a fluorogenic live-cell membrane probe. Staining was performed either before, during, or after incubation for capacitation. …”
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Enterocyte-like differentiation defines metabolic gene signatures of CMS3 colorectal cancers and provides therapeutic vulnerability by Arezo Torang, Aleksandar B. Kirov, Veerle Lammers, Kate Cameron, Valérie M. Wouters, Rene F. Jackstadt, Tamsin R. M. Lannagan, Joan H. de Jong, Jan Koster, Owen Sansom, Jan Paul Medema

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Role of B7‐H3 in predicting response to neoadjuvant chemotherapy in muscle‐invasive bladder cancer by Ekamjit S. Deol, Reza Nabavizadeh, Roxane R. Lavoie, Mihai G. Dumbrava, Edlira Horjeti, Prabin Thapa, John C. Cheville, Igor Frank, Fabrice Lucien

“…B7‐H3 (CD276), an immune checkpoint overexpressed in various cancers, including urothelial‐cell carcinoma (UCC), has been associated with chemoresistance and poor oncologic outcomes. …”
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Phytochemicals for mitigating the COVID-19 crisis: evidence from pre-clinical and clinical studies by Atri Das, Swarnali Khan, Syamal Roy, Shantanabha Das

“…These findings suggest that multiple phytochemicals can interfere with virus entry and replication inside the host cell. Many of them can protect from cytokine storm by acting on intracellular signalling pathways in addition to inhibiting virus multiplication. …”
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Analysis of oral cancer carcinogens in repeatedly heated cooking oils by Vidhant Krishna Nambiar, Vidya Mudliar, Inosi Salababa

“…The incidence of oral cancer in recent years has been on the rise; ninety percent of the cancers present in the oral cavity are squamous cell carcinoma with multiple major contributing lifestyle factors such well as the presence of the human papilloma virus. …”
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Research hotspots and trends in lung cancer STAS: a bibliometric and visualization analysis by Xiuhua Peng, Hupo Bian, Hongxing Zhao, Dan Jia, Mei Li, Wenhui Li, Pengliang Xu

“…Current research hotspots include deep learning, lung squamous cell carcinoma, and air spaces STAS.ConclusionThe current research on lung cancer STAS primarily focuses on pathological studies, biological mechanisms, prognostic assessments, and preoperative imaging model predictions. …”
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Water-Soluble Vitamins: Hypo- and Hypervitaminosis in Pediatric Population by Roberto Paparella, Fabiola Panvino, Lucia Leonardi, Ida Pucarelli, Michela Menghi, Ginevra Micangeli, Francesca Tarani, Marcello Niceta, Debora Rasio, Rouzha Pancheva, Marco Fiore, Luigi Tarani

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Magnitude, Severity, and Associated Factors of Anemia among Under-Five Children Attending Hawassa University Teaching and Referral Hospital, Hawassa, Southern Ethiopia, 2016 by Yeshimebet Gebereselassie, Mesganaw BirhanSelassie, Tadesse Menjetta, Jemal Alemu, Aster Tsegaye

“…Venous blood samples were collected and analyzed for hemoglobin determination using a Cell-Dyn 1800 automated analyzer. Stool samples were collected and processed using direct wet mount and formol-ether concentration method to detect intestinal parasites. …”
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Adenosine A2A receptor activation is necessary to gate the TrkB-dependent intramuscular nerve sprouting during muscle reinnervation after a nerve crush by Michael Di Palma, Davide Lattanzi, Patrizia Ambrogini, Stefano Sartini

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Phytochemical and toxicological evaluation of aqueous leaf extract of Premna integrifolia L. in male balb/c mice by Suman, Pratibha Gaurav, Rajesh Saini, Kavindra Nath Tiwari, Gautam Geeta Jiwatram

“…The parameters studied included total reactive oxygen species (ROS) production, apoptosis, cell viability percentage, and cellular morphology. …”
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Is Lung Disease a Risk Factor for Sudden Cardiac Death? A Comparative Case–Control Histopathological Study by Ioana Radu, Anca Otilia Farcas, Septimiu Voidazan, Carmen Corina Radu, Klara Brinzaniuc

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Primary and tertiary management of ocular surface lesions in HIV-infected patients in Ehlanzeni, Mpumalanga Province by S Mhlanga, A C Turner, S J Biddulph

“…Fifty percent had carcinoma-in situ and squamous cell carcinoma of the conjunctiva. Thirty-one (50%) of the patients were lost to follow-up. …”
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Prognostic Value of the Preoperative Lymphocyte‐to‐Monocyte Ratio for Postoperative Adverse Events in Patients with Acute Type a Aortic Dissection by Jia L, Wang Y, Wang J, Lin Y, Wang C, Chen C

“…Clinical data, including white blood cell counts (WBCs), D-dimer (D-D) levels, lymphocyte count (LYM) and platelet count (PLT), were compared between the two groups. …”
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