Disparities in stage at diagnosis of head and neck tumours in Brazil: a comprehensive analysis of hospital-based cancer registriesResearch in context by Flávia Nascimento de Carvalho, Marianna de Camargo Cancela, Luciano Mesentier da Costa, Luís Felipe Leite Martins, Fernando Luiz Dias, Dyego Leandro Bezerra de Souza, Luis Felipe Ribeiro Pinto

“…Head and neck squamous cell carcinomas (HNSCC) are highly incident in Brazil, but similarly to many Low and Middle-Income Countries, data is limited regarding the proportion of tumours diagnosed at advanced clinical stages and the main factors associated with it. …”
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Complete Genome Sequence of Photobacterium damselae Subsp. damselae Strain SSPD1601 Isolated from Deep-Sea Cage-Cultured Sebastes schlegelii with Septic Skin Ulcer by Yongxiang Yu, Zheng Zhang, Yingeng Wang, Meijie Liao, Xiaojun Rong, Bin Li, Kai Wang, Jing Chen, Hao Zhang

“…The results revealed that PDD strain SSPD1601 is a rod-shaped cell with a single polar flagellum, and the clinical symptoms were replicated during artificial infection. …”
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Transcriptomics-based analysis of neurotoxic and reproductive effects in turbot (Scophthalmus maximus) after exposure to tris (2-chloroethyl) phosphate (TCEP) by Xiaoqian Zhou, Weifeng Liu, Bailin Cong, Aifang Deng, Jing Lin, Linlin Zhao, Shenghao Liu

“…Among these genes, those encoding the components of the electron transport chain presented an initial increase in expression followed by a decrease, indicating that TCEP stress might affect mitochondrial function and lead to cell damage. This finding was also supported by the upregulation of apoptosis-related gene expression. …”
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Distinct Murine Pancreatic Transcriptomic Signatures during Chronic Pancreatitis Recovery by Yinjie Zhang, Baibing Yang, Joy M. Davis, Madeline M. Drake, Mamoun Younes, Qiang Shen, Zhongming Zhao, Yanna Cao, Tien C. Ko

“…In conclusion, we identified a distinct set of DEGs in association with extracellular matrix and cancer cell activities to contrast CP and CPR. Once during ongoing CP recovery, DEGs relevant to DNA methylation and specific signaling pathways were induced to express. …”
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Clinical and biochemical characteristics for patients with polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome: a pilot observational study by Pei Li, Ye Zhang, Li-Min Luo, Wen-Qing Wang, Jing Li, Yan Cheng, Xiao Dang, Yang Chen, Wei Jiang

“…BackgroundPolyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is rare life-threatening condition associated with a clonal plasma cell neoplasm.ObjectiveThe aim of this study is to investigate the clinical and biochemical features in patients with POEMS syndrome before and post-therapy.MethodsCharacteristics of demographic information, underlying diseases, clinical manifestations, laboratory indicators, and imaging examination were retrospectively collected when diagnosed and post-therapy in the patients POEMS syndrome between 2018 and 2024.ResultsNineteen newly-diagnosed, treatment-naïve patients with POEMS syndrome were enrolled. …”
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Computer-assisted discovery of natural inhibitors for platelet-derived growth factor alpha as novel therapeutics for thyroid cancer by Hira Khalid, Farah Sattar, Iqra Ahmad, Valdir Ferreira de Paula Junior, Valdir Ferreira de Paula Junior, Umar Nishan, Umar Nishan, Riaz Ullah, Hanna Dib, Khaled W. Omari, Mohibullah Shah, Mohibullah Shah

“…PDGFRA expression boosts thyroid cancer cell proliferation and metastasis. Radiorefractory thyroid cancer is poorly differentiated, very aggressive, and resistant to radioiodine therapy. …”
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Clinical Effect and Rotational Stability of TICL in the Treatment of Myopic Astigmatism by Manhui Zhu, Linling Zhu, Qiujian Zhu, Cailian Xu, Peng Yu, Haiyang Xiao, Ying Wang, You Yuan

“…The uncorrected and best-corrected visual acuity (UCVA and BCVA), astigmatism and spherical equivalent, intraocular pressure, vault, endothelial cell morphometry, and rotation of the TICL axis were assessed at l day, 1 week, 1 month, 3 months, 6 months, and 12 months postoperatively. …”
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Genetically predicted brain cortical structure mediates the causality between insulin resistance and cognitive impairment by Chaojuan Huang, Yuyang Zhang, Mingxu Li, Qiuju Gong, Siqi Yu, Zhiwei Li, Mengmeng Ren, Xia Zhou, Xiaoqun Zhu, Zhongwu Sun

“…Our investigation aims to establish the causal relationship and direction between insulin resistance and cognition, while also quantifying the mediating role of brain cortical structure in this association.MethodsThe publicly available data sources for insulin resistance (fasting insulin, homeostasis model assessment beta-cell function and homeostasis model assessment insulin resistance, proinsulin), brain cortical structure, and cognitive phenotypes (visual memory, reaction time) were obtained from the MAGIC, ENIGMA, and UK Biobank datasets, respectively. …”
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A human acellular dermal matrix coated with zinc oxide nanoparticles accelerates tendon repair in patients with hand flexor tendon injuries in zone 5 of the hand by Seyedeh-Sara Hashemi, Mohsen Pirmoradi, Alireza Rafati, Mehdi Kian, Ali Akbar Mohammadi, Mohamad Ali Hoghoughi

“…Methods: Morphological, mechanical, cell viability, and antibacterial tests were performed to evaluate the physical and biological properties of the fabricated ADM/ZnO-NPs graft. …”
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Ferroptosis in kidney disease: a bibliometric analysis from 2012 to 2024 by Yuxin Hu, Yuxin Hu, Yuxin Hu, Jingyi Tang, Jingyi Tang, Jingyi Tang, Hanzhang Hong, Hanzhang Hong, Yexin Chen, Yexin Chen, Beibei Ye, Ziheng Gao, Ziheng Gao, Gegongming Zhu, Lin Wang, Lin Wang, Lin Wang, Weijing Liu, Weijing Liu, Weijing Liu, Yaoxian Wang, Yaoxian Wang, Yaoxian Wang

“…Background and aimsFerroptosis, a novel concept of programmed cell death proposed in 2012, in kidney disease, has garnered significant attention based on evidence of abnormal iron deposition and lipid peroxidation damage in the kidney. …”
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Using machine learning to predict patients with polycystic ovary disease in Chinese women by Chen-Yu Wang, Dee Pei, Chun-Kai Wang, Jyun-Cheng Ke, Siou-Ting Lee, Ta-Wei Chu, Yao-Jen Liang

“…Finally, age, TG, GPT, white blood cell count (WBC), uric acid (UA), and platelet (Plt) were the six most important risk factors selected by Mach-L. …”
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How Do the Four Core Factors of High Entropy Affect the Electrochemical Properties of Energy‐Storage Materials? by Wenze Wang, Qian Zhang, Liting Yang, Guisheng Liang, Xuhui Xiong, Yifeng Cheng, Limin Wu, Chunfu Lin, Renchao Che

“…The lattice distortion in HE‐LaNb3O9 leads to its decreased unit‐cell‐volume variations, which benefits its cyclability. …”
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Concentration-dependent interactive toxicity of cadmium and mercury: Non-negligible effects on phytoremediation by indigenous Artemisia lavandulaefolia by Gangyang Zhang, Guo Chen, Rui Yang, Chunlian Bai, Weiyuhao Yang, Juan Zhang, Xuyang Yin, Fang Yang, Chandra Shekhar Seth, Haitao Liu

“…Furthermore, the elevation of Cd in the solution increased the proportion of Hg in the cell walls to 31.5 %; however, increasing the Hg dose did not change the Cd concentration in this substructure. …”
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Biomarker combinations from different modalities predict early disability accumulation in multiple sclerosis by Vinzenz Fleischer, Tobias Brummer, Muthuraman Muthuraman, Muthuraman Muthuraman, Falk Steffen, Milena Heldt, Maria Protopapa, Muriel Schraad, Gabriel Gonzalez-Escamilla, Sergiu Groppa, Stefan Bittner, Frauke Zipp

“…Two key measures from each modality were determined and related to subsequent disability progression: lesion volume (LV), gray matter volume (GMV), retinal nerve fiber layer, ganglion cell-inner plexiform layer, serum neurofilament light chain (sNfL) and serum glial fibrillary acidic protein. …”
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Does tocilizumab eliminate inflammation in GCA? A cohort study on repeated temporal artery biopsies by Chiara Marvisi, Francesco Muratore, Carlo Salvarani, Pierluigi Macchioni, Pamela Mancuso, Luigi Boiardi, Stefania Croci, Paolo Giorgi Rossi, Alberto Cavazza, Annibale Versari, Rexhep Durmo, Caterina Ricordi, Martina Bonacini, Giuseppe Malchiodi

“…Background Vascular inflammation persists in temporal artery biopsy (TAB) of giant cell arteritis (GCA) patients even after prolonged glucocorticoid (GC) therapy. …”
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Investigation of Coolant Local Hydrodynamics in the Mixed Core of the VVER Reactor by S. M. Dmitriev, A. V. Gerasimov, A. A. Dobrov, D. V. Doronkov, A. N. Pronin, A. V. Ryazanov, D. N. Solntsev, A. E. Khrobostov

“…The results of the study of the coolant cross flow between fuel assemblies interaction, i.e. between the adjacent TVSA-T and TVSA-T mod.2 fuel assemblies were adopted for practical use in the JSC of “Afrikantov OKB Mechanical Engineering” for assessing the heat engineering reliability of VVER reactor cores; also, they were included in the database for verification of computational hydrodynamics programs (CFD codes) and for detailed cell-based calculation of the reactor core.…”
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Preparation and Electrochemical Characterization of Y-Doped Li_1.3Al_0.3Ti_1.7(PO₄)₃ Solid Electrolytes for Lithium-Metal Batter... by Zhongran Yao, Fen Qi, Qiang Sun, Lin Ye, Xiaowei Yang, Guojie Chao, Pei Tang, Kongjun Zhu

“…When paired with the NCM811 cathode, the Li/LAYTP-0.03/NCM811 cell exhibited outstanding electrochemical performance: a high capacity of 155 mAh/g was achieved at 0.2C after 50 cycles with a Coulombic efficiency of approximately 100%, indicating highly reversible lithium plating/stripping facilitated by the LAYTP-0.03 electrolyte. …”
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S6P mutation in Delta and Omicron variant spike protein significantly enhances the efficacy of mRNA COVID-19 vaccines by Yong-Sik Bong, David Brown, Ezra Chung, Neeti Ananthaswamy, Renxiang Chen, Renxiang Chen, Evan Lewoczko, William Sabbers, Athéna C. Patterson-Orazem, Zachary Dorsey, Yiqing Zou, Xue Yu, Jiening Liang, Jiaxi He, Steven Long, Dong Shen

“…Additionally, the effectiveness of RV-1730 as a heterologous booster following primary vaccination with BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna-NIAID) was assessed.ResultsRV-1730 elicited significantly stronger B and T cell responses and more durable neutralizing antibodies compared to S2P-based vaccines. …”
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Reactogenicity and Immunogenicity Against MPXV of the Intradermal Administration of Modified Vaccinia Ankara Compared to the Standard Subcutaneous Route by Valentina Mazzotta, Pierluca Piselli, Alessandro Cozzi Lepri, Giulia Matusali, Eleonora Cimini, Rozenn Esvan, Francesca Colavita, Roberta Gagliardini, Stefania Notari, Alessandra Oliva, Silvia Meschi, Rita Casetti, Giulia Micheli, Licia Bordi, Alessandro Giacinta, Germana Grassi, Saba Gebremeskel Tekle, Claudia Cimaglia, Jessica Paulicelli, Alessandro Caioli, Paola Gallì, Giulia Del Duca, Miriam Lichtner, Loredana Sarmati, Enrica Tamburrini, Claudio Mastroianni, Alessandra Latini, Paolo Faccendini, Carla Fontana, Emanuele Nicastri, Andrea Siddu, Alessandra Barca, Francesco Vaia, Enrico Girardi, Fabrizio Maggi, Andrea Antinori

“…Moreover, no data are available on the T-cell response elicited by MVA-BN administered subcutaneously or intradermally. …”
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Molecular Characterization of the Tumor Suppressor Candidate 5 Gene: Regulation by PPARγ and Identification of TUSC5 Coding Variants in Lean and Obese Humans by Trina A. Knotts, Hyun Woo Lee, Jae Bum Kim, Pieter J. Oort, Ruth McPherson, Robert Dent, Keisuke Tachibana, Takefumi Doi, Songtao Yu, Janardan K. Reddy, Kenji Uno, Hideki Katagiri, Magdalena Pasarica, Steven R. Smith, Dorothy D. Sears, Michel Grino, Sean H. Adams

“…Strong adipocyte expression and increased expression following peroxisome proliferator activated receptor γ (PPARγ) agonist treatment of 3T3-L1 adipocytes suggested a role for Tusc5 in fat cell proliferation and/or metabolism. However, the regulation of Tusc5 in WAT and its potential association with obesity phenotypes remain unclear. …”
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