Remote symptom monitoring with patient-reported outcomes and nudges during lung cancer immunotherapy in China (PRO-NET): protocol for a randomised controlled trial by Ping He, Yanan Luo, Zhenyu Shi, Yiqi Xia, Xiaolong Guan

“…Introduction Lung cancer is the leading cause of cancer-related mortality globally, with non-small cell lung cancer (NSCLC) comprising the majority of cases. …”
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Eye removal surgical techniques by M.B. Gushсhina, N.S. Yuzhakova, N.A. Gavrilova, T.S. Kondratenko

“…It was demonstrated that minimal risks of tumor cell dissemination and sympathetic ophthalmia as well as the possibility to perform detailed morphology of excised tissues are the advantages of enucleation. …”
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THE ROLE OF DISPOSITION OF CONNECTING TISSUE IN THE RISE OF NONTRAUMATIC SUBARACHNOIDAL HEMORRHAGE IN YOUNG AGE by E. V. Petrova, T. F. Popova, I. A. Gribacheva, G. K. Taitubayeva

“…Attention was also paid to the presence of visible small vessels on the face, chest and other parts of the body, telangiectasias, angiomas, thoracic cell deformities, scoliosis, flat feet, arachnodactyly, diastase of the rectus abdominis muscles, hernia of the anterior abdominal wall. …”
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Ferroelectric Transistor-Based Synaptic Crossbar Arrays: The Impact of Ferroelectric Thickness and Device-Circuit Interactions by Chunguang Wang, Sumeet Kumar Gupta

“…Offering CMOS compatibility, nonvolatility, compact bit cell, and CiM-amenable features, such as multilevel storage and voltage-driven conductance tuning, FeFETs are among the foremost candidates for synaptic devices. …”
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Evaluation of [Cu]Cu-DOTA and [Cu]Cu-CB-TE2A Chelates for Targeted Positron Emission Tomography with an αβ-Specific Peptide by Sven H. Hausner, David L. Kukis, M. Karen J. Gagnon, Catherine E. Stanecki, Riccardo Ferdani, John F. Marshall, Carolyn J. Anderson, Julie L. Sutcliffe

“…The compounds were evaluated in vitro by enzyme-linked immunosorbent assay (against the integrin α v β 6 and the closely related integrin α v β 6 ) and by cell labeling (α v β 6 -positive DX3puroβ6/α v β 6 -negative DX3puro) and in vivo using micro-positron emission tomography in a mouse model bearing paired DX3puroβ6/Dx3puro xenografts. …”
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Population pharmacokinetics of iruplinalkib in healthy volunteers and patients with solid tumors by Guihong Yang, Yimei Wang, Huimin Zhao, Ziyi Jiang, Shansong Zheng, Mingjing Ge, Meimei Si, Xiaoyan Kang

“…Abstract Iruplinalkib (WX‐0593), a selective oral ALK/ROS1 tyrosine kinase inhibitor, was approved in China as first‐line therapy for ALK‐positive non‐small‐cell lung cancer (NSCLC) and for the treatment of locally advanced or metastatic ALK‐positive NSCLC that has progressed following crizotinib therapy. …”
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Characterization of pathogenic bacteria in eel Anguilla bicolor bicolor by Dinamella Wahjuningrum, Acep Muhamad Hidayat, Tatag Budiardi

“…The observation were colony and cell morphology, physiology, and biochemical characterization of bacteria, hemolysis test, and bacteria identification performed by KIT API 20 E, KIT API 20 Strep, and KIT API 20 Listeria. …”
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Identification of blast resistant finger millet (Eleusine coracana L.) genotype through phenotypic screening and molecular profiling by Isha Ojha, Kamaluddin, Vijay Sharma, Mohd. Tariq, Mukul Jain, Hoshiyar Singh Negi, Mukul Kumar, Shalesh Kumar Singh, Nitin Kumar, Vijay Kumar Kushwaha, Prashant Kaushik, Kirtan Dave

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Dextran sodium sulfate-induced colitis alters the proportion and composition of replicating gut bacteria by Eve T. Beauchemin, Claire Hunter, Corinne F. Maurice

“…Here, we use a recently developed single-cell technique alongside existing metagenomics-based tools to identify, track, and quantify replicating gut bacteria both ex vivo and in situ in the dextran sodium sulfate (DSS) mouse model of colitis. …”
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rAAV1-EGFP和rAAV2-EGFP转染犬骨髓间充质 干细胞的比较

“…【目的】 研究不同血清型腺相关病毒(rAAV)载体介导的增强绿色荧光蛋白基因(EGFP)对体外培养犬骨髓间充质干细胞(MSC)的转染效率及其毒性作用65377;【方法】 应用密度梯度离心法及贴壁筛选法分离培养犬MSC,倒置显微镜及Giemsa染色观察细胞形态,透射电镜观察其超微结构,流式细胞仪鉴定其表面标记物65377;取第3代MSC,以MOI为104 ~ 105 v.g./cell 的rAAV1-EGFP 和rAAV2-EGFP进行转染,3 d65380;7 d65380;21 d后荧光显微镜观察检测转染效率;MTT法检测rAAV1-EGFP 和rAAV2-EGFP对MSC的毒性作用65377; 【结果】 原代及传代培养的MSC呈梭形外观,具有较强的增殖能力65377;MSC超微结构显示其胞体较小,细胞核/浆比例大,胞浆少,染色质较疏松65377;细胞表面抗原CD2965380;CD44表达阳性,CD34表达阴性65377;随MOI的增加及时间的延长,rAAV1-EGFP65380;rAAV2-EGFP对犬MSC的转染效率逐渐增加,rAAV2-EGFP转染效率明显高于rAAV1-EGFP(P < 0.01)65377;转染MSC细胞后,细胞生长正常,MTT法显示各转染组与未转染组的OD值无统计学差异(P > 0.05)65377; 【结论】 相对犬MSC,rAAV2是一种比rAAV1更优越的转基因载体,而且对细胞生长无明显抑制,做为组织工程种子细胞的载体是安全可行的65377;…”
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Jiangzhi Granule Ameliorates JNK-Mediated Mitochondrial Dysfunction to Reduce Lipotoxic Liver Injury in NASH by Jiang Y, Xu J, Ding J, Liu T, Liu Y, Huang P, Wang Q, Zheng P, Song H, Yang L

“…Lipotoxic injury in hepatocytes or mice liver tissues, as well as JNK signaling-related molecules, were further investigated.Results: JZG improved PA-induced lipid deposition, cell viability, apoptosis, and mitochondrial dysfunction in hepatocytes. …”
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Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening by Hengrui Liu, Arie Zask, Farhad Forouhar, Sho Iketani, Alana Williams, Daniel R. Vaz, Dahlya Habashi, Karenna Choi, Samuel J. Resnick, Seo Jung Hong, David H. Lovett, Tian Bai, Alejandro Chavez, David D. Ho, Brent R. Stockwell

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Targeting Nrf2/KEAP1 signaling pathway using bioactive compounds to combat mastitis by Muhammad Zahoor Khan, Liangliang Li, Yandong Zhan, Huang Binjiang, Xiaotong Liu, Xiyan Kou, Adnan Khan, Abdul Qadeer, Qudrat Ullah, Khalid J. Alzahrani, Tongtong Wang, Changfa Wang, Muhammad Zahoor

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Assessment of Microbiological Indoor Air Quality in Cattle Breeding Farms by Justyna Szulc, Małgorzata Okrasa, Katarzyna Dybka-Stępień, Michael Sulyok, Adriana Nowak, Anna Otlewska, Bogumiła Szponar, Katarzyna Majchrzycka

“…In addition, the cytotoxicity of the dust to the human epithelial lung cell line was determined by using the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay. …”
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Innovative Solid Lipid Nanoparticle-Enriched Hydrogels for Enhanced Topical Delivery of L-Glutathione: A Novel Approach to Anti-Ageing by Mengyang Liu, Manisha Sharma, Guoliang Lu, Zhiwen Zhang, Wenting Song, Jingyuan Wen

“…The hydrogel significantly improved antioxidant capacity, protecting human fibroblasts from UVA-induced oxidative stress and enhancing cell viability. Stability studies indicated that 4 °C was optimal for storage over three months. …”
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Tyrosine hydroxylase of the brain and it’s regulation by glucocorticoids by E. V. Sukhareva, T. S. Kalinina, V. V. Bulygina, N. N. Dygalo

“…Furthermore, as has been shown recently, the GRE / AP-1 composite site is the major site of interaction of glucocorticoids with  the TH gene in the pheochromocytoma cell line. Ontogenetic variation in the expression of Fos and Jun family proteins, which affects their ratio, can be one of the reasons for the TH gene regulation by glucocorticoids at near-term fetuses and neonates. …”
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Ghrelin通过JNK信号通路抑制LPS诱导的肺泡巨噬细胞凋亡

“…【目的】 观察体外条件下加入外源性ghrelin对内毒素(LPS)诱导大鼠肺泡巨噬细胞NR8383凋亡以及吞噬能力的影响,并探讨JNK(c-Jun N-terminal kinase)信号通路在其中所起的作用? 【方法】 用CCK-8(Cell Counting Kit-8)法检测加入LPS或者ghrelin与LPS共孵育后NR8383的细胞毒性;流式细胞技术?…”
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A complex case of right heart masses in a leukemia patient: a case report by Xiaoning Wang, Mahsa Fatahichegeni, Mohammad Amin Ansarian, Seifollah Ranjbarha, Juan Ren

“…During medical check-ups before allogeneic hematopoietic stem cell transplant (allo-HSCT), cardiac ultrasound revealed several mobile and homogenous masses of unidentified nature in his right atrium and right ventricle. …”
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SECONDARY PROPHYLAXIS OF VENOUS THROMBOEMBOLISM (VTE) WITH LOW DOSE APIXABAN OR RIVAROXABAN: RESULTS FROM A PATIENT POPULATION WITH MORE THAN 2 YEARS OF MEDIAN FOLLOW-UP by Alessandro Laganà, Giovanni Manfredi Assanto, Chiara Masucci, Mauro Passucci, Livia Donzelli, Alessandra Serrao, Erminia Baldacci, Cristina Santoro, Antonio Chistolini

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A Microflow Chip Technique for Monitoring Platelets in Late Pregnancy: A Possible Risk Factor for Thrombosis by He C, Ma H, Zhang T, Liu Y, Zhang C, Deng S

“…Flow cytometry was used to analyse the effect of shear rate induction on the expression of platelet membrane surface fibrin receptor (PAC-1) and P-selectin (CD62P) in pregnant women.Results: Compared to the non-pregnant healthy control group, the white blood cell count increased and platelet count decreased significantly in late pregnant women (P < 0.05), and platelet reactivity to agonists increased under non-flow conditions (adhesion and aggregation rates, P < 0.05). …”
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